{"entity": "researcher", "timestamp": "2026-08-20T21:01:43.696Z", "family": "H\u00e4ggstr\u00f6m", "given": "Jens", "initials": "J", "orcid": "0000-0003-3402-023X", "affiliations": [], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/72f5852ea390478a8f8dcaa0a4d8390c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/72f5852ea390478a8f8dcaa0a4d8390c"}}, "publications": [{"entity": "publication", "iuid": "c7590809e3954fe399b662f54d35606c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c7590809e3954fe399b662f54d35606c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c7590809e3954fe399b662f54d35606c"}}, "title": "Multiple Genetic Loci Associated with Pug Dog Thoracolumbar Myelopathy.", "authors": [{"family": "Brander", "given": "Gustaf", "initials": "G", "orcid": "0000-0002-9549-4909", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e1bb9b8988545c5afa1a0499af45004.json"}}, {"family": "Rohdin", "given": "Cecilia", "initials": "C"}, {"family": "Bianchi", "given": "Matteo", "initials": "M"}, {"family": "Bergvall", "given": "Kerstin", "initials": "K"}, {"family": "Andersson", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0001-5131-3144", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/52a4de0ac8e245919d68e7d96dd49914.json"}}, {"family": "Ljungvall", "given": "Ingrid", "initials": "I"}, {"family": "Hultin J\u00e4derlund", "given": "Karin", "initials": "K"}, {"family": "H\u00e4ggstr\u00f6m", "given": "Jens", "initials": "J", "orcid": "0000-0003-3402-023X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/72f5852ea390478a8f8dcaa0a4d8390c.json"}}, {"family": "Hedhammar", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/612a779b69494f1ca9b6c5f1d84fd711.json"}}, {"family": "Tengvall", "given": "Katarina", "initials": "K"}], "type": "journal article", "published": "2023-02-01", "journal": {"title": "Genes (Basel)", "issn": "2073-4425", "volume": "14", "issue": "2", "issn-l": "2073-4425"}, "abstract": "Pug dogs with thoracolumbar myelopathy (PDM) present with a specific clinical phenotype that includes progressive pelvic limb ataxia and paresis, commonly accompanied by incontinence. Vertebral column malformations and lesions, excessive scar tissue of the meninges, and central nervous system inflammation have been described. PDM has a late onset and affects more male than female dogs. The breed-specific presentation of the disorder suggests that genetic risk factors are involved in the disease development. To perform a genome-wide search for PDM-associated loci, we applied a Bayesian model adapted for mapping complex traits (BayesR) and a cross-population extended haplotype homozygosity test (XP-EHH) in 51 affected and 38 control pugs. Nineteen associated loci (harboring 67 genes in total, including 34 potential candidate genes) and three candidate regions under selection (with four genes within or next to the signal) were identified. The multiple candidate genes identified have implicated functions in bone homeostasis, fibrotic scar tissue, inflammatory responses, or the formation, regulation, and differentiation of cartilage, suggesting the potential relevance of these processes to the pathogenesis of PDM.", "doi": "10.3390/genes14020385", "pmid": "36833311", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9957375"}, {"db": "pii", "key": "genes14020385"}], "notes": [], "created": "2026-08-20T13:40:54.626Z", "modified": "2026-08-20T13:40:54.785Z"}, {"entity": "publication", "iuid": "96454a1397bc498088524ab353dfaadb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/96454a1397bc498088524ab353dfaadb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/96454a1397bc498088524ab353dfaadb"}}, "title": "A new long-read dog assembly uncovers thousands of exons and functional elements missing in the previous reference", "authors": [{"family": "Wang", "given": "Chao", "initials": "C", "orcid": "0000-0003-3936-4023", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cfac9dfcdfc04a88b002ffe4ee8a5bb4.json"}}, {"family": "Wallerman", "given": "Ola", "initials": "O", "orcid": "0000-0003-1037-7904", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/567836f4582a4f79b9fbb362c656b8c9.json"}}, {"family": "Arendt", "given": "Maja Louise", "initials": "ML", "orcid": "0000-0003-1404-172X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f488b6df9c149a3bf6a26be886073cc.json"}}, {"family": "Sundstr\u00f6m", "given": "Elisabeth", "initials": "E", "orcid": "0000-0001-9526-8541", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7ba04d84aa2401da56c1b438d7ee741.json"}}, {"family": "Karlsson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0003-0198-4796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a000fad9c474ed09fdc5c136d3f0493.json"}}, {"family": "Nordin", "given": "Jessika", "initials": "J", "orcid": "0000-0002-8414-2190", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a285875862f24b6fa0b378550da371fa.json"}}, {"family": "M\u00e4kel\u00e4inen", "given": "Suvi", "initials": "S", "orcid": "0000-0001-7378-4991", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f7781ef7a4f4e9daa8621c0f9910180.json"}}, {"family": "Pielberg", "given": "Gerli