{"entity": "researcher", "timestamp": "2026-09-23T16:46:04.815Z", "family": "Paulin", "given": "Cynthia B J", "initials": "CBJ", "orcid": "0000-0002-5698-7962", "affiliations": ["Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/8290bdaf864c4f7980ce2b5637897653.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/8290bdaf864c4f7980ce2b5637897653"}}, "publications": [{"entity": "publication", "iuid": "a23049ab7358499e961c8b95b86b483a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a23049ab7358499e961c8b95b86b483a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a23049ab7358499e961c8b95b86b483a"}}, "title": "Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.", "authors": [{"family": "Visnes", "given": "Torkild", "initials": "T", "orcid": "0000-0003-1047-988X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9fef10d6a8604971a6ad1849b9f8b029.json"}}, {"family": "C\u00e1zares-K\u00f6rner", "given": "Armando", "initials": "A", "orcid": "0000-0003-0765-3787", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8ba54907c24343e1b604095523ceea78.json"}}, {"family": "Hao", "given": "Wenjing", "initials": "W", "orcid": "0000-0002-8487-5968", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a208bb26ff04b32a2903dbd2311a530.json"}}, {"family": "Wallner", "given": "Olov", "initials": "O", "orcid": "0000-0002-6481-237X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3601a5a4d88f4452b6d1ac5f22c79d9f.json"}}, {"family": "Masuyer", "given": "Geoffrey", "initials": "G", "orcid": "0000-0002-9527-2310", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c62ba219d3e34662aaa458dbd361cf31.json"}}, {"family": "Loseva", "given": "Olga", "initials": "O"}, {"family": "Mortusewicz", "given": "Oliver", "initials": "O"}, {"family": "Wiita", "given": "Elis\u00e9e", "initials": "E"}, {"family": "Sarno", "given": "Antonio", "initials": "A", "orcid": "0000-0002-9308-8018", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22883e442f534ba99f2917cf45d95b3d.json"}}, {"family": "Manoilov", "given": "Aleksandr", "initials": "A"}, {"family": "Astorga-Wells", "given": "Juan", "initials": "J", "orcid": "0000-0003-1017-8841", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/855ef6e5db6f4791a52eeae9ffb95a30.json"}}, {"family": "Jemth", "given": "Ann-Sofie", "initials": "AS"}, {"family": "Pan", "given": "Lang", "initials": "L"}, {"family": "Sanjiv", "given": "Kumar", "initials": "K"}, {"family": "Karsten", "given": "Stella", "initials": "S", "orcid": "0000-0001-6191-4314", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a27ec21e4a34600aa24a7213372e19c.json"}}, {"family": "Gokturk", "given": "Camilla", "initials": "C"}, {"family": "Grube", "given": "Maurice", "initials": "M"}, {"family": "Homan", "given": "Evert J", "initials": "EJ"}, {"family": "Hanna", "given": "Bishoy M F", "initials": "BMF", "orcid": "0000-0001-7027-6553", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/61301102836e44d189f5628bb33c1335.json"}}, {"family": "Paulin", "given": "Cynthia B J", "initials": "CBJ", "orcid": "0000-0002-5698-7962", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8290bdaf864c4f7980ce2b5637897653.json"}}, {"family": "Pham", "given": "Therese", "initials": "T"}, {"family": "Rasti", "given": "Azita", "initials": "A"}, {"family": "Berglund", "given": "Ulrika Warpman", "initials": "UW"}, {"family": "von Nicolai", "given": "Catharina", "initials": "C"}, {"family": "Benitez-Buelga", "given": "Carlos", "initials": "C"}, {"family": "Koolmeister", "given": "Tobias", "initials": "T"}, {"family": "Ivanic", "given": "Dag", "initials": "D", "orcid": "0000-0002-6052-2236", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/537e93ab027c4287bbe06df648ef5e74.json"}}, {"family": "Iliev", "given": "Petar", "initials": "P", "orcid": "0000-0002-3905-9814", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88791a216afa4eee80e5b0dfdd851d6f.json"}}, {"family": "Scobie", "given": "Martin", "initials": "M", "orcid": "0000-0002-7073-8495", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bdce0df415d54e9d84a4fcbb4d1350e5.json"}}, {"family": "Krokan", "given": "Hans E", "initials": "HE"}, {"family": "Baranczewski", "given": "Pawel", "initials": "P"}, {"family": "Artursson", "given": "Per", "initials": "P", "orcid": "0000-0002-3708-7395", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9908209a413a4088b6bf44a924d27319.json"}}, {"family": "Altun", "given": "Mikael", "initials": "M"}, {"family": "Jensen", "given": "Annika Jenmalm", "initials": "AJ"}, {"family": "Kalder\u00e9n", "given": "Christina", "initials": "C"}, {"family": "Ba", "given": "Xueqing", "initials": "X", "orcid": "0000-0002-1075-5496", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e75bc54b28c54cbc9b4a3c0856aefedf.json"}}, {"family": "Zubarev", "given": "Roman