{"entity": "researcher", "timestamp": "2026-08-20T20:36:39.231Z", "family": "Govender", "given": "Thavendran", "initials": "T", "orcid": "0000-0003-2511-2503", "affiliations": ["Catalysis and Peptide Research Unit University of KwaZulu Natal  Durban 4001 S\u00fcdafrika"], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/77ef43839d9e476f95d124c9c34b81fa.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/77ef43839d9e476f95d124c9c34b81fa"}}, "publications": [{"entity": "publication", "iuid": "da6da19db6c54f17924bb0a191669f82", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/da6da19db6c54f17924bb0a191669f82.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/da6da19db6c54f17924bb0a191669f82"}}, "title": "Base-Mediated Tandem Michael Addition and SuFEx Cyclization for the Synthesis of Sultone-Containing Spirooxindoles.", "authors": [{"family": "Govender", "given": "Kimberleigh B", "initials": "KB"}, {"family": "Simelane", "given": "Sandile B", "initials": "SB"}, {"family": "Chetty", "given": "Lloyd C", "initials": "LC"}, {"family": "Kruger", "given": "Hendrik G", "initials": "HG", "orcid": "0000-0003-0606-2053", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88f669867879452ca86ab92c27fd285c.json"}}, {"family": "Govender", "given": "Thavendran", "initials": "T", "orcid": "0000-0003-2511-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77ef43839d9e476f95d124c9c34b81fa.json"}}, {"family": "Arvidsson", "given": "Per I", "initials": "PI"}, {"family": "Naicker", "given": "Tricia", "initials": "T", "orcid": "0000-0002-7134-6258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f5b1b1625e8c43859647736baa3e83d9.json"}}], "type": "journal article", "published": "2025-10-07", "journal": {"title": "ACS Omega", "issn": "2470-1343", "volume": "10", "issue": "39", "pages": "45516-45523", "issn-l": "2470-1343"}, "abstract": "Sulfur-containing spirooxindoles are recognized for their significant biological activity, yet accessing these compounds with diverse heteroatoms in the spirocyclic core has remained challenging. This study introduces a simple and efficient base-mediated tandem Michael addition reaction and SuFEx cyclization to synthesize novel sultone-containing spirooxindoles. The transformation occurred in a green solvent, which proved essential in suppressing side reactions, leading to the successful synthesis of 20 novel sultone-spirooxindoles and two sulfonates that are resistant to cyclization. Additionally, a chiral variant of the reaction was explored, laying the groundwork for the future development of enantioselective methods.", "doi": "10.1021/acsomega.5c05571", "pmid": "41078771", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12508956"}], "notes": [], "created": "2026-08-20T08:12:38.900Z", "modified": "2026-08-20T08:12:38.985Z"}, {"entity": "publication", "iuid": "4ac8f8e029534d7ab11311450b1553c2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4ac8f8e029534d7ab11311450b1553c2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4ac8f8e029534d7ab11311450b1553c2"}}, "title": "Facile Synthesis of Oxazolidinones as Potential Antibacterial Agents.", "authors": [{"family": "Els", "given": "Secret P", "initials": "SP"}, {"family": "Govender", "given": "Kimberleigh B", "initials": "KB"}, {"family": "Sokhela", "given": "Mxolisi K", "initials": "MK"}, {"family": "Bhatt", "given": "Nilay", "initials": "N"}, {"family": "Reddy", "given": "Nakita", "initials": "N", "orcid": "0000-0003-4428-2241", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c720c72b0734659b2cc966792015076.json"}}, {"family": "Kruger", "given": "Hendrik G", "initials": "HG", "orcid": "0000-0003-0606-2053", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88f669867879452ca86ab92c27fd285c.json"}}, {"family": "Arvidsson", "given": "Per I", "initials": "PI", "orcid": "0000-0002-9453-6812", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/84789ce64d004c83919336cdf43c903e.json"}}, {"family": "Gunosewoyo", "given": "Hendra", "initials": "H", "orcid": "0000-0003-3897-1948", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f0b4c9d19e04464c933f01f32674c4b2.json"}}, {"family": "Govender", "given": "Thavendran", "initials": "T", "orcid": "0000-0003-2511-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77ef43839d9e476f95d124c9c34b81fa.json"}}, {"family": "Naicker", "given": "Tricia", "initials": "T", "orcid": "0000-0002-7134-6258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f5b1b1625e8c43859647736baa3e83d9.json"}}], "type": "journal article", "published": "2025-07-00", "journal": {"title": "ChemistryOpen", "issn": "2191-1363", "volume": "14", "issue": "7", "pages": "e202400432", "issn-l": "2191-1363"}, "abstract": "An efficient microwave-assisted synthesis route for novel oxazolidinone analogues has been developed. The general synthesis of these compounds began with an L-proline-mediated three-component Mannich reaction between