{"entity": "researcher", "timestamp": "2026-08-20T20:42:29.273Z", "family": "Herzog", "given": "Laura K", "initials": "LK", "orcid": "0000-0002-3322-7864", "affiliations": ["SciLifeLab Department of Chemistry Ume\u00e5 University  90187 Ume\u00e5 Sweden", "Ume\u00e5 Centre for Microbial Research (UCMR) Ume\u00e5 University  90187 Ume\u00e5 Sweden"], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/777eef37d33d4c6a8e4bbf574601cc1e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/777eef37d33d4c6a8e4bbf574601cc1e"}}, "publications": [{"entity": "publication", "iuid": "336851589e67468688a86631d1cb67b7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/336851589e67468688a86631d1cb67b7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/336851589e67468688a86631d1cb67b7"}}, "title": "Cover Feature: Visible\u2010Light\u2010Switchable Molecular Glues for Reversible Control of Protein Function (Chem. Eur. J. 15/2025)", "authors": [{"family": "Zhang", "given": "Jun", "initials": "J", "orcid": "0009-0005-1818-4009", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee4c451f3b27452ba7960653e5ac2fb7.json"}}, {"family": "Herzog", "given": "Laura K", "initials": "LK", "orcid": "0000-0002-3322-7864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/777eef37d33d4c6a8e4bbf574601cc1e.json"}}, {"family": "Li", "given": "Shuang", "initials": "S"}, {"family": "Chen", "given": "Xi", "initials": "X"}, {"family": "Wu", "given": "Yao\u2010Wen", "initials": "Y", "orcid": "0000-0002-2573-8736", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b915c6698bf44f3a88a880af261eb0ad.json"}}], "type": "journal-article", "published": "2025-03-12", "journal": {"title": "Chemistry", "issn": "0947-6539", "volume": "31", "issue": "15", "issn-l": null}, "abstract": null, "doi": "10.1002/chem.202581503", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T06:31:16.167Z", "modified": "2026-08-20T06:31:16.268Z"}, {"entity": "publication", "iuid": "4022d010846e424a90fca0dcba916789", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4022d010846e424a90fca0dcba916789.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4022d010846e424a90fca0dcba916789"}}, "title": "Visible-Light-Switchable Molecular Glues for Reversible Control of Protein Function.", "authors": [{"family": "Zhang", "given": "Jun", "initials": "J", "orcid": "0009-0005-1818-4009", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee4c451f3b27452ba7960653e5ac2fb7.json"}}, {"family": "Herzog", "given": "Laura K", "initials": "LK", "orcid": "0000-0002-3322-7864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/777eef37d33d4c6a8e4bbf574601cc1e.json"}}, {"family": "Li", "given": "Shuang", "initials": "S"}, {"family": "Chen", "given": "Xi", "initials": "X"}, {"family": "Wu", "given": "Yao-Wen", "initials": "YW", "orcid": "0000-0002-2573-8736", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b915c6698bf44f3a88a880af261eb0ad.json"}}], "type": "journal article", "published": "2025-03-12", "journal": {"title": "Chemistry", "issn": "1521-3765", "volume": "31", "issue": "15", "pages": "e202403808", "issn-l": "0947-6539"}, "abstract": "Chemically induced dimerization/proximity (CID/CIP) systems controlled by chemical dimerizers (also known as molecular glues) provide valuable means for understanding and manipulating complex, dynamic biological systems. In this study, we present the development of versatile chemo-optogenetic systems utilizing azobenzene-based photoswitchable molecular glues (sMGs) for reversible protein dimerization controlled by visible light. These systems allow multiple cycles of light-induced dimerization, overcoming the limitations of irreversible photolysis in previous systems. Through optimizing photoswitch properties and linker strategies, we achieved efficient and reversible control using blue, green, and red light. We demonstrate that these systems enable rapid and reversible control of protein function in vitro and in cells. The findings represent a significant advancement in chemo-optogenetics, offering opportunities to expand applications requiring precise spatiotemporal regulation of dynamic biological