{"entity": "researcher", "timestamp": "2026-03-10T04:07:23.444Z", "family": "Elfstrand", "given": "Malin", "initials": "M", "orcid": "0000-0002-0214-5284", "affiliations": ["Uppsala Biocentre, Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ea896e8946240f587aecc990b6b8bfd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ea896e8946240f587aecc990b6b8bfd"}}, "publications": [{"entity": "publication", "iuid": "36894e0c80354ca88d9d6ce3737a3dec", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/36894e0c80354ca88d9d6ce3737a3dec.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/36894e0c80354ca88d9d6ce3737a3dec"}}, "title": "Killing two enemies with one stone? Genomics of resistance to two sympatric pathogens in Norway spruce.", "authors": [{"family": "Capador-Barreto", "given": "Hern\u00e1n D", "initials": "HD", "orcid": "0000-0002-4811-7756", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b9f642cc42174892ab5f3e416f28b823.json"}}, {"family": "Bernhardsson", "given": "Carolina", "initials": "C"}, {"family": "Milesi", "given": "Pascal", "initials": "P"}, {"family": "Vos", "given": "Ingrid", "initials": "I"}, {"family": "Lund\u00e9n", "given": "Karl", "initials": "K"}, {"family": "Wu", "given": "Harry X", "initials": "HX", "orcid": "0000-0002-7072-4704", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d09d9cea430d4bf7907374fd9fc44b18.json"}}, {"family": "Karlsson", "given": "Bo", "initials": "B"}, {"family": "Ingvarsson", "given": "P\u00e4r K", "initials": "PK", "orcid": "0000-0001-9225-7521", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb09a6889bc64651ac6eb90b67edca3d.json"}}, {"family": "Stenlid", "given": "Jan", "initials": "J"}, {"family": "Elfstrand", "given": "Malin", "initials": "M", "orcid": "0000-0002-0214-5284", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ea896e8946240f587aecc990b6b8bfd.json"}}], "type": "journal article", "published": "2021-09-00", "journal": {"title": "Mol. Ecol.", "issn": "1365-294X", "volume": "30", "issue": "18", "pages": "4433-4447", "issn-l": "0962-1083"}, "abstract": "Trees must cope with the attack of multiple pathogens, often simultaneously during their long lifespan. Ironically, the genetic and molecular mechanisms controlling this process are poorly understood. The objective of this study was to compare the genetic component of resistance in Norway spruce to Heterobasidion annosum s.s. and its sympatric congener Heterobasidion parviporum. Heterobasidion root- and stem-rot is a major disease of Norway spruce caused by members of the Heterobasidion annosum species complex. Resistance to both pathogens was measured using artificial inoculations in half-sib families of Norway spruce trees originating from central to northern Europe. The genetic component of resistance was analysed using 63,760 genome-wide exome-capture sequenced SNPs and multitrait genome-wide associations. No correlation was found for resistance to the two pathogens; however, associations were found between genomic variants and resistance traits with synergic or antagonist pleiotropic effects to both pathogens. Additionally, a latitudinal cline in resistance in the bark to H. annosum s.s. was found; trees from southern latitudes, with a later bud-set and thicker stem diameter, allowed longer lesions, but this was not the case for H. parviporum. In summary, this study detects genomic variants with pleiotropic effects which explain multiple disease resistance from a genic level and could be useful for selection of resistant trees to both pathogens. Furthermore, it highlights the need for additional research to understand the evolution of resistance traits to multiple pathogens in trees.", "doi": "10.1111/mec.16058", "pmid": "34218489", "labels": {"Pascal Milesi": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2022-01-10T21:20:08.770Z", "modified": "2022-11-04T11:32:12.610Z"}, {"entity": "publication", "iuid": "3afb4cfd1e344d4cb4c1336796de29f1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3afb4cfd1e344d4cb4c1336796de29f1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3afb4cfd1e344d4cb4c1336796de29f1"}}, "title": "The Norway spruce genome sequence and conifer genome evolution.", "authors": [{"family": "Nystedt", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Street", "given": "Nathaniel R", "initials": "NR"}, {"family": "Wetterbom", "given": "Anna", "initials": "A"}, {"family": "Zuccolo", "given": "Andrea", "initials": "A"}, {"family": "Lin", "given": "Yao-Cheng", "initials": "YC"}, {"family": "Scofield", "given": "Douglas