{"entity": "researcher", "timestamp": "2026-09-28T11:47:57.050Z", "family": "Yates", "given": "Andrew", "initials": "A", "orcid": "0000-0003-4606-4483", "affiliations": ["Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America.", "Institute of Infection, Immunity & Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/80969307dc9e40049e7a001128bc12c5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/80969307dc9e40049e7a001128bc12c5"}}, "publications": [{"entity": "publication", "iuid": "f2b13cab732440e1984e7f35123d76d8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f2b13cab732440e1984e7f35123d76d8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f2b13cab732440e1984e7f35123d76d8"}}, "title": "Cell generation dynamics underlying naive T-cell homeostasis in adult humans.", "authors": [{"family": "Mold", "given": "Jeff E", "initials": "JE", "orcid": "0000-0003-2195-2978", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3190bb256fcb4a9eb4f4ef06bb99eb5c.json"}}, {"family": "R\u00e9u", "given": "Pedro", "initials": "P"}, {"family": "Olin", "given": "Axel", "initials": "A", "orcid": "0000-0002-1161-4476", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b1789de408e54413b99ae1f851876a90.json"}}, {"family": "Bernard", "given": "Samuel", "initials": "S", "orcid": "0000-0002-8442-9968", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/37f6517e5e764314bc0a29028b39647b.json"}}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J"}, {"family": "Rane", "given": "Sanket", "initials": "S"}, {"family": "Yates", "given": "Andrew", "initials": "A", "orcid": "0000-0003-4606-4483", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80969307dc9e40049e7a001128bc12c5.json"}}, {"family": "Khosravi", "given": "Azadeh", "initials": "A"}, {"family": "Salehpour", "given": "Mehran", "initials": "M"}, {"family": "Possnert", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0002-4840-291X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/991f0a1d8d2846018641a2df10338e7c.json"}}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Fris\u00e9n", "given": "Jonas", "initials": "J", "orcid": "0000-0001-5819-458X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c428941167b42c495b9fcdb6eb85729.json"}}], "type": "journal article", "published": "2019-10-00", "journal": {"title": "PLoS Biol.", "issn": "1545-7885", "volume": "17", "issue": "10", "pages": "e3000383", "issn-l": "1544-9173"}, "abstract": "Thymic involution and proliferation of naive T cells both contribute to shaping the naive T-cell repertoire as humans age, but a clear understanding of the roles of each throughout a human life span has been difficult to determine. By measuring nuclear bomb test-derived 14C in genomic DNA, we determined the turnover rates of CD4+ and CD8+ naive T-cell populations and defined their dynamics in healthy individuals ranging from 20 to 65 years of age. We demonstrate that naive T-cell generation decreases with age because of a combination of declining peripheral division and thymic production during adulthood. Concomitant decline in T-cell loss compensates for decreased generation rates. We investigated putative mechanisms underlying age-related changes in homeostatic regulation of CD4+ naive T-cell turnover, using mass cytometry to profile candidate signaling pathways involved in T-cell activation and proliferation relative to CD31 expression, a marker of thymic proximity for the CD4+ naive T-cell population. We show that basal nuclear factor \u03baB (NF-\u03baB) phosphorylation positively correlated with CD31 expression and thus is decreased in peripherally expanded naive T-cell clones. Functionally, we found that NF-\u03baB signaling was essential for naive T-cell proliferation to the homeostatic growth factor interleukin (IL)-7, and reduced NF-\u03baB phosphorylation in CD4+CD31- naive T cells is linked to reduced homeostatic proliferation potential. Our results reveal an age-related decline in naive T-cell turnover as a putative regulator of naive T-cell diversity and identify a molecular pathway that restricts proliferation of peripherally expanded naive T-cell clones that accumulate with age.", "doi": "10.1371/journal.pbio.3000383", "pmid": "31661488", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6818757"}, {"db": "pii", "key": "PBIOLOGY-D-19-01355"}], "notes": [], "created": "2026-09-23T09:15:24.879Z", "modified": "2026-09-23T09:15:25.077Z"}]}