{"entity": "researcher", "timestamp": "2026-08-20T21:03:07.839Z", "family": "van Guelpen", "given": "Bethany", "initials": "B", "orcid": "0000-0002-9692-101X", "affiliations": ["Department of Radiation Sciences, Oncology, Ume\u00e5 University, Ume\u00e5, Sweden. bethany.vanguelpen@umu.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/696a220cec294b12a5288a36e56abcf9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/696a220cec294b12a5288a36e56abcf9"}}, "publications": [{"entity": "publication", "iuid": "73972805d3e345e593e162d4eef68f39", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/73972805d3e345e593e162d4eef68f39.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/73972805d3e345e593e162d4eef68f39"}}, "title": "Targeted plasma proteomics identifies a novel, robust association between cornulin and Swedish moist snuff.", "authors": [{"family": "Sundkvist", "given": "Anneli", "initials": "A"}, {"family": "Myte", "given": "Robin", "initials": "R", "orcid": "0000-0002-2974-2003", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5402d1b85f474f198ef1f0abaf9140e4.json"}}, {"family": "Bod\u00e9n", "given": "Stina", "initials": "S"}, {"family": "Enroth", "given": "Stefan", "initials": "S", "orcid": "0000-0002-5056-9137", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae9be8ef3b1145239a4e0231e2a148cd.json"}}, {"family": "Gyllensten", "given": "Ulf", "initials": "U"}, {"family": "Harlid", "given": "Sophia", "initials": "S", "orcid": "0000-0001-8540-6891", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8ed1eea77e1f4ede87f3bc73e6f66a56.json"}}, {"family": "van Guelpen", "given": "Bethany", "initials": "B", "orcid": "0000-0002-9692-101X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/696a220cec294b12a5288a36e56abcf9.json"}}], "type": "journal article", "published": "2018-02-02", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "8", "issue": "1", "pages": "2320", "issn-l": "2045-2322"}, "abstract": "Lifestyle behaviors are believed to influence the body's inflammatory state. Chronic low-grade inflammation contributes to the development of major non-communicable diseases such as diabetes, cardiovascular disease and cancer. Inflammation may thus be an important link between lifestyle and disease. We evaluated self-reported physical activity, tobacco use and alcohol consumption in relation to plasma levels of 160 validated inflammatory and cancer biomarkers. The study included 138 participants from a population-based cohort, all with repeated sampling of plasma and data ten years apart, allowing consideration of both intra- and inter-individual variation. Of 17 relationships identified, the strongest was an independent, positive association between cornulin (CRNN) and Swedish moist snuff (snus) use. We replicated the finding in a second cohort of 501 individuals, in which a dose-response relationship was also observed. Snus explained approximately one fifth of the variance in CRNN levels in both sample sets (18% and 23%). In conclusion, we identified a novel, independent, dose-dependent association between CRNN and snus use. Further study is warranted, to evaluate the performance of CRNN as a potential snus biomarker. The putative importance of lifestyle behaviors on a wide range of protein biomarkers illustrates the need for more personalized biomarker cut-offs.", "doi": "10.1038/s41598-018-20794-3", "pmid": "29396534", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5797131"}, {"db": "pii", "key": "10.1038/s41598-018-20794-3"}], "notes": [], "created": "2026-08-20T09:04:19.352Z", "modified": "2026-08-20T09:04:19.537Z"}]}