{"entity": "researcher", "timestamp": "2026-08-20T21:03:20.067Z", "family": "Sabater-Lleal", "given": "Maria", "initials": "M", "orcid": "0000-0002-0128-379X", "affiliations": ["Research Institute of Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Genomics of Complex Diseases Group, Barcelona, Spain.", "Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/75767107e4c74735959e7b893b4687de.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/75767107e4c74735959e7b893b4687de"}}, "publications": [{"entity": "publication", "iuid": "4de3caf2d2cd4dc3adf0900895b32426", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4de3caf2d2cd4dc3adf0900895b32426.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4de3caf2d2cd4dc3adf0900895b32426"}}, "title": "A multiomics approach reveals novel regulators of plasma factor V levels, highlighting CLEC4M as a clearance receptor.", "authors": [{"family": "Munsch", "given": "Ga\u00eblle", "initials": "G", "orcid": "0000-0003-1564-9825", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed62bf6aa35643f283511d68d2aa4b01.json"}}, {"family": "Mohapatra", "given": "Adarsh K", "initials": "AK"}, {"family": "van Hylckama Vlieg", "given": "Astrid", "initials": "A"}, {"family": "Kleber", "given": "Marcus E", "initials": "ME", "orcid": "0000-0003-0663-7275", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22bc3077d1244542bcd6222f70dd7c96.json"}}, {"family": "Martinez-Perez", "given": "Angel", "initials": "A", "orcid": "0000-0002-5934-1454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0fa8f32fb99f46dcb16d3a64643dbbfa.json"}}, {"family": "Le", "given": "Ngoc-Quynh", "initials": "NQ"}, {"family": "Hindberg", "given": "Kristian Dalsb\u00f8", "initials": "KD", "orcid": "0000-0002-8194-6679", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0cc1f81d466440319191a085318aa835.json"}}, {"family": "Dusart", "given": "Philip", "initials": "P", "orcid": "0000-0003-2747-3214", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26cf50c230954da190746c16b5ac2b7d.json"}}, {"family": "Germain", "given": "Marine", "initials": "M"}, {"family": "Thibord", "given": "Florian", "initials": "F", "orcid": "0000-0003-2229-8322", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0981da3047e498db6a7542a0a6fb62e.json"}}, {"family": "Deleuze", "given": "Jean-Fran\u00e7ois", "initials": "JF", "orcid": "0000-0002-5358-4463", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/33bb50dc6b8045bd9dbbde4423f66129.json"}}, {"family": "Delgado", "given": "Graciela E", "initials": "GE"}, {"family": "Goumidi", "given": "Louisa", "initials": "L", "orcid": "0000-0003-4164-8471", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7d3df066e5e54e32bb99110289ab8a45.json"}}, {"family": "Suchon", "given": "Pierre", "initials": "P"}, {"family": "Saut", "given": "No\u00e9mie", "initials": "N", "orcid": "0000-0002-8365-7731", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bbd3b3a76ea14e5a89a86562d105f672.json"}}, {"family": "Souto", "given": "Juan-Carlos", "initials": "JC", "orcid": "0000-0003-2092-5142", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/164af41db2204f2591c719a8b024d32a.json"}}, {"family": "Butler", "given": "Lynn M", "initials": "LM"}, {"family": "Soria", "given": "Jose-Manuel", "initials": "JM", "orcid": "0000-0002-6226-4293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f92c6ebe3d7475e9c2b3cf15f05e227.json"}}, {"family": "Hansen", "given": "John-Bjarne", "initials": "JB", "orcid": "0000-0003-4854-3162", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/87ec023048ad47a8b363503f14b912de.json"}}, {"family": "M\u00e4rz", "given": "Winfried", "initials": "W"}, {"family": "Rosendaal", "given": "Frits R", "initials": "FR", "orcid": "0000-0003-2558-7496", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4d9bab1db8ba4d7197afa1a7ebe750b5.json"}}, {"family": "Castoldi", "given": "Elisabetta", "initials": "E"}, {"family": "Peiretti", "given": "Franck", "initials": "F", "orcid": "0000-0001-7198-0534", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/541aecbb8fc54c7d830147c95982d837.json"}}, {"family": "Sabater-Lleal", "given": "Maria", "initials": "M", "orcid": "0000-0002-0128-379X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/75767107e4c74735959e7b893b4687de.json"}}, {"family": "Tr\u00e9gou\u00ebt", "given": "David-Alexandre", "initials": "DA", "orcid": "0000-0001-9084-7800", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/74ca463a0d804b1ab97dac4750563220.json"}}, {"family": "Morange", "given": "Pierre-Emmanuel", "initials": "PE", "orcid": "0000-0002-9065-722X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/50bca11c313740c299901843e86e5d48.json"}}], "type": "journal