{"entity": "researcher", "timestamp": "2026-09-12T07:53:11.236Z", "family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "affiliations": ["Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, Turkey. enes.aslan@erzurum.edu.tr."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6"}}, "publications": [{"entity": "publication", "iuid": "ed31608ff2ba46a4a0625215002090e5", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ed31608ff2ba46a4a0625215002090e5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ed31608ff2ba46a4a0625215002090e5"}}, "title": "Synthesis and Characterization of Memantine-Loaded Niosomes for Enhanced Alzheimer's Disease Targeting.", "authors": [{"family": "Turkez", "given": "Hasan", "initials": "H", "orcid": "0000-0002-7046-8990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2f1748757d45cabfe56fdfaccead6a.json"}}, {"family": "Oner", "given": "Sena", "initials": "S"}, {"family": "Y\u0131ld\u0131r\u0131m", "given": "Ozge Caglar", "initials": "OC", "orcid": "0000-0003-1412-8411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513eed83e3b643088ebb66284a761ee5.json"}}, {"family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "Dimmito", "given": "Marilisa Pia", "initials": "MP", "orcid": "0000-0002-9381-7196", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9d82763d1a1c40f1acfaac9db311abe5.json"}}, {"family": "Kahraman", "given": "\u00c7igdem Yuce", "initials": "\u00c7Y", "orcid": "0000-0003-1957-9596", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/20f608344b0340d0a12e82dd5a918dce.json"}}, {"family": "Marinelli", "given": "Lisa", "initials": "L", "orcid": "0000-0001-8611-6538", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/97c00bbd21584fd7a44200f607877276.json"}}, {"family": "Sonmez", "given": "Erdal", "initials": "E"}, {"family": "Kiki", "given": "\u00d6zlem", "initials": "\u00d6"}, {"family": "Tatar", "given": "Abdulgani", "initials": "A"}, {"family": "Cacciatore", "given": "Ivana", "initials": "I", "orcid": "0000-0001-6253-0443", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/31661d5900cc4711923f4bf51cf47a93.json"}}, {"family": "Di Stefano", "given": "Antonio", "initials": "A", "orcid": "0000-0002-3042-2234", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/413d1857e18c4eef8929bb9ceedc5af0.json"}}, {"family": "Mardinoglu", "given": "Adil", "initials": "A"}], "type": "journal article", "published": "2025-02-17", "journal": {"title": "Pharmaceutics", "issn": "1999-4923", "volume": "17", "issue": "2", "issn-l": null}, "abstract": "Background/Objectives: Over the past 25 years, numerous biological molecules, like recombinant lysosomal enzymes, neurotrophins, receptors, and therapeutic antibodies, have been tested in clinical trials for neurological diseases. However, achieving significant success in clinical applications has remained elusive. A primary challenge has been the inability of these molecules to traverse the blood-brain barrier (BBB). Recognizing this hurdle, our study aimed to utilize niosomes as delivery vehicles, leveraging the \"molecular Trojan horse\" technology, to enhance the transport of molecules across the BBB. Methods: Previously synthesized memantine derivatives (MP1-4) were encapsulated into niosomes for improved BBB permeability, hypothesizing that this approach could minimize peripheral drug toxicity while ensuring targeted brain delivery. Using the human neuroblastoma (SH-SY5Y) cell line differentiated into neuron-like structures with retinoic acid and then exposed to amyloid beta 1-42 peptide, we established an in vitro Alzheimer's disease (AD) model. In this model, the potential usability of MP1-4 was assessed through viability tests (MTT) and toxicological response analysis. The niosomes' particle size and morphological structures were characterized using scanning electron microscopy (SEM), with their loading and release capacities determined via UV spectroscopy. Crucially, the ability of the niosomes to cross the BBB and their potential anti-Alzheimer efficacy were analyzed in an in vitro transwell system with endothelial cells. Results: The niosomal formulations demonstrated effective drug encapsulation (encapsulation efficiency: 85.3% \u00b1 2.7%), controlled release (72 h release: 38.5% \u00b1 1.2%), and stable morphology (PDI: 0.22 \u00b1 0.03, zeta potential: -31.4 \u00b1 1.5 mV). Among the derivatives, MP1, MP2, and MP4 exhibited significant neuroprotective effects, enhancing cell viability by approximately 40% (p < 0.05) in the presence of A\u03b21-42 at a concentration of 47 \u00b5g/mL. The niosomal delivery system improved BBB permeability by 2.5-fold compared to free drug derivatives, as confirmed using an in vitro bEnd.3 cell model. Conclusions: Memantine-loaded niosomes provide a promising platform for overcoming BBB limitations and enhancing the therapeutic efficacy of Alzheimer's disease treatments. This study highlights the potential of nanotechnology-based delivery systems in developing targeted therapies for neurodegenerative diseases. Further in vivo studies are warranted to validate these findings and explore clinical applications.", "doi": "10.3390/pharmaceutics17020267", "pmid": "40006634", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11860023"}, {"db": "pii", "key": "pharmaceutics17020267"}], "notes": [], "created": "2026-08-20T13:43:09.091Z", "modified": "2026-08-20T13:43:09.237Z"}, {"entity": "publication", "iuid": "8e5c7fbf590d440ca295256f0a558586", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8e5c7fbf590d440ca295256f0a558586.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8e5c7fbf590d440ca295256f0a558586"}}, "title": "Synthesis, Characterization, Theoretical Studies and in Vitro Embriyotoxic, Genotoxic and Anticancer Effects of Novel Phenyl(1,4,6-Triphenyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidin-5-yl)Methanone", "authors": [{"family": "Akbas", "given": "Esvet", "initials": "E", "orcid": "0000-0001-6260-5556", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dd3594ceeb545d9941909ccf8c47f00.json"}}, {"family": "Othman", "given": "Khdir A", "initials": "KA", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "\u00c7elikezen", "given": "Fatih \u00c7a\u011flar", "initials": "F\u00c7", "orcid": "0000-0001-5489-7384", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5590782238b04494ae2378c2e65ab4f7.json"}}, {"family": "Aydogan Ejder", "given": "Nebahat", "initials": "N", "orcid": "0000-0001-9557-2033", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a92398fdd60491db8e5eb41eb160656.json"}}, {"family": "Turkez", "given": "Hasan", "initials": "H", "orcid": "0000-0002-7046-8990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2f1748757d45cabfe56fdfaccead6a.json"}}, {"family": "Yapca", "given": "Omer Erkan", "initials": "OE", "orcid": "0000-0002-5578-0126", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ea9b4f98ad24d549984a2c9e00a58d9.json"}}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal-article", "published": "2024-10-20", "journal": {"title": "Polycyclic Aromatic