{"entity": "researcher", "timestamp": "2026-09-25T18:00:31.871Z", "family": "Olsson", "given": "Lina M", "initials": "LM", "orcid": "0000-0002-1359-0295", "affiliations": ["Department of Immunotechnology, Lund University, 221 00 Lund, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/675f08c2d5db4b40bce7fa233b618a3b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/675f08c2d5db4b40bce7fa233b618a3b"}}, "publications": [{"entity": "publication", "iuid": "01aa670515c141988687470e44a6762c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/01aa670515c141988687470e44a6762c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/01aa670515c141988687470e44a6762c"}}, "title": "Quantification and Profiling of Early and Late Differentiation Stage T Cells in Mantle Cell Lymphoma Reveals Immunotherapeutic Targets in Subsets of Patients.", "authors": [{"family": "Lokhande", "given": "Lavanya", "initials": "L"}, {"family": "Nilsson", "given": "Daniel", "initials": "D", "orcid": "0009-0001-6214-198X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bc5bb733433b4d6b8721900739105fb5.json"}}, {"family": "de Matos Rodrigues", "given": "Joana", "initials": "J"}, {"family": "Hassan", "given": "May", "initials": "M"}, {"family": "Olsson", "given": "Lina M", "initials": "LM", "orcid": "0000-0002-1359-0295", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/675f08c2d5db4b40bce7fa233b618a3b.json"}}, {"family": "Pyl", "given": "Paul-Theodor", "initials": "PT", "orcid": "0000-0002-7651-883X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9b778ed88a694ddd84a2a3358eb60b4f.json"}}, {"family": "Vasquez", "given": "Louella", "initials": "L"}, {"family": "Porwit", "given": "Anna", "initials": "A"}, {"family": "Gerdtsson", "given": "Anna Sandstr\u00f6m", "initials": "AS", "orcid": "0000-0003-1932-0365", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a421e038391a4e368d9460c7b5867579.json"}}, {"family": "Jerkeman", "given": "Mats", "initials": "M"}, {"family": "Ek", "given": "Sara", "initials": "S", "orcid": "0000-0002-1388-4912", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e439837a691847bea96ecaf13c9c4b74.json"}}], "type": "journal article", "published": "2024-06-21", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "volume": "16", "issue": "13", "issn-l": "2072-6694"}, "abstract": "With the aim to advance the understanding of immune regulation in MCL and to identify targetable T-cell subsets, we set out to combine image analysis and spatial omic technology focused on both early and late differentiation stages of T cells. MCL patient tissue (n = 102) was explored using image analysis and GeoMx spatial omics profiling of 69 proteins and 1812 mRNAs. Tumor cells, T helper (TH) cells and cytotoxic (TC) cells of early (CD57-) and late (CD57+) differentiation stage were analyzed. An image analysis workflow was developed based on fine-tuned Cellpose models for cell segmentation and classification. TC and CD57+ subsets of T cells were enriched in tumor-rich compared to tumor-sparse regions. Tumor-sparse regions had a higher expression of several key immune suppressive proteins, tentatively controlling T-cell expansion in regions close to the tumor. We revealed that T cells in late differentiation stages (CD57+) are enriched among MCL infiltrating T cells and are predictive of an increased expression of immune suppressive markers. CD47, IDO1 and CTLA-4 were identified as potential targets for patients with T-cell-rich MCL TIME, while GITR might be a feasible target for MCL patients with sparse T-cell infiltration. In subgroups of patients with a high degree of CD57+ TC-cell infiltration, several immune checkpoint inhibitors, including TIGIT, PD-L1 and LAG3 were increased, emphasizing the immune-suppressive features of this highly differentiated T-cell subset not previously described in MCL.", "doi": "10.3390/cancers16132289", "pmid": "39001353", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11240320"}, {"db": "pii", "key": "cancers16132289"}], "notes": [], "created": "2026-09-23T12:24:44.119Z", "modified": "2026-09-23T12:24:44.335Z"}]}