Rosengren", "initials": "GR", "orcid": "0000-0001-5582-7054", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e85a82d4887740cca6450039a1025043.json"}}, {"family": "Hanson", "given": "Jeanette", "initials": "J", "orcid": "0000-0001-5596-9538", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d5cbb6bf2a24ba7a809f822d450acb3.json"}}, {"family": "Ohlsson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0002-7735-7919", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f98b0d8854e0431881c5ce2179d4383b.json"}}, {"family": "Saellstr\u00f6m", "given": "Sara", "initials": "S", "orcid": "0000-0001-5253-5830", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/85a961c79c6541a99bd227f3846fc56b.json"}}, {"family": "R\u00f6nnberg", "given": "Henrik", "initials": "H", "orcid": "0000-0001-6098-5364", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/46c497dfc2b3477b95906859a654cf41.json"}}, {"family": "Ljungvall", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-6617-0454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf94e422f2bf4db3a4c873b9882ca4c6.json"}}, {"family": "H\u00e4ggstr\u00f6m", "given": "Jens", "initials": "J", "orcid": "0000-0003-3402-023X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/72f5852ea390478a8f8dcaa0a4d8390c.json"}}, {"family": "Bergstr\u00f6m", "given": "Tomas F", "initials": "TF", "orcid": "0000-0002-7480-2669", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f503392d65ac4ab1a4b1d459ea0f37bb.json"}}, {"family": "Hedhammar", "given": "\u00c5ke", "initials": "\u00c5", "orcid": "0000-0001-7048-3851", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04f22152817b4e3e8fb7890e1566791a.json"}}, {"family": "Meadows", "given": "Jennifer R S", "initials": "JRS", "orcid": "0000-0002-0850-230X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f363e8d74594ffeb0d68aa6d774b242.json"}}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/612a779b69494f1ca9b6c5f1d84fd711.json"}}], "type": "posted-content", "published": "2020-07-02", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.07.02.185108", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T09:57:48.394Z", "modified": "2026-08-20T09:57:48.992Z"}, {"entity": "publication", "iuid": "daaccc704a2d4190ace6f34418b6877e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/daaccc704a2d4190ace6f34418b6877e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/daaccc704a2d4190ace6f34418b6877e"}}, "title": "Thoracolumbar meningeal fibrosis in pugs.", "authors": [{"family": "Rohdin", "given": "Cecilia", "initials": "C", "orcid": "0000-0002-7698-550X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22e03664ae6048dfb63792efbcd91649.json"}}, {"family": "Ljungvall", "given": "Ingrid", "initials": "I"}, {"family": "H\u00e4ggstr\u00f6m", "given": "Jens", "initials": "J", "orcid": "0000-0003-3402-023X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/72f5852ea390478a8f8dcaa0a4d8390c.json"}}, {"family": "Leijon", "given": "Alexandra", "initials": "A"}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K"}, {"family": "Matiasek", "given": "Kaspar", "initials": "K"}, {"family": "Rosati", "given": "Marco", "initials": "M"}, {"family": "Wohlsein", "given": "Peter", "initials": "P"}, {"family": "J\u00e4derlund", "given": "Karin Hultin", "initials": "KH"}], "type": "journal article", "published": "2020-03-00", "journal": {"title": "J. Vet. Intern. Med.", "issn": "1939-1676", "volume": "34", "issue": "2", "pages": "797-807", "issn-l": "0891-6640"}, "abstract": "Thoracolumbar myelopathies associated with spinal cord and vertebral column lesions, with a similar clinical phenotype, but different underlying etiologies, occur in pugs.\n\nTo further characterize the clinical and neuropathological characteristics of pugs with longstanding thoracolumbar myelopathy.\n\nThirty client-owned pure-bred pugs with a history of more than a month of ataxia and paresis of the pelvic limbs, suggesting a myelopathy localized to the thoracolumbar spinal cord, were included in the study.\n\nProspective clinicopathological study. Included pugs underwent a complete neurological examination and gross and histopathologic postmortem studies with focus on the spinal cord. Computed tomography (n = 18), magnetic resonance imaging (n = 17), and cerebrospinal fluid analysis (n = 27) were performed before or immediately after death.\n\nTwenty male and 10 female pugs had a median age at clinical onset of 84 months (interquartile range, 66-96). Affected pugs presented with a progressive clinical course and 80% were incontinent. There was circumferential meningeal fibrosis with concomitant focal, malacic, destruction of the neuroparenchyma in the thoracolumbar spinal cord in 24/30 pugs. Vertebral lesions accompanied the focal spinal cord lesion, and there was lympho-histiocytic inflammation associated or not to the parenchymal lesion in 43% of the pugs.\n\nMeningeal fibrosis with associated focal spinal cord destruction and neighboring vertebral column lesions were common findings in pugs with long-standing thoracolumbar myelopathy.", "doi": "10.1111/jvim.15716", "pmid": "32003496", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7096664"}], "notes": [], "created": "2026-08-20T11:18:44.733Z", "modified": "2026-08-20T11:18:44.843Z"}]}