Compounds", "issn": "1040-6638", "volume": "44", "issue": "9", "pages": "6284-6301", "issn-l": null}, "abstract": null, "doi": "10.1080/10406638.2023.2276243", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T09:35:13.514Z", "modified": "2026-08-20T09:35:13.686Z"}, {"entity": "publication", "iuid": "6a3b0c9ce07f4a68a9a63574763057bd", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6a3b0c9ce07f4a68a9a63574763057bd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6a3b0c9ce07f4a68a9a63574763057bd"}}, "title": "Drug Synergism of Anticancer Action in Combination with Favipiravir and Paclitaxel on Neuroblastoma Cells.", "authors": [{"family": "Turkez", "given": "Hasan", "initials": "H"}, {"family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "Selvitopi", "given": "Harun", "initials": "H"}, {"family": "Kadi", "given": "Abdurrahim", "initials": "A", "orcid": "0000-0001-9250-9397", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5abbff5bc3084711a38e85f42c15c6af.json"}}, {"family": "Oner", "given": "Sena", "initials": "S"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal article", "published": "2023-12-30", "journal": {"title": "Medicina (Kaunas)", "issn": "1648-9144", "volume": "60", "issue": "1", "issn-l": null}, "abstract": "Background and Objectives: Favipiravir (FPV) is an antiviral medication and has an inhibitory effect on Cytochrome P450 (CYP2C8) protein, which is mainly involved in drug metabolism in the liver, and the expression of this gene is known to be enhanced in neuronal cells. The metabolization of Paclitaxel (PTX), a chemotherapeutic drug used in cancer patients, was analyzed for the first time in the human SH-SY5Y neuroblastoma cell line for monitoring possible synergistic effects when administered with FPV. Materials and Methods: Further, in vitro cytotoxic and genotoxic evaluations of FPV and PTX were also performed using wide concentration ranges in a human fibroblast cell culture (HDFa). Nuclear abnormalities were examined under a fluorescent microscope using the Hoechst 33258 fluorescent staining technique. In addition, the synergistic effects of these two drugs on cultured SH-SY5Y cells were determined by MTT cell viability assay. In addition, the death mechanisms that can occur in SHSY-5Y were revealed by using the flow cytometry technique. Results: Cell viability analyses on the HDFa healthy cell culture showed that both FPV and PTX have inhibitory effects at higher concentrations. On the other hand, there were no significant differences in nuclear abnormality numbers when both of the compounds were applied together. Cell viability analyses showed that FPV and PTX applications have higher cytotoxicity, which indicated synergistic toxicity against the SHSY-5Y cell line. Also, PTX exhibited higher anticancer properties against the neuroblastoma cell line when applied with FPV, as shown in both cytotoxicity and flow cytometry analyses. Conclusions: In light of our findings, the anticancer properties of PTX can be enhanced when the drug application is coupled with FPV exposure. Moreover, these results put forth that the anticancer drug dosage should be evaluated carefully in cancer patients who take COVID-19 treatment with FPV.", "doi": "10.3390/medicina60010082", "pmid": "38256343", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10820816"}, {"db": "pii", "key": "medicina60010082"}], "notes": [], "created": "2026-08-20T13:42:12.397Z", "modified": "2026-08-20T13:42:12.495Z"}, {"entity": "publication", "iuid": "4b5d46046c5b4b679bda60abe8aaf0d4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4b5d46046c5b4b679bda60abe8aaf0d4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4b5d46046c5b4b679bda60abe8aaf0d4"}}, "title": "Novel styryl-thiazole hybrids as potential anti-Alzheimer's agents.", "authors": [{"family": "Gouleni", "given": "Niki", "initials": "N"}, {"family": "Di Rienzo", "given": "Annalisa", "initials": "A", "orcid": "0000-0002-9994-6968", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/21b8ecd7e661415bbec3d6cc141a2ddf.json"}}, {"family": "Y\u0131lmaz", "given": "Ahmet", "initials": "A"}, {"family": "Selvitopi", "given": "Harun", "initials": "H", "orcid": "0000-0001-5958-7625", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a48920bce92d48ba8da645c87d2738ce.json"}}, {"family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}, {"family": "Turkez", "given": "Hasan", "initials": "H", "orcid": "0000-0002-7046-8990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2f1748757d45cabfe56fdfaccead6a.json"}}, {"family": "Di Stefano", "given": "Antonio", "initials": "A", "orcid": "0000-0002-3042-2234", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/413d1857e18c4eef8929bb9ceedc5af0.json"}}, {"family": "Vassiliou", "given": "Stamatia", "initials": "S", "orcid": "0000-0002-0734-6579", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1aa27118ccdf4c37af17b810e51140fe.json"}}, {"family": "Cacciatore", "given": "Ivana", "initials": "I", "orcid": "0000-0001-6253-0443", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/31661d5900cc4711923f4bf51cf47a93.json"}}], "type": "journal article", "published": "2023-11-15", "journal": {"title": "RSC Med Chem", "issn": "2632-8682", "volume": "14", "issue": "11", "pages": "2315-2326", "issn-l": null}, "abstract": "In this study, combining the thiazole and cinnamoyl groups into the styryl-thiazole scaffold, a series of novel styryl-thiazole hybrids (6a-p) was rationally designed, synthesized, and evaluated by the multi-target-directed ligands strategy as potential candidates for the treatment of Alzheimer's disease (AD). Hybrids 6e and 6i are the most promising among the synthesized hybrids since they are able to significantly increase cell viabilities in A\u03b21-42-exposed-human neuroblastoma cell line (6i at the concentration of 50 \u03bcg mL-1 and 6e at the concentration of 25 \u03bcg mL-1 resulted in \u223c34% and \u223c30% increase in cell viabilities, respectively). Compounds 6e and 6i exhibit highly AChE inhibitory properties in the experimental AD model at 375.6 \u00b1 18.425 mU mL-1 and 397.6 \u00b1 32.152 mU mL-1, respectively. Moreover, these data were also confirmed by docking studies and in vitro enzyme inhibition assays. Compared to hybrid 6e and according to the results, 6i also has the highest potential against A\u03b21-42 aggregation with over 80% preventive activity. The in silico prediction of the physicochemical properties confirms that 6i possesses a better profile compared to 6e. Therefore, compound 6i presents a promising multi-targeted active molecular profile for treating AD considering the multifactorial nature of AD, and it is reasonable to deepen its mechanisms of action in an in vivo experimental model of AD.", "doi": "10.1039/d3md00308f", "pmid": "38020070", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC10650344"}, {"db": "pii", "key": "d3md00308f"}], "notes": [], "created": "2023-12-04T14:46:29.246Z", "modified": "2025-04-11T07:24:01.942Z"}, {"entity": "publication", "iuid": "36b439cbd2cc49199b28dfcbdd588f94", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/36b439cbd2cc49199b28dfcbdd588f94.