{"entity": "researcher", "timestamp": "2026-08-25T09:31:35.215Z", "family": "Wang", "given": "Xin", "initials": "X", "orcid": "0000-0001-6292-3087", "affiliations": ["Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, University of Toronto, Toronto, M5G 0A4, Ontario, Canada."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/6a9a71612fcf43d596f7394b1d123c47.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/6a9a71612fcf43d596f7394b1d123c47"}}, "publications": [{"entity": "publication", "iuid": "0e206590ad7346aab687fb682950a84b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0e206590ad7346aab687fb682950a84b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0e206590ad7346aab687fb682950a84b"}}, "title": "Publisher Correction: Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma.", "authors": [{"family": "Kahn", "given": "Suzana A", "initials": "SA"}, {"family": "Wang", "given": "Xin", "initials": "X", "orcid": "0000-0001-6292-3087", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6a9a71612fcf43d596f7394b1d123c47.json"}}, {"family": "Nitta", "given": "Ryan T", "initials": "RT"}, {"family": "Gholamin", "given": "Sharareh", "initials": "S"}, {"family": "Theruvath", "given": "Johanna", "initials": "J"}, {"family": "Hutter", "given": "Gregor", "initials": "G", "orcid": "0000-0002-7570-3902", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2914359ec9cf4ed4a2af02fa865fbccf.json"}}, {"family": "Azad", "given": "Tej D", "initials": "TD"}, {"family": "Wadi", "given": "Lina", "initials": "L"}, {"family": "Bolin", "given": "Sara", "initials": "S"}, {"family": "Ramaswamy", "given": "Vijay", "initials": "V"}, {"family": "Esparza", "given": "Rogelio", "initials": "R"}, {"family": "Liu", "given": "Kun-Wei", "initials": "KW"}, {"family": "Edwards", "given": "Michael", "initials": "M", "orcid": "0000-0001-9591-1242", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fd7ed8485b5b46e78cfbb8f241742ea9.json"}}, {"family": "Swartling", "given": "Fredrik J", "initials": "FJ"}, {"family": "Sahoo", "given": "Debashis", "initials": "D"}, {"family": "Li", "given": "Gordon", "initials": "G"}, {"family": "Wechsler-Reya", "given": "Robert J", "initials": "RJ"}, {"family": "Reimand", "given": "J\u00fcri", "initials": "J"}, {"family": "Cho", "given": "Yoon-Jae", "initials": "YJ"}, {"family": "Taylor", "given": "Michael D", "initials": "MD"}, {"family": "Weissman", "given": "Irving L", "initials": "IL", "orcid": "0000-0002-9077-7467", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a2c0a5cf4bb48468cda535a1669d11b.json"}}, {"family": "Mitra", "given": "Siddhartha S", "initials": "SS", "orcid": "0000-0002-1829-7856", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d4c537550f34b89b657ab95c7d46a2a.json"}}, {"family": "Cheshier", "given": "Samuel H", "initials": "SH"}], "type": "journal article", "published": "2018-11-02", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "9", "issue": "1", "pages": "4651", "issn-l": "2041-1723"}, "abstract": "The original version of this Article omitted Suzana A. Kahn, Siddhartha S. Mitra & Samuel H. Cheshier as jointly supervising authors. This has now been corrected in both the PDF and HTML versions of the Article.", "doi": "10.1038/s41467-018-07182-1", "pmid": "30389946", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6214967"}, {"db": "pii", "key": "10.1038/s41467-018-07182-1"}], "notes": [], "created": "2026-08-20T08:50:20.382Z", "modified": "2026-08-20T08:50:20.489Z"}, {"entity": "publication", "iuid": "99ee4feee6c54977bb19647878b9bde4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/99ee4feee6c54977bb19647878b9bde4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/99ee4feee6c54977bb19647878b9bde4"}}, "title": "Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma.", "authors": [{"family": "Kahn", "given": "Suzana A", "initials": "SA"}, {"family": "Wang", "given": "Xin", "initials": "X", "orcid": "0000-0001-6292-3087", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6a9a71612fcf43d596f7394b1d123c47.json"}}, {"family": "Nitta", "given": "Ryan T", "initials": "RT"}, {"family": "Gholamin", "given": "Sharareh", "initials": "S"}, {"family": "Theruvath", "given": "Johanna", "initials": "J"}, {"family": "Hutter", "given": "Gregor", "initials": "G", "orcid": "0000-0002-7570-3902", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2914359ec9cf4ed4a2af02fa865fbccf.json"}}, {"family": "Azad", "given": "Tej D", "initials": "TD"}, {"family": "Wadi", "given": "Lina", "initials": "L"}, {"family": "Bolin", "given": "Sara", "initials": "S"}, {"family": "Ramaswamy", "given": "Vijay", "initials": "V"}, {"family": "Esparza", "given": "Rogelio", "initials": "R"}, {"family": "Liu", "given": "Kun-Wei", "initials": "KW"}, {"family": "Edwards", "given": "Michael", "initials": "M", "orcid": "0000-0001-9591-1242", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fd7ed8485b5b46e78cfbb8f241742ea9.json"}}, {"family": "Swartling", "given": "Fredrik J", "initials": "FJ"}, {"family": "Sahoo", "given": "Debashis", "initials": "D"}, {"family": "Li", "given": "Gordon", "initials": "G"}, {"family": "Wechsler-Reya", "given": "Robert J", "initials": "RJ"}, {"family": "Reimand", "given": "J\u00fcri", "initials": "J"}, {"family": "Cho", "given": "Yoon-Jae", "initials": "YJ"}, {"family": "Taylor", "given": "Michael D", "initials": "MD"}, {"family": "Weissman", "given": "Irving L", "initials": "IL", "orcid": "0000-0002-9077-7467", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a2c0a5cf4bb48468cda535a1669d11b.json"}}, {"family": "Mitra", "given": "Siddhartha S", "initials": "SS", "orcid": "0000-0002-1829-7856", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d4c537550f34b89b657ab95c7d46a2a.json"}}, {"family": "Cheshier", "given": "Samuel H", "initials": "SH"}], "type": "journal article", "published": "2018-10-08", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "9", "issue": "1", "pages": "4121", "issn-l": "2041-1723"}, "abstract": "Medulloblastoma is the most common malignant brain tumor of childhood. Group 3 medulloblastoma, the most aggressive molecular subtype, frequently disseminates through the leptomeningeal cerebral spinal fluid (CSF) spaces in the brain and spinal cord. The mechanism of dissemination through the CSF remains poorly understood, and the molecular pathways involved in medulloblastoma metastasis and self-renewal are largely unknown. Here we show that NOTCH1 signaling pathway regulates both the initiation of metastasis and the self-renewal of medulloblastoma. We identify a mechanism in which NOTCH1 activates BMI1 through the activation of TWIST1. NOTCH1 expression and activity are directly related to medulloblastoma metastasis and decreased survival rate of tumor-bearing mice. Finally, medulloblastoma-bearing mice intrathecally treated with anti-NRR1, a NOTCH1 blocking antibody, present lower frequency of spinal metastasis and higher survival rate. These findings identify NOTCH1 as a pivotal driver of Group 3 medulloblastoma metastasis and self-renewal, supporting the development of therapies targeting this pathway.", "doi": "10.1038/s41467-018-06564-9", "pmid": "30297829", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6175869"}, {"db": "pii", "key": "10.1038/s41467-018-06564-9"}], "notes": [], "created": "2026-08-20T08:50:16.517Z", "modified": "2026-08-20T08:50:16.777Z"}]}