{"entity": "researcher", "timestamp": "2026-08-21T21:48:00.446Z", "family": "Dimberg", "given": "Anna", "initials": "A", "orcid": "0000-0003-4422-9125", "affiliations": ["The Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75185, Uppsala, Sweden. Anna.Dimberg@igp.uu.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f5d91c4b8784d8081a41604bb3d78d4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f5d91c4b8784d8081a41604bb3d78d4"}}, "publications": [{"entity": "publication", "iuid": "9059e450fd9d4c138ea27fe11b42e03d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9059e450fd9d4c138ea27fe11b42e03d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9059e450fd9d4c138ea27fe11b42e03d"}}, "title": "Keeping Wnt in check for efficient checkpoint blockade in glioblastoma.", "authors": [{"family": "Melssen", "given": "Marit", "initials": "M"}, {"family": "Dimberg", "given": "Anna", "initials": "A", "orcid": "0000-0003-4422-9125", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f5d91c4b8784d8081a41604bb3d78d4.json"}}], "type": "journal article", "published": "2025-11-04", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "122", "issue": "44", "pages": "e2523639122", "issn-l": "0027-8424"}, "abstract": null, "doi": "10.1073/pnas.2523639122", "pmid": "41144679", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12595493"}], "notes": [], "created": "2026-08-20T09:32:06.189Z", "modified": "2026-08-20T09:32:06.254Z"}, {"entity": "publication", "iuid": "1cbd88174bb94040ad897cc3f47cc7cb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1cbd88174bb94040ad897cc3f47cc7cb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1cbd88174bb94040ad897cc3f47cc7cb"}}, "title": "Trogocytosis of chimeric antigen receptors between T cells is regulated by their transmembrane domains.", "authors": [{"family": "Barbera", "given": "Stefano", "initials": "S", "orcid": "0000-0001-9544-455X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/666ca561c7494caa90336bddf52b4f09.json"}}, {"family": "Schuiling", "given": "Matthijs J A", "initials": "MJA", "orcid": "0009-0005-2049-3601", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/127743eb9ad34ee5915cca1fd3958fef.json"}}, {"family": "Sanjaya", "given": "Nathaniel A", "initials": "NA", "orcid": "0009-0001-8912-9921", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7a0c2cf45419465b9d2d1c5e3677839b.json"}}, {"family": "Pietil\u00e4", "given": "Ilkka", "initials": "I", "orcid": "0000-0001-7398-5769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6056d3fa76c41c6943f50faba0d8cd7.json"}}, {"family": "Sar\u00e9n", "given": "Tina", "initials": "T", "orcid": "0000-0001-5227-6779", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed75a6dcbb9940e49481280af6183d69.json"}}, {"family": "Essand", "given": "Magnus", "initials": "M", "orcid": "0000-0002-9725-0422", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2e56cdd77634c01ab6d98dea8c60430.json"}}, {"family": "Dimberg", "given": "Anna", "initials": "A", "orcid": "0000-0003-4422-9125", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f5d91c4b8784d8081a41604bb3d78d4.json"}}], "type": "journal article", "published": "2025-01-31", "journal": {"title": "Sci Immunol", "issn": "2470-9468", "volume": "10", "issue": "103", "pages": "eado2054", "issn-l": "2470-9468"}, "abstract": "Trogocytosis is an exchange of membrane-associated molecules between cells that can either halt or boost immune responses. However, the mechanism that regulates trogocytosis in T cells and its consequences are not yet clear. Here, we demonstrate that T cells can exchange chimeric antigen receptors (CARs) by trogocytosis, thereby arming recipient T cells with the capacity to respond to tumor antigens by up-regulating proteins associated with a cytotoxic response and killing of target cells. We demonstrate that although trogocytosis is dependent on cell-cell contact, the exchange of a specific cell membrane protein does not require