{"entity": "researcher", "timestamp": "2026-08-20T20:40:16.479Z", "family": "Yu", "given": "Di", "initials": "D", "orcid": "0000-0002-8636-0351", "affiliations": ["Department of Immunology Genetics and Pathology Science for Life Laboratory Uppsala University  Uppsala 752 37 Sweden"], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/80a3098e7db143a5b76d27912d59852f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/80a3098e7db143a5b76d27912d59852f"}}, "publications": [{"entity": "publication", "iuid": "b0ec87d2cabf4f83aa4d8d30b2ce86ee", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b0ec87d2cabf4f83aa4d8d30b2ce86ee.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b0ec87d2cabf4f83aa4d8d30b2ce86ee"}}, "title": "Enhanced Cellular Uptake through Nanotopography\u2010Induced Macropinocytosis", "authors": [{"family": "Aramesh", "given": "Morteza", "initials": "M", "orcid": "0000-0003-2071-1929", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/361031207ed94603aa1e013d5826c102.json"}}, {"family": "Yu", "given": "Di", "initials": "D", "orcid": "0000-0002-8636-0351", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80a3098e7db143a5b76d27912d59852f.json"}}, {"family": "Essand", "given": "Magnus", "initials": "M", "orcid": "0000-0002-9725-0422", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2e56cdd77634c01ab6d98dea8c60430.json"}}, {"family": "Persson", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-6663-6536", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/34936007fdee4259be4e83bdc12a23eb.json"}}], "type": "journal-article", "published": "2024-07-00", "journal": {"title": "Adv. Funct. Mater.", "issn": "1616-301X", "volume": "34", "issue": "28", "issn-l": null}, "abstract": null, "doi": "10.1002/adfm.202400487", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T06:27:27.977Z", "modified": "2026-08-20T06:27:28.193Z"}, {"entity": "publication", "iuid": "eff604347979431c861fb8ece1f7519c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/eff604347979431c861fb8ece1f7519c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/eff604347979431c861fb8ece1f7519c"}}, "title": "Nanotopography boosts cellular uptake by inducing macropinocytosis", "authors": [{"family": "Aramesh", "given": "Morteza", "initials": "M", "orcid": "0000-0003-2071-1929", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/361031207ed94603aa1e013d5826c102.json"}}, {"family": "Yu", "given": "Di", "initials": "D", "orcid": "0000-0002-8636-0351", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80a3098e7db143a5b76d27912d59852f.json"}}, {"family": "Essand", "given": "Magnus", "initials": "M", "orcid": "0000-0002-9725-0422", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2e56cdd77634c01ab6d98dea8c60430.json"}}, {"family": "Persson", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-6663-6536", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/34936007fdee4259be4e83bdc12a23eb.json"}}], "type": "posted-content", "published": "2023-12-20", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.12.20.571698", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:51:08.003Z", "modified": "2026-08-20T10:51:08.086Z"}, {"entity": "publication", "iuid": "3a63cca4268f41eeac58149fe8a1378d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3a63cca4268f41eeac58149fe8a1378d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3a63cca4268f41eeac58149fe8a1378d"}}, "title": "VLDLR mediates alphavirus neuroinvasion through the blood-cerebrospinal fluid barrier", "authors": [{"family": "Martikainen", "given": "Miika", "initials": "M"}, {"family": "Lugano", "given": "Roberta", "initials": "R"}, {"family": "Pietil\u00e4", "given": "Ilkka", "initials": "I"}, {"family": "Brosch", "given": "Sofie", "initials": "S"}, {"family": "Cabrolier", "given": "Camille", "initials": "C"}, {"family": "Sivaramakrishnam", "given": "Aishwarya", "initials": "A"}, {"family": "Ramachandran", "given": "Mohanraj", "initials": "M"}, {"family": "Yu", "given": "Di", "initials": "D", "orcid": "0000-0002-8636-0351", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80a3098e7db143a5b76d27912d59852f.json"}}, {"family": "Dimberg", "given": "Anna", "initials": "A"}, {"family": "Essand", "given": "Magnus", "initials": "M", "orcid": "0000-0002-9725-0422", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2e56cdd77634c01ab6d98dea8c60430.json"}}], "type": "posted-content", "published": "2023-10-30", "journal": {"issn-l": null}, "abstract": null, "doi": "10.21203/rs.3.rs-3404545/v1", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T12:59:17.703Z", "modified": "2026-08-20T12:59:17.725Z"}, {"entity": "publication", "iuid": "0e9b6e33c6254715b9eaf16751f25ea0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0e9b6e33c6254715b9eaf16751f25ea0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0e9b6e33c6254715b9eaf16751f25ea0"}}, "title": "Intratumoral