{"entity": "researcher", "timestamp": "2026-08-20T20:37:07.056Z", "family": "Ellenberg", "given": "Jan", "initials": "J", "orcid": "0000-0001-5909-701X", "affiliations": ["Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/67f7ee86921648c09c58203cc33343c5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/67f7ee86921648c09c58203cc33343c5"}}, "publications": [{"entity": "publication", "iuid": "170a4ecdd5054214b01b05bb3c3251d3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/170a4ecdd5054214b01b05bb3c3251d3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/170a4ecdd5054214b01b05bb3c3251d3"}}, "title": "Enabling global image data sharing in the life sciences.", "authors": [{"family": "Bajcsy", "given": "Peter", "initials": "P", "orcid": "0000-0002-6968-2615", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/21af7e4a4bda4c4391682864a018922a.json"}}, {"family": "Bhattiprolu", "given": "Sreenivas", "initials": "S"}, {"family": "B\u00f6rner", "given": "Katy", "initials": "K", "orcid": "0000-0002-3321-6137", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b8e7ebf67ae49e3b436a7c1252f7126.json"}}, {"family": "Cimini", "given": "Beth A", "initials": "BA", "orcid": "0000-0001-9640-9318", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cbe15524bb604092be6daf433faa9610.json"}}, {"family": "Collinson", "given": "Lucy", "initials": "L", "orcid": "0000-0003-0260-613X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bf7d324482f7440ea46e98de50a61a25.json"}}, {"family": "Ellenberg", "given": "Jan", "initials": "J", "orcid": "0000-0001-5909-701X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67f7ee86921648c09c58203cc33343c5.json"}}, {"family": "Fiolka", "given": "Reto", "initials": "R", "orcid": "0000-0002-4636-5000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d57124e94b34f8baf84480fd16b4ae1.json"}}, {"family": "Giger", "given": "Maryellen", "initials": "M", "orcid": "0000-0001-5482-9728", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e799cca204df420b9d4a8cbdfdd64457.json"}}, {"family": "Goscinski", "given": "Wojtek", "initials": "W"}, {"family": "Hartley", "given": "Matthew", "initials": "M", "orcid": "0000-0001-6178-2884", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/891c0d850b244c209d1852b74d2a532f.json"}}, {"family": "Hotaling", "given": "Nathan", "initials": "N", "orcid": "0000-0001-8423-6464", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e526892854084fe5ab16081f86d38d22.json"}}, {"family": "Horwitz", "given": "Rick", "initials": "R"}, {"family": "Jug", "given": "Florian", "initials": "F"}, {"family": "Kemmer", "given": "Isabel", "initials": "I", "orcid": "0000-0002-8799-4671", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a57707af5004625b1e97690db74e488.json"}}, {"family": "Kreshuk", "given": "Anna", "initials": "A", "orcid": "0000-0003-1334-6388", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1408e8d1447d4b56b3d713994bea8152.json"}}, {"family": "Lundberg", "given": "Emma", "initials": "E", "orcid": "0000-0001-7034-0850", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb07e6d0122c4528a927c1fe922e3bc8.json"}}, {"family": "Mathur", "given": "Aastha", "initials": "A", "orcid": "0000-0001-9734-9767", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d5aaf42f4d094459b5efd7aae5a949c9.json"}}, {"family": "Narayan", "given": "Kedar", "initials": "K"}, {"family": "Onami", "given": "Shuichi", "initials": "S", "orcid": "0000-0002-8255-1724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/83ea9aff97ad4f03ac4982160b20365f.json"}}, {"family": "Plant", "given": "Anne L", "initials": "AL", "orcid": "0000-0002-8538-401X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/42209314925d423e9bf2f86950323d3b.json"}}, {"family": "Prior", "given": "Fred", "initials": "F", "orcid": "0000-0002-6314-5683", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/515cf41cf119493487f9ace39279c65a.json"}}, {"family": "Swedlow", "given": "Jason R", "initials": "JR", "orcid": "0000-0002-2198-1958", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/919be1b6ecf34615a2c3e2a05f6c01de.json"}}, {"family": "Taylor", "given": "Adam", "initials": "A", "orcid": "0000-0003-0501-8886", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6415444caf2c46daabfea259cc1d093e.json"}}, {"family": "Keppler", "given": "Antje", "initials": "A", "orcid": "0000-0003-4358-2269", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/034f55795b814833a2382917f5206a27.json"}}], "type": "journal