a cognate binding partner on the surface of recipient cells. Instead, the probability that a protein is exchanged by trogocytosis is determined by its transmembrane domain. This finding opens new avenues for modulating this process in CAR-T cells.", "doi": "10.1126/sciimmunol.ado2054", "pmid": "39888980", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:59:43.101Z", "modified": "2026-08-20T11:59:43.364Z"}, {"entity": "publication", "iuid": "098cbbdf2f40473aa0b4f0616ad077b1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/098cbbdf2f40473aa0b4f0616ad077b1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/098cbbdf2f40473aa0b4f0616ad077b1"}}, "title": "Cellular and molecular events organizing the assembly of tertiary lymphoid structures in glioblastoma", "authors": [{"family": "Vaccaro", "given": "Alessandra", "initials": "A", "orcid": "0000-0003-3515-4117", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/884b4478d0794b48b1a85780d54d7164.json"}}, {"family": "Yang", "given": "Fan", "initials": "F"}, {"family": "van de Walle", "given": "Tiarne", "initials": "T"}, {"family": "Franke", "given": "Saskia", "initials": "S"}, {"family": "Lugano", "given": "Roberta", "initials": "R"}, {"family": "D\u00e9nes", "given": "Anna", "initials": "A"}, {"family": "Magoulopoulou", "given": "Anastasia", "initials": "A"}, {"family": "Cid-Fari\u00f1a", "given": "In\u00e9s", "initials": "I"}, {"family": "Smits", "given": "Anja", "initials": "A"}, {"family": "Uhrbom", "given": "Lene", "initials": "L"}, {"family": "Libard", "given": "Sylwia", "initials": "S"}, {"family": "Latini", "given": "Francesco", "initials": "F"}, {"family": "Essand", "given": "Magnus", "initials": "M"}, {"family": "Nilsson", "given": "Mats", "initials": "M"}, {"family": "He", "given": "Liqun", "initials": "L"}, {"family": "Olsson Bontell", "given": "Thomas", "initials": "T"}, {"family": "Jakola", "given": "Asgeir S", "initials": "AS"}, {"family": "Ramachandran", "given": "Mohanraj", "initials": "M"}, {"family": "Dimberg", "given": "Anna", "initials": "A", "orcid": "0000-0003-4422-9125", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f5d91c4b8784d8081a41604bb3d78d4.json"}}], "type": "posted-content", "published": "2024-07-06", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.07.04.601824", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:55:32.268Z", "modified": "2026-08-20T10:55:32.363Z"}, {"entity": "publication", "iuid": "1ffe21773d764ce9880f60895e445579", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1ffe21773d764ce9880f60895e445579.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1ffe21773d764ce9880f60895e445579"}}, "title": "Author Correction: A method for Boolean analysis of protein interactions at a molecular level.", "authors": [{"family": "Raykova", "given": "Doroteya", "initials": "D", "orcid": "0000-0001-6452-2199", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/310a54498df840bda10ab0cdf6c23c8a.json"}}, {"family": "Kermpatsou", "given": "Despoina", "initials": "D", "orcid": "0000-0001-5872-4472", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1f61b9fa13454f1daf819bf73a541b76.json"}}, {"family": "Malmqvist", "given": "Tony", "initials": "T", "orcid": "0000-0003-0609-2009", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/259cd6b8a1d940f188825846b4bcaba3.json"}}, {"family": "Harrison", "given": "Philip J", "initials": "PJ"}, {"family": "Sander", "given": "Marie