{"entity": "researcher", "timestamp": "2026-08-20T20:36:36.136Z", "family": "V\u00f6lker", "given": "Uwe", "initials": "U", "orcid": "0000-0002-5689-3448", "affiliations": ["German Centre for Cardiovascular Research, Partner Site Greifswald, University Medicine Greifswald, Greifswald, Germany.", "Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/68bb357d1344475596bf14ca926fdac5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/68bb357d1344475596bf14ca926fdac5"}}, "publications": [{"entity": "publication", "iuid": "397f4f28164a4198b37916aac346c8cc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/397f4f28164a4198b37916aac346c8cc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/397f4f28164a4198b37916aac346c8cc"}}, "title": "A standardized framework for circulating blood proteomics.", "authors": [{"family": "Cai", "given": "Xue", "initials": "X"}, {"family": "Geyer", "given": "Philipp E", "initials": "PE"}, {"family": "Perez-Riverol", "given": "Yasset", "initials": "Y"}, {"family": "Omenn", "given": "Gilbert S", "initials": "GS"}, {"family": "Dong", "given": "Lianhua", "initials": "L"}, {"family": "Winkler", "given": "Robert", "initials": "R", "orcid": "0000-0001-6732-1958", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/03391a12e21d476daaabc9f0eb4c7d40.json"}}, {"family": "Ahadi", "given": "Sara", "initials": "S"}, {"family": "L\u00f6ssl", "given": "Philip", "initials": "P"}, {"family": "Yu", "given": "Xiaobo", "initials": "X"}, {"family": "Chang", "given": "Cheng", "initials": "C", "orcid": "0000-0002-0361-2438", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6abdb99d9c504d34ac8eb17b5506007d.json"}}, {"family": "Ralser", "given": "Markus", "initials": "M", "orcid": "0000-0001-9535-7413", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3bd2e773cef04695ae85ab6646092c9f.json"}}, {"family": "Jimenez", "given": "Connie R", "initials": "CR"}, {"family": "Zhao", "given": "Yang", "initials": "Y"}, {"family": "Chen", "given": "Yu-Ju", "initials": "YJ"}, {"family": "Poon", "given": "Terence C W", "initials": "TCW"}, {"family": "Bache", "given": "Nicolai", "initials": "N"}, {"family": "Shi", "given": "Leming", "initials": "L", "orcid": "0000-0002-2981-4150", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a7eb9403fed44eaa67bebe95b6a5e47.json"}}, {"family": "Dai", "given": "Xinhua", "initials": "X"}, {"family": "Wang", "given": "Ziyue", "initials": "Z"}, {"family": "Zhu", "given": "Yi", "initials": "Y", "orcid": "0000-0003-0429-0802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ccc6070e71c647048cb05efe30756a14.json"}}, {"family": "Fang", "given": "Xiang", "initials": "X"}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Van Eyk", "given": "Jennifer E", "initials": "JE", "orcid": "0000-0001-9050-148X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e2a63243b3f4e14959dad947be60cb2.json"}}, {"family": "V\u00f6lker", "given": "Uwe", "initials": "U", "orcid": "0000-0002-5689-3448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/68bb357d1344475596bf14ca926fdac5.json"}}, {"family": "Guo", "given": "Tiannan", "initials": "T", "orcid": "0000-0003-3869-7651", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/730482798d584ac8b5d30f4450ad24ad.json"}}], "type": "journal article", "published": "2025-10-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "57", "issue": "10", "pages": "2371-2380", "issn-l": "1061-4036"}, "abstract": "The circulating blood proteome holds immense potential for biomarker discovery and understanding disease mechanisms. Notable advances in mass spectrometry and affinity-based technologies have been made, but data integration across studies and platforms is hindered by the absence of unified analytical standards. This limitation impedes comprehensive exploration of human biology across diverse phenotypes and cohorts as well as the translation of findings into clinical applications. The disparities between datasets, stemming from a combination of factors related to differences in sample collection, pre-analytical handling, measurement methods and instrumentation, further complicate data integration. In this Perspective, we outline key challenges in blood-based proteomics and propose actionable strategies. Central to our recommendations are high-quality, technology-agnostic reference samples, which can bridge disparate datasets and enable robust cross-study comparisons. By fostering interconnected investigations across proteomic technologies, blood sample collections, clinical phenotypes and different populations, these references will accelerate the field and its translation.", "doi": "10.1038/s41588-025-02319-7", "pmid": "40987950", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41588-025-02319-7"}], "notes": [], "created": "2026-08-20T09:00:20.767Z", "modified": "2026-08-20T09:00:21.026Z"}, {"entity": "publication", "iuid": "6b0e483754dc4e669906dd6236f3c56b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6b0e483754dc4e669906dd6236f3c56b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6b0e483754dc4e669906dd6236f3c56b"}}, "title": "A