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"John N", "initials": "JN"}, {"family": "Menni", "given": "Cristina", "initials": "C", "orcid": "0000-0001-9790-0571", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0996382f79af42938451d690a140a079.json"}}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ", "orcid": "0000-0003-1422-2993", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/462fd4169f41418887a5a979e0808d87.json"}}, {"family": "Khaw", "given": "Kay-Tee", "initials": "KT"}, {"family": "Sun", "given": "Yan V", "initials": "YV", "orcid": "0000-0002-2838-1824", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60b03d484f0c4acb93802ce6e6048a10.json"}}, {"family": "Wilson", "given": "Peter W F", "initials": "PWF", "orcid": "0000-0002-5653-7056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e2fa5a1fb3634b88b3a50c4d31bd3a33.json"}}, {"family": "Cho", "given": "Kelly", "initials": "K"}, {"family": "Visscher", "given": "Peter M", "initials": "PM", "orcid": "0000-0002-2143-8760", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9232be0ea244fb7ab43593e04265c2e.json"}}, {"family": "Denny", "given": "Joshua C", "initials": "JC", "orcid": "0000-0002-3049-7332", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee3b66f9be524dfdb2d95834abad0cbf.json"}}, {"family": "Million Veteran Program", "given": "", "initials": ""}, {"family": "Lifelines Cohort Study", "given": "", "initials": ""}, {"family": "CHARGE consortium", "given": "", "initials": ""}, {"family": "ICBP Consortium", "given": "", "initials": ""}, {"family": "Levy", "given": "Daniel", "initials": "D"}, {"family": "Edwards", "given": "Todd L", "initials": "TL", "orcid": "0000-0003-4318-6119", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8c555d3f6704b69821f39dcac8984d5.json"}}, {"family": "Munroe", "given": "Patricia B", "initials": "PB", "orcid": "0000-0002-4176-2947", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e956b6f17a64fb4b478dbc59950a790.json"}}, {"family": "Snieder", "given": "Harold", "initials": "H", "orcid": "0000-0003-1949-2298", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb5a2135b774429596606e980c9268ec.json"}}, {"family": "Warren", "given": "Helen R", "initials": "HR", "orcid": "0000-0003-0511-1386", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d44ccb685e4b4a4894b8cba8c74333ff.json"}}], "type": "journal article", "published": "2024-05-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "56", "issue": "5", "pages": "778-791", "issn-l": "1061-4036"}, "abstract": "Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 \u00d7 10-8) from the largest single-stage blood pressure (BP) genome-wide association study to date (n = 1,028,980 European individuals). These associations explain more than 60% of single nucleotide polymorphism-based BP heritability. Comparing top versus bottom deciles of polygenic risk scores (PRSs) reveals clinically meaningful differences in BP (16.9 mmHg systolic BP, 95% CI, 15.5-18.2 mmHg, P = 2.22 \u00d7 10-126) and more than a sevenfold higher odds of hypertension risk (odds ratio, 7.33; 95% CI, 5.54-9.70; P = 4.13 \u00d7 10-44) in an independent dataset. Adding PRS into hypertension-prediction models increased the area under the receiver operating characteristic curve (AUROC) from 0.791 (95% CI, 0.781-0.801) to 0.826 (95% CI, 0.817-0.836, \u2206AUROC, 0.035, P = 1.98 \u00d7 10-34). We compare the 2,103 loci results in non-European ancestries and show significant PRS associations in a large African-American sample. Secondary analyses implicate 500 genes previously unreported for BP. Our study highlights the role of increasingly large genomic studies for precision health research.", "doi": "10.1038/s41588-024-01714-w", "pmid": "38689001", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11096100"}, {"db": "pii", "key": "10.1038/s41588-024-01714-w"}], "notes": [], "created": "2026-08-20T09:00:02.525Z", "modified": "2026-08-20T09:00:03.969Z"}, {"entity": "publication", "iuid": "851b3f27657c453ca71099b8c0219ced", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/851b3f27657c453ca71099b8c0219ced.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/851b3f27657c453ca71099b8c0219ced"}}, "title": "Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.", "authors": [{"family": "Evangelou", "given": "Evangelos", "initials": "E", "orcid": "0000-0002-5488-2999", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7726e145c634702b9b55f705feaa6d4.json"}}, {"family": "Warren", "given": "Helen R", "initials": "HR"}, {"family": "Mosen-Ansorena", "given": "David", "initials": "D"}, {"family": "Mifsud", "given": "Borbala", "initials": "B"}, {"family": "Pazoki", "given": "Raha", "initials": "R"}, {"family": "Gao", "given": "He", "initials": "H"}, {"family": "Ntritsos", "given": "Georgios", "initials": "G"}, {"family": "Dimou", "given": "Niki", "initials": "N"}, {"family": "Cabrera", "given": "Claudia P", "initials": "CP"}, {"family": "Karaman", "given": "Ibrahim", "initials": "I", "orcid": "0000-0001-9341-8155", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73a3f0fbb7af4f96b1aca45a0bafa670.json"}}, {"family": "Ng", "given": "Fu Liang", "initials": "FL"}, {"family": "Evangelou", "given": "Marina", "initials": "M"}, {"family": "Witkowska", "given": "Katarzyna", "initials": "K"}, {"family": "Tzanis", "given": "Evan", "initials": "E"}, {"family": "Hellwege", "given": "Jacklyn N", "initials": "JN", "orcid": "0000-0001-7479-0920", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6a0fd444f964dc69f81988f20514862.json"}}, {"family": "Giri", "given": "Ayush", "initials": "A", "orcid": "0000-0002-7786-4670", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/424e945c81e14434a13205bdd2e986ac.json"}}, {"family": "Velez Edwards", "given": "Digna R", "initials": "DR"}, {"family": "Sun", "given": "Yan V", "initials": "YV"}, {"family": "Cho", "given": "Kelly", "initials": "K"}, {"family": "Gaziano", "given": "J Michael", "initials": "JM"}, {"family": "Wilson", "given": "Peter W F", "initials": "PWF"}, {"family": "Tsao", "given": "Philip S", "initials": "PS"}, {"family": "Kovesdy", "given": "Csaba P", "initials": "CP"}, {"family": "Esko", "given": "Tonu", "initials": "T"}, {"family": "M\u00e4gi", "given": "Reedik", "initials": "R"}, {"family": 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