{"entity": "researcher", "timestamp": "2026-08-20T20:49:49.602Z", "family": "Antfolk", "given": "Maria", "initials": "M", "orcid": "0000-0003-0129-5640", "affiliations": ["Department of Biomedical Engineering, Lund University, Lund, Sweden. maria.antfolk@bme.lth.se.", "Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark. maria.antfolk@bme.lth.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d2f93e8ea8f4960801202f708186f84.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d2f93e8ea8f4960801202f708186f84"}}, "publications": [{"entity": "publication", "iuid": "7b04f19bd9d047fc831a2ce144921fb9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7b04f19bd9d047fc831a2ce144921fb9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7b04f19bd9d047fc831a2ce144921fb9"}}, "title": "Cell chirality exhibition of brain microvascular endothelial cells is dependent on micropattern width.", "authors": [{"family": "Porras Hern\u00e1ndez", "given": "Ana Mar\u00eda", "initials": "AM"}, {"family": "Tenje", "given": "Maria", "initials": "M", "orcid": "0000-0002-1264-1337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bd13273274574923b354ca9c605efc8f.json"}}, {"family": "Antfolk", "given": "Maria", "initials": "M", "orcid": "0000-0003-0129-5640", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d2f93e8ea8f4960801202f708186f84.json"}}], "type": "journal article", "published": "2022-10-17", "journal": {"title": "RSC Adv.", "issn": "2046-2069", "volume": "12", "issue": "46", "pages": "30135-30144", "issn-l": "2046-2069"}, "abstract": "Left-right asymmetry is a conserved property in nature and observed in the human body, a property known as cell chirality. Cell chirality is often studied using micropatterned in vitro models. However, micropattern geometry and size often varies across different studies, making it challenging to compare results. Here, we utilized micropatterned RGD-peptide lines on hyaluronic acid hydrogels to investigate the effect of the micropattern width on the exhibited cell chirality bias of brain microvascular endothelial cells. Overall, this cell type exhibited a negative chirality bias on micropatterned lines ranging from 10 \u03bcm to 400 \u03bcm in width, where the negative bias was most pronounced on the 100 \u03bcm wide lines. We also observed that this exhibited chirality bias varied across the line width. This work serves as a guide to determine optimal micropattern width for further investigations on cell chirality bias and its prominence in e.g., disease states or upon exposure to toxic substances.", "doi": "10.1039/d2ra05434e", "pmid": "36329947", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9585451"}, {"db": "pii", "key": "d2ra05434e"}], "notes": [], "created": "2026-08-20T09:27:36.717Z", "modified": "2026-08-20T09:27:36.739Z"}, {"entity": "publication", "iuid": "7e4434caa19c49c0be320d4f43e61fa3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7e4434caa19c49c0be320d4f43e61fa3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7e4434caa19c49c0be320d4f43e61fa3"}}, "title": "Confocal imaging dataset to assess endothelial cell orientation during extreme glucose conditions.", "authors": [{"family": "Porras Hern\u00e1ndez", "given": "Ana Mar\u00eda", "initials": "AM", "orcid": "0000-0001-5952-2418", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b3c7742b33f8499baad542f0a2738a27.json"}}, {"family": "Barbe", "given": "Laurent", "initials": "L"}, {"family": "Pohlit", "given": "Hannah", "initials": "H", "orcid": "0000-0002-6366-7836", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51f92fd9b801400d97400b78a937db6c.json"}}, {"family": "Tenje", "given": "Maria", "initials": "M", "orcid": "0000-0002-1264-1337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bd13273274574923b354ca9c605efc8f.json"}}, {"family": "Antfolk", "given": "Maria", "initials": "M", "orcid": "0000-0003-0129-5640", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d2f93e8ea8f4960801202f708186f84.json"}}], "type": "dataset", "published": "2022-01-27", "journal": {"title": "Sci Data", "issn": "2052-4463", "volume": "9", "issue": "1", "pages": "26", "issn-l": "2052-4463"}, "abstract": "Confocal microscopy offers a mean to extract quantitative data on spatially confined subcellular structures. Here, we provide an imaging dataset of confocal z-stacks on endothelial cells spatially confined on lines with different widths, visualizing the nucleus, F-actin, and zonula occludens-1 (ZO-1), as well as the lines. This dataset also includes confocal images of spatially confined endothelial cells challenged with different glucose conditions. We have validated the image quality by established analytical means using the MeasureImageQuality module of the CellProfilerTM software. We envision that this dataset could be used to extract data on both a population and a single cell level, as well as a learning set for the development of new image analysis tools.", "doi": "10.1038/s41597-022-01130-x", "pmid": "35087120", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8795398"}, {"db": "pii", "key": "10.1038/s41597-022-01130-x"}], "notes": [], "created": "2026-08-20T09:04:13.297Z", "modified": "2026-08-20T09:04:13.391Z"}]}