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"given": "Yuri", "initials": "Y", "orcid": "0000-0002-3697-6617", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ee9d6f30cdd4d958872963c64cbe867.json"}}, {"family": "Marten", "given": "Jonathan", "initials": "J"}, {"family": "Wright", "given": "Alan", "initials": "A"}, {"family": "Zeggini", "given": "Eleftheria", "initials": "E", "orcid": "0000-0003-4238-659X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/94df27518bb34428a8b1f8f2b278d778.json"}}, {"family": "Howson", "given": "Joanna M M", "initials": "JMM", "orcid": "0000-0001-7618-0050", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a1dcd9d189da4d758df6a936d69cc5f6.json"}}, {"family": "O'Donnell", "given": "Christopher J", "initials": "CJ"}, {"family": "Spector", "given": "Tim", "initials": "T", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d79b7af2d7a4f1da46ac2ee2bb1eb0b.json"}}, {"family": "Nalls", "given": "Mike A", "initials": "MA", "orcid": "0000-0003-0319-4325", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/31da8ffb43154866ac25f1fec623ba74.json"}}, {"family": "Simonsick", "given": "Eleanor M", "initials": "EM"}, {"family": "Liu", "given": "Yongmei", "initials": "Y"}, {"family": "van Duijn", "given": "Cornelia M", "initials": "CM", "orcid": "0000-0002-2374-9204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f80ecaf200f24b4092c9a6ed77dfff8d.json"}}, {"family": "Butterworth", "given": "Adam S", "initials": "AS", "orcid": "0000-0002-6915-9015", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88842023860148bb8d155b5c18db72a8.json"}}, {"family": "Danesh", "given": "John N", "initials": "JN"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0996382f79af42938451d690a140a079.json"}}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0003-1422-2993", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/462fd4169f41418887a5a979e0808d87.json"}}, {"family": "Khaw", "given": "Kay-Tee", "initials": "KT"}, {"family": "Sun", "given": "Yan V", "initials": "YV", "orcid": "0000-0002-2838-1824", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60b03d484f0c4acb93802ce6e6048a10.json"}}, {"family": "Wilson", "given": "Peter W F", "initials": "PWF", "orcid": "0000-0002-5653-7056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e2fa5a1fb3634b88b3a50c4d31bd3a33.json"}}, {"family": "Cho", "given": "Kelly", "initials": "K"}, {"family": "Visscher", "given": "Peter M", "initials": "PM", "orcid": "0000-0002-2143-8760", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9232be0ea244fb7ab43593e04265c2e.json"}}, {"family": "Denny", "given": "Joshua C", "initials": "JC", "orcid": "0000-0002-3049-7332", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee3b66f9be524dfdb2d95834abad0cbf.json"}}, {"family": "Million Veteran Program", "given": "", "initials": ""}, {"family": "Lifelines Cohort Study", "given": "", "initials": ""}, {"family": "CHARGE consortium", "given": "", "initials": ""}, {"family": "ICBP Consortium", "given": "", "initials": ""}, {"family": "Levy", "given": "Daniel", "initials": "D"}, {"family": "Edwards", "given": "Todd L", "initials": "TL", "orcid": "0000-0003-4318-6119", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8c555d3f6704b69821f39dcac8984d5.json"}}, {"family": "Munroe", "given": "Patricia B", "initials": "PB", "orcid": "0000-0002-4176-2947", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e956b6f17a64fb4b478dbc59950a790.json"}}, {"family": "Snieder", "given": "Harold", "initials": "H", "orcid": "0000-0003-1949-2298", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb5a2135b774429596606e980c9268ec.json"}}, {"family": "Warren", "given": "Helen R", "initials": "HR", "orcid": "0000-0003-0511-1386", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d44ccb685e4b4a4894b8cba8c74333ff.json"}}], "type": "journal article", "published": "2024-05-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "56", "issue": "5", "pages": "778-791", "issn-l": "1061-4036"}, "abstract": "Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 \u00d7 10-8) from the largest single-stage blood pressure (BP) genome-wide association study to date (n = 1,028,980 European individuals). These associations explain more than 60% of single nucleotide polymorphism-based BP heritability. Comparing top versus bottom deciles of polygenic risk scores (PRSs) reveals clinically meaningful differences in BP (16.9 mmHg systolic BP, 95% CI, 15.5-18.2 mmHg, P = 2.22 \u00d7 10-126) and more than a sevenfold higher odds of hypertension risk (odds ratio, 7.33; 95% CI, 5.54-9.70; P = 4.13 \u00d7 10-44) in an independent dataset. Adding PRS into hypertension-prediction models increased