{"entity": "researcher", "timestamp": "2026-08-20T21:38:58.158Z", "family": "Gerszten", "given": "Robert E", "initials": "RE", "orcid": "0000-0002-6767-7687", "affiliations": ["Department of Medicine, Harvard Medical School, Boston, MA, USA.", "Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ddb55dc5a54401d8d958fac1c46e8b8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ddb55dc5a54401d8d958fac1c46e8b8"}}, "publications": [{"entity": "publication", "iuid": "5a61f0fe135b417a90d6e21489447f0b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5a61f0fe135b417a90d6e21489447f0b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5a61f0fe135b417a90d6e21489447f0b"}}, "title": "Human plasma proteomic profile of clonal hematopoiesis.", "authors": [{"family": "Yu", "given": "Zhi", "initials": "Z", "orcid": "0000-0003-4810-3474", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4b810efe02244148b701c1468543ea3.json"}}, {"family": "Vromman", "given": "Am\u00e9lie", "initials": "A", "orcid": "0000-0002-1724-2095", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c5297e9d22b24ac7beaab07f94c6d1f7.json"}}, {"family": "Nguyen", "given": "Ngoc Quynh H", "initials": "NQH"}, {"family": "Schuermans", "given": "Art", "initials": "A", "orcid": "0000-0001-8146-9692", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/af284c3bd9304f54ac7b8c9970ce56be.json"}}, {"family": "Li", "given": "Linke", "initials": "L", "orcid": "0009-0002-6350-5121", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9afb054682214d1680bca7176679f776.json"}}, {"family": "Rentz", "given": "Thiago", "initials": "T"}, {"family": "Nakao", "given": "Tetsushi", "initials": "T", "orcid": "0000-0001-9979-2682", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7e818cd4544c41c2a7fa91dbce13429e.json"}}, {"family": "Vellarikkal", "given": "Shamsudheen K", "initials": "SK"}, {"family": "Uddin", "given": "Md Mesbah", "initials": "MM", "orcid": "0000-0003-1846-0411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/42f1ac7010c34ba997a3fd9e56c6a56a.json"}}, {"family": "Niroula", "given": "Abhishek", "initials": "A", "orcid": "0000-0002-5904-0635", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/05df7afc7a494ba5af8a378e5ffa53f0.json"}}, {"family": "Griffin", "given": "Gabriel", "initials": "G", "orcid": "0000-0002-4042-6757", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f6153204e19d4660b640dc4467605973.json"}}, {"family": "Honigberg", "given": "Michael C", "initials": "MC", "orcid": "0000-0001-8630-5021", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c541cd0864c947a6bafa7ad6e78bfe49.json"}}, {"family": "Lin", "given": "Amy E", "initials": "AE"}, {"family": "Gibson", "given": "Christopher J", "initials": "CJ", "orcid": "0000-0002-3700-5310", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71ce9f64755e483496f8c28a76a2a1ff.json"}}, {"family": "Katz", "given": "Daniel H", "initials": "DH", "orcid": "0000-0001-7237-8502", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/63cd0c8093e04a73ba23663cfe2240ab.json"}}, {"family": "Tahir", "given": "Usman A", "initials": "UA", "orcid": "0000-0002-3657-6082", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0da2aec3cea841b88b504d4552260a1f.json"}}, {"family": "Fang", "given": "Shi", "initials": "S"}, {"family": "Dron", "given": "Jacqueline S", "initials": "JS", "orcid": "0000-0002-3045-6530", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02b5962312b34edc9d7b6a8f86dbc385.json"}}, {"family": "Pan", "given": "Michael", "initials": "M", "orcid": "0009-0009-8529-897X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02486d3c27894fbf8097fbcaae0494d6.json"}}, {"family": "Haidermota", "given": "Sara", "initials": "S"}, {"family": "Ganesh", "given": "Shriienidhie", "initials": "S", "orcid": "0000-0002-4226-7526", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ab02750ae47045b08d78ad814c146e00.json"}}, {"family": "Antoine", "given": "Tajmara", "initials": "T"}, {"family": "Weinstock", "given": "Joshua", "initials": "J", "orcid": "0000-0001-7013-1899", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2501ed5d8a4e43d488e7267e58ad68cd.json"}}, {"family": "Austin", "given": "Thomas R", "initials": "TR"}, {"family": "Vasan", "given": "Ramachandran S", "initials": "RS", "orcid": "0000-0001-7357-5970", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22de41f77ce541d09a9b04aa59de33f7.json"}}, {"family": "Peloso", "given": "Gina