commercially available 3-fluoro-4-morpholinoaniline, aqueous formaldehyde and \u03b1-hydroxyacetone. This was followed by a one-step cyclisation to form the core structure of oxazolidinone antibiotics which was subsequently derivatized. The novel compounds were evaluated for their antibacterial activity against M. smegmatis. One of the novel oxazolidinone derivatives 18 a1 produced a MIC of 8 mg/L, comparable with the commercial Rifampicin. The methodology is a useful addition to the field since it can make highly sought-after oxazolidinone derivatives, using cheaper, less harsh commercially available reagents, in a short time and one pot.", "doi": "10.1002/open.202400432", "pmid": "39776351", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12256933"}], "notes": [], "created": "2026-08-20T06:34:41.927Z", "modified": "2026-08-20T06:34:42.075Z"}, {"entity": "publication", "iuid": "8c4c237517a64bc6bc0a34d650a64186", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8c4c237517a64bc6bc0a34d650a64186.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8c4c237517a64bc6bc0a34d650a64186"}}, "title": "The Oxidation of Electron-Rich Arenes Using a H2O2-Proline System.", "authors": [{"family": "Chetty", "given": "Lloyd C", "initials": "LC"}, {"family": "Kruger", "given": "Hendrik G", "initials": "HG", "orcid": "0000-0003-0606-2053", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88f669867879452ca86ab92c27fd285c.json"}}, {"family": "Arvidsson", "given": "Per I", "initials": "PI"}, {"family": "Maguire", "given": "Glenn E M", "initials": "GEM"}, {"family": "Govender", "given": "Thavendran", "initials": "T", "orcid": "0000-0003-2511-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77ef43839d9e476f95d124c9c34b81fa.json"}}, {"family": "Naicker", "given": "Tricia", "initials": "T", "orcid": "0000-0002-7134-6258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f5b1b1625e8c43859647736baa3e83d9.json"}}], "type": "journal article", "published": "2024-09-03", "journal": {"title": "ACS Omega", "issn": "2470-1343", "volume": "9", "issue": "35", "pages": "37155-37162", "issn-l": "2470-1343"}, "abstract": "This study introduces a novel proline-catalyzed oxidation system employing hydrogen peroxide to synthesize quinones from a diverse range of substrates, including hydroquinones, phenols, resorcinols, aldehydes, and polycyclic aromatics. This approach is well-aligned with green chemistry principles, offering a more environmentally benign approach than earlier studies. Notably, this approach uses cost-effective reagents, proline as a readily available organocatalyst, reduced equivalents of H2O2, metal-free conditions, and notably short reaction times to achieve moderate-to-high yields. This promising approach encourages further exploration of the H2O2-proline system in oxidation reactions. This study's innovative approach and good results set a strong foundation for future research to expand the scope and efficiency of green oxidation processes.", "doi": "10.1021/acsomega.4c04383", "pmid": "39246484", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11375719"}], "notes": [], "created": "2026-08-20T08:12:36.924Z", "modified": "2026-08-20T08:12:37.006Z"}, {"entity": "publication", "iuid": "91a59cddd46c47eabc483341f2811cbf", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/91a59cddd46c47eabc483341f2811cbf.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/91a59cddd46c47eabc483341f2811cbf"}}, "title": "A 2018-2019 patent review of metallo beta-lactamase inhibitors.", "authors": [{"family": "Reddy", "given": "Nakita", "initials": "N", "orcid": "0000-0003-4428-2241", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c720c72b0734659b2cc966792015076.json"}}, {"family": "Shungube", "given": "Mbongeni", "initials": "M", "orcid": "0000-0001-8405-584X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1d0b9cb57fef4ce5bb7d3c3b04b54f7e.json"}}, {"family": "Arvidsson", "given": "Per I", "initials": "PI", "orcid": "0000-0002-9453-6812", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/84789ce64d004c83919336cdf43c903e.json"}}, {"family": "Baijnath", "given": "Sooraj", "initials": "S", "orcid": "0000-0001-7860-1779", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5cedc06c61074967821fce1c7dd757bb.json"}}, {"family": "Kruger", "given": "Hendrik G", "initials": "HG", "orcid": "0000-0003-0606-2053", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88f669867879452ca86ab92c27fd285c.json"}}, {"family": "Govender", "given": "Thavendran", "initials": "T", "orcid": "0000-0003-2511-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77ef43839d9e476f95d124c9c34b81fa.json"}}, {"family": "Naicker", "given": "Tricia", "initials": "T", "orcid": "0000-0002-7134-6258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f5b1b1625e8c43859647736baa3e83d9.json"}}], "type": "journal article", "published": "2020-07-00", "journal": {"title": "Expert Opin Ther Pat", "issn": "1744-7674", "volume": "30", "issue": "7", "pages": "541-555", "issn-l": null}, "abstract": "Antibiotic resistance caused by beta-lactamase expressing bacteria poses a concern given its global dissemination and proliferation. The emergence of the metallo beta-lactamases is an indefinite health threat toward which current antibiotics have limited clinical efficacy. One solution is to develop metallo beta-lactamase inhibitors (MBLIs) capable of restoring the activity of beta-lactam drugs.