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/36b439cbd2cc49199b28dfcbdd588f94"}}, "title": "Costunolide and Parthenolide Ameliorate MPP+ Induced Apoptosis in the Cellular Parkinson's Disease Model.", "authors": [{"family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "T\u00fcrkez", "given": "Hasan", "initials": "H"}, {"family": "Sevim", "given": "Yasemin", "initials": "Y"}, {"family": "Selvitopi", "given": "Harun", "initials": "H", "orcid": "0000-0001-5958-7625", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a48920bce92d48ba8da645c87d2738ce.json"}}, {"family": "Kadi", "given": "Abdurrahim", "initials": "A", "orcid": "0000-0001-9250-9397", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5abbff5bc3084711a38e85f42c15c6af.json"}}, {"family": "\u00d6ner", "given": "Sena", "initials": "S"}, {"family": "Mardino\u011flu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal article", "published": "2023-03-24", "journal": {"title": "Cells", "issn": "2073-4409", "volume": "12", "issue": "7", "issn-l": "2073-4409"}, "abstract": "Monoamine oxidase B (MAO-B) is an enzyme that metabolizes several chemicals, including dopamine. MAO-B inhibitors are used in the treatment of Parkinson's Disease (PD), and the inhibition of this enzyme reduces dopamine turnover and oxidative stress. The absence of dopamine results in PD pathogenesis originating from decreased Acetylcholinesterase (AChE) activity and elevated oxidative stress. Here, we performed a molecular docking analysis for the potential use of costunolide and parthenolide terpenoids as potential MAO-B inhibitors in the treatment of PD. Neuroprotective properties of plant-originated costunolide and parthenolide terpenoids were investigated in a cellular PD model that was developed by using MPP+ toxicity. We investigated neuroprotection mechanisms through the analysis of oxidative stress parameters, acetylcholinesterase activity and apoptotic cell death ratios. Our results showed that 100 \u00b5g/mL and 50 \u00b5g/mL of costunolide, and 50 \u00b5g/mL of parthenolide applied to the cellular disease model ameliorated the cytotoxicity caused by MPP+ exposure. We found that acetylcholinesterase activity assays exhibited that terpenoids could ameliorate and restore the enzyme activity as in negative control levels. The oxidative stress parameter analyses revealed that terpenoid application could enhance antioxidant levels and decrease oxidative stress in the cultures. In conclusion, we reported that these two terpenoid molecules could be used in the development of efficient treatment strategies for PD patients.", "doi": "10.3390/cells12070992", "pmid": "37048065", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC10093699"}, {"db": "pii", "key": "cells12070992"}], "notes": [], "created": "2023-12-04T14:49:53.482Z", "modified": "2023-12-04T14:49:53.649Z"}, {"entity": "publication", "iuid": "bf2e720a1d8245d6a6c7f3e0aa12254d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bf2e720a1d8245d6a6c7f3e0aa12254d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bf2e720a1d8245d6a6c7f3e0aa12254d"}}, "title": "Lipoic Acid Conjugated Boron Hybrids Enhance Wound Healing and Antimicrobial Processes.", "authors": [{"family": "T\u00fcrkez", "given": "Hasan", "initials": "H"}, {"family": "Y\u0131ld\u0131r\u0131m", "given": "\u00d6zge \u00c7a\u011flar", "initials": "\u00d6\u00c7", "orcid": "0000-0003-1412-8411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513eed83e3b643088ebb66284a761ee5.json"}}, {"family": "\u00d6ner", "given": "Sena", "initials": "S"}, {"family": "Kad\u0131", "given": "Abdurrahim", "initials": "A"}, {"family": "Mete", "given": "Abdulkadir", "initials": "A"}, {"family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "\u015eahin", "given": "\u0130rfan O\u011fuz", "initials": "\u0130O"}, {"family": "Yap\u00e7a", "given": "\u00d6mer Erkan", "initials": "\u00d6E"}, {"family": "Mardino\u011flu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal article", "published": "2022-12-31", "journal": {"title": "Pharmaceutics", "issn": "1999-4923", "volume": "15", "issue": "1", "issn-l": null}, "abstract": "Complications of chronic non-healing wounds led to the emergence of nanotechnology-based therapies to enhance healing, facilitate tissue repair, and prevent wound-related complications like infections. Here, we design alpha lipoic acid (ALA) conjugated hexagonal boron nitride (hBN) and boron carbide (B4C) nanoparticles (NPs) to enhance wound healing in human dermal fibroblast (HDFa) cell culture and characterize its antimicrobial properties against Staphylococcus aureus (S. aureus, gram positive) and Escherichia coli (E. coli, gram negative) bacterial strains. ALA molecules are integrated onto hBN and C4B NPs through esterification procedure, and molecular characterizations are performed by using transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and UV-vis spectroscopy. Wound healing and antimicrobial properties are investigated via the use of cell viability assays, scratch test, oxidative stress, and antimicrobial activity assays. Based on our analysis, we observe that ALA-conjugated hBN NPs have the highest wound-healing feature and antimicrobial activity compared to ALA-B4C. On the other hand, hBN, ALA-B4C, and ALA compounds showed promising regenerative and antimicrobial properties. Also, we find that ALA conjugation enhances wound healing and antimicrobial potency of hBN and B4C NPs. We conclude that the ALA-hBN conjugate is a potential candidate to stimulate regeneration process for injuries.", "doi": "10.3390/pharmaceutics15010149", "pmid": "36678778", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC9863811"}, {"db": "pii", "key": "pharmaceutics15010149"}], "notes": [], "created": "2023-12-04T14:53:04.293Z", "modified": "2023-12-04T14:53:04.398Z"}, {"entity": "publication", "iuid": "58084cae6e974170ba9dbae04e128a08", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/58084cae6e974170ba9dbae04e128a08.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/58084cae6e974170ba9dbae04e128a08"}}, "title": "In Vitro Transcriptome Analysis of Cobalt Boride Nanoparticles on Human Pulmonary Alveolar Cells.", "authors": [{"family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "Tatar", "given": "Arzu", "initials": "A"}, {"family": "Y\u0131ld\u0131r\u0131m", "given": "\u00d6zge \u00c7a\u011flar", "initials": "\u00d6\u00c7", "orcid": "0000-0003-1412-8411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513eed83e3b643088ebb66284a761ee5.json"}}, {"family": "\u015eahin", "given": "\u0130rfan O\u011fuz", "initials": "\u0130O"}, {"family": "Ozdemir", "given": "Ozlem", "initials": "O", "orcid": "0000-0002-5472-8174", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f64b15273ce49348b9ffebf5230ea11.json"}}, {"family": "Sonmez", "given": "Erdal", "initials": "E"}, {"family": "Hac\u0131muftuoglu", "given": "Ahmet", "initials": "A"}, {"family": "Acikyildiz", "given": "Metin", "initials": "M"}, {"family": "Geyiko\u011flu", "given": "Fatime", "initials": "F"}, {"family": "Mardino\u011flu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}, {"family": "T\u00fcrkez", "given": "Hasan", "initials": "H"}], "type": "journal article", "published": "2022-12-06", "journal": {"title": "Materials (Basel)", "issn": "1996-1944", "volume": "15", "issue": "23", "issn-l": null}, "abstract": "Nanobiotechnology influences many different areas, including