Rubin", "initials": "MR", "orcid": "0000-0002-9783-5682", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e17d996e154f4f819aee903a8f386a4e.json"}}, {"family": "Stiller", "given": "Christiane", "initials": "C", "orcid": "0000-0002-6552-8426", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9edd629c5dac43728165118ddd7bc5b5.json"}}, {"family": "Heldin", "given": "Johan", "initials": "J", "orcid": "0000-0002-0915-5303", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0c54a4210f844ab193a951c020d7406b.json"}}, {"family": "Leino", "given": "Mattias", "initials": "M"}, {"family": "Ricardo", "given": "Sara", "initials": "S", "orcid": "0000-0003-4091-2226", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8c28bb20fe04f3ba47b29d0777af023.json"}}, {"family": "Klemm", "given": "Anna", "initials": "A", "orcid": "0000-0002-3466-1320", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bda9a501396248b5a7daa41db01518dc.json"}}, {"family": "David", "given": "Leonor", "initials": "L", "orcid": "0000-0003-4207-9258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b19bb9cf8f342ea878c7978ceca3deb.json"}}, {"family": "Spjuth", "given": "Ola", "initials": "O", "orcid": "0000-0002-8083-2864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c192389f99d4801b91f3350e07dfb9e.json"}}, {"family": "Vemuri", "given": "Kalyani", "initials": "K", "orcid": "0000-0003-2544-5412", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b8cab0dbc72d4e41b3abfee1cb4ea826.json"}}, {"family": "Dimberg", "given": "Anna", "initials": "A", "orcid": "0000-0003-4422-9125", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f5d91c4b8784d8081a41604bb3d78d4.json"}}, {"family": "Sundqvist", "given": "Anders", "initials": "A"}, {"family": "Norlin", "given": "Maria", "initials": "M", "orcid": "0000-0003-4348-6269", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e1637bc43c6243c1adcdfed66140a495.json"}}, {"family": "Klaesson", "given": "Axel", "initials": "A"}, {"family": "Kampf", "given": "Caroline", "initials": "C"}, {"family": "S\u00f6derberg", "given": "Ola", "initials": "O", "orcid": "0000-0003-2883-1925", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8926661e48584c0aa6e6c6cf0ac031de.json"}}], "type": "published erratum", "published": "2023-09-06", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "5450", "issn-l": "2041-1723"}, "abstract": null, "doi": "10.1038/s41467-023-41325-3", "pmid": "37673885", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10482831"}, {"db": "pii", "key": "10.1038/s41467-023-41325-3"}], "notes": [], "created": "2026-08-20T08:52:51.278Z", "modified": "2026-08-20T08:52:51.779Z"}, {"entity": "publication", "iuid": "84d8fc89c1b24ae29417295f9b68c916", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/84d8fc89c1b24ae29417295f9b68c916.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/84d8fc89c1b24ae29417295f9b68c916"}}, "title": "Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy.", "authors": [{"family": "Sun", "given": "Yi", "initials": "Y", "orcid": "0000-0002-0194-2476", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c509e8cd5821465b9eef8f724742bc86.json"}}, {"family": "Chen", "given": "Wei", "initials": "W"}, {"family": "Torphy", "given": "Robert J", "initials": "RJ", "orcid": "0000-0003-3941-0886", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/74fd443dfd2140c5810014e08a98e21d.json"}}, {"family": "Yao", "given": "Sheng", "initials": "S", "orcid": "0000-0003-0988-9937", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0d2eb3ec625846c597671d1b479ad35a.json"}}, {"family": "Zhu", "given": "Gefeng", "initials": "G"}, {"family": "Lin", "given": "Ronggui", "initials": "R"}, {"family": "Lugano", "given": "Roberta", "initials": "R"}, {"family": "Miller", "given": "Emily N", "initials": "EN", "orcid": "0000-0002-2939-407X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/16c4ce8810a44f8b9a4f3649ad663dca.json"}}, {"family": "Fujiwara", "given": "Yuki", "initials": "Y", "orcid": "0000-0002-8801-4284", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f9245ddcdcf4ed589222d9f4d95855e.json"}}, {"family": "Bian", "given": "Li", "initials": "L"}, {"family": "Zheng", "given": "Linghua", "initials": "L", "orcid": "0000-0001-7770-4098", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57869976eabb4d989334b29bd139c8b7.json"}}, {"family": "Anand", "given": "Sudarshan", "initials": "S", "orcid": "0000-0002-4969-6884", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e2be48cd6594a4eb0a36602fc7dc28d.json"}}, {"family": "Gao", "given": "Fan", "initials": "F", "orcid": "0000-0001-6832-3402", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe97b01491794cebb42959625470c732.json"}}, {"family": "Zhang", "given": "Weizhou", "initials": "W", "orcid": "0000-0002-8236-0346", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2b19a9aa9b5b421a9efee632ac935681.json"}}, {"family": "Ferrara", "given": "Sarah