{"entity": "researcher", "timestamp": "2026-09-01T09:04:57.676Z", "family": "Revez", "given": "Joana A", "initials": "JA", "orcid": "0000-0003-3204-5396", "affiliations": ["QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/676884893903466f9d6e48630512846f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/676884893903466f9d6e48630512846f"}}, "publications": [{"entity": "publication", "iuid": "5b9db7b8dd2f44f1a00540111157187f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5b9db7b8dd2f44f1a00540111157187f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5b9db7b8dd2f44f1a00540111157187f"}}, "title": "Genome-wide association study of circulating interleukin 6 levels identifies novel loci.", "authors": [{"family": "Ahluwalia", "given": "Tarunveer S", "initials": "TS", 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"Eriksson", "given": "Johan G", "initials": "JG"}, {"family": "Evans", "given": "David M", "initials": "DM"}, {"family": "Ferreira", "given": "Manuel A", "initials": "MA"}, {"family": "Gaunt", "given": "Tom", "initials": "T"}, {"family": "Gudnason", "given": "Vilmundur", "initials": "V"}, {"family": "Hamsten", "given": "Anders", "initials": "A"}, {"family": "Heinrich", "given": "Joachim", "initials": "J"}, {"family": "Hingorani", "given": "Aroon", "initials": "A"}, {"family": "Humphries", "given": "Steve E", "initials": "SE"}, {"family": "Jukema", "given": "J Wouter", "initials": "JW"}, {"family": "Koenig", "given": "Wolfgang", "initials": "W"}, {"family": "Kumari", "given": "Meena", "initials": "M"}, {"family": "Kutalik", "given": "Zoltan", "initials": "Z"}, {"family": "Lawlor", "given": "Deborah A", "initials": "DA"}, {"family": "Lehtim\u00e4ki", "given": "Terho", "initials": "T"}, {"family": "M\u00e4rz", "given": "Winfried", "initials": "W"}, {"family": "Mather", "given": "Karen A", "initials": "KA"}, {"family": "Naitza", "given": "Silvia", "initials": "S"}, {"family": "Nauck", "given": "Matthias", "initials": "M"}, {"family": "Ohlsson", "given": "Claes", "initials": "C"}, {"family": "Price", "given": "Jackie F", "initials": "JF"}, {"family": "Raitakari", "given": "Olli", "initials": "O"}, {"family": "Rice", "given": "Ken", "initials": "K"}, {"family": "Sachdev", "given": "Perminder S", "initials": "PS"}, {"family": "Slagboom", "given": "Eline", "initials": "E"}, {"family": "S\u00f8rensen", "given": "Thorkild I A", "initials": "TIA"}, {"family": "Spector", "given": "Tim", "initials": "T"}, {"family": "Stacey", "given": "David", "initials": "D"}, {"family": "Stathopoulou", "given": "Maria G", "initials": "MG"}, {"family": "Tanaka", "given": "Toshiko", "initials": "T"}, {"family": "Wannamethee", "given": "S Goya", "initials": "SG"}, {"family": "Whincup", "given": "Peter", "initials": "P"}, {"family": "Rotter", "given": "Jerome I", "initials": "JI"}, {"family": "Dehghan", "given": "Abbas", "initials": "A"}, {"family": "Boerwinkle", "given": "Eric", "initials": "E"}, {"family": "Psaty", "given": "Bruce M", "initials": "BM"}, {"family": "Snieder", "given": "Harold", "initials": "H"}, {"family": "Alizadeh", "given": "Behrooz Z", "initials": "BZ"}], "type": "journal article", "published": "2021-04-27", "journal": {"title": "Hum. Mol. Genet.", "issn": "1460-2083", "volume": "30", "issue": "5", "pages": "393-409", "issn-l": "0964-6906"}, "abstract": "Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (Pcombined = 1.8 \u00d7 10-11), HLA-DRB1/DRB5 rs660895 on Chr6p21 (Pcombined = 1.5 \u00d7 10-10) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (Pcombined = 1.2 \u00d7 10-122). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.", "doi": "10.1093/hmg/ddab023", "pmid": "33517400", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8098112"}, {"db": "pii", "key": "6124523"}], "notes": [], "created": "2026-08-21T12:08:57.869Z", "modified": "2026-08-21T12:08:57.976Z"}]}