{"entity": "researcher", "timestamp": "2026-08-23T10:13:03.438Z", "family": "Ljungdahl", "given": "Per O", "initials": "PO", "orcid": "0000-0002-6625-3540", "affiliations": ["Department of Molecular Biosciences, The Wenner-Gren Institute, SciLifeLab, Stockholm University, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/683fcaec33bf44159f021fde794c746c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/683fcaec33bf44159f021fde794c746c"}}, "publications": [{"entity": "publication", "iuid": "5ab9db4f7d94446bb0b65b6eae14fdca", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5ab9db4f7d94446bb0b65b6eae14fdca.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5ab9db4f7d94446bb0b65b6eae14fdca"}}, "title": "Proline catabolism is a key factor facilitating Candida albicans pathogenicity.", "authors": [{"family": "Silao", "given": "Fitz Gerald S", "initials": "FGS"}, {"family": "Jiang", "given": "Tong", "initials": "T"}, {"family": "Bereczky-Veress", "given": "Biborka", "initials": "B"}, {"family": "K\u00fchbacher", "given": "Andreas", "initials": "A"}, {"family": "Ryman", "given": "Kicki", "initials": "K"}, {"family": "Uwamohoro", "given": "Nathalie", "initials": "N"}, {"family": "Jenull", "given": "Sabrina", "initials": "S"}, {"family": "Nogueira", "given": "Filomena", "initials": "F"}, {"family": "Ward", "given": "Meliza", "initials": "M"}, {"family": "Lion", "given": "Thomas", "initials": "T"}, {"family": "Urban", "given": "Constantin F", "initials": "CF"}, {"family": "Rupp", "given": "Steffen", "initials": "S"}, {"family": "Kuchler", "given": "Karl", "initials": "K"}, {"family": "Chen", "given": "Changbin", "initials": "C"}, {"family": "Peuckert", "given": "Christiane", "initials": "C"}, {"family": "Ljungdahl", "given": "Per O", "initials": "PO", "orcid": "0000-0002-6625-3540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/683fcaec33bf44159f021fde794c746c.json"}}], "type": "journal article", "published": "2023-11-00", "journal": {"title": "PLoS Pathog", "issn": "1553-7374", "volume": "19", "issue": "11", "pages": "e1011677", "issn-l": "1553-7366"}, "abstract": "Candida albicans, the primary etiology of human mycoses, is well-adapted to catabolize proline to obtain energy to initiate morphological switching (yeast to hyphal) and for growth. We report that put1-/- and put2-/- strains, carrying defective Proline UTilization genes, display remarkable proline sensitivity with put2-/- mutants being hypersensitive due to the accumulation of the toxic intermediate pyrroline-5-carboxylate (P5C), which inhibits mitochondrial respiration. The put1-/- and put2-/- mutations attenuate virulence in Drosophila and murine candidemia models and decrease survival in human neutrophils and whole blood. Using intravital 2-photon microscopy and label-free non-linear imaging, we visualized the initial stages of C. albicans cells infecting a kidney in real-time, directly deep in the tissue of a living mouse, and observed morphological switching of wildtype but not of put2-/- cells. Multiple members of the Candida species complex, including C. auris, are capable of using proline as a sole energy source. Our results indicate that a tailored proline metabolic network tuned to the mammalian host environment is a key feature of opportunistic fungal pathogens.", "doi": "10.1371/journal.ppat.1011677", "pmid": "37917600", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10621835"}, {"db": "pii", "key": "PPATHOGENS-D-23-01138"}], "notes": [], "created": "2026-08-20T12:44:55.325Z", "modified": "2026-08-20T12:44:55.391Z"}, {"entity": "publication", "iuid": "9a364201be9a48ed9ca77152e18a2f74", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9a364201be9a48ed9ca77152e18a2f74.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9a364201be9a48ed9ca77152e18a2f74"}}, "title": "ER-localized Shr3 is a selective co-translational folding chaperone necessary for amino acid permease biogenesis.", "authors": [{"family": "Myronidi", "given": "Ioanna", "initials": "I", "orcid": "0009-0002-3935-7886", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5a4d8f40c13c4036a43df4348544afdb.json"}}, {"family": "Ring", "given": "Andreas", "initials": "A", "orcid": "0009-0005-7590-827X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/824ad42d0b4641c992e6e3fe7a866e0b.json"}}, {"family": "Wu", "given": "Fei", "initials": "F", "orcid": "0000-0002-0120-7586", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ab3c51eb8ec34ecb86ec4b5ea576507d.json"}}, {"family": "Ljungdahl", "given": "Per O", "initials": "PO", "orcid": "0000-0002-6625-3540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/683fcaec33bf44159f021fde794c746c.json"}}], "type": "journal article", "published": "2023-09-04", "journal": {"title": "J. Cell