E", "initials": "SE"}, {"family": "Goodspeed", "given": "Andrew E", "initials": "AE", "orcid": "0000-0001-7055-7128", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d23bcbdc60a44532a2468917e4f4d974.json"}}, {"family": "Dimberg", "given": "Anna", "initials": "A", "orcid": "0000-0003-4422-9125", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f5d91c4b8784d8081a41604bb3d78d4.json"}}, {"family": "Wang", "given": "Xiao-Jing", "initials": "XJ", "orcid": "0000-0001-8695-7361", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/819d20bbb3504b9f899ea41b28f7d2a8.json"}}, {"family": "Edil", "given": "Barish H", "initials": "BH", "orcid": "0000-0003-1467-9723", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c1b1576c9af436c815591b52a5df480.json"}}, {"family": "Barnett", "given": "Carlton C", "initials": "CC", "orcid": "0000-0002-5686-8357", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e638b2f9e1b74c63ac11ff3373e791e0.json"}}, {"family": "Schulick", "given": "Richard D", "initials": "RD", "orcid": "0000-0001-7360-7338", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/637df4b3b1f04ce599fafd65e8769a42.json"}}, {"family": "Chen", "given": "Lieping", "initials": "L", "orcid": "0000-0002-6825-3069", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76b1f8d2ba5940f9a1de6065de69fb71.json"}}, {"family": "Zhu", "given": "Yuwen", "initials": "Y", "orcid": "0000-0003-1434-6590", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29243bf212ae4b82995b89f9e274b18b.json"}}], "type": "journal article", "published": "2021-07-28", "journal": {"title": "Sci Transl Med", "issn": "1946-6242", "volume": "13", "issue": "604", "issn-l": "1946-6234"}, "abstract": "The immature and dysfunctional vascular network within solid tumors poses a substantial obstacle to immunotherapy because it creates a hypoxic tumor microenvironment that actively limits immune cell infiltration. The molecular basis underpinning this vascular dysfunction is not fully understood. Using genome-scale receptor array technology, we showed here that insulin-like growth factor binding protein 7 (IGFBP7) interacts with its receptor CD93, and we subsequently demonstrated that this interaction contributes to abnormal tumor vasculature. Both CD93 and IGFBP7 were up-regulated in tumor-associated endothelial cells. IGFBP7 interacted with CD93 via a domain different from multimerin-2, the known ligand for CD93. In two mouse tumor models, blockade of the CD93/IGFBP7 interaction by monoclonal antibodies promoted vascular maturation to reduce leakage, leading to reduced tumor hypoxia and increased tumor perfusion. CD93 blockade in mice increased drug delivery, resulting in an improved antitumor response to gemcitabine or fluorouracil. Blockade of the CD93 pathway triggered a substantial increase in intratumoral effector T cells, thereby sensitizing mouse tumors to immune checkpoint therapy. Last, analysis of samples from patients with cancer under anti-programmed death 1/programmed death-ligand 1 treatment revealed that overexpression of the IGFBP7/CD93 pathway was associated with poor response to therapy. Thus, our study identified a molecular interaction involved in tumor vascular dysfunction and revealed an approach to promote a favorable tumor microenvironment for therapeutic intervention.", "doi": "10.1126/scitranslmed.abc8922", "pmid": "34321321", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1760639"}, {"db": "pmc", "key": "PMC8749958"}, {"db": "pii", "key": "13/604/eabc8922"}], "notes": [], "created": "2026-08-20T11:59:49.353Z", "modified": "2026-08-20T11:59:50.004Z"}, {"entity": "publication", "iuid": "4483b18743b14bb1a2babad1da90d3ca", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4483b18743b14bb1a2babad1da90d3ca.