\n\nThis review focuses on potential metallo beta-lactamase inhibitors that have been patented during the period of 2018-2019. The aim is to provide insight into the diverse class of compounds which exhibit a synergistic inhibitory effect on carbapenem-resistant bacteria, when co-administered with a beta-lactam antibiotic.\n\nThe treatment strategy, of creating a broad-spectrum beta-lactamase inhibitor, is beneficial to the health sector as well as rural communities. Unfortunately, most of the inhibitors lack published data from both in vitro and in vivo evaluation, thus preventing an expert opinion on the likelihood to progress as candidates for clinical trials. From this report, the bismuth complexes, pyridinyl-nicotinamide derived sugars, boronic acid, and thiazole sulfonamide derivatives, portray promising properties for further advancement. Since there is currently no FDA approved MBLI, there remains an urgent need for the development of these combination treatment strategies.", "doi": "10.1080/13543776.2020.1767070", "pmid": "32393078", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T09:35:21.446Z", "modified": "2026-08-20T09:35:21.613Z"}, {"entity": "publication", "iuid": "6d36f2ccf8614f7d820afc22850dcbbd", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6d36f2ccf8614f7d820afc22850dcbbd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6d36f2ccf8614f7d820afc22850dcbbd"}}, "title": "Microwave-Accelerated N-Acylation of Sulfoximines with Aldehydes under Catalyst-Free Conditions", "authors": [{"family": "Rajbongshi", "given": "Kamal K", "initials": "KK", "orcid": "0000-0003-0128-663X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a1473c288f83416a823fb0b599f003b3.json"}}, {"family": "Ambala", "given": "Srinivas", "initials": "S"}, {"family": "Govender", "given": "Thavendran", "initials": "T", "orcid": "0000-0003-2511-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77ef43839d9e476f95d124c9c34b81fa.json"}}, {"family": "Kruger", "given": "Hendrik G", "initials": "HG", "orcid": "0000-0003-0606-2053", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88f669867879452ca86ab92c27fd285c.json"}}, {"family": "Arvidsson", "given": "Per I", "initials": "PI", "orcid": "0000-0002-9453-6812", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/84789ce64d004c83919336cdf43c903e.json"}}, {"family": "Naicker", "given": "Tricia", "initials": "T", "orcid": "0000-0002-7134-6258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f5b1b1625e8c43859647736baa3e83d9.json"}}], "type": "journal-article", "published": "2020-04-00", "journal": {"title": "Synthesis", "issn": "0039-7881", "volume": "52", "issue": "08", "pages": "1279-1286", "issn-l": null}, "abstract": null, "doi": "10.1055/s-0039-1691589", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T09:28:47.693Z", "modified": "2026-08-20T09:28:47.831Z"}, {"entity": "publication", "iuid": "cc8fc79453d64061b1a40363b98d5d41", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/cc8fc79453d64061b1a40363b98d5d41.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/cc8fc79453d64061b1a40363b98d5d41"}}, "title": "Sulfonimidamide in medizinischer Chemie und Agrochemie", "authors": [{"family": "Chinthakindi", "given": "Praveen K", "initials": "PK"}, {"family": "Naicker", "given": "Tricia", "initials": "T", "orcid": "0000-0002-7134-6258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f5b1b1625e8c43859647736baa3e83d9.json"}}, {"family": "Thota", "given": "Niranjan", "initials": "N"}, {"family": "Govender", "given": "Thavendran", "initials": "T", "orcid": "0000-0003-2511-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77ef43839d9e476f95d124c9c34b81fa.json"}}, {"family": "Kruger", "given": "Hendrik G", "initials": "HG", "orcid": "0000-0003-0606-2053", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88f669867879452ca86ab92c27fd285c.json"}}, {"family": "Arvidsson", "given": "Per I", "initials": "PI", "orcid": "0000-0002-9453-6812", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/84789ce64d004c83919336cdf43c903e.json"}}], "type": "journal-article", "published": "2017-04-03", "journal": {"title": "Angewandte Chemie", "issn": "0044-8249", "volume": "129", "issue": "15", "pages": "4160-4170", "issn-l": null}, "abstract": null, "doi": "10.1002/ange.201610456", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T06:29:26.808Z", "modified": "2026-08-20T06:29:26.901Z"}]}