article", "published": "2025-04-00", "journal": {"title": "Nat. Methods", "issn": "1548-7105", "volume": "22", "issue": "4", "pages": "672-676", "issn-l": "1548-7091"}, "abstract": "Despite the importance of imaging in biological and medical research, a large body of informative and precious image data never sees the light of day. To ensure scientific rigor as well as the reuse of data for scientific discovery, image data need to be made FAIR (findable, accessible, interoperable and reusable). Image data experts are working together globally to agree on common data formats, metadata, ontologies and supporting tools toward image data FAIRification. With this Perspective, we call on public funders to join these efforts to support their national scientists. What researchers most urgently need are openly accessible resources for image data storage that are operated under long-term commitments by their funders. Although existing resources in Australia, Japan and Europe are already collaborating to enable global image data sharing, these efforts will fall short unless more countries invest in operating and federating their own open data resources. This will allow us to harvest the enormous potential of existing image data, preventing substantial loss of unrealized value from past investments in imaging acquisition infrastructure.", "doi": "10.1038/s41592-024-02585-z", "pmid": "40155720", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS2083445"}, {"db": "pmc", "key": "PMC12617600"}, {"db": "pii", "key": "10.1038/s41592-024-02585-z"}], "notes": [], "created": "2026-08-20T09:03:23.272Z", "modified": "2026-08-20T09:03:23.746Z"}, {"entity": "publication", "iuid": "a528428064ae4b38b54f7b2697c725bb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a528428064ae4b38b54f7b2697c725bb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a528428064ae4b38b54f7b2697c725bb"}}, "title": "Quantitative imaging of loop extruders rebuilding interphase genome architecture after mitosis.", "authors": [{"family": "Brunner", "given": "Andreas", "initials": "A", "orcid": "0000-0003-3136-6382", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/af4031a5e48b487f81f15fdb0f862e57.json"}}, {"family": "Morero", "given": "Natalia Rosal\u00eda", "initials": "NR", "orcid": "0000-0003-0092-5663", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ff53c1e01ed049bc8660fdaffee89b82.json"}}, {"family": "Zhang", "given": "Wanlu", "initials": "W", "orcid": "0000-0002-7119-1874", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bec7104b7d554641827c511cb16b7581.json"}}, {"family": "Hossain", "given": "M Julius", "initials": "MJ", "orcid": "0000-0003-3303-5755", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a4b2458c84c4b7580e6c74e351025ff.json"}}, {"family": "Lampe", "given": "Marko", "initials": "M", "orcid": "0000-0002-4510-9048", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cea6fdf3137c41b08ad8f8eec9f12a83.json"}}, {"family": "Pflaumer", "given": "Hannah", "initials": "H", "orcid": "0000-0003-4927-0899", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/17f536901684477b8fdc2c0ce72717fa.json"}}, {"family": "Halavatyi", "given": "Aliaksandr", "initials": "A", "orcid": "0000-0002-9002-457X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a828d30a9035425d87aff870c52c8417.json"}}, {"family": "Peters", "given": "Jan-Michael", "initials": "JM", "orcid": "0000-0003-2820-3195", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c58f6fb420e84e1d8bc9d8a6d45bbdb0.json"}}, {"family": "Beckwith", "given": "Kai S", "initials": "KS", "orcid": "0000-0001-5598-5482", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8532ff94e6f44e78e036eaf6c4df22a.json"}}, {"family": "Ellenberg", "given": "Jan", "initials": "J", "orcid": "0000-0001-5909-701X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67f7ee86921648c09c58203cc33343c5.json"}}], "type": "journal article", "published": "2025-03-03", "journal": {"title": "J. Cell Biol.", "issn": "1540-8140", "volume": "224", "issue": "3", "issn-l": "0021-9525"}, "abstract": "How cells establish the interphase genome organization after mitosis is incompletely understood. Using quantitative and super-resolution