{"entity": "researcher", "timestamp": "2026-08-20T20:53:19.504Z", "family": "Pieti\u00e4inen", "given": "Vilja", "initials": "V", "orcid": "0000-0003-3125-2406", "affiliations": ["Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.", "iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d24125e51334b94bce4ef70fed1e585.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d24125e51334b94bce4ef70fed1e585"}}, "publications": [{"entity": "publication", "iuid": "a2d4d6d4a5c5405aa4e890d419216721", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a2d4d6d4a5c5405aa4e890d419216721.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a2d4d6d4a5c5405aa4e890d419216721"}}, "title": "Distinct molecular profiles and shared drug vulnerabilities in pancreatic metastases of renal cell carcinoma.", "authors": [{"family": "Roos-Mattila", "given": "Matilda", "initials": "M", "orcid": "0000-0002-2834-3211", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9dd8feca623400d8e0c17b2725b6dc7.json"}}, {"family": "Kallio", "given": "Pauliina", "initials": "P", "orcid": "0000-0001-6374-6203", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/341466e88f824af587e257b73582d6dd.json"}}, {"family": "Luck", "given": "Tamara J", "initials": "TJ"}, {"family": "Polso", "given": "Minttu", "initials": "M"}, {"family": "Kumari", "given": "Romika", "initials": "R"}, {"family": "Mikkonen", "given": "Piia", "initials": "P"}, {"family": "V\u00e4lim\u00e4ki", "given": "Katja", "initials": "K", "orcid": "0000-0001-9117-7589", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e4948127dec4455803fa8c74fefbde5.json"}}, {"family": "Malmstedt", "given": "Minna", "initials": "M"}, {"family": "Ellonen", "given": "Pekka", "initials": "P"}, {"family": "Pellinen", "given": "Teijo", "initials": "T", "orcid": "0000-0001-9652-7373", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e73595c0cc64a68a59cd95772784859.json"}}, {"family": "Heckman", "given": "Caroline A", "initials": "CA", "orcid": "0000-0002-4324-8706", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0490f5eb61a4d92a44815d03de84af4.json"}}, {"family": "Mustonen", "given": "Harri", "initials": "H", "orcid": "0000-0001-5632-6796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f009308cd84542ae8c384fbfe87501d2.json"}}, {"family": "Puolakkainen", "given": "Pauli A", "initials": "PA"}, {"family": "Alitalo", "given": "Kari", "initials": "K", "orcid": "0000-0002-7331-0902", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9a1a31264694e4fba6026b293655ff0.json"}}, {"family": "Kallioniemi", "given": "Olli", "initials": "O", "orcid": "0000-0002-3231-0332", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb8605b07c884323afe4e1f2da37a031.json"}}, {"family": "Mirtti", "given": "Tuomas", "initials": "T", "orcid": "0000-0003-0455-9891", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1963bc5086f4b45b9a48cb60115d578.json"}}, {"family": "Rannikko", "given": "Antti S", "initials": "AS"}, {"family": "Pieti\u00e4inen", "given": "Vilja M", "initials": "VM", "orcid": "0000-0003-3125-2406", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d24125e51334b94bce4ef70fed1e585.json"}}, {"family": "Sepp\u00e4nen", "given": "Hanna E", "initials": "HE"}], "type": "journal article", "published": "2024-10-20", "journal": {"title": "Commun Biol", "issn": "2399-3642", "volume": "7", "issue": "1", "pages": "1355", "issn-l": "2399-3642"}, "abstract": "Clear-cell renal cell carcinoma (ccRCC) is the most common origin of pancreatic metastases (PM). Distinct genomic aberrations, favorable prognosis, and clinical observations on high angiogenesis, and succeeding tyrosine kinase inhibitor (TKI) sensitivity have been reported in PM-ccRCC. However, no functional or single-cell studies have been conducted thus far. We recruited five PM-ccRCC patients and investigated the genomic, single-cell transcriptomic, and drug