administration of pro-inflammatory allogeneic dendritic cells improved the anti-tumor response of systemic anti-CTLA-4 treatment via unleashing a T cell-dependent response.", "authors": [{"family": "Jin", "given": "Chuan", "initials": "C"}, {"family": "Ali", "given": "Arwa", "initials": "A"}, {"family": "Iskantar", "given": "Alexandros", "initials": "A"}, {"family": "Fotaki", "given": "Grammatiki", "initials": "G"}, {"family": "Wang", "given": "Hai", "initials": "H"}, {"family": "Essand", "given": "Magnus", "initials": "M"}, {"family": "Karlsson-Parra", "given": "Alex", "initials": "A"}, {"family": "Yu", "given": "Di", "initials": "D", "orcid": "0000-0002-8636-0351", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80a3098e7db143a5b76d27912d59852f.json"}}], "type": "journal article", "published": "2022-07-13", "journal": {"title": "Oncoimmunology", "issn": "2162-402X", "volume": "11", "issue": "1", "pages": "2099642", "issn-l": "2162-4011"}, "abstract": "Immune checkpoint inhibitors (ICIs) have revolutionized the oncology field. However, a significant number of patients do not respond, at least partly due to the lack of preexisting anti-tumor T-cell immunity. Therefore, it is emergent to add an immune-priming step to improve efficacy. Here, we report a combined approach consisting of intratumoral administration of pro-inflammatory allogeneic dendritic cells (AlloDCs) and systemic treatment with \u03b1CTLA-4 that can drastically improve the anti-tumor efficacy compared to \u03b1CTLA-4 monotherapy. When evaluated in mice with large established CT-26 tumors, monotherapy with \u03b1CTLA-4 neither delayed tumor progression nor improved mice survival. However, combination treatment of AlloDCs and \u03b1CTLA-4 drastically improved the effectiveness, with 70% of mice being cured. This effect was T cell-dependent, and all survived mice rejected a subsequent tumor re-challenge. Further investigation revealed an immune-inflamed tumor microenvironment (TME) in the combination treatment group characterized by enhanced infiltration of activated antigen-presenting endogenous DCs and CD8+ T cells with a tissue-resident memory (TRM) phenotype (CD49a+CD103+). This correlated with elevated levels of tumor-specific CD39+CD103+CD8+ T cells in the tumor and \"tumor-matching\" NKG2D+CD39+CX3CR1+CD8+ T cells in peripheral blood. Moreover, splenocytes from mice in the combination treatment group secreted significantly higher IFN-\u03b3 upon stimulation with the peptide from the endogenous CT-26 retroviral gp70 (model neoantigen), confirming the induction of a tumor-specific CD8+ T-cell response. Taken together, these data indicate a strong anti-tumor synergy between AlloDCs and \u03b1CTLA-4 that warrant further clinical investigation with the corresponding human AlloDC product (ilixadencel) for patients receiving \u03b1CTLA-4 therapy.", "doi": "10.1080/2162402X.2022.2099642", "pmid": "35859733", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9291714"}, {"db": "pii", "key": "2099642"}], "notes": [], "created": "2026-08-20T09:37:35.234Z", "modified": "2026-08-20T09:37:35.307Z"}, {"entity": "publication", "iuid": "43981b7005d4408b970786e4ef79a2af", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/43981b7005d4408b970786e4ef79a2af.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/43981b7005d4408b970786e4ef79a2af"}}, "title": "CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers.", "authors": [{"family": "Jin", "given": "Chuan", "initials": "C"}, {"family": "Ma", "given": "Jing", "initials": "J"}, {"family": "Ramachandran", "given": "Mohanraj", "initials": "M", "orcid": "0000-0003-2685-0575", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd947633edf949aba9e680e63a1e178b.json"}}, {"family": "Yu", "given": "Di", "initials": "D", "orcid": "0000-0002-8636-0351", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80a3098e7db143a5b76d27912d59852f.json"}}, {"family": "Essand", "given": "Magnus", "initials": "M", "orcid": "0000-0002-9725-0422", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2e56cdd77634c01ab6d98dea8c60430.json"}}], "type": "journal