microscopy, we show that the transition from a Condensin to a Cohesin-based genome organization occurs dynamically over 2 h. While a significant fraction of Condensins remains chromatin-bound until early G1, Cohesin-STAG1 and its boundary factor CTCF are rapidly imported into daughter nuclei in telophase, immediately bind chromosomes as individual complexes, and are sufficient to build the first interphase TAD structures. By contrast, the more abundant Cohesin-STAG2 accumulates on chromosomes only gradually later in G1, is responsible for compaction inside TAD structures, and forms paired complexes upon completed nuclear import. Our quantitative time-resolved mapping of mitotic and interphase loop extruders in single cells reveals that the nested loop architecture formed by the sequential action of two Condensins in mitosis is seamlessly replaced by a less compact but conceptually similar hierarchically nested loop architecture driven by the sequential action of two Cohesins.", "doi": "10.1083/jcb.202405169", "pmid": "39786339", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11716112"}, {"db": "pii", "key": "277205"}], "notes": [], "created": "2026-08-20T09:38:06.478Z", "modified": "2026-08-20T09:38:06.935Z"}, {"entity": "publication", "iuid": "d2daa621c5554d7192e988d86c89389a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d2daa621c5554d7192e988d86c89389a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d2daa621c5554d7192e988d86c89389a"}}, "title": "Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine.", "authors": [{"family": "Rajewsky", "given": "Nikolaus", "initials": "N", "orcid": "0000-0002-4785-4332", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0cf747828b154767998f0cae7fbb34d5.json"}}, {"family": "Almouzni", "given": "Genevi\u00e8ve", "initials": "G", "orcid": "0000-0001-5570-0723", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88fe5eb60772442bb6da89fd543d9310.json"}}, {"family": "Gorski", "given": "Stanislaw A", "initials": "SA", "orcid": "0000-0003-0539-3395", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b1a674ee82748cbb9ed568585802ba3.json"}}, {"family": "Aerts", "given": "Stein", "initials": "S", "orcid": "0000-0002-8006-0315", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/be6cbc0893a042ffbc7defa3aceb3a2b.json"}}, {"family": "Amit", "given": "Ido", "initials": "I", "orcid": "0000-0003-2968-877X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eeb03f7c1069416c97c07624c32f3a88.json"}}, {"family": "Bertero", "given": "Michela G", "initials": "MG"}, {"family": "Bock", "given": "Christoph", "initials": "C", "orcid": "0000-0001-6091-3088", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/78502e5803db472980b13c6f5d24f9e6.json"}}, {"family": "Bredenoord", "given": "Annelien L", "initials": "AL", "orcid": "0000-0002-7542-8963", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e245f46e1294028a3378ab914e469ca.json"}}, {"family": "Cavalli", "given": "Giacomo", "initials": "G", "orcid": "0000-0003-3709-3469", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a1f64a0909ee42c481b87ed65a0aa475.json"}}, {"family": "Chiocca", "given": "Susanna", "initials": "S", "orcid": "0000-0002-9721-0850", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e947e71699a43b2a92a296df895fdd9.json"}}, {"family": "Clevers", "given": "Hans", "initials": "H", "orcid": "0000-0002-3077-5582", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1064100a57194938b25d307e5f069b20.json"}}, {"family": "De Strooper", "given": "Bart", "initials": "B"}, {"family": "Eggert", "given": "Angelika", "initials": "A"}, {"family": "Ellenberg", "given": "Jan", "initials": "J", "orcid": "0000-0001-5909-701X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67f7ee86921648c09c58203cc33343c5.json"}}, {"family": "Fern\u00e1ndez", "given": "Xos\u00e9 M", "initials": "XM", "orcid": "0000-0001-7139-6215", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5639aec2151c4f55bbaf4e44e78de388.json"}}, {"family": "Figlerowicz", "given": "Marek", "initials": "M"}, {"family": "Gasser", "given": "Susan M", "initials": "SM", "orcid": "0000-0003-3610-9123", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c1274a1f1e34f93bbebe0ab2ab0c77c.json"}}, {"family": "Hubner", "given": "Norbert", "initials": "N", "orcid": "0000-0002-1218-6223", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f8fcb2e3ce2473b8a89b74727da5bb0.json"}}, {"family": "Kjems", "given": "J\u00f8rgen", "initials": "J"}, {"family": "Knoblich", "given": "J\u00fcrgen