sensitivity profiles of their patient-derived cells (PDCs). The PM depicted both expected and novel genomic alterations. Further, the transcriptomics differed from both primary and metastatic ccRCC, with upregulations of the PI3K/mTOR and - supporting the clinical observations - angiogenesis pathways. Data integration at pathway level showed that transcriptomics explained drug sensitivities the best. Accordingly, PM-ccRCC PDCs shared sensitivity to many PI3K/mTOR inhibitors. Altogether, we show distinct genomic and transcriptomic signatures in PM-ccRCC, highlight the superiority of transcriptomics in interpreting drug sensitivities, and encourage the use of TKIs and PI3K/mTOR inhibitors in PM-ccRCC.", "doi": "10.1038/s42003-024-07004-9", "pmid": "39427059", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11490566"}, {"db": "pii", "key": "10.1038/s42003-024-07004-9"}], "notes": [], "created": "2026-08-20T09:25:17.594Z", "modified": "2026-08-20T09:25:17.901Z"}, {"entity": "publication", "iuid": "95296c52bd3b4c108f944528c87402fb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/95296c52bd3b4c108f944528c87402fb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/95296c52bd3b4c108f944528c87402fb"}}, "title": "Drug response profiles in patient-derived cancer cells across histological subtypes of ovarian cancer: real-time therapy tailoring for a patient with low-grade serous carcinoma.", "authors": [{"family": "Murum\u00e4gi", "given": "Astrid", "initials": "A", "orcid": "0000-0002-7797-188X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/44376ab482ab42c3a4f3bbc68c27c97d.json"}}, {"family": "Ungureanu", "given": "Daniela", "initials": "D"}, {"family": "Khan", "given": "Suleiman", "initials": "S"}, {"family": "Arjama", "given": "Mariliina", "initials": "M"}, {"family": "V\u00e4lim\u00e4ki", "given": "Katja", "initials": "K"}, {"family": "Ianevski", "given": "Aleksandr", "initials": "A"}, {"family": "Ianevski", "given": "Philipp", "initials": "P"}, {"family": "Bergstr\u00f6m", "given": "Rebecka", "initials": "R"}, {"family": "Dini", "given": "Alice", "initials": "A", "orcid": "0000-0002-2720-4551", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c00ed4eb41e45629cfc525e737f99c4.json"}}, {"family": "Kanerva", "given": "Anna", "initials": "A"}, {"family": "Koivisto-Korander", "given": "Riitta", "initials": "R"}, {"family": "Tapper", "given": "Johanna", "initials": "J"}, {"family": "Lassus", "given": "Heini", "initials": "H", "orcid": "0000-0003-0598-5147", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c854daf0fada43ee97951cba27414def.json"}}, {"family": "Loukovaara", "given": "Mikko", "initials": "M"}, {"family": "M\u00e4gi", "given": "Andrus", "initials": "A"}, {"family": "Hirasawa", "given": "Akira", "initials": "A"}, {"family": "Aoki", "given": "Daisuke", "initials": "D"}, {"family": "Pieti\u00e4inen", "given": "Vilja", "initials": "V", "orcid": "0000-0003-3125-2406", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d24125e51334b94bce4ef70fed1e585.json"}}, {"family": "Pellinen", "given": "Teijo", "initials": "T", "orcid": "0000-0001-9652-7373", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e73595c0cc64a68a59cd95772784859.json"}}, {"family": "B\u00fctzow", "given": "Ralf", "initials": "R", "orcid": "0000-0003-4366-5099", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6e16836d19645bbbec8bb1a851a02e0.json"}}, {"family": "Aittokallio", "given": "Tero", "initials": "T", "orcid": "0000-0002-0886-9769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/433e429e6a5b49818cf54f5fc102fff7.json"}}, {"family": "Kallioniemi", "given": "Olli", "initials": "O"}], "type": "journal article", "published": "2023-02-00", "journal": {"title": "Br. J. Cancer", "issn": "1532-1827", "volume": "128", "issue": "4", "pages": "678-690", "issn-l": "0007-0920"}, "abstract": "Many efforts are underway to develop