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4483b18743b14bb1a2babad1da90d3ca"}}, "title": "Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma.", "authors": [{"family": "van Hooren", "given": "Luuk", "initials": "L", "orcid": "0000-0002-0780-5827", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5faf9219a47d426ba7dfe9cfb1f68418.json"}}, {"family": "Vaccaro", "given": "Alessandra", "initials": "A"}, {"family": "Ramachandran", "given": "Mohanraj", "initials": "M"}, {"family": "Vazaios", "given": "Konstantinos", "initials": "K"}, {"family": "Libard", "given": "Sylwia", "initials": "S"}, {"family": "van de Walle", "given": "Tiarne", "initials": "T"}, {"family": "Georganaki", "given": "Maria", "initials": "M"}, {"family": "Huang", "given": "Hua", "initials": "H"}, {"family": "Pietil\u00e4", "given": "Ilkka", "initials": "I"}, {"family": "Lau", "given": "Joey", "initials": "J", "orcid": "0000-0002-8302-3253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f5eb1f51bb1455998df895c889f7309.json"}}, {"family": "Ulvmar", "given": "Maria H", "initials": "MH"}, {"family": "Karlsson", "given": "Mikael C I", "initials": "MCI", "orcid": "0000-0001-5582-614X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0e5ec40c808e467c95d42e4d35395093.json"}}, {"family": "Zetterling", "given": "Maria", "initials": "M"}, {"family": "Mangsbo", "given": "Sara M", "initials": "SM"}, {"family": "Jakola", "given": "Asgeir S", "initials": "AS"}, {"family": "Olsson Bontell", "given": "Thomas", "initials": "T"}, {"family": "Smits", "given": "Anja", "initials": "A"}, {"family": "Essand", "given": "Magnus", "initials": "M", "orcid": "0000-0002-9725-0422", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2e56cdd77634c01ab6d98dea8c60430.json"}}, {"family": "Dimberg", "given": "Anna", "initials": "A", "orcid": "0000-0003-4422-9125", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f5d91c4b8784d8081a41604bb3d78d4.json"}}], "type": "journal article", "published": "2021-07-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "4127", "issn-l": "2041-1723"}, "abstract": "Gliomas are brain tumors characterized by an immunosuppressive microenvironment. Immunostimulatory agonistic CD40 antibodies (\u03b1CD40) are in clinical development for solid tumors, but are yet to be evaluated for glioma. Here, we demonstrate that systemic delivery of \u03b1CD40 in preclinical glioma models induces the formation of tertiary lymphoid structures (TLS) in proximity of meningeal tissue. In treatment-na\u00efve glioma patients, the presence of TLS correlates with increased T cell infiltration. However, systemic delivery of \u03b1CD40 induces hypofunctional T cells and impairs the response to immune checkpoint inhibitors in pre-clinical glioma models. This is associated with a systemic induction of suppressive CD11b+ B cells post-\u03b1CD40 treatment, which accumulate in the tumor microenvironment. Our work unveils the pleiotropic effects of \u03b1CD40 therapy in glioma and reveals that immunotherapies can modulate TLS formation in the brain, opening up for future opportunities to regulate the immune response.", "doi": "10.1038/s41467-021-24347-7", "pmid": "34226552", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8257767"}, {"db": "pii", "key": "10.1038/s41467-021-24347-7"}], "notes": [], "created": "2026-08-20T08:51:35.457Z", "modified": "2026-08-20T08:51:35.651Z"}, {"entity": "publication", "iuid": "8811b71722d14703a1c26af455bf31d4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8811b71722d14703a1c26af455bf31d4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8811b71722d14703a1c26af455bf31d4"}}, "title": "Agonistic CD40 antibody therapy induces tertiary lymphoid structures