Biol.", "issn": "1540-8140", "volume": "222", "issue": "9", "issn-l": "0021-9525"}, "abstract": "Proteins with multiple membrane-spanning segments (MS) co-translationally insert into the endoplasmic reticulum (ER) membrane of eukaryotic cells. Shr3, an ER membrane-localized chaperone in Saccharomyces cerevisiae, is required for the functional expression of a family of 18 amino acid permeases (AAP) comprised of 12 MS. We have used comprehensive scanning mutagenesis and deletion analysis of Shr3 combined with a modified split-ubiquitin approach to probe chaperone-substrate interactions in vivo. Shr3 selectively interacts with nested C-terminal AAP truncations in marked contrast to similar truncations of non-Shr3 substrate sugar transporters. Shr3-AAP interactions initiate with the first four MS of AAP and successively strengthen but weaken abruptly when all 12 MS are present. Shr3-AAP interactions are based on structural rather than sequence-specific interactions involving membrane and luminal domains of Shr3. The data align with Shr3 engaging nascent N-terminal chains of AAP, functioning as a scaffold to facilitate folding as translation completes.", "doi": "10.1083/jcb.202208060", "pmid": "37477900", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10359922"}, {"db": "pii", "key": "214248"}], "notes": [], "created": "2026-08-20T09:38:00.519Z", "modified": "2026-08-20T09:38:00.745Z"}, {"entity": "publication", "iuid": "8bb1885075cf4edfaef5f47786b3f22e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8bb1885075cf4edfaef5f47786b3f22e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8bb1885075cf4edfaef5f47786b3f22e"}}, "title": "Diverse mechanisms control amino acid-dependent environmental alkalization by Candida albicans", "authors": [{"family": "Silao", "given": "Fitz Gerald S", "initials": "FGS", "orcid": "0000-0002-4350-8395", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2759166353e14a7683c0833cb5503b43.json"}}, {"family": "Valeriano", "given": "Valerie Diane", "initials": "VD"}, {"family": "Uddstr\u00f6m", "given": "Erika", "initials": "E"}, {"family": "Falconer", "given": "Emilie", "initials": "E"}, {"family": "Ljungdahl", "given": "Per O", "initials": "PO", "orcid": "0000-0002-6625-3540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/683fcaec33bf44159f021fde794c746c.json"}}], "type": "posted-content", "published": "2023-08-04", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.08.04.551922", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:47:21.535Z", "modified": "2026-08-20T10:47:21.614Z"}, {"entity": "publication", "iuid": "fda6602a682b452199d8327ac62bf06f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fda6602a682b452199d8327ac62bf06f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fda6602a682b452199d8327ac62bf06f"}}, "title": "Proline catabolism is key to facilitating Candida albicans pathogenicity", "authors": [{"family": "Silao", "given": "Fitz Gerald S", "initials": "FGS"}, {"family": "Jiang", "given": "Tong", "initials": "T"}, {"family": "Bereczky-Veress", "given": "Biborka", "initials": "B"}, {"family": "K\u00fchbacher", "given": "Andreas", "initials": "A"}, {"family": "Ryman", "given": "Kicki", "initials": "K"}, {"family": "Uwamohoro", "given": "Nathalie", "initials": "N"}, {"family": "Jenull", "given": "Sabrina", "initials": "S"}, {"family": "Nogueira", "given": "Filomena", "initials": "F"}, {"family": "Ward", "given": "Meliza", "initials": "M"}, {"family": "Lion", "given": "Thomas", "initials": "T", "orcid": "0000-0001-9346-0994", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49bab12498c7499c80e625210a29bcf0.json"}}, {"family": "Urban", "given": "Constantin F", "initials": "CF", "orcid": "0000-0003-1438-1134", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d8ba3b5dad14d9988ec43b3ca1021d5.json"}}, {"family": "Rupp", "given": "Steffen", "initials": "S"}, {"family": "Kuchler", "given": "Karl", "initials": "K", "orcid": "0000-0003-2719-5955", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40c1b4b13ca9424193b663f33cf48056.json"}}, {"family": "Chen", "given": "Changbin", "initials": "C", "orcid": "0000-0002-7961-3488", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2f0b4d61ffba48a5bd133ee4515c54d8.json"}}, {"family": "Peuckert", "given": "Christiane", "initials": "C", "orcid": "0000-0002-5973-1241", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bfe091a9c2294c55be444b704d7e0711.json"}}, {"family": "Ljungdahl", "given": "Per O", "initials": "PO", "orcid": "0000-0002-6625-3540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/683fcaec33bf44159f021fde794c746c.json"}}], "type": "posted-content", "published": "2023-01-18", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.01.17.524449", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:43:29.095Z", "modified": "2026-08-20T10:43:29.322Z"}]}