article", "published": "2025-07-31", "journal": {"title": "Blood", "issn": "1528-0020", "volume": "146", "issue": "5", "pages": "628-637", "issn-l": "0006-4971"}, "abstract": "Coagulation factor V (FV) is a key protein in maintaining the hemostatic balance, with abnormal plasma levels associated with both thrombotic and hemorrhagic conditions. We propose a comprehensive bioinformatic analysis integrating large-scale proteogenomics and transcriptomic data from original and public data sets. We identify a biological fingerprint of 26 new proteins and loci involved in the regulation of plasma FV levels. Furthermore, the messenger RNA expression levels of 10 of these components demonstrate strong correlation in the liver. In addition, we provide experimental evidence for the involvement of one of the newly identified players (CLEC4M) in the clearance of FV. This work opens new avenues for a better understanding of the physiological processes involved in thrombotic and bleeding disorders.", "doi": "10.1182/blood.2024027006", "pmid": "40359434", "labels": [], "xrefs": [{"db": "pii", "key": "537238"}], "notes": [], "created": "2026-08-20T12:18:26.207Z", "modified": "2026-08-20T12:18:26.692Z"}, {"entity": "publication", "iuid": "ecfe414277de43cb834382379d90e39b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ecfe414277de43cb834382379d90e39b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ecfe414277de43cb834382379d90e39b"}}, "title": "Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases.", "authors": [{"family": "Paloschi", "given": "Valentina", "initials": "V", "orcid": "0000-0002-5778-8981", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/66de19d73cc54d8592ce6fe0a6d6f3aa.json"}}, {"family": "Sabater-Lleal", "given": "Maria", "initials": "M", "orcid": "0000-0002-0128-379X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/75767107e4c74735959e7b893b4687de.json"}}, {"family": "Middelkamp", "given": "Heleen", "initials": "H"}, {"family": "Vivas", "given": "Aisen", "initials": "A", "orcid": "0000-0003-1721-8682", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d35883f8b84481290cdbd8801e4ed33.json"}}, {"family": "Johansson", "given": "Sofia", "initials": "S", "orcid": "0000-0003-3672-9883", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d976bdc17d7248d6b60c4f7a47fc84c7.json"}}, {"family": "van der Meer", "given": "Andries", "initials": "A", "orcid": "0000-0002-8761-4077", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4232e14ac59d40fea9c6f3ba0ddaa65c.json"}}, {"family": "Tenje", "given": "Maria", "initials": "M", "orcid": "0000-0002-1264-1337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bd13273274574923b354ca9c605efc8f.json"}}, {"family": "Maegdefessel", "given": "Lars", "initials": "L", "orcid": "0000-0001-5228-2634", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/17d6648126d04eaab303a92744664c64.json"}}], "type": "journal article", "published": "2021-12-17", "journal": {"title": "Cardiovasc Res", "issn": "1755-3245", "volume": "117", "issue": "14", "pages": "2742-2754", "issn-l": null}, "abstract": "The development of organs-on-chip (OoC) has revolutionized in vitro cell-culture experiments by allowing a better mimicry of human physiology and pathophysiology that has consequently led researchers to gain more meaningful insights into disease mechanisms. Several models of hearts-on-chips and vessels-on-chips have been demonstrated to recapitulate fundamental aspects of the human cardiovascular system in the recent past. These 2D and 3D systems include synchronized beating cardiomyocytes in hearts-on-chips and vessels-on-chips with layer-based structures and the inclusion of physiological and pathological shear stress conditions. The opportunities to discover novel targets and to perform drug testing with chip-based platforms have substantially enhanced, thanks to the utilization of patient-derived cells and precise control of their microenvironment. These organ models will provide an important asset for future approaches to personalized cardiovascular medicine and improved patient care. However, certain technical and biological challenges remain, making the global utilization of OoCs to tackle unanswered questions in cardiovascular science still rather challenging. This review article aims to introduce and summarize published work on hearts- and vessels-on chips but also to provide an outlook and perspective on how these advanced in vitro systems can be used to tailor disease models with patient-specific characteristics.", "doi": "10.1093/cvr/cvab088", "pmid": "33729461", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8683705"}, {"db": "pii", "key": "6174689"}], "notes": [], "created": "2026-08-20T09:40:37.026Z", "modified": "2026-08-20T09:40:37.253Z"}]}