{"entity": "researcher", "timestamp": "2026-08-29T04:18:14.124Z", "family": "Nobeli", "given": "Irene", "initials": "I", "orcid": "0000-0001-8616-170X", "affiliations": ["Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, London WC1E 7HX, UK."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/7439a333959a4d2780363120857ba45e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/7439a333959a4d2780363120857ba45e"}}, "publications": [{"entity": "publication", "iuid": "005c4fd8f6fa4f03858a3ce41c160865", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/005c4fd8f6fa4f03858a3ce41c160865.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/005c4fd8f6fa4f03858a3ce41c160865"}}, "title": "flexiMAP: a regression-based method for discovering differential alternative polyadenylation events in standard RNA-seq data.", "authors": [{"family": "Szkop", "given": "Krzysztof J", "initials": "KJ"}, {"family": "Moss", "given": "David S", "initials": "DS"}, {"family": "Nobeli", "given": "Irene", "initials": "I", "orcid": "0000-0001-8616-170X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7439a333959a4d2780363120857ba45e.json"}}], "type": "journal article", "published": "2021-06-16", "journal": {"title": "Bioinformatics", "issn": "1367-4811", "volume": "37", "issue": "10", "pages": "1461-1464", "issn-l": "1367-4803"}, "abstract": "We present flexible Modeling of Alternative PolyAdenylation (flexiMAP), a new beta-regression-based method implemented in R, for discovering differential alternative polyadenylation events in standard RNA-seq data.\n\nWe show, using both simulated and real data, that flexiMAP exhibits a good balance between specificity and sensitivity and compares favourably to existing methods, especially at low fold changes. In addition, the tests on simulated data reveal some hitherto unrecognized caveats of existing methods. Importantly, flexiMAP allows modeling of multiple known covariates that often confound the results of RNA-seq data analysis.\n\nThe flexiMAP R package is available at: https://github.com/kszkop/flexiMAP. Scripts and data to reproduce the analysis in this paper are available at: https://doi.org/10.5281/zenodo.3689788.\n\nSupplementary data are available at Bioinformatics online.", "doi": "10.1093/bioinformatics/btaa854", "pmid": "33051680", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8208744"}, {"db": "pii", "key": "5922816"}], "notes": [], "created": "2026-08-21T12:06:48.609Z", "modified": "2026-08-21T12:06:48.675Z"}]}