M", "initials": "GM", "orcid": "0000-0002-5355-8636", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b1478b88eafd41d09194cf8967e8ea5f.json"}}, {"family": "Hornsby", "given": "Whitney", "initials": "W"}, {"family": "Ganz", "given": "Peter", "initials": "P", "orcid": "0000-0002-0437-8882", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/055c271c41bc4123a10eaff5a3a63671.json"}}, {"family": "Manson", "given": "JoAnn E", "initials": "JE", "orcid": "0000-0002-9426-7595", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e39f122c5fd4f0ea0dcf2353ed4a274.json"}}, {"family": "Haring", "given": "Bernhard", "initials": "B", "orcid": "0000-0001-6109-431X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ea851352ae64f9c82e0c464c588987c.json"}}, {"family": "Kooperberg", "given": "Charles", "initials": "C", "orcid": "0000-0002-7986-8560", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f8fbc0fa2df5467ca8c6e65def4485cd.json"}}, {"family": "Reiner", "given": "Alexander P", "initials": "AP", "orcid": "0000-0002-1427-4470", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/244e81f4f21645e9b66f7b2ba6a8eb07.json"}}, {"family": "Bis", "given": "Joshua C", "initials": "JC", "orcid": "0000-0002-3409-1110", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de8dd43c6fe64ebbaf718500e4fef3d9.json"}}, {"family": "Psaty", "given": "Bruce M", "initials": "BM", "orcid": "0000-0002-7278-2190", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b4dfcdad9074df781cd6c8f3c303789.json"}}, {"family": "Min", "given": "Yuan-I", "initials": "YI", "orcid": "0000-0003-2470-0004", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed696d19aad3484787841ca7ac0dded8.json"}}, {"family": "Correa", "given": "Adolfo", "initials": "A", "orcid": "0000-0002-9501-600X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5148730ad2904845aafb1bf3c4d30211.json"}}, {"family": "Lange", "given": "Leslie A", "initials": "LA"}, {"family": "Post", "given": "Wendy S", "initials": "WS", "orcid": "0000-0002-8655-5204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8f908e31bf344ee80d308b22c3a42fb.json"}}, {"family": "Rotter", "given": "Jerome I", "initials": "JI", "orcid": "0000-0001-7191-1723", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/50edc25b80cc48b699db367e372fded5.json"}}, {"family": "Rich", "given": "Stephen S", "initials": "SS", "orcid": "0000-0003-3872-7793", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b55061262f4541c1b28d3081e4001833.json"}}, {"family": "Wilson", "given": "James G", "initials": "JG"}, {"family": "Ebert", "given": "Benjamin L", "initials": "BL", "orcid": "0000-0003-0197-5451", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/56e4f1c53a4348e2b0ceb44a38850a17.json"}}, {"family": "Yu", "given": "Bing", "initials": "B", "orcid": "0000-0003-4818-1077", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e408849bd8f14fd99a2ae255990c1f49.json"}}, {"family": "Ballantyne", "given": "Christie M", "initials": "CM", "orcid": "0000-0002-6432-1730", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27dc5297c262410bad3bbb66a488d4b4.json"}}, {"family": "Coresh", "given": "Josef", "initials": "J", "orcid": "0000-0002-4598-0669", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e26609ab79774b89a8d85a1a3634dac5.json"}}, {"family": "Sankaran", "given": "Vijay G", "initials": "VG", "orcid": "0000-0003-0044-443X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a967a5a378f406299b3fefe244361c9.json"}}, {"family": "Bick", "given": "Alexander G", "initials": "AG", "orcid": "0000-0001-5824-9595", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2da5a35a4984921b19dfafe64cea2de.json"}}, {"family": "Jaiswal", "given": "Siddhartha", "initials": "S", "orcid": "0000-0002-9597-0477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a1901e08f989434fb01dfa17b0a85470.json"}}, {"family": "Gerszten", "given": "Robert E", "initials": "RE", "orcid": "0000-0002-6767-7687", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ddb55dc5a54401d8d958fac1c46e8b8.json"}}, {"family": "NHLBI Trans-Omics for Precision Medicine", "given": "", "initials": ""}, {"family": "Libby", "given": "Peter", "initials": "P", "orcid": "0000-0002-1502-502X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/39fb20acff0442bd92fc7931d3ee6cf9.json"}}, {"family": "Gupta", "given": "Rajat M", "initials": "RM", "orcid": "0000-0001-9865-4106", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb15f2cb8f6044889d0e974a23884320.json"}}, {"family": "Natarajan", "given": "Pradeep", "initials": "P", "orcid": "0000-0001-8402-7435", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe8bd48c61c047cd8e61c35d9e9ac650.json"}}], "type": "journal