A", "initials": "JA", "orcid": "0000-0002-6751-3404", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b97769df0fcb489ebe52aab850d9848f.json"}}, {"family": "Krabbe", "given": "Grietje", "initials": "G"}, {"family": "Lichter", "given": "Peter", "initials": "P", "orcid": "0000-0002-2960-5279", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e2111252b5343e6b5779f1304754ff0.json"}}, {"family": "Linnarsson", "given": "Sten", "initials": "S", "orcid": "0000-0002-3491-3444", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/638b2874e1144bf497bc96f9bce5ccb9.json"}}, {"family": "Marine", "given": "Jean-Christophe", "initials": "JC"}, {"family": "Marioni", "given": "John C", "initials": "JC", "orcid": "0000-0001-9092-0852", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/179ba540a36e46c382cde6998c0a7571.json"}}, {"family": "Marti-Renom", "given": "Marc A", "initials": "MA", "orcid": "0000-0002-0151-4279", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/62d556042a4d4bbb98fcd1919c30ab80.json"}}, {"family": "Netea", "given": "Mihai G", "initials": "MG", "orcid": "0000-0003-2421-6052", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc9fee096a4840d49b0fce39e25fdb0e.json"}}, {"family": "Nickel", "given": "D\u00f6rthe", "initials": "D"}, {"family": "Nollmann", "given": "Marcelo", "initials": "M", "orcid": "0000-0003-3339-2349", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1f756c3d68a749d0b35b034f8494275e.json"}}, {"family": "Novak", "given": "Halina R", "initials": "HR"}, {"family": "Parkinson", "given": "Helen", "initials": "H"}, {"family": "Piccolo", "given": "Stefano", "initials": "S", "orcid": "0000-0002-1600-3092", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/90e37cdcdb4d4234a02c0c7ebd0184c7.json"}}, {"family": "Pinheiro", "given": "In\u00eas", "initials": "I"}, {"family": "Pombo", "given": "Ana", "initials": "A", "orcid": "0000-0002-7493-6288", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38221f014128457ba26570dc7f39ee03.json"}}, {"family": "Popp", "given": "Christian", "initials": "C"}, {"family": "Reik", "given": "Wolf", "initials": "W", "orcid": "0000-0003-0216-9881", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a94169b900448e6b103dc7a676bdc80.json"}}, {"family": "Roman-Roman", "given": "Sergio", "initials": "S"}, {"family": "Rosenstiel", "given": "Philip", "initials": "P"}, {"family": "Schultze", "given": "Joachim L", "initials": "JL", "orcid": "0000-0003-2812-9853", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f3fd61f889ea417c8d866cdc3eee9dc4.json"}}, {"family": "Stegle", "given": "Oliver", "initials": "O"}, {"family": "Tanay", "given": "Amos", "initials": "A", "orcid": "0000-0001-9419-3824", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/79d89f91321f481c88ae8cb3ac47b91e.json"}}, {"family": "Testa", "given": "Giuseppe", "initials": "G"}, {"family": "Thanos", "given": "Dimitris", "initials": "D"}, {"family": "Theis", "given": "Fabian J", "initials": "FJ", "orcid": "0000-0002-2419-1943", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8969d033a36f40aab191ad1b3960114d.json"}}, {"family": "Torres-Padilla", "given": "Maria-Elena", "initials": "ME", "orcid": "0000-0002-1020-2074", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eff16da68dab4d46824ef56f3285de75.json"}}, {"family": "Valencia", "given": "Alfonso", "initials": "A"}, {"family": "Vallot", "given": "C\u00e9line", "initials": "C", "orcid": "0000-0003-1601-2359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3094c4eff5fd46349912630f1770636a.json"}}, {"family": "van Oudenaarden", "given": "Alexander", "initials": "A", "orcid": "0000-0002-9442-3551", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/33649d3f227046eea9f3b3ce835d9057.json"}}, {"family": "Vidal", "given": "Marie", "initials": "M", "orcid": "0000-0003-1186-9994", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/077f341fdc4441d681ee1ecbd8edd039.json"}}, {"family": "Voet", "given": "Thierry", "initials": "T"}, {"family": "LifeTime Community Working Groups", "given": "", "initials": ""}], "type": "published