{"entity": "researcher", "timestamp": "2026-08-20T21:35:58.169Z", "family": "Mustjoki", "given": "Satu", "initials": "S", "orcid": "0000-0002-0816-8241", "affiliations": ["Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland. satu.mustjoki@helsinki.fi.", "Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland. satu.mustjoki@helsinki.fi.", "Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland. satu.mustjoki@helsinki.fi."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/77ae8c3136924c22b8f56b35a24fc507.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/77ae8c3136924c22b8f56b35a24fc507"}}, "publications": [{"entity": "publication", "iuid": "b4c37168301940ce9efedc7b49904d36", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b4c37168301940ce9efedc7b49904d36.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b4c37168301940ce9efedc7b49904d36"}}, "title": "Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia.", "authors": [{"family": "Malani", "given": "Disha", "initials": "D"}, {"family": "Kumar", "given": "Ashwini", "initials": "A"}, {"family": "Br\u00fcck", "given": "Oscar", "initials": "O"}, {"family": "Kontro", "given": "Mika", "initials": "M", "orcid": "0000-0001-6353-0664", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0661dd63c7df44d79aa7c50a309c55db.json"}}, {"family": "Yadav", "given": "Bhagwan", "initials": "B", "orcid": "0000-0002-3502-9335", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f979e77a9854141b2077a3d10164d08.json"}}, {"family": "Helles\u00f8y", "given": "Monica", "initials": "M", "orcid": "0000-0002-0115-7427", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65449b403fe24b85b0b1956e899ee9b8.json"}}, {"family": "Kuusanm\u00e4ki", "given": "Heikki", "initials": "H"}, {"family": "Dufva", "given": "Olli", "initials": "O"}, {"family": "Kankainen", "given": "Matti", "initials": "M"}, {"family": "Eldfors", "given": "Samuli", "initials": "S", "orcid": "0000-0001-5056-4750", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/84b0e10b975c44fc88a5997ca1ee09b7.json"}}, {"family": "Potdar", "given": "Swapnil", "initials": "S", "orcid": "0000-0002-2778-6918", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e17191dcbef4dc7917d15792cfe5d6e.json"}}, {"family": "Saarela", "given": "Jani", "initials": "J", "orcid": "0000-0001-7306-7175", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8ba79c74ec3c489ab321465d195c0844.json"}}, {"family": "Turunen", "given": "Laura", "initials": "L", "orcid": "0000-0003-0274-4794", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35779e69fefa43cdb2d13c9e7fd05df7.json"}}, {"family": "Parsons", "given": "Alun", "initials": "A"}, {"family": "V\u00e4strik", "given": "Imre", "initials": "I", "orcid": "0000-0001-6658-9311", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5cb6a5a735404b78823b54059bf0990c.json"}}, {"family": "Kivinen", "given": "Katja", "initials": "K"}, {"family": "Saarela", "given": "Janna", "initials": "J", "orcid": "0000-0002-0853-6219", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80f36bfb769b400fadd19daa0f80565c.json"}}, {"family": "R\u00e4ty", "given": "Riikka", "initials": "R"}, {"family": "Lehto", "given": "Minna", "initials": "M"}, {"family": "Wolf", "given": "Maija", "initials": "M"}, {"family": "Gjertsen", "given": "Bjorn Tore", "initials": "BT"}, {"family": "Mustjoki", "given": "Satu", "initials": "S", "orcid": "0000-0002-0816-8241", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77ae8c3136924c22b8f56b35a24fc507.json"}}, {"family": "Aittokallio", "given": "Tero", "initials": "T", "orcid": "0000-0002-0886-9769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/433e429e6a5b49818cf54f5fc102fff7.json"}}, {"family": "Wennerberg", "given": "Krister", "initials": "K", "orcid": "0000-0002-1352-4220", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40883b183a28459a9b7b515312c8c44c.json"}}, {"family": "Heckman", "given": "Caroline A", "initials": "CA", "orcid": "0000-0002-4324-8706", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0490f5eb61a4d92a44815d03de84af4.json"}}, {"family": "Kallioniemi", "given": "Olli", "initials": "O"}, {"family": "Porkka", "given": "Kimmo", "initials": "K"}], "type": "journal article", "published": "2022-02-00", "journal": {"title": "Cancer Discov", "issn": "2159-8290", "volume": "12", "issue": "2", "pages": "388-401", "issn-l": "2159-8274"}, "abstract": "We generated ex vivo drug-response and multiomics profiling data for a prospective series of 252 samples from 186 patients with acute myeloid leukemia (AML). A functional precision