the medical, food, energy, clothing, and cosmetics industries. Considering the wide usage of nanomaterials, it is necessary to investigate the toxicity potentials of specific nanosized molecules. Boron-containing nanoparticles (NPs) are attracting much interest from scientists due to their unique physicochemical properties. However, there is limited information concerning the toxicity of boron-containing NPs, including cobalt boride (Co2B) NPs. Therefore, in this study, Co2B NPs were characterized using X-ray crystallography (XRD), transmission electron microscope (TEM), scanning electron microscope (SEM), and energy-dispersive X-ray spectroscopy (EDX) techniques. Then, we performed 3-(4,5-dimethyl-thiazol-2-yl) 2,5-diphenyltetrazolium bromide (MTT), lactate dehydrogenase (LDH) release, and neutral red (NR) assays for assessing cell viability against Co2B NP exposure on cultured human pulmonary alveolar epithelial cells (HPAEpiC). In addition, whole-genome microarray analysis was carried out to reveal the global gene expression differentiation of HPAEpiC cells after Co2B NP application. The cell viability tests unveiled an IC50 value for Co2B NPs of 310.353 mg/L. The results of our microarray analysis displayed 719 gene expression differentiations (FC \u2265 2) among the analyzed 40,000 genes. The performed visualization and integrated discovery (DAVID) analysis revealed that there were interactions between various gene pathways and administration of the NPs. Based on gene ontology biological processes analysis, we found that the P53 signaling pathway, cell cycle, and cancer-affecting genes were mostly affected by the Co2B NPs. In conclusion, we suggested that Co2B NPs would be a safe and effective nanomolecule for industrial applications, particularly for medical purposes.", "doi": "10.3390/ma15238683", "pmid": "36500178", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC9740129"}, {"db": "pii", "key": "ma15238683"}], "notes": [], "created": "2023-12-04T14:53:08.498Z", "modified": "2023-12-04T14:53:08.593Z"}, {"entity": "publication", "iuid": "9da9a80f2d2f4eb081de73a7584fe558", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9da9a80f2d2f4eb081de73a7584fe558.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9da9a80f2d2f4eb081de73a7584fe558"}}, "title": "Toxicity of Glycyl-l-Prolyl-l-Glutamate Pseudotripeptides: Cytotoxic, Oxidative, Genotoxic, and Embryotoxic Perspectives.", "authors": [{"family": "Turkez", "given": "Hasan", "initials": "H", "orcid": "0000-0002-7046-8990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2f1748757d45cabfe56fdfaccead6a.json"}}, {"family": "Ozdemir Tozlu", "given": "Ozlem", "initials": "O", "orcid": "0000-0002-5472-8174", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f64b15273ce49348b9ffebf5230ea11.json"}}, {"family": "Tatar", "given": "Arzu", "initials": "A", "orcid": "0000-0002-4486-2695", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3b34bfb83ab14a95bc03c974d39f816c.json"}}, {"family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "Cadirci", "given": "Kenan", "initials": "K", "orcid": "0000-0002-2765-4288", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/305106d191054c26a2de64f9ca54437f.json"}}, {"family": "Marinelli", "given": "Lisa", "initials": "L", "orcid": "0000-0001-8611-6538", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/97c00bbd21584fd7a44200f607877276.json"}}, {"family": "Yapca", "given": "Omer Erkan", "initials": "OE", "orcid": "0000-0002-5578-0126", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ea9b4f98ad24d549984a2c9e00a58d9.json"}}, {"family": "Cacciatore", "given": "Ivana", "initials": "I", "orcid": "0000-0001-6253-0443", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/31661d5900cc4711923f4bf51cf47a93.json"}}, {"family": "Di Stefano", "given": "Antonio", "initials": "A", "orcid": "0000-0002-3042-2234", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/413d1857e18c4eef8929bb9ceedc5af0.json"}}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal article", "published": "2022-11-19", "journal": {"title": "J Toxicol", "issn": "1687-8191", "volume": "2022", "pages": "3775194", "issn-l": null}, "abstract": "The tripeptide H-Gly-Pro-Glu-OH (GPE) and its analogs began to take much interest from scientists for developing effective novel molecules in the treatment of several disorders including Alzheimer's disease, Parkinson's disease, and stroke. The peptidomimetics of GPEs exerted significant biological properties involving anti-inflammatory, antiapoptotic, and anticancer properties. The assessments of their hematological toxicity potentials are critically required for their possible usage in further preclinical and clinical trials against a wide range of pathological conditions. However, there is so limited information on the safety profiling of GPE and its analogs on human blood tissue from cytotoxic, oxidative, and genotoxic perspectives. And, their embryotoxicity potentials were not investigated yet. Therefore, in this study, measurements of mitochondrial viability (using MTT assay) and lactate dehydrogenase (LDH) release as well as total antioxidant capacity (TAC) assays were performed on cultured human whole blood cells after treatment with GPE and its three novel peptidomimetics for 72 h. Sister chromatid exchange (SCE), micronucleus (MN), and 8-oxo-2-deoxyguanosine (8-OH-dG) assays were performed for determining the genotoxic damage potentials. In addition, the nuclear division index (NDI) was figured out for revealing their cytostatic potentials. Embryotoxicity assessments were performed on cultured human pluripotent NT2 embryonal carcinoma cells by MTT and LDH assays. The present results from cytotoxicity, oxidative, genotoxicity, and embryotoxicity testing clearly propounded that GPEs had good biosafety profiles and were trouble-free from the toxicological point of view. Noncytotoxic, antioxidative, nongenotoxic, noncytostatic, and nonembryotoxic features of GPE analogs are worthwhile exploring further and may exert high potentials for improving the development of novel disease-modifying agents.", "doi": "10.1155/2022/3775194", "pmid": "36444193", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC9701129"}], "notes": [], "created": "2023-12-04T14:53:09.961Z", "modified": "2023-12-04T14:53:10.249Z"}, {"entity": "publication", "iuid": "bdb94abf6bb749cba40f945d5699263b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bdb94abf6bb749cba40f945d5699263b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bdb94abf6bb749cba40f945d5699263b"}}, "title": "Ameliorative Effects by Hexagonal Boron Nitride Nanoparticles against Beta Amyloid Induced Neurotoxicity.", "authors": [{"family": "Aydin", "given": "Nursah", "initials": "N"}, {"family": "Turkez", "given": "Hasan", "initials": "H", "orcid": "0000-0002-7046-8990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2f1748757d45cabfe56fdfaccead6a.json"}}, {"family": "Tozlu", "given": "Ozlem Ozdemir", "initials": "OO"}, {"family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "Yavuz", "given": "Mehmet", "initials": "M"}, {"family": "Sonmez", "given": "Erdal", "initials": "E"}, {"family": "Ozpolat", "given": "Ozgur