roadmap to the molecular human linking multiomics with population traits and diabetes subtypes.", "authors": [{"family": "Halama", "given": "Anna", "initials": "A", "orcid": "0000-0003-4910-6255", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6bf58441e02e4551acc6ac4b0c90cb63.json"}}, {"family": "Zaghlool", "given": "Shaza", "initials": "S", "orcid": "0000-0002-9132-8030", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65a0b2fff6f9424193601954b7e308d9.json"}}, {"family": "Thareja", "given": "Gaurav", "initials": "G", "orcid": "0000-0003-2277-6400", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2b19fec03764ccfacd116990720c73b.json"}}, {"family": "Kader", "given": "Sara", "initials": "S"}, {"family": "Al Muftah", "given": "Wadha", "initials": "W", "orcid": "0000-0003-2549-082X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/78994cfb3e4844ec847cf859b83f7cbd.json"}}, {"family": "Mook-Kanamori", "given": "Marjonneke", "initials": "M"}, {"family": "Sarwath", "given": "Hina", "initials": "H"}, {"family": "Mohamoud", "given": "Yasmin Ali", "initials": "YA"}, {"family": "Stephan", "given": "Nisha", "initials": "N"}, {"family": "Ameling", "given": "Sabine", "initials": "S", "orcid": "0000-0002-3095-8362", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5029d87b57024fa9bccd8b18a2f12bc3.json"}}, {"family": "Pucic Bakovi\u0107", "given": "Maja", "initials": "M", "orcid": "0000-0003-0866-623X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b3c288f6c19a4216b9e751d58d08aa5b.json"}}, {"family": "Krumsiek", "given": "Jan", "initials": "J", "orcid": "0000-0003-4734-3791", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73e5e475bd3b44e7aec1d82ef0a810d1.json"}}, {"family": "Prehn", "given": "Cornelia", "initials": "C", "orcid": "0000-0002-1274-4715", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c280da18ddda4abb816f6db3dbadc6e9.json"}}, {"family": "Adamski", "given": "Jerzy", "initials": "J", "orcid": "0000-0001-9259-0199", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6871f2a0d4414a58be2e7f26a59d3ca9.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Friedrich", "given": "Nele", "initials": "N"}, {"family": "V\u00f6lker", "given": "Uwe", "initials": "U", "orcid": "0000-0002-5689-3448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/68bb357d1344475596bf14ca926fdac5.json"}}, {"family": "Wuhrer", "given": "Manfred", "initials": "M", "orcid": "0000-0002-0814-4995", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ab9812914744ccf9c4f93794cab9293.json"}}, {"family": "Lauc", "given": "Gordan", "initials": "G"}, {"family": "Najafi-Shoushtari", "given": "S Hani", "initials": "SH"}, {"family": "Malek", "given": "Joel A", "initials": "JA", "orcid": "0000-0002-1516-8477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8f8b4ff9a0214bfc8e822ef97285f2fe.json"}}, {"family": "Graumann", "given": "Johannes", "initials": "J", "orcid": "0000-0002-3015-5850", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/991390e9be11418e9679d4781ee0bf1e.json"}}, {"family": "Mook-Kanamori", "given": "Dennis", "initials": "D"}, {"family": "Schmidt", "given": "Frank", "initials": "F"}, {"family": "Suhre", "given": "Karsten", "initials": "K"}], "type": "journal article", "published": "2024-08-19", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "7111", "issn-l": "2041-1723"}, "abstract": "In-depth multiomic phenotyping provides molecular insights into complex physiological processes and their pathologies. Here, we report on integrating 18 diverse deep molecular phenotyping (omics-) technologies applied to urine, blood, and saliva samples from 391 participants of the multiethnic diabetes Qatar Metabolomics Study of Diabetes (QMDiab). Using 6,304 quantitative molecular traits with 1,221,345 genetic variants, methylation at 470,837 DNA CpG sites, and gene expression of 57,000 transcripts, we determine (1) within-platform partial correlations, (2) between-platform mutual best correlations, and (3) genome-, epigenome-, transcriptome-, and phenome-wide associations. Combined into a molecular network of > 34,000 statistically significant trait-trait links in biofluids, our study portrays \"The Molecular Human\". We describe the variances explained by each omics in the phenotypes (age, sex, BMI, and diabetes state), platform complementarity, and the inherent correlation structures of multiomics data. Further, we construct multi-molecular network of diabetes subtypes. Finally, we generated an open-access web interface to \"The Molecular Human\" ( http://comics.metabolomix.com ), providing interactive data exploration and hypotheses generation possibilities.", "doi": "10.1038/s41467-024-51134-x", "pmid": "39160153", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11333501"}, {"db": "pii", "key": "10.1038/s41467-024-51134-x"}], "notes": [], "created": "2026-08-20T08:53:34.466Z", "modified": "2026-08-20T08:53:34.953Z"}]}