novel therapies against the aggressive high-grade serous ovarian cancers (HGSOCs), while our understanding of treatment options for low-grade (LGSOC) or mucinous (MUCOC) of ovarian malignancies is not developing as well. We describe here a functional precision oncology (fPO) strategy in epithelial ovarian cancers (EOC), which involves high-throughput drug testing of patient-derived ovarian cancer cells (PDCs) with a library of 526 oncology drugs, combined with genomic and transcriptomic profiling. HGSOC, LGSOC and MUCOC PDCs had statistically different overall drug response profiles, with LGSOCs responding better to targeted inhibitors than HGSOCs. We identified several subtype-specific drug responses, such as LGSOC PDCs showing high sensitivity to MDM2, ERBB2/EGFR inhibitors, MUCOC PDCs to MEK inhibitors, whereas HGSOCs showed strongest effects with CHK1 inhibitors and SMAC mimetics. We also explored several drug combinations and found that the dual inhibition of MEK and SHP2 was synergistic in MAPK-driven EOCs. We describe a clinical case study, where real-time fPO analysis of samples from a patient with metastatic, chemorefractory LGSOC with a CLU-NRG1 fusion guided clinical therapy selection. fPO-tailored therapy with afatinib, followed by trastuzumab and pertuzumab, successfully reduced tumour burden and blocked disease progression over a five-year period. In summary, fPO is a powerful approach for the identification of systematic drug response differences across EOC subtypes, as well as to highlight patient-specific drug regimens that could help to optimise therapies to individual patients in the future.", "doi": "10.1038/s41416-022-02067-z", "pmid": "36476658", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9938120"}, {"db": "pii", "key": "10.1038/s41416-022-02067-z"}], "notes": [], "created": "2026-08-20T08:49:06.144Z", "modified": "2026-08-20T08:49:06.456Z"}, {"entity": "publication", "iuid": "116375c46f0f4465babb49ac15873e83", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/116375c46f0f4465babb49ac15873e83.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/116375c46f0f4465babb49ac15873e83"}}, "title": "Image-based & machine learning-guided multiplexed serology test for SARS-CoV-2", "authors": [{"family": "Pieti\u00e4inen", "given": "Vilja", "initials": "V", "orcid": "0000-0003-3125-2406", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d24125e51334b94bce4ef70fed1e585.json"}}, {"family": "Polso", "given": "Minttu", "initials": "M"}, {"family": "Migh", "given": "Ede", "initials": "E", "orcid": "0000-0002-8312-6463", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4a9d973b4474ca29f83b6410283878c.json"}}, {"family": "Guckelsberger", "given": "Christian", "initials": "C", "orcid": "0000-0003-1977-1887", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b1a3ccdb99c423fb4be5ac6723aa481.json"}}, {"family": "Harmati", "given": "Maria", "initials": "M", "orcid": "0000-0002-4875-5723", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad4de6747fb546c6aae2ae968fe09223.json"}}, {"family": "Diosdi", "given": "Akos", "initials": "A", "orcid": "0000-0002-3118-5576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc1ccb2e03cb453ea55516d4565cdf7b.json"}}, {"family": "Turunen", "given": "Laura", "initials": "L", "orcid": "0000-0003-0274-4794", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35779e69fefa43cdb2d13c9e7fd05df7.json"}}, {"family": "Hassinen", "given": "Antti", "initials": "A", "orcid": "0000-0001-9491-2868", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0c77bf3f19d44f259ed3a23622d803ba.json"}}, {"family": "Potdar", "given": "Swapnil", "initials": "S", "orcid": "0000-0002-2778-6918", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e17191dcbef4dc7917d15792cfe5d6e.json"}}, {"family": "Koponen", "given": "Annika", "initials": "A", "orcid": "0000-0002-3348-9661", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4fb15acd5bb445aaa6454891ed6ca25d.json"}}, {"family": "Sebestyen", "given": "Edina