{"entity": "researcher", "timestamp": "2026-08-20T20:49:34.212Z", "family": "Kojic", "given": "Marija", "initials": "M", "orcid": "0000-0001-6437-283X", "affiliations": [], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/77e8f76b0a144796becbc1dab6da9205.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/77e8f76b0a144796becbc1dab6da9205"}}, "publications": [{"entity": "publication", "iuid": "05bb661123804612a71398516300deb1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/05bb661123804612a71398516300deb1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/05bb661123804612a71398516300deb1"}}, "title": "Data from SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation", "authors": [{"family": "Adolphe", "given": "Christelle", "initials": "C"}, {"family": "Millar", "given": "Amanda", "initials": "A"}, {"family": "Kojic", "given": "Marija", "initials": "M", "orcid": "0000-0001-6437-283X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77e8f76b0a144796becbc1dab6da9205.json"}}, {"family": "Barkauskas", "given": "Deborah S", "initials": "DS"}, {"family": "Sundstr\u00f6m", "given": "Anders", "initials": "A", "orcid": "0000-0003-3942-6271", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/63e6602d2807417684239b93eb065a26.json"}}, {"family": "Swartling", "given": "Fredrik J", "initials": "FJ", "orcid": "0000-0002-8460-4367", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e673fa8c86348fb8c1a2ae34ba7ba9a.json"}}, {"family": "Hediyeh-zadeh", "given": "Soroor", "initials": "S", "orcid": "0000-0001-7513-6779", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5a9996c51c9d43c6a40db9c46d213399.json"}}, {"family": "Tan", "given": "Chin Wee", "initials": "CW", "orcid": "0000-0001-9695-7218", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5277887d70f84d1d98fa163ee066817a.json"}}, {"family": "Davis", "given": "Melissa J", "initials": "MJ", "orcid": "0000-0003-4864-7033", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca0ff39b0e06406d9bf637043b2e2221.json"}}, {"family": "Genovesi", "given": "Laura A", "initials": "LA", "orcid": "0000-0001-6277-8422", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35c473636ad549d5a005b2680901551c.json"}}, {"family": "Wainwright", "given": "Brandon J", "initials": "BJ"}], "type": "posted-content", "published": "2023-04-03", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1158/1541-7786.c.6545124.v1", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T12:14:02.202Z", "modified": "2026-08-20T12:14:02.430Z"}, {"entity": "publication", "iuid": "9dcdc4592a8c4e0dab74f807fc254b1b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9dcdc4592a8c4e0dab74f807fc254b1b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9dcdc4592a8c4e0dab74f807fc254b1b"}}, "title": "SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation.", "authors": [{"family": "Adolphe", "given": "Christelle", "initials": "C"}, {"family": "Millar", "given": "Amanda", "initials": "A"}, {"family": "Kojic", "given": "Marija", "initials": "M", "orcid": "0000-0001-6437-283X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77e8f76b0a144796becbc1dab6da9205.json"}}, {"family": "Barkauskas", "given": "Deborah S", "initials": "DS"}, {"family": "Sundstr\u00f6m", "given": "Anders", "initials": "A", "orcid": "0000-0003-3942-6271", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/63e6602d2807417684239b93eb065a26.json"}}, {"family": "Swartling", "given": "Fredrik J", "initials": "FJ", "orcid": "0000-0002-8460-4367", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e673fa8c86348fb8c1a2ae34ba7ba9a.json"}}, {"family": "Hediyeh-Zadeh", "given": "Soroor", "initials": "S", "orcid": "0000-0001-7513-6779", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5a9996c51c9d43c6a40db9c46d213399.json"}}, {"family": "Tan", "given": "Chin Wee", "initials": "CW", "orcid": "0000-0001-9695-7218", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5277887d70f84d1d98fa163ee066817a.json"}}, {"family": "Davis", "given": "Melissa J", "initials": "MJ", "orcid": "0000-0003-4864-7033", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca0ff39b0e06406d9bf637043b2e2221.json"}}, {"family": "Genovesi", "given": "Laura A", "initials": "LA", "orcid": "0000-0001-6277-8422", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35c473636ad549d5a005b2680901551c.json"}}, {"family": "Wainwright", "given": "Brandon J", "initials": "BJ"}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Mol. Cancer Res.", "issn": "1557-3125", "volume": "19", "issue": "11", "pages": "1831-1839", "issn-l": "1541-7786"}, "abstract": "Medulloblastoma is the most common malignant pediatric brain tumor and there is an urgent need for molecularly targeted and subgroup-specific therapies. The stem cell factor SOX9, has been proposed as a potential therapeutic target for the treatment of Sonic Hedgehog medulloblastoma (SHH-MB) subgroup tumors, given its role as a downstream target of Hedgehog signaling and in functionally promoting SHH-MB metastasis and treatment resistance. However, the functional requirement for SOX9 in the genesis of medulloblastoma remains to be determined. Here we report a previously undocumented level of SOX9 expression exclusively in proliferating granule cell precursors (GCP) of the postnatal mouse cerebellum, which function as the medulloblastoma-initiating cells of SHH-MBs. Wild-type GCPs express comparatively lower levels of SOX9 than neural stem cells and mature astroglia and SOX9low GCP-like tumor cells constitute the bulk of both infant (Math1Cre:Ptch1 ) and adult (lox/loxPtch1 ) SHH-MB mouse models. Human medulloblastoma single-cell RNA data analyses reveal three distinct LacZ/+SOX9 populations present in SHH-MB and noticeably absent in other medulloblastoma subgroups: SOX9 + MATH1 + (GCP), SOX9 + GFAP + (astrocytes) and SOX9 + MATH1 + GFAP + (potential tumor-derived astrocytes). To functionally address whether SOX9 is required as a downstream effector of Hedgehog signaling in medulloblastoma tumor cells, we ablated Sox9 using a Math1Cre model system. Surprisingly, targeted ablation of Sox9 in GCPs (Math1Cre:Sox9 ) revealed no overt phenotype and loss of lox/loxSox9 in SHH-MB (Math1Cre:Ptch1 ) does not affect tumor formation. IMPLICATIONS: Despite preclinical data indicating SOX9 plays a key role in SHH-MB biology, our data argue against SOX9 as a viable therapeutic target.lox/lox;Sox9lox/lox", "doi": "10.1158/1541-7786.MCR-21-0117", "pmid": "34330843", "labels": [], "xrefs": [{"db": "pii", "key": "1541-7786.MCR-21-0117"}], "notes": [], "created": "2026-08-20T12:14:25.096Z", "modified": "2026-08-20T12:14:25.210Z"}]}