A", "initials": "RA", "orcid": "0000-0001-9839-2089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e3f9910c1ff434c8056bdecf537e9ef.json"}}, {"family": "Stenmark", "given": "P\u00e5l", "initials": "P", "orcid": "0000-0003-4777-3417", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9791bc0d7463417899d6953b5ca1bac3.json"}}, {"family": "Boldogh", "given": "Istvan", "initials": "I"}, {"family": "Helleday", "given": "Thomas", "initials": "T", "orcid": "0000-0002-7384-092X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/385586c159494955a9a72c3381e3ad47.json"}}], "type": "journal article", "published": "2018-11-16", "journal": {"title": "Science (New York, N.Y.)", "issn": "1095-9203", "volume": "362", "issue": "6416", "pages": "834-839", "issn-l": "0036-8075"}, "abstract": "The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because Ogg1-deficient mice are resistant to acute and systemic inflammation, we hypothesized that OGG1 inhibition may represent a strategy for the prevention and treatment of inflammation. We developed TH5487, a selective active-site inhibitor of OGG1, which hampers OGG1 binding to and repair of 8-oxoG and which is well tolerated by mice. TH5487 prevents tumor necrosis factor-\u03b1-induced OGG1-DNA interactions at guanine-rich promoters of proinflammatory genes. This, in turn, decreases DNA occupancy of nuclear factor \u03baB and proinflammatory gene expression, resulting in decreased immune cell recruitment to mouse lungs. Thus, we present a proof of concept that targeting oxidative DNA repair can alleviate inflammatory conditions in vivo.", "doi": "10.1126/science.aar8048", "pmid": "30442810", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1026297"}, {"db": "pmc", "key": "PMC6645780"}, {"db": "pii", "key": "362/6416/834"}], "notes": [], "created": "2026-09-23T06:41:55.642Z", "modified": "2026-09-23T06:41:55.991Z"}, {"entity": "publication", "iuid": "4e7debb35f57425da4e3cf79bac1f78d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4e7debb35f57425da4e3cf79bac1f78d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4e7debb35f57425da4e3cf79bac1f78d"}}, "title": "SAMHD1 protects cancer cells from various nucleoside-based antimetabolites.", "authors": [{"family": "Herold", "given": "Nikolas", "initials": "N", "orcid": "0000-0001-9468-4543", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/749eedaa5f69414aa315bb875eef9475.json"}}, {"family": "Rudd", "given": "Sean G", "initials": "SG", "orcid": "0000-0002-4368-3855", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d65643e96cfe4f3a98cf4f48225eac73.json"}}, {"family": "Sanjiv", "given": "Kumar", "initials": "K"}, {"family": "Kutzner", "given": "Juliane", "initials": "J"}, {"family": "Bladh", "given": "Julia", "initials": "J", "orcid": "0000-0003-1019-8957", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/af57a1dcf9cb444c86a3694c24b5cf22.json"}}, {"family": "Paulin", "given": "Cynthia B J", "initials": "CBJ", "orcid": "0000-0002-5698-7962", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8290bdaf864c4f7980ce2b5637897653.json"}}, {"family": "Helleday", "given": "Thomas", "initials": "T"}, {"family": "Henter", "given": "Jan-Inge", "initials": "JI"}, {"family": "Schaller", "given": "Torsten", "initials": "T", "orcid": "0000-0001-9597-4112", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/93d3003ec7854be68f4e38283bca1da0.json"}}], "type": "journal article", "published": "2017-06-03", "journal": {"title": "Cell Cycle", "issn": "1551-4005", "volume": "16", "issue": "11", "pages": "1029-1038", "issn-l": null}, "abstract": "Recently, we demonstrated that sterile \u03b1 motif and HD domain containing protein 1 (SAMHD1) is a major barrier in acute myelogenous leukemia (AML) cells to the cytotoxicity of cytarabine (ara-C), the most important drug in AML treatment. Ara-C is intracellularly converted by the canonical dNTP synthesis pathway to ara-CTP, which serves as a substrate but not an allosteric activator of SAMHD1. Using an AML mouse model, we show here that wild type but not catalytically inactive SAMHD1 reduces ara-C treatment efficacy in vivo. Expanding the clinically relevant substrates of SAMHD1, we demonstrate that THP-1 CRISPR/Cas9 cells lacking a functional SAMHD1 gene showed increased sensitivity to the antimetabolites nelarabine, fludarabine, decitabine, vidarabine, clofarabine, and trifluridine. Within this Extra View, we discuss and build upon both these and our previously reported findings, and propose SAMHD1 is likely active against a variety of nucleoside analog antimetabolites present in anti-cancer chemotherapies. Thus, SAMHD1 may constitute a promising target to improve a wide range of therapies for both hematological and non-haematological malignancies.", "doi": "10.1080/15384101.2017.1314407", "pmid": "28436707", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5499833"}], "notes": [], "created": "2018-12-05T12:11:12.468Z", "modified": "2026-09-23T13:41:26.564Z"}]}