F\u0131rat", "initials": "OF", "orcid": "0000-0002-4533-4368", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0584d9e39ecf4136bbb259da53314ca8.json"}}, {"family": "Cacciatore", "given": "Ivana", "initials": "I", "orcid": "0000-0001-6253-0443", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/31661d5900cc4711923f4bf51cf47a93.json"}}, {"family": "Di Stefano", "given": "Antonio", "initials": "A", "orcid": "0000-0002-3042-2234", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/413d1857e18c4eef8929bb9ceedc5af0.json"}}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal article", "published": "2022-08-05", "journal": {"title": "Nanomaterials (Basel)", "issn": "2079-4991", "volume": "12", "issue": "15", "issn-l": null}, "abstract": "Alzheimer\u2019s disease (AD) is considered as the most common neurodegenerative disease. Extracellular amyloid beta (A\u03b2) deposition is a hallmark of AD. The options based on degradation and clearance of A\u03b2 are preferred as promising therapeutic strategies for AD. Interestingly, recent findings indicate that boron nanoparticles not only act as a carrier but also play key roles in mediating biological effects. In the present study, the aim was to investigate the effects of different concentrations (0\u2212500 mg/L) of hexagonal boron nitride nanoparticles (hBN-NPs) against neurotoxicity by beta amyloid (A\u03b21-42) in differentiated human SH-SY5Y neuroblastoma cell cultures for the first time. The synthesized hBN-NPs were characterized by X-ray diffraction (XRD) measurements, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). A\u03b21-42-induced neurotoxicity and therapeutic potential by hBN-NPs were assessed on differentiated SH-SY5Y cells using MTT and LDH release assays. Levels of total antioxidant capacity (TAC) and total oxidant status (TOS), expression levels of genes associated with AD and cellular morphologies were examined. The exposure to A\u03b21-42 significantly decreased the rates of viable cells which was accompanied by elevated TOS level. A\u03b21-42 induced both apoptotic and necrotic cell death. A\u03b2 exposure led to significant increases in expression levels of APOE, BACE 1, EGFR, NCTSN and TNF-\u03b1 genes and significant decreases in expression levels of ADAM 10, APH1A, BDNF, PSEN1 and PSENEN genes (p < 0.05). All the A\u03b21-42-induced neurotoxic insults were inhibited by the applications with hBN-NPs. hBN-NPs also suppressed the remarkable elevation in the signal for A\u03b2 following exposure to A\u03b21-42 for 48 h. Our results indicated that hBN-NPs could significantly prevent the neurotoxic damages by A\u03b2. Thus, hBN-NPs could be a novel and promising anti-AD agent for effective drug development, bio-nano imaging or drug delivery strategies.", "doi": "10.3390/nano12152690", "pmid": "35957121", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC9370266"}, {"db": "pii", "key": "nano12152690"}], "notes": [], "created": "2023-12-04T14:58:15.087Z", "modified": "2023-12-04T14:58:15.213Z"}, {"entity": "publication", "iuid": "d17fc111143c4857bdb14386caa8fc92", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d17fc111143c4857bdb14386caa8fc92.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d17fc111143c4857bdb14386caa8fc92"}}, "title": "Boron Compounds Exhibit Protective Effects against Aluminum-Induced Neurotoxicity and Genotoxicity: In Vitro and In Vivo Study.", "authors": [{"family": "Turkez", "given": "Hasan", "initials": "H", "orcid": "0000-0002-7046-8990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2f1748757d45cabfe56fdfaccead6a.json"}}, {"family": "Y\u0131ld\u0131r\u0131m", "given": "Serkan", "initials": "S", "orcid": "0000-0003-2457-3367", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c9ab2604dc1474b93b8903f75ec2465.json"}}, {"family": "Sahin", "given": "Elvan", "initials": "E", "orcid": "0000-0001-8585-9903", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95f44ca19f654d2597c76113c0087b7e.json"}}, {"family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "Emsen", "given": "Bugrahan", "initials": "B", "orcid": "0000-0002-9636-2596", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee7aa89ea3584e40a7378b047b0c759d.json"}}, {"family": "Tozlu", "given": "Ozlem Ozdemir", "initials": "OO", "orcid": "0000-0002-5472-8174", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f64b15273ce49348b9ffebf5230ea11.json"}}, {"family": "Alak", "given": "Gonca", "initials": "G"}, {"family": "Ucar", "given": "Arzu", "initials": "A", "orcid": "0000-0001-5675-9401", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/20041a74c31449f1a58703196999eb14.json"}}, {"family": "Tatar", "given": "Abdulgani", "initials": "A"}, {"family": "Hacimuftuoglu", "given": "Ahmet", "initials": "A"}, {"family": "Keles", "given": "Mevlut Sait", "initials": "MS", "orcid": "0000-0002-4905-219X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/47b54a273f8243e0a6ca52a45151cf54.json"}}, {"family": "Geyikoglu", "given": "Fatime", "initials": "F"}, {"family": "Atamanalp", "given": "Muhammed", "initials": "M", "orcid": "0000-0002-2038-3921", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c7715ca0c6594b84b3cf019aa61f4210.json"}}, {"family": "Saruhan", "given": "Fatih", "initials": "F"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal article", "published": "2022-07-28", "journal": {"title": "Toxics", "issn": "2305-6304", "volume": "10", "issue": "8", "issn-l": null}, "abstract": "Genetic, neuropathological and biochemical investigations have revealed meaningful relationships between aluminum (Al) exposure and neurotoxic and hematotoxic damage. Hence, intensive efforts are being made to minimize the harmful effects of Al. Moreover, boron compounds are used in a broad mix of industries, from cosmetics and pharmaceuticals to agriculture. They affect critical biological functions in cellular events and enzymatic reactions, as well as endocrinal and mineral metabolisms. There are limited dose-related data about boric acid (BA) and other boron compounds, including colemanite (Col), ulexite (UX) and borax (BX), which have commercial prominence. In this study, we evaluate boron compounds' genetic, cytological, biochemical and pathological effects against aluminum chloride (AlCl3)-induced hematotoxicity and neurotoxicity on different cell and animal model systems. First, we perform genotoxicity studies on in vivo rat bone marrow cells and peripheric human blood cultures. To analyze DNA and chromosome damage, we use single cell gel electrophoresis (SCGE or comet assay) and micronucleus (MN) and chromosome aberration (CA) assays. The nuclear division index (NDI) is used to monitor cytostasis. Second, we examine the biochemical parameters (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), total antioxidant capacity (TAC) and total oxidative status (TOS)) to determine oxidative changes in blood and brain. Next, we assess the histopathological alterations by using light and electron microscopes. Our results show that Al increases oxidative stress and genetic damage in blood and brain in vivo and in vitro studies. Al also led to severe histopathological and ultrastructural alterations in the brain. However, the boron compounds alone did