{"entity": "researcher", "timestamp": "2026-08-25T10:34:25.894Z", "family": "Hultqvist", "given": "Greta", "initials": "G", "orcid": "0000-0002-4136-6792", "affiliations": ["Protein Drug Design, Faculty of Pharmacy, Biomedical Centre 591, Uppsala University, 75124 Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ed4198fd7ef45d98cc951c871d0ba17.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ed4198fd7ef45d98cc951c871d0ba17"}}, "publications": [{"entity": "publication", "iuid": "cc0f8cf1e1964faf8cb82fc9c14ba378", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/cc0f8cf1e1964faf8cb82fc9c14ba378.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/cc0f8cf1e1964faf8cb82fc9c14ba378"}}, "title": "Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide.", "authors": [{"family": "Rofo", "given": "Fadi", "initials": "F"}, {"family": "Sandbaumh\u00fcter", "given": "Friederike A", "initials": "FA"}, {"family": "Chourlia", "given": "Aikaterini", "initials": "A"}, {"family": "Metzendorf", "given": "Nicole G", "initials": "NG"}, {"family": "Morrison", "given": "Jamie I", "initials": "JI"}, {"family": "Syv\u00e4nen", "given": "Stina", "initials": "S", "orcid": "0000-0002-8196-4041", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0010802890884cf69351663a1473245d.json"}}, {"family": "Andr\u00e9n", "given": "Per E", "initials": "PE", "orcid": "0000-0002-4062-7743", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1dd27e8b238475383983480e10099f6.json"}}, {"family": "Jansson", "given": "Erik T", "initials": "ET"}, {"family": "Hultqvist", "given": "Greta", "initials": "G", "orcid": "0000-0002-4136-6792", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ed4198fd7ef45d98cc951c871d0ba17.json"}}], "type": "journal article", "published": "2021-07-07", "journal": {"title": "ACS Chem Neurosci", "issn": "1948-7193", "volume": "12", "issue": "13", "pages": "2529-2541", "issn-l": "1948-7193"}, "abstract": "Alzheimer's disease is the most common neurodegenerative disorder characterized by the pathological aggregation of amyloid-\u03b2 (A\u03b2) peptide. A potential therapeutic intervention in Alzheimer's disease is to enhance A\u03b2 degradation by increasing the activity of A\u03b2-degrading enzymes, including neprilysin. The somatostatin (SST) peptide has been identified as an activator of neprilysin. Recently, we demonstrated the ability of a brain-penetrating SST peptide (SST-scFv8D3) to increase neprilysin activity and membrane-bound A\u03b242 degradation in the hippocampus of mice overexpressing the A\u03b2-precursor protein with the Swedish mutation (APPswe). Using LC-MS, we further evaluated the anti-Alzheimer's disease effects of SST-scFv8D3. Following a triple intravenous injection of SST-scFv8D3, the LC-MS analysis of the brain proteome revealed that the majority of downregulated proteins consisted of mitochondrial proteins regulating fatty acid oxidation, which are otherwise upregulated in APPswe mice compared to wild-type mice. Moreover, treatment with SST-scFv8D3 significantly increased hippocampal levels of synaptic proteins regulating cell membrane trafficking and neuronal development. Finally, hippocampal concentrations of growth-regulated \u03b1 (KC/GRO) chemokine and degradation of neuropeptide-Y were elevated after SST-scFv8D3 treatment. In summary, our results demonstrate a multifaceted effect profile in regulating mitochondrial function and neurogenesis following treatment with SST-scFv8D3, further suggesting the development of Alzheimer's disease therapies based on SST peptides.", "doi": "10.1021/acschemneuro.1c00303", "pmid": "34170117", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8291608"}], "notes": [], "created": "2026-08-21T11:35:53.363Z", "modified": "2026-08-21T11:35:53.468Z"}]}