but impairs the response to immune checkpoint blockade in glioma", "authors": [{"family": "van Hooren", "given": "Luuk", "initials": "L"}, {"family": "Vaccaro", "given": "Alessandra", "initials": "A"}, {"family": "Ramachandran", "given": "Mohanraj", "initials": "M"}, {"family": "Vazaios", "given": "Konstantinos", "initials": "K"}, {"family": "Libard", "given": "Sylwia", "initials": "S"}, {"family": "van de Walle", "given": "Tiarne", "initials": "T"}, {"family": "Georganaki", "given": "Maria", "initials": "M"}, {"family": "Huang", "given": "Hua", "initials": "H"}, {"family": "Pietil\u00e4", "given": "Ilkka", "initials": "I"}, {"family": "Lau", "given": "Joey", "initials": "J"}, {"family": "Ulvmar", "given": "Maria H", "initials": "MH", "orcid": "0000-0002-9050-0978", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/081a6551b7b94c36b059410b02f25133.json"}}, {"family": "Karlsson", "given": "Mikael C I", "initials": "MCI"}, {"family": "Zetterling", "given": "Maria", "initials": "M"}, {"family": "Mangsbo", "given": "Sara M", "initials": "SM", "orcid": "0000-0002-1355-2678", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4300802cdbd42b9843fe62bc6c96c33.json"}}, {"family": "Jakola", "given": "Asgeir S", "initials": "AS"}, {"family": "Bontell", "given": "Thomas Olsson", "initials": "TO"}, {"family": "Smits", "given": "Anja", "initials": "A"}, {"family": "Essand", "given": "Magnus", "initials": "M", "orcid": "0000-0002-9725-0422", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2e56cdd77634c01ab6d98dea8c60430.json"}}, {"family": "Dimberg", "given": "Anna", "initials": "A", "orcid": "0000-0003-4422-9125", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f5d91c4b8784d8081a41604bb3d78d4.json"}}], "type": "posted-content", "published": "2021-01-06", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.01.05.425377", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:01:03.881Z", "modified": "2026-08-20T10:01:03.965Z"}, {"entity": "publication", "iuid": "f622c660618c4f9087323e69f133ffba", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f622c660618c4f9087323e69f133ffba.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f622c660618c4f9087323e69f133ffba"}}, "title": "Tumor angiogenesis: causes, consequences, challenges and opportunities.", "authors": [{"family": "Lugano", "given": "Roberta", "initials": "R"}, {"family": "Ramachandran", "given": "Mohanraj", "initials": "M"}, {"family": "Dimberg", "given": "Anna", "initials": "A", "orcid": "0000-0003-4422-9125", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f5d91c4b8784d8081a41604bb3d78d4.json"}}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "Cell. Mol. Life Sci.", "issn": "1420-9071", "volume": "77", "issue": "9", "pages": "1745-1770", "issn-l": "1420-682X"}, "abstract": "Tumor vascularization occurs through several distinct biological processes, which not only vary between tumor type and anatomic location, but also occur simultaneously within the same cancer tissue. These processes are orchestrated by a range of secreted factors and signaling pathways and can involve participation of non-endothelial cells, such as progenitors or cancer stem cells. Anti-angiogenic therapies using either antibodies or tyrosine kinase inhibitors have been approved to treat several types of cancer. However, the benefit of treatment has so far been modest, some patients not responding at all and others acquiring resistance. It is becoming increasingly clear that blocking tumors from accessing the circulation is not an easy task to accomplish. Tumor vessel functionality and gene expression often differ vastly when comparing different cancer subtypes, and vessel phenotype can be markedly heterogeneous within a single tumor. Here, we summarize the current understanding of cellular and molecular mechanisms involved in tumor angiogenesis and discuss challenges and opportunities associated with vascular