medicine tumor board (FPMTB) integrated clinical, molecular, and functional data for application in clinical treatment decisions. Actionable drugs were found for 97% of patients with AML, and the recommendations were clinically implemented in 37 relapsed or refractory patients. We report a 59% objective response rate for the individually tailored therapies, including 13 complete responses, as well as bridging five patients with AML to allogeneic hematopoietic stem cell transplantation. Data integration across all cases enabled the identification of drug response biomarkers, such as the association of IL15 overexpression with resistance to FLT3 inhibitors. Integration of molecular profiling and large-scale drug response data across many patients will enable continuous improvement of the FPMTB recommendations, providing a paradigm for individualized implementation of functional precision cancer medicine. SIGNIFICANCE: Oncogenomics data can guide clinical treatment decisions, but often such data are neither actionable nor predictive. Functional ex vivo drug testing contributes significant additional, clinically actionable therapeutic insights for individual patients with AML. Such data can be generated in four days, enabling rapid translation through FPMTB.See related commentary by Letai, p. 290.This article is highlighted in the In This Issue feature, p. 275.", "doi": "10.1158/2159-8290.CD-21-0410", "pmid": "34789538", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9762335"}, {"db": "pii", "key": "2159-8290.CD-21-0410"}], "notes": [], "created": "2026-08-20T12:14:31.294Z", "modified": "2026-08-20T12:14:31.705Z"}, {"entity": "publication", "iuid": "29c8a63d80254f058f1008d54496c4c1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/29c8a63d80254f058f1008d54496c4c1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/29c8a63d80254f058f1008d54496c4c1"}}, "title": "Immune cell constitution in bone marrow microenvironment predicts outcome in adult ALL.", "authors": [{"family": "Hohtari", "given": "Helena", "initials": "H"}, {"family": "Br\u00fcck", "given": "Oscar", "initials": "O"}, {"family": "Blom", "given": "Sami", "initials": "S"}, {"family": "Turkki", "given": "Riku", "initials": "R"}, {"family": "Sinisalo", "given": "Marjatta", "initials": "M"}, {"family": "Kovanen", "given": "Panu E", "initials": "PE"}, {"family": "Kallioniemi", "given": "Olli", "initials": "O"}, {"family": "Pellinen", "given": "Teijo", "initials": "T"}, {"family": "Porkka", "given": "Kimmo", "initials": "K"}, {"family": "Mustjoki", "given": "Satu", "initials": "S", "orcid": "0000-0002-0816-8241", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77ae8c3136924c22b8f56b35a24fc507.json"}}], "type": "journal article", "published": "2019-07-00", "journal": {"title": "Leukemia", "issn": "1476-5551", "volume": "33", "issue": "7", "pages": "1570-1582", "issn-l": "0887-6924"}, "abstract": "As novel immunological treatments are gaining a foothold in the treatment of acute lymphoblastic leukemia (ALL), it is elemental to examine ALL immunobiology in more detail. We used multiplexed immunohistochemistry (mIHC) to study the immune contexture in adult precursor B cell ALL bone marrow (BM). In addition, we developed a multivariate risk prediction model that stratified a poor survival group based on clinical parameters and mIHC data. We analyzed BM biopsy samples of ALL patients (n = 52) and healthy controls (n = 14) using mIHC with 30 different immunophenotype markers and computerized image analysis. In ALL BM, the proportions of M1-like macrophages, granzyme B+CD57+CD8+ T cells, and CD27+ T cells were decreased, whereas the proportions of myeloid-derived suppressor cells and M2-like macrophages were increased. Also, the expression of checkpoint molecules PD1 and CTLA4 was elevated. In the multivariate model, age, platelet count, and the proportion of PD1+TIM3+ double-positive CD4+ T cells differentiated a poor survival group. These results were validated by flow cytometry in a separate cohort (n = 31). In conclusion, the immune cell contexture in ALL BM differs from healthy controls. CD4+PD1+TIM3+ T cells were independent predictors of poor outcome in our multivariate risk model, suggesting that PD1 might serve as an attractive immuno-oncological target in B-ALL.", "doi": "10.1038/s41375-018-0360-1", "pmid": "30635636", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6755974"}, {"db": "pii", "key": "10.1038/s41375-018-0360-1"}], "notes": [], "created": "2026-08-20T08:47:14.070Z", "modified": "2026-08-20T08:47:40.822Z"}]}