article", "published": "2025-11-27", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "11688", "issn-l": "2041-1723"}, "abstract": "Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer insights into downstream clinical consequences. Here we explore these patterns in clonal hematopoiesis of indeterminate potential (CHIP), which is linked to several cancer and non-cancer outcomes, including coronary artery disease (CAD). Among 61,833 participants (3881 with CHIP) from TOPMed and UK Biobank (UKB) with blood-based DNA sequencing and proteomic measurements (1,148 proteins by SomaScan in TOPMed and 2917 proteins by Olink in UKB), we identify 32 and 345 proteins from TOPMed and UKB, respectively, associated with CHIP and most prevalent driver genes (DNMT3A, TET2, and ASXL1). These associations show substantial heterogeneity by driver genes, sex, and race, and were enriched for immune response and inflammation pathways. Mendelian randomization in humans, coupled with ELISA in hematopoietic Tet2-/- vs wild-type mice validation, disentangle causal proteomic perturbations from TET2 CHIP. Lastly, we identify plasma proteins shared between CHIP and CAD.", "doi": "10.1038/s41467-025-66755-z", "pmid": "41309676", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12748892"}, {"db": "pii", "key": "10.1038/s41467-025-66755-z"}], "notes": [], "created": "2026-08-20T08:54:22.606Z", "modified": "2026-08-20T08:54:23.224Z"}, {"entity": "publication", "iuid": "9b584b66544649dfae4781915c418be4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9b584b66544649dfae4781915c418be4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9b584b66544649dfae4781915c418be4"}}, "title": "An atlas of genetic scores to predict multi-omic traits.", "authors": [{"family": "Xu", "given": "Yu", "initials": "Y", "orcid": "0000-0002-7304-5045", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3ac4920de9564d809602c26f92e4aeca.json"}}, {"family": "Ritchie", "given": "Scott C", "initials": "SC", "orcid": "0000-0002-8454-9548", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36a4d823852c4bae97ddc68a05030b72.json"}}, {"family": "Liang", "given": "Yujian", "initials": "Y"}, {"family": "Timmers", "given": "Paul R H J", "initials": "PRHJ", "orcid": "0000-0002-5197-1267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1a7fb58cb2f4bd1b48f23be33de0c6e.json"}}, {"family": "Pietzner", "given": "Maik", "initials": "M", "orcid": "0000-0003-3437-9963", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3304844cece945168cbec0b5e3d9a9cf.json"}}, {"family": "Lannelongue", "given": "Lo\u00efc", "initials": "L", "orcid": "0000-0002-9135-1345", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d2fdb81bd8c4b93af2d061f6421540f.json"}}, {"family": "Lambert", "given": "Samuel A", "initials": "SA", "orcid": "0000-0001-8222-008X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/23811479ba0a41a99a94f9c0d3f06bd4.json"}}, {"family": "Tahir", "given": "Usman A", "initials": "UA"}, {"family": "May-Wilson", "given": "Sebastian", "initials": "S", "orcid": "0000-0003-2668-5717", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d39731ddad649e88c6958a9fc03008b.json"}}, {"family": "Foguet", "given": "Carles", "initials": "C", "orcid": "0000-0001-8494-9595", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c41865149ac74c4695959ced5ce4ec9f.json"}}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0002-2915-4498", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0bac3e1e64949fcbac4b4d839e1144d.json"}}, {"family": "Surendran", "given": "Praveen", "initials": "P"}, {"family": "Nath", "given": "Artika P", "initials": "AP"}, {"family": "Persyn", "given": "Elodie", "initials": "E", "orcid": "0000-0001-9104-1972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d882b5f4416425ab28deb0a35d905ef.json"}}, {"family": "Peters", "given": "James E", "initials": "JE", "orcid": "0000-0002-9415-3440", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cdf78018d1448498239609190aade2d.json"}}, {"family": "Oliver-Williams", "given": "Clare", "initials": "C"}, {"family": "Deng", "given": "Shuliang", "initials": "S"}, {"family": "Prins", "given": "Bram", "initials": "B", "orcid": "0000-0001-5774-034X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2677fba12f9549b193a0498b539cd793.json"}}, {"family": "Luan", "given": "Jian'an", "initials": "J", "orcid": "0000-0003-3137-6337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f2180f4f03be411ba2c80c18a78e6645.json"}}, {"family": "Bomba", "given": "Lorenzo", "initials": "L"}, {"family": "Soranzo", "given": "Nicole", "initials": "N", "orcid": "0000-0003-1095-3852", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/751b4656807c42f9a668ebb98e8da987.json"}}, {"family": "Di