processes.", "doi": "10.1002/chem.202403808", "pmid": "39805011", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T06:31:09.668Z", "modified": "2026-08-20T06:31:09.802Z"}, {"entity": "publication", "iuid": "803ec714a74043dbb8dcbf67e25ae5f2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/803ec714a74043dbb8dcbf67e25ae5f2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/803ec714a74043dbb8dcbf67e25ae5f2"}}, "title": "Modular Photoswitchable Molecular Glues for Chemo-Optogenetic Control of Protein Function in Living Cells.", "authors": [{"family": "Zhang", "given": "Jun", "initials": "J"}, {"family": "Herzog", "given": "Laura K", "initials": "LK", "orcid": "0000-0002-3322-7864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/777eef37d33d4c6a8e4bbf574601cc1e.json"}}, {"family": "Corkery", "given": "Dale P", "initials": "DP"}, {"family": "Lin", "given": "Tzu-Chen", "initials": "TC"}, {"family": "Klewer", "given": "Laura", "initials": "L"}, {"family": "Chen", "given": "Xi", "initials": "X"}, {"family": "Xin", "given": "Xiaoyi", "initials": "X"}, {"family": "Li", "given": "Yaozong", "initials": "Y"}, {"family": "Wu", "given": "Yao-Wen", "initials": "YW", "orcid": "0000-0002-2573-8736", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b915c6698bf44f3a88a880af261eb0ad.json"}}], "type": "journal article", "published": "2025-02-10", "journal": {"title": "Angew. Chem. Int. Ed. Engl.", "issn": "1521-3773", "volume": "64", "issue": "7", "pages": "e202416456", "issn-l": "1433-7851"}, "abstract": "Optogenetic systems using photosensitive proteins and chemically induced dimerization/proximity (CID/CIP) approaches enabled by chemical dimerizers (also termed molecular glues), are powerful tools to elucidate the dynamics of biological systems and to dissect complex biological regulatory networks. Here, we report a versatile chemo-optogenetic system using modular, photoswitchable molecular glues (sMGs) that can undergo repeated cycles of optical control to switch protein function on and off. We use molecular dynamics (MD) simulations to rationally design the sMGs and further expand their scope by incorporating different photoswitches, resulting in sMGs with customizable properties. We demonstrate that this system can be used to reversibly control protein localization, organelle positioning, protein-fragment complementation as well as posttranslational protein levels by light with high spatiotemporal precision. This system enables sophisticated optical manipulation of cellular processes and thus opens up a new avenue for chemo-optogenetics.", "doi": "10.1002/anie.202416456", "pmid": "39777946", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T06:30:00.143Z", "modified": "2026-08-20T06:30:00.237Z"}, {"entity": "publication", "iuid": "9b8c4b7cb693426f9a51603cc8ed62fc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9b8c4b7cb693426f9a51603cc8ed62fc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9b8c4b7cb693426f9a51603cc8ed62fc"}}, "title": "Modular Photoswitchable Molecular Glues for Chemo\u2010Optogenetic Control of Protein Function in Living Cells", "authors": [{"family": "Zhang", "given": "Jun", "initials": "J"}, {"family": "Herzog", "given": "Laura K", "initials": "LK", "orcid": "0000-0002-3322-7864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/777eef37d33d4c6a8e4bbf574601cc1e.json"}}, {"family": "Corkery", "given": "Dale P", "initials": "DP"}, {"family": "Lin", "given": "Tzu\u2010Chen", "initials": "T"}, {"family": "Klewer", "given": "Laura", "initials": "L"}, {"family": "Chen", "given": "Xi", "initials": "X"}, {"family": "Xin", "given": "Xiaoyi", "initials": "X"}, {"family": "Li", "given": "Yaozong", "initials": "Y"}, {"family": "Wu", "given": "Yao\u2010Wen", "initials": "Y", "orcid": "0000-0002-2573-8736", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b915c6698bf44f3a88a880af261eb0ad.json"}}], "type": "journal-article", "published": "2025-02-10", "journal": {"title": "Angewandte Chemie", "issn": "0044-8249", "volume": "137", "issue": "7", "issn-l": null}, "abstract": null, "doi": "10.1002/ange.202416456", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T06:29:50.004Z", "modified": "2026-08-20T06:29:50.101Z"}]}