erratum", "published": "2021-04-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "592", "issue": "7852", "pages": "E8", "issn-l": "0028-0836"}, "abstract": null, "doi": "10.1038/s41586-021-03287-8", "pmid": "33731935", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8009763"}, {"db": "pii", "key": "10.1038/s41586-021-03287-8"}], "notes": [], "created": "2026-08-20T08:56:24.854Z", "modified": "2026-08-20T08:57:10.035Z"}, {"entity": "publication", "iuid": "bf2cb9d3c9e34c97be339d2b8fbb480d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bf2cb9d3c9e34c97be339d2b8fbb480d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bf2cb9d3c9e34c97be339d2b8fbb480d"}}, "title": "LifeTime and improving European healthcare through cell-based interceptive medicine.", "authors": [{"family": "Rajewsky", "given": "Nikolaus", "initials": "N", "orcid": "0000-0002-4785-4332", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0cf747828b154767998f0cae7fbb34d5.json"}}, {"family": "Almouzni", "given": "Genevi\u00e8ve", "initials": "G", "orcid": "0000-0001-5570-0723", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88fe5eb60772442bb6da89fd543d9310.json"}}, {"family": "Gorski", "given": "Stanislaw A", "initials": "SA", "orcid": "0000-0003-0539-3395", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b1a674ee82748cbb9ed568585802ba3.json"}}, {"family": "Aerts", "given": "Stein", "initials": "S", "orcid": "0000-0002-8006-0315", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/be6cbc0893a042ffbc7defa3aceb3a2b.json"}}, {"family": "Amit", "given": "Ido", "initials": "I", "orcid": "0000-0003-2968-877X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eeb03f7c1069416c97c07624c32f3a88.json"}}, {"family": "Bertero", "given": "Michela G", "initials": "MG"}, {"family": "Bock", "given": "Christoph", "initials": "C", "orcid": "0000-0001-6091-3088", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/78502e5803db472980b13c6f5d24f9e6.json"}}, {"family": "Bredenoord", "given": "Annelien L", "initials": "AL", "orcid": "0000-0002-7542-8963", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e245f46e1294028a3378ab914e469ca.json"}}, {"family": "Cavalli", "given": "Giacomo", "initials": "G", "orcid": "0000-0003-3709-3469", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a1f64a0909ee42c481b87ed65a0aa475.json"}}, {"family": "Chiocca", "given": "Susanna", "initials": "S", "orcid": "0000-0002-9721-0850", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e947e71699a43b2a92a296df895fdd9.json"}}, {"family": "Clevers", "given": "Hans", "initials": "H", "orcid": "0000-0002-3077-5582", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1064100a57194938b25d307e5f069b20.json"}}, {"family": "De Strooper", "given": "Bart", "initials": "B"}, {"family": "Eggert", "given": "Angelika", "initials": "A"}, {"family": "Ellenberg", "given": "Jan", "initials": "J", "orcid": "0000-0001-5909-701X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67f7ee86921648c09c58203cc33343c5.json"}}, {"family": "Fern\u00e1ndez", "given": "Xos\u00e9 M", "initials": "XM", "orcid": "0000-0001-7139-6215", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5639aec2151c4f55bbaf4e44e78de388.json"}}, {"family": "Figlerowicz", "given": "Marek", "initials": "M"}, {"family": "Gasser", "given": "Susan M", "initials": "SM", "orcid": "0000-0003-3610-9123", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c1274a1f1e34f93bbebe0ab2ab0c77c.json"}}, {"family": "Hubner", "given": "Norbert", "initials": "N", "orcid": "0000-0002-1218-6223", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f8fcb2e3ce2473b8a89b74727da5bb0.json"}}, {"family": "Kjems", "given": "J\u00f8rgen", "initials": "J"}, {"family": "Knoblich", "given": "J\u00fcrgen A", "initials": "JA", "orcid": "0000-0002-6751-3404", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b97769df0fcb489ebe52aab850d9848f.json"}}, {"family": "Krabbe", "given": "Grietje", "initials": "G"}, {"family": "Lichter", "given": "Peter", "initials": "P", "orcid": "0000-0002-2960-5279", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e2111252b5343e6b5779f1304754ff0.json"}}, {"family": "Linnarsson", "given": "Sten", "initials": "S", "orcid": "0000-0002-3491-3444", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/638b2874e1144bf497bc96f9bce5ccb9.json"}}, {"family": "Marine", "given": "Jean-Christophe", "initials": "JC"}, {"family": "Marioni", "given": "John