{"entity": "researcher", "timestamp": "2026-09-25T23:40:39.297Z", "family": "Ajnakina", "given": "Olesya", "initials": "O", "orcid": "0000-0003-3987-1236", "affiliations": ["Department of Behavioural Science and Health, Institute of Epidemiology and Health Care, University College London, London WC1E 7HBUK.", "Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/7d6e01ade1044bc98af90b3f982c377f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/7d6e01ade1044bc98af90b3f982c377f"}}, "publications": [{"entity": "publication", "iuid": "3d23dbd1e2e74c8d87221df257fa700b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3d23dbd1e2e74c8d87221df257fa700b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3d23dbd1e2e74c8d87221df257fa700b"}}, "title": "The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals.", "authors": [{"family": "Gong", "given": "Tong", "initials": "T", "orcid": "0000-0002-6887-9432", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/37f9f4ea7a05458f9284267ddfb20c44.json"}}, {"family": "Karlsson", "given": "Robert", "initials": "R", "orcid": "0000-0002-8949-2587", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/620b82d1c76c45dd8d1b131cec3c478c.json"}}, {"family": "Yao", "given": "Shuyang", "initials": "S"}, {"family": "Magnusson", "given": "Patrik K E", "initials": "PKE"}, {"family": "Ajnakina", "given": "Olesya", "initials": "O", "orcid": "0000-0003-3987-1236", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7d6e01ade1044bc98af90b3f982c377f.json"}}, {"family": "Steptoe", "given": "Andrew", "initials": "A", "orcid": "0000-0001-7808-4943", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6860ae61ab249b58ec8c837a2bb76e7.json"}}, {"family": "Bhatta", "given": "Laxmi", "initials": "L"}, {"family": "Brumpton", "given": "Ben", "initials": "B"}, {"family": "Kumar", "given": "Ashish", "initials": "A"}, {"family": "M\u00e9len", "given": "Erik", "initials": "E"}, {"family": "23andMe research team", "given": "", "initials": ""}, {"family": "Lin", "given": "Keng-Han", "initials": "KH"}, {"family": "Tian", "given": "Chao", "initials": "C"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Almqvist", "given": "Catarina", "initials": "C", "orcid": "0000-0002-1045-1898", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/780c252310f449fc96d864b0134aab85.json"}}], "type": "journal article", "published": "2024-08-07", "journal": {"title": "G3", "issn": "2160-1836", "volume": "14", "issue": "8", "issn-l": "2160-1836"}, "abstract": "Dog ownership has been associated with several complex traits, and there is evidence of genetic influence. We performed a genome-wide association study of dog ownership through a meta-analysis of 31,566 Swedish twins in 5 discovery cohorts and an additional 65,986 European-ancestry individuals in 3 replication cohorts from Sweden, Norway, and the United Kingdom. Association tests with >7.4 million single-nucleotide polymorphisms were meta-analyzed using a fixed effect model after controlling for population structure and relatedness. We identified 2 suggestive loci using discovery cohorts, which did not reach genome-wide significance after meta-analysis with replication cohorts. Single-nucleotide polymorphism-based heritability of dog ownership using linkage disequilibrium score regression was estimated at 0.123 (CI 0.038-0.207) using the discovery cohorts and 0.018 (CI -0.002 to 0.039) when adding in replication cohorts. Negative genetic correlation with complex traits including type 2 diabetes, depression, neuroticism, and asthma was only found using discovery summary data. Furthermore, we did not identify any genes/gene-sets reaching even a suggestive level of significance. This genome-wide association study does not, by itself, provide clear evidence on common genetic variants that influence dog ownership among European-ancestry individuals.", "doi": "10.1093/g3journal/jkae116", "pmid": "38820132", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11304603"}, {"db": "pii", "key": "7686067"}, {"db": "figshare", "key": "10.25387/g3.25713189"}], "notes": [], "created": "2026-09-23T13:01:35.777Z", "modified": "2026-09-23T13:01:36.118Z"}]}