{"entity": "researcher", "timestamp": "2026-09-25T21:38:52.542Z", "family": "Furic", "given": "Luc", "initials": "L", "orcid": "0000-0002-1893-9812", "affiliations": ["d Cancer Program , Biomedicine Discovery Institute and Department of Anatomy & Developmental Biology, Monash University , Victoria , Australia.", "e Prostate Cancer Translational Research Laboratory, Peter MacCallum Cancer Centre , Melbourne , Victoria , Australia."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d3fff390b43428392318962213bb59b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d3fff390b43428392318962213bb59b"}}, "publications": [{"entity": "publication", "iuid": "24238b8a934a49d58f14b161f0d6d727", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/24238b8a934a49d58f14b161f0d6d727.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/24238b8a934a49d58f14b161f0d6d727"}}, "title": "Translational offsetting as a mode of estrogen receptor \u03b1-dependent regulation of gene expression.", "authors": [{"family": "Lorent", "given": "Julie", "initials": "J"}, {"family": "Kusnadi", "given": "Eric P", "initials": "EP"}, {"family": "van Hoef", "given": "Vincent", "initials": "V"}, {"family": "Rebello", "given": "Richard J", "initials": "RJ"}, {"family": "Leibovitch", "given": "Matthew", "initials": "M"}, {"family": "Ristau", "given": "Johannes", "initials": "J"}, {"family": "Chen", "given": "Shan", "initials": "S"}, {"family": "Lawrence", "given": "Mitchell G", "initials": "MG"}, {"family": "Szkop", "given": "Krzysztof J", "initials": "KJ"}, {"family": "Samreen", "given": "Baila", "initials": "B"}, {"family": "Balanathan", "given": "Preetika", "initials": "P"}, {"family": "Rapino", "given": "Francesca", "initials": "F"}, {"family": "Close", "given": "Pierre", "initials": "P"}, {"family": "Bukczynska", "given": "Patricia", "initials": "P"}, {"family": "Scharmann", "given": "Karin", "initials": "K"}, {"family": "Takizawa", "given": "Itsuhiro", "initials": "I"}, {"family": "Risbridger", "given": "Gail P", "initials": "GP"}, {"family": "Selth", "given": "Luke A", "initials": "LA"}, {"family": "Leidel", "given": "Sebastian A", "initials": "SA", "orcid": "0000-0002-0523-6325", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a783a69dc3164efbb16cffa8db91e241.json"}}, {"family": "Lin", "given": "Qishan", "initials": "Q"}, {"family": "Topisirovic", "given": "Ivan", "initials": "I", "orcid": "0000-0002-5510-9762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1bca1813f34c4864940ac6593044a9cc.json"}}, {"family": "Larsson", "given": "Ola", "initials": "O", "orcid": "0000-0003-1412-1308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f81c6cbbe564d38bc78d1af5153d804.json"}}, {"family": "Furic", "given": "Luc", "initials": "L", "orcid": "0000-0002-1893-9812", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d3fff390b43428392318962213bb59b.json"}}], "type": "journal article", "published": "2019-12-02", "journal": {"title": "EMBO J.", "issn": "1460-2075", "volume": "38", "issue": "23", "pages": "e101323", "issn-l": "0261-4189"}, "abstract": "Estrogen receptor alpha (ER\u03b1) activity is associated with increased cancer cell proliferation. Studies aiming to understand the impact of ER\u03b1 on cancer-associated phenotypes have largely been limited to its transcriptional activity. Herein, we demonstrate that ER\u03b1 coordinates its transcriptional output with selective modulation of mRNA translation. Importantly, translational perturbations caused by depletion of ER\u03b1 largely manifest as \"translational offsetting\" of the transcriptome, whereby amounts of translated mRNAs and corresponding protein levels are maintained constant despite changes in mRNA abundance. Transcripts whose levels, but not polysome association, are reduced following ER\u03b1 depletion lack features which limit translation efficiency including structured 5'UTRs and miRNA target sites. In contrast, mRNAs induced upon ER\u03b1 depletion whose polysome association remains unaltered are enriched in codons requiring U34-modified tRNAs for efficient decoding. Consistently, ER\u03b1 regulates levels of U34-modifying enzymes and thereby controls levels of U34-modified tRNAs. These findings unravel a hitherto unprecedented mechanism of ER\u03b1-dependent orchestration of transcriptional and translational programs that may be a pervasive mechanism of proteome maintenance in hormone-dependent cancers.", "doi": "10.15252/embj.2018101323", "pmid": "31556460", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6885737"}, {"db": "GEO", "key": "GSE120917"}, {"db": "GEO", "key": "GSE107590"}, {"db": "GEO", "key": "GSE117569"}, {"db": "GEO", "key": "GSE35428"}, {"db": "GEO", "key": "GSE104399"}, {"db": "GEO", "key": "GSE72249"}], "notes": [], "created": "2026-09-23T09:24:59.418Z", "modified": "2026-09-23T09:24:59.542Z"}, {"entity": "publication", "iuid": "593a11f1155c4d4c90457f0dc4d644b6", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/593a11f1155c4d4c90457f0dc4d644b6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/593a11f1155c4d4c90457f0dc4d644b6"}}, "title": "mTOR-sensitive translation: Cleared fog reveals more trees.", "authors": [{"family": "Masvidal", "given": "Laia", "initials": "L"}, {"family": "Hulea", "given": "Laura", "initials": "L"}, {"family": "Furic", "given": "Luc", "initials": "L", "orcid": "0000-0002-1893-9812", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d3fff390b43428392318962213bb59b.json"}}, {"family": "Topisirovic", "given": "Ivan", "initials": "I"}, {"family": "Larsson", "given": "Ola", "initials": "O"}], "type": "journal article", "published": "2017-10-03", "journal": {"title": "RNA Biol", "issn": "1555-8584", "volume": "14", "issue": "10", "pages": "1299-1305", "issn-l": "1547-6286"}, "abstract": "Translation is fundamental for many biologic processes as it enables cells to rapidly respond to stimuli without requiring de novo mRNA synthesis. The mammalian/mechanistic target of rapamycin (mTOR) is a key regulator of translation. Although mTOR affects global protein synthesis, translation of a subset of mRNAs appears to be exceptionally sensitive to changes in mTOR activity. Recent efforts to catalog these mTOR-sensitive mRNAs resulted in conflicting results. Whereas ribosome-profiling almost exclusively identified 5'-terminal oligopyrimidine (TOP) mRNAs as mTOR-sensitive, polysome-profiling suggested that mTOR also regulates translation of non-TOP mRNAs. This inconsistency was explained by analytical and technical biases limiting the efficiency of ribosome-profiling in detecting mRNAs showing differential translation. Moreover, genome-wide characterization of 5'UTRs of non-TOP mTOR-sensitive mRNAs revealed 2 subsets of transcripts which differ in their requirement for translation initiation factors and biologic functions. We summarize these recent advances and their impact on the understanding of mTOR-sensitive translation.", "doi": "10.1080/15476286.2017.1290041", "pmid": "28277937", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5711451"}], "notes": [], "created": "2018-12-05T12:25:24.793Z", "modified": "2026-09-23T08:31:12.057Z"}]}