C", "initials": "JC", "orcid": "0000-0001-9092-0852", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/179ba540a36e46c382cde6998c0a7571.json"}}, {"family": "Marti-Renom", "given": "Marc A", "initials": "MA", "orcid": "0000-0002-0151-4279", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/62d556042a4d4bbb98fcd1919c30ab80.json"}}, {"family": "Netea", "given": "Mihai G", "initials": "MG", "orcid": "0000-0003-2421-6052", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc9fee096a4840d49b0fce39e25fdb0e.json"}}, {"family": "Nickel", "given": "D\u00f6rthe", "initials": "D"}, {"family": "Nollmann", "given": "Marcelo", "initials": "M", "orcid": "0000-0003-3339-2349", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1f756c3d68a749d0b35b034f8494275e.json"}}, {"family": "Novak", "given": "Halina R", "initials": "HR"}, {"family": "Parkinson", "given": "Helen", "initials": "H"}, {"family": "Piccolo", "given": "Stefano", "initials": "S", "orcid": "0000-0002-1600-3092", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/90e37cdcdb4d4234a02c0c7ebd0184c7.json"}}, {"family": "Pinheiro", "given": "In\u00eas", "initials": "I"}, {"family": "Pombo", "given": "Ana", "initials": "A", "orcid": "0000-0002-7493-6288", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38221f014128457ba26570dc7f39ee03.json"}}, {"family": "Popp", "given": "Christian", "initials": "C"}, {"family": "Reik", "given": "Wolf", "initials": "W", "orcid": "0000-0003-0216-9881", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a94169b900448e6b103dc7a676bdc80.json"}}, {"family": "Roman-Roman", "given": "Sergio", "initials": "S"}, {"family": "Rosenstiel", "given": "Philip", "initials": "P"}, {"family": "Schultze", "given": "Joachim L", "initials": "JL", "orcid": "0000-0003-2812-9853", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f3fd61f889ea417c8d866cdc3eee9dc4.json"}}, {"family": "Stegle", "given": "Oliver", "initials": "O"}, {"family": "Tanay", "given": "Amos", "initials": "A", "orcid": "0000-0001-9419-3824", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/79d89f91321f481c88ae8cb3ac47b91e.json"}}, {"family": "Testa", "given": "Giuseppe", "initials": "G"}, {"family": "Thanos", "given": "Dimitris", "initials": "D"}, {"family": "Theis", "given": "Fabian J", "initials": "FJ", "orcid": "0000-0002-2419-1943", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8969d033a36f40aab191ad1b3960114d.json"}}, {"family": "Torres-Padilla", "given": "Maria-Elena", "initials": "ME", "orcid": "0000-0002-1020-2074", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eff16da68dab4d46824ef56f3285de75.json"}}, {"family": "Valencia", "given": "Alfonso", "initials": "A"}, {"family": "Vallot", "given": "C\u00e9line", "initials": "C", "orcid": "0000-0003-1601-2359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3094c4eff5fd46349912630f1770636a.json"}}, {"family": "van Oudenaarden", "given": "Alexander", "initials": "A", "orcid": "0000-0002-9442-3551", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/33649d3f227046eea9f3b3ce835d9057.json"}}, {"family": "Vidal", "given": "Marie", "initials": "M", "orcid": "0000-0003-1186-9994", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/077f341fdc4441d681ee1ecbd8edd039.json"}}, {"family": "Voet", "given": "Thierry", "initials": "T"}, {"family": "LifeTime Community Working Groups", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "587", "issue": "7834", "pages": "377-386", "issn-l": "0028-0836"}, "abstract": "Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during the progression from health to disease. The analysis of large molecular and clinical datasets will identify molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. The timely detection and interception of disease embedded in an ethical and patient-centred vision will be achieved through interactions across academia, hospitals, patient associations, health data management systems and industry. The application of this strategy to key medical challenges in cancer, neurological and neuropsychiatric disorders, and infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.", "doi": "10.1038/s41586-020-2715-9", "pmid": "32894860", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7656507"}, {"db": "pii", "key": "10.1038/s41586-020-2715-9"}], "notes": [], "created": "2026-08-20T08:56:17.301Z", "modified": "2026-08-20T08:56:55.192Z"}]}