{"entity": "researcher", "timestamp": "2026-08-20T21:12:29.118Z", "family": "Papareddy", "given": "Praveen", "initials": "P", "orcid": "0000-0002-3872-478X", "affiliations": ["Department of Laboratory Medicine, Biomedical Center (BMC), Lund University, Lund, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e792ecc29554294a087324dc8801447.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e792ecc29554294a087324dc8801447"}}, "publications": [{"entity": "publication", "iuid": "03f98235d6314f8f8966034a7e51ed65", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/03f98235d6314f8f8966034a7e51ed65.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/03f98235d6314f8f8966034a7e51ed65"}}, "title": "Factor XII-driven coagulation traps bacterial infections.", "authors": [{"family": "Nickel", "given": "Katrin F", "initials": "KF", "orcid": "0000-0003-1287-6766", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/482416cc32564e4980f996de9b3de984.json"}}, {"family": "J\u00e4ms\u00e4", "given": "Anne", "initials": "A", "orcid": "0009-0009-7663-5700", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f56b24c8baa045be95193ce608ec0081.json"}}, {"family": "Konrath", "given": "Sandra", "initials": "S", "orcid": "0009-0007-2336-8982", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2fd5bf1c58d5482382218c59b5348a18.json"}}, {"family": "Papareddy", "given": "Praveen", "initials": "P", "orcid": "0000-0002-3872-478X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e792ecc29554294a087324dc8801447.json"}}, {"family": "Butler", "given": "Lynn M", "initials": "LM", "orcid": "0000-0002-2352-8217", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca98647aea15499485d755977bd0869a.json"}}, {"family": "Stavrou", "given": "Evi X", "initials": "EX", "orcid": "0000-0002-6075-7609", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/be1e7e09fffc4a14960e7d0d0212d6be.json"}}, {"family": "Frye", "given": "Maike", "initials": "M", "orcid": "0000-0002-6257-7636", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8484d63bbba4163a7642d14bcf42bf3.json"}}, {"family": "Gelderblom", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4254-3439", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d4756de195ef4097aba06331228b9e34.json"}}, {"family": "Nieswandt", "given": "Bernhard", "initials": "B", "orcid": "0000-0003-1454-7413", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/029fabbfec9e4a0b96c829a9767454f3.json"}}, {"family": "Hammerschmidt", "given": "Sven", "initials": "S", "orcid": "0000-0002-6382-6681", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c25ea9a2059c465b941a4ffc55bd8e09.json"}}, {"family": "Herwald", "given": "Heiko", "initials": "H", "orcid": "0000-0002-8111-2842", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6cf2d138f75140f68de333390b1c3adc.json"}}, {"family": "Renn\u00e9", "given": "Thomas", "initials": "T", "orcid": "0000-0003-4594-5975", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c1703d52e6c4a3f9832eb469ca19167.json"}}], "type": "journal article", "published": "2025-07-07", "journal": {"title": "J. Exp. Med.", "issn": "1540-9538", "volume": "222", "issue": "7", "issn-l": "0022-1007"}, "abstract": "Blood coagulation is essential for stopping bleeding but also drives thromboembolic disorders. Factor XII (FXII)-triggered coagulation promotes thrombosis while being dispensable for hemostasis, making it a potential anticoagulant target. However, its physiological role remains unclear. Here, we demonstrate that FXII-driven coagulation enhances innate immunity by trapping pathogens and restricting bacterial infection in mice. Streptococcus pneumoniae infection was more severe in FXII-deficient (F12-/-) mice, with increased pulmonary bacterial burden, systemic spread, and mortality. Similarly, Staphylococcus aureus skin infections and systemic dissemination were exacerbated in F12-/- mice. Reconstitution with human FXII restored bacterial containment. Plasma kallikrein amplifies FXII activation, and its deficiency aggravated S. aureus skin infections, similarly to F12-/- mice. FXII deficiency impaired fibrin deposition in abscess walls, leading to leaky capsules and bacterial escape. Bacterial long-chain polyphosphate activated FXII, triggering fibrin formation. Deficiency in FXII substrate factor XI or FXII/factor XI co-deficiency similarly exacerbated S. aureus infection. The data reveal a protective role for FXII-driven coagulation in host defense, urging caution in developing therapeutic strategies targeting this pathway.", "doi": "10.1084/jem.20250049", "pmid": "40261297", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12013512"}, {"db": "pii", "key": "277405"}], "notes": [], "created": "2026-08-20T09:38:18.221Z", "modified": "2026-08-20T09:38:18.685Z"}]}