{"entity": "researcher", "timestamp": "2026-08-25T13:45:13.878Z", "family": "Sander", "given": "Birgitta", "initials": "B", "orcid": "0000-0002-1214-1340", "affiliations": ["Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ded64c528454282832f32deef610665.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ded64c528454282832f32deef610665"}}, "publications": [{"entity": "publication", "iuid": "6683f926733344d0b11254175321706f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6683f926733344d0b11254175321706f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6683f926733344d0b11254175321706f"}}, "title": "Expression of GNAZ, encoding the G\u03b1z protein, predicts survival in mantle cell lymphoma.", "authors": [{"family": "Mundt", "given": "Filip", "initials": "F"}, {"family": "Merrien", "given": "Magali", "initials": "M"}, {"family": "Nygren", "given": "Lina", "initials": "L"}, {"family": "Sutton", "given": "Lesley A", "initials": "LA"}, {"family": "Christensson", "given": "Birger", "initials": "B"}, {"family": "Wahlin", "given": "Bj\u00f6rn E", "initials": "BE", "orcid": "0000-0003-3566-8847", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ba19b8ac7924b53be135b913b219400.json"}}, {"family": "Rosenquist", "given": "Richard", "initials": "R"}, {"family": "Sander", "given": "Birgitta", "initials": "B", "orcid": "0000-0002-1214-1340", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ded64c528454282832f32deef610665.json"}}, {"family": "Wasik", "given": "Agata M", "initials": "AM", "orcid": "0000-0002-5020-3856", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/433aec503d3149f6820daee76d8dd0e3.json"}}], "type": "journal article", "published": "2019-05-00", "journal": {"title": "Br. J. Haematol.", "issn": "1365-2141", "volume": "185", "issue": "4", "pages": "708-712", "issn-l": "0007-1048"}, "abstract": "Mantle cell lymphoma (MCL), a malignancy of B-lymphocytes, has a poor prognosis. It is thus necessary to improve the understanding of the pathobiology of MCL and identify factors contributing to its aggressiveness. Our studies, based on Affymetrix data from 17 MCL biopsies, real-time quantitative polymerase chain reaction data from 18 sorted primary MCL cells and 108 MCL biopsies compared to non-malignant tissue, reveals that GNAZ expression predicts poor clinical outcome of MCL patients (Cox regression, P = 0\u00b7014) and lymphocytosis (Mann-Whitney, P = 0\u00b7011). We show that GNAZ translates to G\u03b1z protein - a signalling molecule within the G-protein coupled receptor network. Our findings suggest that GNAZ/G\u03b1z contribute to the MCL pathobiology.", "doi": "10.1111/bjh.15810", "pmid": "30788840", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-21T12:17:44.350Z", "modified": "2026-08-21T12:17:44.493Z"}]}