not cause adverse changes based on the above-studied parameters. Moreover, these compounds exhibit different levels of beneficial effects by removing the harmful impact of Al. The antioxidant, antigenotoxic and cytoprotective effects of boron compounds against Al-induced damage indicate that boron may have a high potential for use in medical purposes in humans. In conclusion, our analysis suggests that boron compounds (especially BA, BX and UX) can be administered to subjects to prevent neurodegenerative and hematological disorders at determined doses.", "doi": "10.3390/toxics10080428", "pmid": "36006107", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC9413983"}, {"db": "pii", "key": "toxics10080428"}], "notes": [], "created": "2023-12-04T14:58:10.555Z", "modified": "2023-12-04T14:58:10.874Z"}, {"entity": "publication", "iuid": "a49efe33765d420782d0888eab45a04f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a49efe33765d420782d0888eab45a04f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a49efe33765d420782d0888eab45a04f"}}, "title": "Molecular Genetics and Cytotoxic Responses to Titanium Diboride and Zinc Borate Nanoparticles on Cultured Human Primary Alveolar Epithelial Cells.", "authors": [{"family": "T\u00fcrkez", "given": "Hasan", "initials": "H", "orcid": "0000-0002-7046-8990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2f1748757d45cabfe56fdfaccead6a.json"}}, {"family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "Tatar", "given": "Arzu", "initials": "A"}, {"family": "\u00d6zdemir", "given": "\u00d6zlem", "initials": "\u00d6", "orcid": "0000-0002-5472-8174", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f64b15273ce49348b9ffebf5230ea11.json"}}, {"family": "S\u00f6nmez", "given": "Erdal", "initials": "E"}, {"family": "\u00c7adirci", "given": "Kenan", "initials": "K"}, {"family": "Hacim\u00fcft\u00fco\u011flu", "given": "Ahmet", "initials": "A"}, {"family": "Ceylan", "given": "Bahattin", "initials": "B"}, {"family": "A\u00e7ikyildiz", "given": "Metin", "initials": "M"}, {"family": "Kahraman", "given": "Cigdem Yuce", "initials": "CY", "orcid": "0000-0003-1957-9596", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/20f608344b0340d0a12e82dd5a918dce.json"}}, {"family": "Geyiko\u011flu", "given": "Fatime", "initials": "F"}, {"family": "Tatar", "given": "Abdulgani", "initials": "A"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal article", "published": "2022-03-22", "journal": {"title": "Materials (Basel)", "issn": "1996-1944", "volume": "15", "issue": "7", "issn-l": null}, "abstract": "Titanium diboride (TiB2) and zinc borate (Zn3BO6) have been utilized in wide spectrum industrial areas because of their favorable properties such as a high melting point, good wear resistance, high hardness and thermal conductivity. On the other hand, the biomedical potentials of TiB2 and Zn3BO6 are still unknown because there is no comprehensive analysis that uncovers their biocompatibility features. Thus, the toxicogenomic properties of TiB2 and Zn3BO6 nanoparticles (NPs) were investigated on human primary alveolar epithelial cell cultures (HPAEpiC) by using different cell viability assays and microarray analyses. Protein-Protein Interaction Networks Functional Enrichment Analysis (STRING) was used to associate differentially expressed gene probes. According to the results, up to 10 mg/L concentration of TiB2 and Zn3BO6 NPs application did not stimulate a cytotoxic effect on the HPAEpiC cell cultures. Microarray analysis revealed that TiB2 NPs exposure enhances cellular adhesion molecules, proteases and carrier protein expression. Furthermore, Zn3BO6 NPs caused differential gene expressions in the cell cycle, cell division and extracellular matrix regulators. Finally, STRING analyses put forth that inflammation, cell regeneration and tissue repair-related gene interactions were affected by TiB2 NPs application. Zn3BO6 NPs exposure significantly altered inflammation, lipid metabolism and infection response activator-related gene interactions. These investigations illustrated that TiB2 and Zn3BO6 NPs exposure may affect different aspects of cellular machineries such as immunogenic responses, tissue regeneration and cell survival. Thus, these types of cellular mechanisms should be taken into account before the use of the related NPs in further biomedical applications.", "doi": "10.3390/ma15072359", "pmid": "35407693", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC9000154"}, {"db": "pii", "key": "ma15072359"}], "notes": [], "created": "2023-12-04T15:02:10.941Z", "modified": "2023-12-04T15:02:11.035Z"}, {"entity": "publication", "iuid": "12ce50cfbfcc4e50bfd5ecbb3ca08e0b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/12ce50cfbfcc4e50bfd5ecbb3ca08e0b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/12ce50cfbfcc4e50bfd5ecbb3ca08e0b"}}, "title": "Synthesis and in Vitro Toxicity Assessment of Different Nano-Calcium Phosphate Nanoparticles", "authors": [{"family": "Ba\u015fak", "given": "To\u011far", "initials": "T", "orcid": "0000-0003-0883-0458", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/07b6340296114aba944cd8c042247ad9.json"}}, {"family": "Hasan", "given": "T\u00fcrkez", "initials": "T", "orcid": "0000-0002-7046-8990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2f1748757d45cabfe56fdfaccead6a.json"}}, {"family": "Feray", "given": "Bakan", "initials": "B", "orcid": "0000-0001-6467-8943", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3acf71231c984eecaa4222bfafb718b3.json"}}, {"family": "Enes", "given": "Arslan Mehmet", "initials": "AM", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "Abdulgani", "given": "Tatar", "initials": "T", "orcid": "0000-0001-7273-1679", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2fbf32132b04542b3e78cdc6ee22865.json"}}, {"family": "Ivana", "given": "Cacc\u0131atore", "initials": "C", "orcid": "0000-0001-6253-0443", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/31661d5900cc4711923f4bf51cf47a93.json"}}, {"family": "Ahmet", "given": "Hac\u0131m\u00fcft\u00fco\u011flu", "initials": "H", "orcid": "0000-0002-9658-3313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d0c9dec14df94851a001e59ea81eaf75.json"}}, {"family": "Kenan", "given": "\u00c7ad\u0131rc\u0131", "initials": "\u00c7", "orcid": "0000-0002-2765-4288", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/305106d191054c26a2de64f9ca54437f.json"}}, {"family": "Di", "given": "Stefano Antonio", "initials": "SA", "orcid": "0000-0002-3042-2234", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/413d1857e18c4eef8929bb9ceedc5af0.json"}}, {"family": "Adil", "given": "Mardino\u011flu", "initials": "M", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal-article", "published": "2022-00-00", "journal": {"title": "Braz. arch. biol. technol.", "issn": "1678-4324", "volume": "65", "issn-l": null}, "abstract": null, "doi": "10.1590/1678-4324-2022200784", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-21T12:54:45.819Z", "modified": "2026-08-21T12:54:46.015Z"}, {"entity": "publication", "iuid": "588adee402ee4779924e0e8bbd99b6d7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/588adee402ee4779924e0e8bbd99b6d7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/588adee402ee4779924e0e8bbd99b6d7"}}, "title": "Therapeutic