the area under the receiver operating characteristic curve (AUROC) from 0.791 (95% CI, 0.781-0.801) to 0.826 (95% CI, 0.817-0.836, \u2206AUROC, 0.035, P = 1.98 \u00d7 10-34). We compare the 2,103 loci results in non-European ancestries and show significant PRS associations in a large African-American sample. Secondary analyses implicate 500 genes previously unreported for BP. Our study highlights the role of increasingly large genomic studies for precision health research.", "doi": "10.1038/s41588-024-01714-w", "pmid": "38689001", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11096100"}, {"db": "pii", "key": "10.1038/s41588-024-01714-w"}], "notes": [], "created": "2026-08-20T09:00:02.525Z", "modified": "2026-08-20T09:00:03.969Z"}, {"entity": "publication", "iuid": "97dcb877641d4da1b812ef995b72d5d3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/97dcb877641d4da1b812ef995b72d5d3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/97dcb877641d4da1b812ef995b72d5d3"}}, "title": "Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits.", "authors": [{"family": "Brown", "given": "Andrew A", "initials": "AA", "orcid": "0000-0002-8087-3033", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b690d27df56b44dc8a070e4265afc8ca.json"}}, {"family": "Fernandez-Tajes", "given": "Juan J", "initials": "JJ"}, {"family": "Hong", "given": "Mun-Gwan", "initials": "MG", "orcid": "0000-0001-8603-8293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d12504acae5c4f31b83f75c3d7786cd4.json"}}, {"family": "Brorsson", "given": "Caroline A", "initials": "CA"}, {"family": "Koivula", "given": "Robert W", "initials": "RW"}, {"family": "Davtian", "given": "David", "initials": "D"}, {"family": "Dupuis", "given": "Th\u00e9o", "initials": "T"}, {"family": "Sartori", "given": "Ambra", "initials": "A"}, {"family": "Michalettou", "given": "Theodora-Dafni", "initials": "TD", "orcid": "0000-0003-2119-1099", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f0a44cd4ea604ce4a93b16870965dcc2.json"}}, {"family": "Forgie", "given": "Ian M", "initials": "IM"}, {"family": "Adam", "given": "Jonathan", "initials": "J"}, {"family": "Allin", "given": "Kristine H", "initials": "KH"}, {"family": "Caiazzo", "given": "Robert", "initials": "R", "orcid": "0000-0001-5383-0540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/155b9c8799064e04be5118147542a25c.json"}}, {"family": "Cederberg", "given": "Henna", "initials": "H"}, {"family": "De Masi", "given": "Federico", "initials": "F"}, {"family": "Elders", "given": "Petra J M", "initials": "PJM"}, {"family": "Giordano", "given": "Giuseppe N", "initials": "GN", "orcid": "0000-0002-6719-6680", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dc30138be60e49d481bfc5f03a8fe61f.json"}}, {"family": "Haid", "given": "Mark", "initials": "M", "orcid": "0000-0001-6118-1333", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c4398da6ddb245bdb982ac3a0b352c40.json"}}, {"family": "Hansen", "given": "Torben", "initials": "T", "orcid": "0000-0001-8748-3831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e9a365eccb44b28b293c7decc6f4b9f.json"}}, {"family": "Hansen", "given": "Tue H", "initials": "TH", "orcid": "0000-0001-5948-8993", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73418e2efdc1459483138da74b0abad6.json"}}, {"family": "Hattersley", "given": "Andrew T", "initials": "AT", "orcid": "0000-0001-5620-473X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dfbb9bb951f04ed3ac56eb4890d3186a.json"}}, {"family": "Heggie", "given": "Alison J", "initials": "AJ"}, {"family": "Howald", "given": "C\u00e9dric", "initials": "C"}, {"family": "Jones", "given": "Angus G", "initials": "AG", "orcid": "0000-0002-0883-7599", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb98d0951469460d8e87bbd7e71741db.json"}}, {"family": "Kokkola", "given": "Tarja", "initials": "T", "orcid": "0000-0002-3303-3912", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc389880431a46e49fcbe0eae12908ea.json"}}, {"family": "Laakso", "given": "Markku", "initials": "M", "orcid": "0000-0002-3394-7749", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81c631c24b2e4c479ac6976eab7b1e88.json"}}, {"family": "Mahajan", "given": "Anubha", "initials": "A"}, {"family": "Mari", "given": "Andrea", "initials": "A", "orcid": "0000-0002-1436-5591", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b7dd1ab06074d1188e40713d8807c48.json"}}, {"family": "McDonald", "given": "Timothy J", "initials": "TJ"}, {"family": "McEvoy", "given": "Donna", "initials": "D"}, {"family": "Mourby", "given": "Miranda", "initials": "M"}, {"family": "Musholt", "given": "Petra