{"entity": "researcher", "timestamp": "2026-09-30T15:39:37.269Z", "family": "Wang", "given": "Chuande", "initials": "C", "orcid": "0000-0002-3102-0931", "affiliations": ["Universit\u00e9 Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin (IJPB), 78000 Versailles, France."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/705243873508474187ec8089fefccee1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/705243873508474187ec8089fefccee1"}}, "publications": [{"entity": "publication", "iuid": "0aa05b85298d4a05befb40be22063e8f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0aa05b85298d4a05befb40be22063e8f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0aa05b85298d4a05befb40be22063e8f"}}, "title": "An mTRAN-mRNA interaction mediates mitochondrial translation initiation in plants.", "authors": [{"family": "Tran", "given": "Huy Cuong", "initials": "HC", "orcid": "0000-0002-7670-2215", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e76543b392594e1eb774530c16be45ce.json"}}, {"family": "Schmitt", "given": "Vivian", "initials": "V", "orcid": "0000-0001-9260-4853", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/018e49a9f23946ab8271c5adb3c95653.json"}}, {"family": "Lama", "given": "Sbatie", "initials": "S", "orcid": "0000-0003-0093-8915", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ba65b049edd46e889585bdc162e6948.json"}}, {"family": "Wang", "given": "Chuande", "initials": "C", "orcid": "0000-0002-3102-0931", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/705243873508474187ec8089fefccee1.json"}}, {"family": "Launay-Avon", "given": "Alexandra", "initials": "A", "orcid": "0000-0002-1993-313X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8a46fb422d04148ac4e66296798787b.json"}}, {"family": "Bernfur", "given": "Katja", "initials": "K", "orcid": "0000-0002-7927-9563", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9de098f285774da583545f697f7032cf.json"}}, {"family": "Sultan", "given": "Kristin", "initials": "K", "orcid": "0009-0002-5619-517X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c74258423194f769a20304ce161fe5f.json"}}, {"family": "Khan", "given": "Kasim", "initials": "K", "orcid": "0000-0001-7336-2764", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/768432365858446ea3afe0a28621e16a.json"}}, {"family": "Brunaud", "given": "V\u00e9ronique", "initials": "V", "orcid": "0000-0002-6246-3161", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0e63007c181541d7bf6b612875aed497.json"}}, {"family": "Liehrmann", "given": "Arnaud", "initials": "A", "orcid": "0000-0002-4936-1056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8156c29daad4b5db25e51df022ac30c.json"}}, {"family": "Castandet", "given": "Beno\u00eet", "initials": "B", "orcid": "0000-0003-1948-8651", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d0e103bf6394ceda5ff8ea44c7b5eed.json"}}, {"family": "Levander", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-0710-9792", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d3aaa3dcdb4f4e9f9b4bd44097d85d0c.json"}}, {"family": "Rasmusson", "given": "Allan G", "initials": "AG", "orcid": "0000-0003-0734-5020", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8714d6bebceb440f9b4d0bb8130ee9f9.json"}}, {"family": "Mireau", "given": "Hakim", "initials": "H", "orcid": "0000-0002-2299-5139", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f272fa0851b8496faf77735ad1513853.json"}}, {"family": "Delannoy", "given": "Etienne", "initials": "E", "orcid": "0000-0002-0866-2063", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/99cbd34b74334565814f4a89a4a0f892.json"}}, {"family": "Van Aken", "given": "Olivier", "initials": "O", "orcid": "0000-0003-4024-968X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95b452d731194dbf9e04b63a1a22abd8.json"}}], "type": "journal article", "published": "2023-09-00", "journal": {"title": "Science (New York, N.Y.)", "issn": "1095-9203", "volume": "381", "issue": "6661", "pages": "eadg0995", "issn-l": "0036-8075"}, "abstract": "Plant mitochondria represent the largest group of respiring organelles on the planet. Plant mitochondrial messenger RNAs (mRNAs) lack Shine-Dalgarno-like ribosome-binding sites, so it is unknown how plant mitoribosomes recognize mRNA. We show that \"mitochondrial translation factors\" mTRAN1 and mTRAN2 are land plant-specific proteins, required for normal mitochondrial respiration chain biogenesis. Our studies suggest that mTRANs are noncanonical pentatricopeptide repeat (PPR)-like RNA binding proteins of the mitoribosomal \"small\" subunit. We identified conserved Adenosine (A)/Uridine (U)-rich motifs in the 5' regions of plant mitochondrial mRNAs. mTRAN1 binds this motif, suggesting that it is a mitoribosome homing factor to identify mRNAs. We demonstrate that mTRANs are likely required for translation of all plant mitochondrial mRNAs. Plant mitochondrial translation initiation thus appears to use a protein-mRNA interaction that is divergent from bacteria or mammalian mitochondria.", "doi": "10.1126/science.adg0995", "pmid": "37651534", "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T10:59:21.737Z", "modified": "2026-09-23T10:59:22.568Z"}]}