Potential of Ferulic Acid in Alzheimer's Disease.", "authors": [{"family": "Turkez", "given": "Hasan", "initials": "H", "orcid": "0000-0002-7046-8990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2f1748757d45cabfe56fdfaccead6a.json"}}, {"family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "Barboza", "given": "Joice Nascimento", "initials": "JN"}, {"family": "Kahraman", "given": "Cigdem Yuce", "initials": "CY", "orcid": "0000-0003-1957-9596", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/20f608344b0340d0a12e82dd5a918dce.json"}}, {"family": "de Sousa", "given": "Damiao Pergentino", "initials": "DP"}, {"family": "Mardino\u011flu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal article", "published": "2021-12-30", "journal": {"title": "Curr Drug Deliv", "issn": "1875-5704", "volume": "19", "issue": "8", "pages": "860-873", "issn-l": "1567-2018"}, "abstract": "Alzheimer's Disease (AD) is one of the most important neurodegenerative diseases, accounting for 60% of all dementia cases. AD is a progressive neurodegenerative disease that occurs due to the production of \u03b2-amyloid (A\u03b2) protein and accumulation of hyper-phosphorylated tau protein; it causes breakage in the synaptic bonds and neuronal deaths to a large extent. Millions of people worldwide suffer from AD because there is no definitive drug for disease prevention, treatment, or slowing down its progression. Over the last decade, multiple target applications have been developed for AD treatments. These targets include A\u03b2 accumulations, hyper-phosphorylated tau proteins, mitochondrial dysfunction, and oxidative stress, resulting in toxicity. Various natural or semisynthetic antioxidant formulations have been shown to protect brain cells from A\u03b2-induced toxicity and provide promising potentials for AD treatment. Ferulic acid (FA), a high-capacity antioxidant molecule, is naturally synthesized from certain plants. FA has been shown to have different substantial biological properties, such as anticancer, antidiabetic, antimicrobial, anti-inflammatory, hepatoprotective, and cardioprotective actions, etc. Furthermore, FA exerts neuroprotection via preventing A\u03b2-fibril formation, acting as an anti-inflammatory agent, and inhibiting free radical generation and acetylcholinesterase (AChE) enzyme activity. In this review, we present key biological roles of FA and several FA derivatives in preventing A\u03b2-induced neurotoxicity, protecting against free radical attacks, and exhibiting enzyme inhibitions and evaluate them as possible therapeutic agents for the treatment of AD.", "doi": "10.2174/1567201819666211228153801", "pmid": "34963433", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "CDD-EPUB-119739"}], "notes": [], "created": "2023-12-04T15:04:52.971Z", "modified": "2025-04-11T09:16:54.216Z"}, {"entity": "publication", "iuid": "1d06c91cd8f94a37816f1fce4309535c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1d06c91cd8f94a37816f1fce4309535c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1d06c91cd8f94a37816f1fce4309535c"}}, "title": "In vitro transcriptome response to propolis in differentiated SH-SY5Y neurons.", "authors": [{"family": "Turkez", "given": "Hasan", "initials": "H"}, {"family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "Yilmaz", "given": "Ahmet", "initials": "A"}, {"family": "Doru", "given": "Funda", "initials": "F"}, {"family": "Caglar", "given": "Ozge", "initials": "O"}, {"family": "Arslan", "given": "Elif", "initials": "E"}, {"family": "Tatar", "given": "Abdulgani", "initials": "A"}, {"family": "Hac\u0131muftuoglu", "given": "Ahmet", "initials": "A"}, {"family": "Abd El-Aty", "given": "A M", "initials": "AM"}, {"family": "Mardinoglu", "given": "Adil", "initials": "A"}], "type": "journal article", "published": "2021-12-00", "journal": {"title": "J Food Biochem", "issn": "1745-4514", "volume": "45", "issue": "12", "pages": "e13990", "issn-l": null}, "abstract": "Propolis is the extract of a resinous compound that protects plants from both cold and microorganism attack and has gained a strong and sticky property because it is transformed after being collected by honey bees. Up to date, many studies have shown that propolis exhibited various beneficial biological activities, such as antifungal, antibacterial, antiviral, antioxidant, antimutagenic, and antitumor effects. Recent reports propounded the in vitro and in vivo neuroprotective effect of propolis; however, the exact molecular genetic mechanisms are still unclear. Therefore, we aimed to investigate the toxicogenomic and beneficial properties, including cytotoxic, antioxidant, apoptotic/necrotic as well as genotoxic effects of propolis (1.56-200 \u00b5g/ml) on differentiated SH-SY5Y neuronal cells. Additionally, microarray analysis was conducted on cell cultures following propolis application to explore gene differentiation. Differentially expressed genes were further analyzed using string software to characterize protein-protein interactions between gene pathways. Our results revealed that propolis applications could not have a prominent effect on cell viability even at concentrations up to 200 \u00b5g/ml. The highest propolis concentration induced apoptotic rather than necrotic cell death. The alterations in gene expression profiles, including CYP26A1, DHRS2, DHRS3, DYNC1I1, IGF2, ITGA4, SVIL, TGF\u03b21, and TGM2 could participate in the neuroprotective effects of propolis. In conclusion, propolis supplementation exerted remarkable advantageous; thus, it may offer great potential as a natural component in the prevention and treatment of neurodegenerative disorders. Whole-genome gene expression pattern following propolis application was investigated for the first time in neuronal cell culture to fill a gap in the literature about propolis toxicogenomics. PRACTICAL APPLICATIONS: Propolis is a very rich product in terms of benefits. In addition to its antibacterial, antiviral, antifungal, and anti-inflammatory content, it is known to have preventive and therapeutic properties for many different ailments. On the other hand, molecular mechanisms of propolis on gene expression differentiations haven't been investigated until now. Moreover, gene expression pattern is vital for all living organisms to maintain homeostasis. Thus, we conduct an experiment series for analyzing gene expression differentiation effects on neuronal cells to understand beneficial properties of propolis. Hence, it could be possible to comment on the use of propolis as a nutritional factor and beneficial diet.", "doi": "10.1111/jfbc.13990", "pmid": "34730243", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2023-12-04T15:04:59.413Z", "modified": "2023-12-04T15:04:59.443Z"}, {"entity": "publication", "iuid": "3ae4c17393104f42a6c63d35d2616f52", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3ae4c17393104f42a6c63d35d2616f52.