article", "published": "2022-07-00", "journal": {"title": "Nat Biomed Eng", "issn": "2157-846X", "volume": "6", "issue": "7", "pages": "830-841", "issn-l": null}, "abstract": "Chimeric antigen receptor T cells (CAR T cells) are effective against haematologic malignancies. However, in solid tumours, their potency is hampered by local immunosuppression and by the heterogeneous expression of the antigen that the CAR targets. Here we show that CAR T cells expressing a pluripotent pro-inflammatory neutrophil-activating protein (NAP) from Helicobacter pylori trigger endogenous bystander T-cell responses against solid cancers. In mice with subcutaneous murine pancreatic ductal adenocarcinomas, neuroblastomas or colon carcinomas, CAR(NAP) T cells led to slower tumour growth and higher survival rates than conventional mouse CAR T cells, regardless of target antigen, tumour type and host haplotype. In tumours with heterogeneous antigen expression, NAP secretion induced the formation of an immunologically 'hot' microenvironment that supported dendritic cell maturation and bystander responses, as indicated by epitope spreading and infiltration of cytotoxic CD8+ T cells targeting tumour-associated antigens other than the CAR-targeted antigen. CAR T cells armed with NAP neither increased off-tumour toxicity nor hampered the efficacy of CAR T cells, and hence may have advantageous translational potential.", "doi": "10.1038/s41551-022-00875-5", "pmid": "35379957", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9288934"}, {"db": "pii", "key": "10.1038/s41551-022-00875-5"}], "notes": [], "created": "2026-08-20T08:54:49.254Z", "modified": "2026-08-20T08:54:49.396Z"}, {"entity": "publication", "iuid": "823a79ac5f2a4fb881c3277207b11482", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/823a79ac5f2a4fb881c3277207b11482.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/823a79ac5f2a4fb881c3277207b11482"}}, "title": "Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer.", "authors": [{"family": "Ma", "given": "Jing", "initials": "J"}, {"family": "Ramachandran", "given": "Mohanraj", "initials": "M"}, {"family": "Jin", "given": "Chuan", "initials": "C"}, {"family": "Quijano-Rubio", "given": "Clara", "initials": "C"}, {"family": "Martikainen", "given": "Miika", "initials": "M"}, {"family": "Yu", "given": "Di", "initials": "D", "orcid": "0000-0002-8636-0351", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80a3098e7db143a5b76d27912d59852f.json"}}, {"family": "Essand", "given": "Magnus", "initials": "M"}], "type": "journal article", "published": "2020-01-22", "journal": {"title": "Cell Death Dis", "issn": "2041-4889", "volume": "11", "issue": "1", "pages": "48", "issn-l": "2041-4889"}, "abstract": "Oncolytic viruses have the potential to induce immunogenic cell death (ICD) that may provoke potent and long-lasting anti-cancer immunity. Here we aimed to characterize the ICD-inducing ability of wild-type Adenovirus (Ad), Semliki Forest virus (SFV) and Vaccinia virus (VV). We did so by investigating the cell death and immune-activating properties of virus-killed tumor cells. Ad-infection of tumor cells primarily activates autophagy, but also activate events of necroptotic and pyroptotic cell death. SFV infection on the other hand primarily activates immunogenic apoptosis while VV activates necroptosis. All viruses mediated lysis of tumor cells leading to the release of danger-associated molecular patterns, triggering of phagocytosis and maturation of dendritic cells (DCs). However, only SFV-infected tumor cells triggered significant T helper type 1 (Th1)-cytokine release by DCs and induced antigen-specific T-cell activation. Our results elucidate cell death processes activated upon Ad, SFV, and VV infection and their potential to induce T cell-mediated anti-tumor immune responses. This knowledge provides important insight for the choice and design of therapeutically successful virus-based immunotherapies.", "doi": "10.1038/s41419-020-2236-3", "pmid": "31969562", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6976683"}, {"db": "pii", "key": "10.1038/s41419-020-2236-3"}], "notes": [], "created": "2026-08-20T08:49:34.686Z", "modified": "2026-08-20T08:49:34.756Z"}]}