G", "initials": "DG", "orcid": "0000-0001-5235-6461", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6a2cc7a4bad04f5ab664027a374f5698.json"}}, {"family": "Vezzi", "given": "Francesco", "initials": "F"}, {"family": "Delhomme", "given": "Nicolas", "initials": "N"}, {"family": "Giacomello", "given": "Stefania", "initials": "S", "orcid": "0000-0003-0738-1574", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5a9c4a7494ba4284ab52158e6cbc85da.json"}}, {"family": "Alexeyenko", "given": "Andrey", "initials": "A", "orcid": "0000-0001-8812-6481", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8078f1505d9747e1ac76cf2f6d4ee606.json"}}, {"family": "Vicedomini", "given": "Riccardo", "initials": "R"}, {"family": "Sahlin", "given": "Kristoffer", "initials": "K", "orcid": "0000-0001-7378-2320", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca3f1ebe1b9946a9ad9eb4b3058a911c.json"}}, {"family": "Sherwood", "given": "Ellen", "initials": "E"}, {"family": "Elfstrand", "given": "Malin", "initials": "M", "orcid": "0000-0002-0214-5284", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ea896e8946240f587aecc990b6b8bfd.json"}}, {"family": "Gramzow", "given": "Lydia", "initials": "L"}, {"family": "Holmberg", "given": "Kristina", "initials": "K"}, {"family": "H\u00e4llman", "given": "Jimmie", "initials": "J"}, {"family": "Keech", "given": "Olivier", "initials": "O"}, {"family": "Klasson", "given": "Lisa", "initials": "L"}, {"family": "Koriabine", "given": "Maxim", "initials": "M"}, {"family": "Kucukoglu", "given": "Melis", "initials": "M"}, {"family": "K\u00e4ller", "given": "Max", "initials": "M"}, {"family": "Luthman", "given": "Johannes", "initials": "J"}, {"family": "Lysholm", "given": "Fredrik", "initials": "F"}, {"family": "Niittyl\u00e4", "given": "Totte", "initials": "T"}, {"family": "Olson", "given": "Ake", "initials": "A"}, {"family": "Rilakovic", "given": "Nemanja", "initials": "N"}, {"family": "Ritland", "given": "Carol", "initials": "C"}, {"family": "Rossell\u00f3", "given": "Josep A", "initials": "JA"}, {"family": "Sena", "given": "Juliana", "initials": "J"}, {"family": "Svensson", "given": "Thomas", "initials": "T"}, {"family": "Talavera-L\u00f3pez", "given": "Carlos", "initials": "C"}, {"family": "Thei\u00dfen", "given": "G\u00fcnter", "initials": "G"}, {"family": "Tuominen", "given": "Hannele", "initials": "H"}, {"family": "Vanneste", "given": "Kevin", "initials": "K"}, {"family": "Wu", "given": "Zhi-Qiang", "initials": "ZQ"}, {"family": "Zhang", "given": "Bo", "initials": "B", "orcid": "0000-0002-9199-1115", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ce4d3f145f14816a0c6f42481475c3a.json"}}, {"family": "Zerbe", "given": "Philipp", "initials": "P"}, {"family": "Arvestad", "given": "Lars", "initials": "L"}, {"family": "Bhalerao", "given": "Rishikesh", "initials": "R"}, {"family": "Bohlmann", "given": "Joerg", "initials": "J"}, {"family": "Bousquet", "given": "Jean", "initials": "J"}, {"family": "Garcia Gil", "given": "Rosario", "initials": "R"}, {"family": "Hvidsten", "given": "Torgeir R", "initials": "TR"}, {"family": "de Jong", "given": "Pieter", "initials": "P"}, {"family": "MacKay", "given": "John", "initials": "J"}, {"family": "Morgante", "given": "Michele", "initials": "M"}, {"family": "Ritland", "given": "Kermit", "initials": "K"}, {"family": "Sundberg", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Thompson", "given": "Stacey Lee", "initials": "SL"}, {"family": "Van de Peer", "given": "Yves", "initials": "Y"}, {"family": "Andersson", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0003-2975-9400", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/869d72720cd9462dba09cbc861556de6.json"}}, {"family": "Nilsson", "given": "Ove", "initials": "O", "orcid": "0000-0003-2716-2563", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e197da18897400e9babda511e0e31cb.json"}}, {"family": "Ingvarsson", "given": "P\u00e4r K", "initials": "PK", "orcid": "0000-0001-9225-7521", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb09a6889bc64651ac6eb90b67edca3d.json"}}, {"family": "Lundeberg", "given": "Joakim", "initials": "J", "orcid": "0000-0003-4313-1601", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9fa47767cd14ef2b9528c8b998cf095.json"}}, {"family": "Jansson", "given": "Stefan", "initials": "S"}], "type": "journal article", "published": "2013-05-30", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "497", "issue": "7451", "pages": "579-584", "issn-l": "0028-0836"}, "abstract": "Conifers have dominated forests for more than 200 million years and are of huge ecological and economic importance. Here we present the draft assembly of the 20-gigabase genome of Norway spruce (Picea abies), the first available for any gymnosperm. The number of well-supported genes (28,354) is similar to the >100 times smaller genome of Arabidopsis thaliana, and there is no evidence of a recent whole-genome duplication in the gymnosperm lineage. Instead, the large genome size seems to result from the slow and steady accumulation of a diverse set of long-terminal repeat transposable elements, possibly owing to the lack of an efficient elimination mechanism. Comparative sequencing of Pinus sylvestris, Abies sibirica, Juniperus communis, Taxus baccata and Gnetum gnemon reveals that the transposable element diversity is shared among extant conifers. Expression of 24-nucleotide small RNAs, previously implicated in transposable element silencing, is tissue-specific and much lower than in other plants. We further identify numerous long (>10,000 base pairs) introns, gene-like fragments, uncharacterized long non-coding RNAs and short RNAs. This opens up new genomic avenues for conifer forestry and breeding.", "doi": "10.1038/nature12211", "pmid": "23698360", "labels": {"Affiliated researcher": null, "Kristoffer Sahlin": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "nature12211"}], "notes": [], "created": "2018-12-05T08:19:22.709Z", "modified": "2025-11-04T14:23:20.985Z"}]}