{"entity": "researcher", "timestamp": "2026-08-25T03:33:39.156Z", "family": "Sharma", "given": "Ravi Kumar", "initials": "RK", "orcid": "0000-0002-2658-0002", "affiliations": ["Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/6eb05ea5583c462493eaacdd8d4efb64.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/6eb05ea5583c462493eaacdd8d4efb64"}}, "publications": [{"entity": "publication", "iuid": "e195ec5ac014446bbef7583332fc6e31", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e195ec5ac014446bbef7583332fc6e31.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e195ec5ac014446bbef7583332fc6e31"}}, "title": "Rheumatoid Arthritis Related B-Cell Changes Are Found Already in the Risk-RA Phase.", "authors": [{"family": "de Vries", "given": "Charlotte", "initials": "C"}, {"family": "Huang", "given": "Wenqi", "initials": "W"}, {"family": "Sharma", "given": "Ravi Kumar", "initials": "RK", "orcid": "0000-0002-2658-0002", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6eb05ea5583c462493eaacdd8d4efb64.json"}}, {"family": "Wangriatisak", "given": "Kittikorn", "initials": "K"}, {"family": "Turcinov", "given": "Sara", "initials": "S"}, {"family": "C\u00eerciumaru", "given": "Alexandra", "initials": "A"}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L"}, {"family": "Gr\u00f6nwall", "given": "Caroline", "initials": "C", "orcid": "0000-0002-9111-5537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/83f1ca4cc59840a6adcbad718dd64aef.json"}}, {"family": "Hensvold", "given": "Aase", "initials": "A", "orcid": "0000-0002-7669-3777", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/960b6d6803b241478a6ec63adee7bcc6.json"}}, {"family": "Lundberg", "given": "Karin", "initials": "K"}, {"family": "Malmstr\u00f6m", "given": "Vivianne", "initials": "V", "orcid": "0000-0001-9251-8082", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/206e1bc761464dd3bc906afdee8c49c2.json"}}], "type": "journal article", "published": "2025-02-00", "journal": {"title": "Eur. J. Immunol.", "issn": "1521-4141", "volume": "55", "issue": "2", "pages": "e202451391", "issn-l": "0014-2980"}, "abstract": "Anti-cyclic citrullinated peptide2 (CCP2) antibody positivity in rheumatoid arthritis (RA) and in the predisease phase, together with the success of B-cell depletion, support a crucial role for B cells in RA pathogenesis. Yet, knowledge of B cells in the transition from autoimmunity to RA is limited, and therefore we here investigated B-cell changes during the risk-RA phase. B-cell phenotypes in 18 CCP2-positive risk-RA individuals with musculoskeletal complaints were studied, parallel with ten CCP2-positive RA patients and nine healthy controls. Nine of the risk-RA individuals progressed to RA. B-cell phenotypes were investigated using spectral flow cytometry. The results demonstrate that unswitched and switched memory B-cell frequencies in the risk-RA cohort were more similar to controls than RA patients. Yet, risk-RA progressors displayed an early activation profile amongst na\u00efve B cells. Deeper characterization of the memory compartment revealed expansion of CD27-negative IgG+ B cells both in RA compared with controls (p = 0.0172) and in risk-RA progressors versus non-progressors (p = 0.0295). Overall, we demonstrate that the phenotypic distribution of B cells is altered in the risk-RA phase. This includes changes in CD27-negative class-switched B cells, which have been attributed to autoreactive and anergic features implicating a possible contribution to RA development.", "doi": "10.1002/eji.202451391", "pmid": "39931747", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11811808"}], "notes": [], "created": "2026-08-21T11:01:48.889Z", "modified": "2026-08-21T11:01:49.080Z"}]}