Angelantonio", "given": "Emanuele", "initials": "E"}, {"family": "Pirastu", "given": "Nicola", "initials": "N"}, {"family": "Tai", "given": "E Shyong", "initials": "ES", "orcid": "0000-0003-2929-8966", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d116286b0f524b6d835ef78c4f1dfd14.json"}}, {"family": "van Dam", "given": "Rob M", "initials": "RM"}, {"family": "Parkinson", "given": "Helen", "initials": "H"}, {"family": "Davenport", "given": "Emma E", "initials": "EE"}, {"family": "Paul", "given": "Dirk S", "initials": "DS", "orcid": "0000-0002-8230-0116", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2169975c0a46456c9f29a2b7b3da0b30.json"}}, {"family": "Yau", "given": "Christopher", "initials": "C", "orcid": "0000-0001-7615-8523", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bbc82d06ec19459d99e5809ddbf36145.json"}}, {"family": "Gerszten", "given": "Robert E", "initials": "RE", "orcid": "0000-0002-6767-7687", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ddb55dc5a54401d8d958fac1c46e8b8.json"}}, {"family": "M\u00e4larstig", "given": "Anders", "initials": "A", "orcid": "0000-0003-2608-1358", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32b012456e6f490e99b12f5fb1216ce8.json"}}, {"family": "Danesh", "given": "John", "initials": "J"}, {"family": "Sim", "given": "Xueling", "initials": "X", "orcid": "0000-0002-1233-7642", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b9aec75e482049f5b169a9cfc517a351.json"}}, {"family": "Langenberg", "given": "Claudia", "initials": "C", "orcid": "0000-0002-5017-7344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f287f3248cc24c6cbfc100c249b87418.json"}}, {"family": "Wilson", "given": "James F", "initials": "JF", "orcid": "0000-0001-5751-9178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513b6983cc9d478ab9d81c2f21579961.json"}}, {"family": "Butterworth", "given": "Adam S", "initials": "AS", "orcid": "0000-0002-6915-9015", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88842023860148bb8d155b5c18db72a8.json"}}, {"family": "Inouye", "given": "Michael", "initials": "M", "orcid": "0000-0001-9413-6520", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d1abe69d2ee548b9b754ebcd5eeabac7.json"}}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "616", "issue": "7955", "pages": "123-131", "issn-l": "0028-0836"}, "abstract": "The use of omic modalities to dissect the molecular underpinnings of common diseases and traits is becoming increasingly common. But multi-omic traits can be genetically predicted, which enables highly cost-effective and powerful analyses for studies that do not have multi-omics1. Here we examine a large cohort (the INTERVAL study2; n = 50,000 participants) with extensive multi-omic data for plasma proteomics (SomaScan, n = 3,175; Olink, n = 4,822), plasma metabolomics (Metabolon HD4, n = 8,153), serum metabolomics (Nightingale, n = 37,359) and whole-blood Illumina RNA sequencing (n = 4,136), and use machine learning to train genetic scores for 17,227 molecular traits, including 10,521 that reach Bonferroni-adjusted significance. We evaluate the performance of genetic scores through external validation across cohorts of individuals of European, Asian and African American ancestries. In addition, we show the utility of these multi-omic genetic scores by quantifying the genetic control of biological pathways and by generating a synthetic multi-omic dataset of the UK Biobank3 to identify disease associations using a phenome-wide scan. We highlight a series of biological insights with regard to genetic mechanisms in metabolism and canonical pathway associations with disease; for example, JAK-STAT signalling and coronary atherosclerosis. Finally, we develop a portal ( https://www.omicspred.org/ ) to facilitate public access to all genetic scores and validation results, as well as to serve as a platform for future extensions and enhancements of multi-omic genetic scores.", "doi": "10.1038/s41586-023-05844-9", "pmid": "36991119", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1905816"}, {"db": "pmc", "key": "PMC10323211"}, {"db": "pii", "key": "10.1038/s41586-023-05844-9"}], "notes": [], "created": "2026-08-20T08:58:33.726Z", "modified": "2026-08-20T08:58:34.418Z"}]}