{"entity": "researcher", "timestamp": "2026-09-28T23:49:59.008Z", "family": "Hellstr\u00f6m", "given": "Ann", "initials": "A", "orcid": "0000-0002-9259-1244", "affiliations": ["Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. ann.hellstrom@medfak.gu.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/7fb84f855c884e23bd064a0f5401c41d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/7fb84f855c884e23bd064a0f5401c41d"}}, "publications": [{"entity": "publication", "iuid": "1e27914b34b34c0aa75cc91b1b0407f0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1e27914b34b34c0aa75cc91b1b0407f0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1e27914b34b34c0aa75cc91b1b0407f0"}}, "title": "The development of blood protein profiles in extremely preterm infants follows a stereotypic evolution pattern.", "authors": [{"family": "Zhong", "given": "Wen", "initials": "W", "orcid": "0000-0002-7422-6104", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6ffb1140aaa42c5ac63fe76653fc63b.json"}}, {"family": "Danielsson", "given": "Hanna", "initials": "H", "orcid": "0000-0001-6959-7704", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1d92443884bf4e25ae040761708edb70.json"}}, {"family": "Brusselaers", "given": "Nele", "initials": "N", "orcid": "0000-0003-0137-447X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/70d0a6a2f4eb4272be4865e7e369c0e9.json"}}, {"family": "Wackernagel", "given": "Dirk", "initials": "D"}, {"family": "Sj\u00f6bom", "given": "Ulrika", "initials": "U"}, {"family": "S\u00e4vman", "given": "Karin", "initials": "K"}, {"family": "Hansen Pupp", "given": "Ingrid", "initials": "I"}, {"family": "Ley", "given": "David", "initials": "D"}, {"family": "Nilsson", "given": "Anders K", "initials": "AK", "orcid": "0000-0003-3631-0783", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/11e566cf078e429db14bdcb3f3e1a074.json"}}, {"family": "Fagerberg", "given": "Linn", "initials": "L", "orcid": "0000-0003-0198-7137", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/abbbf8193d5a4376a5c726768d039439.json"}}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Hellstr\u00f6m", "given": "Ann", "initials": "A", "orcid": "0000-0002-9259-1244", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7fb84f855c884e23bd064a0f5401c41d.json"}}], "type": "journal article", "published": "2023-08-02", "journal": {"title": "Commun Med (Lond)", "issn": "2730-664X", "volume": "3", "issue": "1", "pages": "107", "issn-l": null}, "abstract": "Preterm birth is the leading cause of neonatal mortality and morbidity. Early diagnosis and interventions are critical to improving the clinical outcomes of extremely premature infants. Blood protein profiling during the first months of life in preterm infants can shed light on the role of early extrauterine development and provide an increased understanding of maturation after extremely preterm birth and the underlying mechanisms of prematurity-related disorders.\n\nWe have investigated the blood protein profiles during the first months of life in preterm infants on the role of early extrauterine development. The blood protein levels were analyzed using next generation blood profiling on 1335 serum samples, collected longitudinally at nine time points from birth to full-term from 182 extremely preterm infants.\n\nThe protein analysis reveals evident predestined serum evolution patterns common for all included infants. The majority of the variations in blood protein expression are associated with the postnatal age of the preterm infants rather than any other factors. There is a uniform protein pattern on postnatal day 1 and after 30 weeks postmenstrual age (PMA), independent of gestational age (GA). However, during the first month of life, GA had a significant impact on protein variability.\n\nThe unified pattern of protein development for all included infants suggests an age-dependent stereotypic development of blood proteins after birth. This knowledge should be considered in neonatal settings and might alter the clinical approach within neonatology, where PMA is today the most dominant age variable.", "doi": "10.1038/s43856-023-00338-1", "pmid": "37532738", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10397184"}, {"db": "pii", "key": "10.1038/s43856-023-00338-1"}], "notes": [], "created": "2026-09-23T11:22:11.379Z", "modified": "2026-09-23T11:22:11.481Z"}, {"entity": "publication", "iuid": "27505b00b3b345d7a489df7555e0686d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/27505b00b3b345d7a489df7555e0686d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/27505b00b3b345d7a489df7555e0686d"}}, "title": "Blood protein profiles related to preterm birth and retinopathy of prematurity.", "authors": [{"family": "Danielsson", "given": "Hanna", "initials": "H"}, {"family": "Tebani", "given": "Abdellah", "initials": "A"}, {"family": "Zhong", "given": "Wen", "initials": "W"}, {"family": "Fagerberg", "given": "Linn", "initials": "L"}, {"family": "Brusselaers", "given": "Nele", "initials": "N"}, {"family": "H\u00e5rd", "given": "Anna-Lena", "initials": "AL"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M"}, {"family": "Hellstr\u00f6m", "given": "Ann", "initials": "A", "orcid": "0000-0002-9259-1244", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7fb84f855c884e23bd064a0f5401c41d.json"}}], "type": "journal article", "published": "2022-03-00", "journal": {"title": "Pediatr. Res.", "issn": "1530-0447", "volume": "91", "issue": "4", "pages": "937-946", "issn-l": "0031-3998"}, "abstract": "Nearly one in ten children is born preterm. The degree of immaturity is a determinant of the infant's health. Extremely preterm infants have higher morbidity and mortality than term infants. One disease affecting extremely preterm infants is retinopathy of prematurity (ROP), a multifactorial neurovascular disease that can lead to retinal detachment and blindness. The advances in omics technology have opened up possibilities to study protein expressions thoroughly with clinical accuracy, here used to increase the understanding of protein expression in relation to immaturity and ROP.\n\nLongitudinal serum protein profiles the first months after birth in 14 extremely preterm infants were integrated with perinatal and ROP data. In total, 448 unique protein targets were analyzed using Proximity Extension Assays.\n\nWe found 20 serum proteins associated with gestational age and/or ROP functioning within mainly angiogenesis, hematopoiesis, bone regulation, immune function, and lipid metabolism. Infants with severe ROP had persistent lower levels of several identified proteins during the first postnatal months.\n\nThe study contributes to the understanding of the relationship between longitudinal serum protein levels and immaturity and abnormal retinal neurovascular development. This is essential for understanding pathophysiological mechanisms and to optimize diagnosis, treatment and prevention for ROP.\n\nLongitudinal protein profiles of 14 extremely preterm infants were analyzed using a novel multiplex protein analysis platform combined with perinatal data. Proteins associated with gestational age at birth and the neurovascular disease ROP were identified. Among infants with ROP, longitudinal levels of the identified proteins remained largely unchanged during the first postnatal months. The main functions of the proteins identified were angiogenesis, hematopoiesis, immune function, bone regulation, lipid metabolism, and central nervous system development. The study contributes to the understanding of longitudinal serum protein patterns related to gestational age and their association with abnormal retinal neuro-vascular development.", "doi": "10.1038/s41390-021-01528-0", "pmid": "33895781", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9064798"}, {"db": "pii", "key": "10.1038/s41390-021-01528-0"}], "notes": [], "created": "2026-09-23T11:54:53.639Z", "modified": "2026-09-23T11:54:53.702Z"}]}