Gyukity", "initials": "EG", "orcid": "0000-0003-1383-6301", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0d872131baba4155abcfef726c36b490.json"}}, {"family": "Kovacs", "given": "Ferenc", "initials": "F"}, {"family": "Kriston", "given": "Andras", "initials": "A"}, {"family": "Hollandi", "given": "Reka", "initials": "R", "orcid": "0000-0002-4052-6846", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/117b8088839f4ebda621d67b779c7e73.json"}}, {"family": "Burian", "given": "Katalin", "initials": "K", "orcid": "0000-0003-1300-2374", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e1e2e86addab4aad8994820e70a8d53d.json"}}, {"family": "Terhes", "given": "Gabriella", "initials": "G", "orcid": "0000-0002-7301-9672", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e49d17b8ceb64d7080791b1f74304cc7.json"}}, {"family": "Visnyovszki", "given": "Adam", "initials": "A", "orcid": "0000-0001-6825-1496", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2d12073011245ddacca62d8874bf51a.json"}}, {"family": "Fodor", "given": "Eszter", "initials": "E", "orcid": "0000-0002-9487-2824", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/deae7182f8184f85a097e767a18bfcac.json"}}, {"family": "Lacza", "given": "Zsombor", "initials": "Z", "orcid": "0000-0002-6776-9530", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/118f2ec2ab264251ab967a3686291e0d.json"}}, {"family": "Kantele", "given": "Anu", "initials": "A", "orcid": "0000-0002-0004-1000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/232b375319534904bc586ae646d1f0b5.json"}}, {"family": "Kolehmainen", "given": "Pekka", "initials": "P", "orcid": "0000-0001-5997-8167", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2cdf087c0964868ad5632b95c548f28.json"}}, {"family": "Kakkola", "given": "Laura", "initials": "L", "orcid": "0000-0001-9271-4059", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c4d3ee3c7e2c423b8b2c719592833ef9.json"}}, {"family": "Strandin", "given": "Tomas", "initials": "T", "orcid": "0000-0002-2454-7479", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/955f45a3a7ee4342b8f1047ad6ebb6e2.json"}}, {"family": "Levanov", "given": "Lev", "initials": "L"}, {"family": "Kallioniemi", "given": "Olli", "initials": "O", "orcid": "0000-0002-3231-0332", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb8605b07c884323afe4e1f2da37a031.json"}}, {"family": "Kemeny", "given": "Lajos", "initials": "L", "orcid": "0000-0002-2119-9501", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c295a034673a447faea4e206f9830dba.json"}}, {"family": "Julkunen", "given": "Ilkka", "initials": "I", "orcid": "0000-0003-0165-2564", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2f969d54ca504175b5f25446c91428c6.json"}}, {"family": "Vapalahti", "given": "Olli", "initials": "O", "orcid": "0000-0003-2270-6824", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/adcc581bfe28463585c3fc5ecdb717ee.json"}}, {"family": "Buzas", "given": "Krisztina", "initials": "K", "orcid": "0000-0001-8933-2033", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d950f0eab87348118beb24015e338d92.json"}}, {"family": "Paavolainen", "given": "Lassi", "initials": "L", "orcid": "0000-0003-1508-2718", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb150cb5204f4f20a6dadd2048f9d610.json"}}, {"family": "Horvath", "given": "Peter", "initials": "P"}, {"family": "Hepojoki", "given": "Jussi", "initials": "J", "orcid": "0000-0001-5699-214X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac9397d670bf4b5b8c46657c99219e8c.json"}}], "type": "posted-content", "published": "2022-09-09", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.09.08.22279729", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:14:03.834Z", "modified": "2026-08-20T10:14:04.733Z"}]}