B", "initials": "PB"}, {"family": "Nilsson", "given": "Birgitte", "initials": "B"}, {"family": "Pattou", "given": "Francois", "initials": "F", "orcid": "0000-0001-8388-3766", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0769cc7e166943cb98978c45c12d749a.json"}}, {"family": "Penet", "given": "Deborah", "initials": "D"}, {"family": "Raverdy", "given": "Violeta", "initials": "V"}, {"family": "Ridderstr\u00e5le", "given": "Martin", "initials": "M"}, {"family": "Romano", "given": "Luciana", "initials": "L"}, {"family": "Rutters", "given": "Femke", "initials": "F"}, {"family": "Sharma", "given": "Sapna", "initials": "S"}, {"family": "Teare", "given": "Harriet", "initials": "H"}, {"family": "'t Hart", "given": "Leen", "initials": "L", "orcid": "0000-0003-4401-2938", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c36c8ed413ed4d6f975341fe511035e3.json"}}, {"family": "Tsirigos", "given": "Konstantinos D", "initials": "KD"}, {"family": "Vangipurapu", "given": "Jagadish", "initials": "J"}, {"family": "Vestergaard", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3090-269X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e2fa5c4f74894d6a833afd105ec72848.json"}}, {"family": "Brunak", "given": "S\u00f8ren", "initials": "S"}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8263a26f474946de8b61a2080051d37b.json"}}, {"family": "Frost", "given": "Gary", "initials": "G", "orcid": "0000-0003-0529-6325", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/894534933d064d1f802f1690ea56f162.json"}}, {"family": "Grallert", "given": "Harald", "initials": "H"}, {"family": "Jablonka", "given": "Bernd", "initials": "B"}, {"family": "McCarthy", "given": "Mark I", "initials": "MI"}, {"family": "Pavo", "given": "Imre", "initials": "I", "orcid": "0000-0002-2016-7049", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1691b459fdb84772b1e8595e8de617f3.json"}}, {"family": "Pedersen", "given": "Oluf", "initials": "O", "orcid": "0000-0002-3321-3972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0ef37542aea4e67a322b0d6179cd59e.json"}}, {"family": "Ruetten", "given": "Hartmut", "initials": "H"}, {"family": "Walker", "given": "Mark", "initials": "M"}, {"family": "DIRECT Consortium", "given": "", "initials": ""}, {"family": "Adamski", "given": "Jerzy", "initials": "J", "orcid": "0000-0001-9259-0199", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6871f2a0d4414a58be2e7f26a59d3ca9.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Pearson", "given": "Ewan R", "initials": "ER", "orcid": "0000-0001-9237-8585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e27e9e47f1cc4a969268eb5a65b8045b.json"}}, {"family": "Dermitzakis", "given": "Emmanouil T", "initials": "ET", "orcid": "0000-0002-9302-6490", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6683f17defc34cad9389fd7fef36aca4.json"}}, {"family": "Vi\u00f1uela", "given": "Ana", "initials": "A", "orcid": "0000-0003-3771-8537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02cba70871df48eb84c17e82f95baae4.json"}}], "type": "journal article", "published": "2023-08-21", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "5062", "issn-l": "2041-1723"}, "abstract": "We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant associates with multiple molecular phenotypes over multiple genomic regions. The highest proportion of share genetic regulation is detected between gene expression and proteins (66.6%), with a further median shared genetic associations across 49 different tissues of 78.3% and 62.4% between plasma proteins and gene expression. We represent the genetic and molecular associations in networks including 2828 known GWAS variants, showing that GWAS variants are more often connected to gene expression in trans than other molecular phenotypes in the network. Our work provides a roadmap to understanding molecular networks and deriving the underlying mechanism of action of GWAS variants using different molecular phenotypes in an accessible tissue.", "doi": "10.1038/s41467-023-40569-3", "pmid": "37604891", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10442420"}, {"db": "pii", "key": "10.1038/s41467-023-40569-3"}], "notes": [], "created": "2026-08-20T08:52:44.576Z", "modified": "2026-08-20T08:52:45.407Z"}, {"entity": "publication", "iuid": "967be0398ae444168838f6c87c44e030", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/967be0398ae444168838f6c87c44e030.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/967be0398ae444168838f6c87c44e030"}}, "title": "Physical activity and sedentary behavior; mechanistic insights and role in disease prevention", "authors": [{"family": "Hoed", "given": "Marcel den", "initials": "Md", "orcid": "0000-0001-8081-428X", "researcher": 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