targeting.", "doi": "10.1007/s00018-019-03351-7", "pmid": "31690961", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7190605"}, {"db": "pii", "key": "10.1007/s00018-019-03351-7"}], "notes": [], "created": "2026-08-20T06:38:34.318Z", "modified": "2026-08-20T06:38:34.418Z"}, {"entity": "publication", "iuid": "5bb8ae8f6ba84927ace55253c2cc8ae1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5bb8ae8f6ba84927ace55253c2cc8ae1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5bb8ae8f6ba84927ace55253c2cc8ae1"}}, "title": "Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy.", "authors": [{"family": "Georganaki", "given": "Maria", "initials": "M"}, {"family": "Ramachandran", "given": "Mohanraj", "initials": "M"}, {"family": "Tuit", "given": "Sander", "initials": "S"}, {"family": "N\u00fa\u00f1ez", "given": "Nicol\u00e1s Gonzalo", "initials": "NG"}, {"family": "Karampatzakis", "given": "Alexandros", "initials": "A"}, {"family": "Fotaki", "given": "Grammatiki", "initials": "G"}, {"family": "van Hooren", "given": "Luuk", "initials": "L"}, {"family": "Huang", "given": "Hua", "initials": "H"}, {"family": "Lugano", "given": "Roberta", "initials": "R"}, {"family": "Ulas", "given": "Thomas", "initials": "T", "orcid": "0000-0002-9785-4197", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1fe5950df6e141b7aab952703e0c0c46.json"}}, {"family": "Kaunisto", "given": "Aura", "initials": "A"}, {"family": "Holland", "given": "Eric C", "initials": "EC"}, {"family": "Ellmark", "given": "Peter", "initials": "P"}, {"family": "Mangsbo", "given": "Sara M", "initials": "SM"}, {"family": "Schultze", "given": "Joachim", "initials": "J"}, {"family": "Essand", "given": "Magnus", "initials": "M"}, {"family": "Tugues", "given": "Sonia", "initials": "S"}, {"family": "Dimberg", "given": "Anna", "initials": "A", "orcid": "0000-0003-4422-9125", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f5d91c4b8784d8081a41604bb3d78d4.json"}}], "type": "journal article", "published": "2020-03-09", "journal": {"title": "Oncoimmunology", "issn": "2162-4011", "volume": "9", "issue": "1", "pages": "1730538", "issn-l": null}, "abstract": "CD40-stimulating immunotherapy can elicit potent anti-tumor responses by activating dendritic cells and enhancing T-cell priming. Tumor vessels orchestrate T-cell recruitment during immune response, but the effect of CD40-stimulating immunotherapy on tumor endothelial cells has not been evaluated. Here, we have investigated how tumor endothelial cells transcriptionally respond to CD40-stimulating immunotherapy by isolating tumor endothelial cells from agonistic CD40 mAb- or isotype-treated mice bearing B16-F10 melanoma, and performing RNA-sequencing. Gene set enrichment analysis revealed that agonistic CD40 mAb therapy increased interferon (IFN)-related responses in tumor endothelial cells, including up-regulation of the immunosuppressive enzyme Indoleamine 2, 3-Dioxygenase 1 (IDO1). IDO1 was predominantly expressed in endothelial cells within the tumor microenvironment, and its expression in tumor endothelium was positively correlated to T-cell infiltration and to increased intratumoral expression of IFN\u03b3. In vitro, endothelial cells up-regulated IDO1 in response to T-cell-derived IFN\u03b3, but not in response to CD40-stimulation. Combining agonistic CD40 mAb therapy with the IDO1 inhibitor epacadostat delayed tumor growth in B16-F10 melanoma, associated with increased activation of tumor-infiltrating T-cells. Hereby, we show that the tumor endothelial cells up-regulate IDO1 upon CD40-stimulating immunotherapy in response to increased IFN\u03b3-secretion by T-cells, revealing a novel immunosuppressive feedback mechanism whereby tumor vessels limit T-cell activation.", "doi": "10.1080/2162402X.2020.1730538", "pmid": "32231867", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7094447"}, {"db": "pii", "key": "1730538"}], "notes": [], "created": "2026-08-20T09:37:30.762Z", "modified": "2026-08-21T09:28:20.269Z"}]}