{"entity": "researcher", "timestamp": "2026-09-30T04:56:02.143Z", "family": "Ohlsson", "given": "Bodil", "initials": "B", "orcid": "0000-0002-9142-5244", "affiliations": ["Department of Internal Medicine, Sk\u00e5ne University Hospital, Lund, Sweden.", "Department of Clinical Sciences, Lund University, Lund, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/7710b06597494fc68a95a950547e34f4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/7710b06597494fc68a95a950547e34f4"}}, "publications": [{"entity": "publication", "iuid": "36a3187dd6f448ffb90bd4885ef62d43", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/36a3187dd6f448ffb90bd4885ef62d43.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/36a3187dd6f448ffb90bd4885ef62d43"}}, "title": "An Okinawan-Based Nordic Diet Leads to Profound Effects on Gut Microbiota and Plasma Metabolites Linked to Glucose and Lipid Metabolism.", "authors": [{"family": "Manoharan", "given": "Lokeshwaran", "initials": "L", "orcid": "0000-0001-9751-5745", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0fe480c35ff04ae88c36224e740f2264.json"}}, {"family": "Roth", "given": "Bodil", "initials": "B"}, {"family": "Bang", "given": "Corinna", "initials": "C"}, {"family": "Stenlund", "given": "Hans", "initials": "H", "orcid": "0000-0001-9943-296X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fd141a862d4c4d01af8ff55cfb59b1d3.json"}}, {"family": "Ohlsson", "given": "Bodil", "initials": "B", "orcid": "0000-0002-9142-5244", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7710b06597494fc68a95a950547e34f4.json"}}], "type": "journal article", "published": "2023-07-24", "journal": {"title": "Nutrients", "issn": "2072-6643", "volume": "15", "issue": "14", "issn-l": "2072-6643"}, "abstract": "Dietary interventions modify gut microbiota and clinical outcomes. Weight reduction and improved glucose and lipid homeostasis were observed after adopting an Okinawan-based Nordic diet (O-BN) in individuals with type 2 diabetes. The aim of the present study was to explore changes in metabolomics and gut microbiota during O-BN and correlate changes with clinical outcomes. A total of 30 patients (17 women), aged 57.5 \u00b1 8.2 years, diabetes duration 10.4 \u00b1 7.6 years, 90% over-weight, were included. Participants were provided an O-BN for 12 weeks. Before and after intervention, and 16 weeks afterwards, anthropometry and clinical data were estimated and questionnaires were collected, as well as samples of blood and stool. Plasma metabolomics were determined by gas- (GC-MS) or liquid- (LC-MS) chromatography-based mass spectrometry and fecal microbiota determination was based on 16S rRNA amplicons from regions V1-V2. During the intervention, weight (6.8%), waist circumference (6.1%), and levels of glucose, HbA1c, insulin, triglycerides, and cholesterol were decreased. Of 602 metabolites, 323 were changed for any or both periods; 199 (101 lipids) metabolites were decreased while 58 (43 lipids) metabolites were increased during the intervention. Changes in glucose homeostasis were linked to changes in, e.g., 1,5-anhydroglucitol, thyroxine, and chiro-inositol. Changes of microbe beta diversity correlated positively with food components and negatively with IL-18 (p = 0.045). Abundance differences at phylum and genus levels were found. Abundances of Actinobacteria, Bacteroidetes, Firmicutes, and Verrucomicrobia correlated with anthropometry, HbA1c, lipids, inflammation, and food. Changes in metabolites and microbiota were reversed after the intervention. The O-BN-induced changes in metabolomics and gut microbiota correspond to clinical outcomes of reduced weight and inflammation and improved glucose and lipid metabolism.", "doi": "10.3390/nu15143273", "pmid": "37513690", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10384944"}, {"db": "pii", "key": "nu15143273"}], "notes": [], "created": "2026-09-23T12:10:06.338Z", "modified": "2026-09-23T12:10:06.390Z"}, {"entity": "publication", "iuid": "9bdbbf0529ab4f679a357bcef2819163", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9bdbbf0529ab4f679a357bcef2819163.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9bdbbf0529ab4f679a357bcef2819163"}}, "title": "A starch- and sucrose-reduced dietary intervention in irritable bowel syndrome patients produced a shift in gut microbiota composition along with changes in phylum, genus, and amplicon sequence variant abundances, without affecting the micro-RNA levels.", "authors": [{"family": "Nilholm", "given": "Clara", "initials": "C"}, {"family": "Manoharan", "given": "Lokeshwaran", "initials": "L"}, {"family": "Roth", "given": "Bodil", "initials": "B"}, {"family": "D'Amato", "given": "Mauro", "initials": "M"}, {"family": "Ohlsson", "given": "Bodil", "initials": "B", "orcid": "0000-0002-9142-5244", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7710b06597494fc68a95a950547e34f4.json"}}], "type": "journal article", "published": "2022-05-00", "journal": {"title": "United European Gastroenterol J", "issn": "2050-6414", "volume": "10", "issue": "4", "pages": "363-375", "issn-l": null}, "abstract": "A randomized clinical trial with a starch- and sucrose-reduced diet (SSRD) in irritable bowel syndrome (IBS) patients has shown clear improvement of participants' symptoms. The present study aimed to explore the effects of the SSRD on the gut microbiota and circulating micro-RNA in relation to nutrient intake and gastrointestinal symptoms.\n\nIBS patients were randomized to a 4-week SSRD intervention (n = 80) or control group (n = 25); habitual diet). At baseline and 4 weeks, blood and fecal samples, 4 day-dietary records, and symptom questionnaires were collected, that is, Rome IV questionnaires, IBS-symptom severity score (IBS-SSS) and visual analog scale for IBS (VAS-IBS). Micro-RNA was analyzed in blood and microbiota in faeces by 16S rRNA from regions V1-V2.\n\nThe alpha diversity was unaffected, whereas beta diversity was decreased (p < 0.001) along with increased abundance of Proteobacteria (p = 0.0036) and decreased abundance of Bacteroidetes phyla (p < 0.001) in the intervention group at 4 weeks. Few changes were noted in the controls. The shift in beta diversity and phyla abundance correlated with decreased intakes of carbohydrates, disaccharides, and starch and increased fat and protein intakes. Proteobacteria abundance also correlated positively (R2 = 0.07, p = 0.0016), and Bacteroidetes negatively (R2 = 0.07, p = 0.0017), with reduced total IBS-SSS. Specific genera, for example, Eubacterium eligens, Lachnospiraceae UCG-001, Victivallis, and Lachnospira increased significantly in the intervention group (p < 0.001 for all), whereas Marvinbryantia, DTU089 (Ruminoccocaceae family), Enterorhabdus, and Olsenella decreased, together with changes in amplicon sequence variant (ASV) levels. Modest changes of genus and ASV abundance were observed in the control group. No changes were observed in micro-RNA expression in either group.\n\nThe SSRD induced a shift in beta diversity along with several bacteria at different levels, associated with changes in nutrient intakes and reduced gastrointestinal symptoms. No corresponding changes were observed in the control group. Neither the nutrient intake nor the microbiota changes affected micro-RNA expression. The study was registered at ClinicalTrials.gov data base (NCT03306381).", "doi": "10.1002/ueg2.12227", "pmid": "35484927", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9103372"}, {"db": "ClinicalTrials.gov", "key": "NCT03306381"}], "notes": [], "created": "2026-09-23T10:15:07.146Z", "modified": "2026-09-23T10:53:35.358Z"}]}