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3ae4c17393104f42a6c63d35d2616f52"}}, "title": "Safety Assessments of Nickel Boride Nanoparticles on the Human Pulmonary Alveolar Cells by Using Cell Viability and Gene Expression Analyses.", "authors": [{"family": "T\u00fcrkez", "given": "Hasan", "initials": "H"}, {"family": "Arslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "S\u00f6nmez", "given": "Erdal", "initials": "E"}, {"family": "Tatar", "given": "Abdulgani", "initials": "A"}, {"family": "Geyiko\u011flu", "given": "Fatime", "initials": "F"}, {"family": "A\u00e7ikyildiz", "given": "Metin", "initials": "M"}, {"family": "Mardino\u011flu", "given": "Adil", "initials": "A"}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Biol Trace Elem Res", "issn": "1559-0720", "issn-l": "0163-4984", "volume": "199", "issue": "7", "pages": "2602-2611"}, "abstract": "Nickel boride is generally used in the steel industry as a melting accelerator due to its feature of creating a protective and stable attribute at high temperatures. It is also used to improve the hardenability of the steel with boron addition in the production. Thus, safety studies and biocompatibility analysis of nickel boride should be performed comprehensively to understand the limitations of use in various areas. In the present study, nickel boride nanoparticles (Ni2B NPs) were synthesized by a single-step method and molecule characterizations were performed via the use of X-ray diffraction analysis (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and energy dispersive X-ray (EDX) analyses. Cytotoxicity properties of Ni2B NPs were identified on human pulmonary alveolar epithelial cells (HPAEpiC) by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), neutral red (NR), and lactate dehydrogenase (LDH) assays. Illumina human ht-12 v4.0 whole-genome microarray analysis was conducted to investigate NiB2 NPs effects on gene expression regulations of HPAEpiC cells. The database for annotation, visualization, and integrated discovery (DAVID) analysis was performed to reveal the relationship between Ni2B NP application and cellular pathway alterations. According to cytotoxicity analysis, the IC50 value for Ni2B NP application was found as 81.99 mg/L concentration. Microarray analysis of Ni2B NP application was shown for the first time that 693 gene expression changes (FC \u2265 2) occurred significantly over 40.000 gene probes and Ni2B NPs were observed to affect microtubule regulation, centrosome organization, and phosphoprotein synthesis.", "doi": "10.1007/s12011-020-02374-7", "pmid": "32909113", "labels": {"Adil Mardinoglu": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "10.1007/s12011-020-02374-7"}], "notes": [], "created": "2020-11-30T03:13:21.411Z", "modified": "2022-11-04T11:32:12.905Z"}, {"entity": "publication", "iuid": "c971d66e98cf491ba57655eca1b416b2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c971d66e98cf491ba57655eca1b416b2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c971d66e98cf491ba57655eca1b416b2"}}, "title": "Glycyl-L-Prolyl-L-Glutamate Pseudotripeptides for Treatment of Alzheimer's Disease.", "authors": [{"family": "Turkez", "given": "Hasan", "initials": "H"}, {"family": "Cacciatore", "given": "Ivana", "initials": "I"}, {"family": "Marinelli", "given": "Lisa", "initials": "L"}, {"family": "Fornasari", "given": "Erika", "initials": "E"}, {"family": "Aslan", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "Cadirci", "given": "Kenan", "initials": "K"}, {"family": "Kahraman", "given": "Cigdem Yuce", "initials": "CY", "orcid": "0000-0003-1957-9596", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/20f608344b0340d0a12e82dd5a918dce.json"}}, {"family": "Caglar", "given": "Ozge", "initials": "O"}, {"family": "Tatar", "given": "Abdulgani", "initials": "A"}, {"family": "Di Biase", "given": "Giuseppe", "initials": "G"}, {"family": "Hacimuftuoglu", "given": "Ahmet", "initials": "A"}, {"family": "Di Stefano", "given": "Antonio", "initials": "A", "orcid": "0000-0002-3042-2234", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/413d1857e18c4eef8929bb9ceedc5af0.json"}}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal article", "published": "2021-01-19", "journal": {"title": "Biomolecules", "issn": "2218-273X", "volume": "11", "issue": "1", "issn-l": null}, "abstract": "So far, there is no effective disease-modifying therapies for Alzheimer's Disease (AD) in clinical practice. In this context, glycine-L-proline-L-glutamate (GPE) and its analogs may open the way for developing a novel molecule for treating neurodegenerative disorders, including AD. In turn, this study was aimed to investigate the neuroprotective potentials exerted by three novel GPE peptidomimetics (GPE1, GPE2, and GPE3) using an in vitro AD model. Anti-Alzheimer potentials were determined using a wide array of techniques, such as measurements of mitochondrial viability (MTT) and lactate dehydrogenase (LDH) release assays, determination of acetylcholinesterase (AChE), \u03b1-secretase and \u03b2-secretase activities, comparisons of total antioxidant capacity (TAC) and total oxidative status (TOS) levels, flow cytometric and microscopic detection of apoptotic and necrotic neuronal death, and investigating gene expression responses via PCR arrays involving 64 critical genes related to 10 different pathways. Our analysis showed that GPE peptidomimetics modulate oxidative stress, ACh depletion, \u03b1-secretase inactivation, apoptotic, and necrotic cell death. In vitro results suggested that treatments with novel GPE analogs might be promising therapeutic agents for treatment and/or or prevention of AD.", "doi": "10.3390/biom11010126", "pmid": "33478054", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7835747"}, {"db": "pii", "key": "biom11010126"}], "notes": [], "created": "2026-08-20T13:38:36.213Z", "modified": "2026-08-20T13:38:36.323Z"}, {"entity": "publication", "iuid": "ac4a4bb874ed4253aba6a1a622ec7da8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ac4a4bb874ed4253aba6a1a622ec7da8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ac4a4bb874ed4253aba6a1a622ec7da8"}}, "title": "Nonpharmacological treatment options for Alzheimer\u2019s disease: from animal testing to clinical studies", "authors": [{"family": "T\u00dcRKEZ", "given": "Hasan", "initials": "H", "orcid": "0000-0002-7046-8990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2f1748757d45cabfe56fdfaccead6a.json"}}, {"family": "ARSLAN", "given": "Mehmet Enes", "initials": "ME", "orcid": "0000-0002-1600-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c5dd8a766b948efa5f040ceb43e60a6.json"}}, {"family": "STEFANO", "given": "Antonio Di", "initials": "AD", "orcid": "0000-0002-3042-2234", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/413d1857e18c4eef8929bb9ceedc5af0.json"}}, {"family": "CACCIATORE", "given": "Ivana", "initials": "I", "orcid": "0000-0001-6253-0443", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/31661d5900cc4711923f4bf51cf47a93.json"}}, {"family": "MARD\u0130NO\u011eLU", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal-article", "published": "2020-03-04", "journal": {"title": "Turk J Zool", "issn": "1303-6114", "volume": "44", "issue": "2", "pages": "81-89", "issn-l": null}, "abstract": null, "doi": "10.3906/zoo-1911-32", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-21T13:05:52.285Z", "modified": "2026-08-21T13:05:52.406Z"}]}