{"entity": "researcher", "timestamp": "2026-08-20T19:46:38.534Z", "family": "F\u00fcrth", "given": "Daniel", "initials": "D", "orcid": "0000-0002-6017-3419", "affiliations": ["SciLifeLab, Department of Immunology, Genetics & Pathology, Uppsala University, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/6709d239a58943ee88187f2b8e6139f6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/6709d239a58943ee88187f2b8e6139f6"}}, "publications": [{"entity": "publication", "iuid": "ed87f797d1474321a2389ed928709f95", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ed87f797d1474321a2389ed928709f95.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ed87f797d1474321a2389ed928709f95"}}, "title": "Heterocyclic scaffold-fused dimethoxy-dibenzocyclooctynes for photoactivatable click chemistry.", "authors": [{"family": "Larsson", "given": "N Alfred", "initials": "NA", "orcid": "0009-0009-2877-858X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/201ff21d71f24675831e0acdaba2bd77.json"}}, {"family": "Jo", "given": "Taegeun", "initials": "T", "orcid": "0000-0001-7112-6186", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e968b4e747c44608f24c2bcb1db5ae9.json"}}, {"family": "Bremberg", "given": "Ulf", "initials": "U"}, {"family": "Crespi", "given": "Stefano", "initials": "S", "orcid": "0000-0002-0279-4903", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/947baff1224e41febb0c8b1820c81340.json"}}, {"family": "Odell", "given": "Luke R", "initials": "LR", "orcid": "0000-0001-7658-5103", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49395660c6af4fce9ad0f7f8fc793744.json"}}, {"family": "F\u00fcrth", "given": "Daniel", "initials": "D", "orcid": "0000-0002-6017-3419", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6709d239a58943ee88187f2b8e6139f6.json"}}], "type": "journal article", "published": "2026-01-07", "journal": {"title": "Org. Biomol. Chem.", "issn": "1477-0539", "volume": "24", "issue": "1", "pages": "120-126", "issn-l": "1477-0520"}, "abstract": "Dibenzocyclooctynes (DBCOs) are widely used in bioorthogonal chemistry for strain-promoted azide-alkyne cycloaddition (SPAAC), but generally lack reactivity toward inverse-electron-demand Diels-Alder cycloaddition (iEDDAC) with tetrazines. While photoactivatable DBCOs for SPAAC are well established and photoresponsive cyclooctynes for iEDDAC have recently been reported, photoactivatable DBCOs designed for dual reactivity remain scarce. Motivated by the possibility that heterocyclic fusions could tune reactivity and introduce new photochemical properties, we developed a modular synthetic route to a previously inaccessible heterocycle-fused DBCO. Upon photoactivation, the pyrrolidine fusions efficiently released the alkyne from the cyclopropenone cage, exhibiting strong SPAAC reactivity but, contrary to computational predictions, showing no detectable reactivity with tetrazines in iEDDAC. By contrast, triazole fusions, previously described as fluorogenic dibenzocyclooctyne (FL-DIBO), have not been evaluated in photo-click chemistry. We found that the cyclopropenone cage is essential for fluorescence, and its decarbonylation produced non-alkyne byproducts with no functional reactivity. This work expands the chemical space of DBCOs and establishes pyrrolidine-fused derivatives as the first functional heterocyclic-fused photoactivatable alkyne within the dimethoxy-DBCO scaffold class.", "doi": "10.1039/d5ob01314c", "pmid": "41212084", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T09:28:14.122Z", "modified": "2026-08-20T09:28:14.307Z"}, {"entity": "publication", "iuid": "544415e5349a4eab8044fc925da15498", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/544415e5349a4eab8044fc925da15498.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/544415e5349a4eab8044fc925da15498"}}, "title": "Syngap1 promotes cognitive function through regulation of cortical sensorimotor dynamics.", "authors": [{"family": "Vaissiere", "given": "Thomas", "initials": "T", "orcid": "0000-0001-9510-7510", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4135290c6693466da098d5ded94694af.json"}}, {"family": "Michaelson", "given": "Sheldon D", "initials": "SD"}, {"family": "Creson", "given": "Thomas", "initials": "T"}, {"family": "Goins", "given": "Jessie", "initials": "J"}, {"family": "F\u00fcrth", "given": "Daniel", "initials": "D", "orcid": "0000-0002-6017-3419", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6709d239a58943ee88187f2b8e6139f6.json"}}, {"family": "Balazsfi", "given": "Diana", "initials": "D"}, {"family": "Rojas", "given": "Camilo", "initials": "C"}, {"family": "Golovin", "given": "Randall", "initials": "R"}, {"family": "Meletis", "given": "Konstantinos", "initials": "K", "orcid": "0000-0001-5665-4781", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/314d93feac4048799b81ca9cb04fc078.json"}}, {"family": "Miller", "given": "Courtney A", "initials": "CA"}, {"family": "O'Connor", "given": "Daniel", "initials": "D", "orcid": "0000-0002-9193-6714", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/46ba3b8146db4197b839b1ddba28993c.json"}}, {"family": "Fontolan", "given": "Lorenzo", "initials": "L"}, {"family": "Rumbaugh", "given": "Gavin", "initials": "G", "orcid": "0000-0001-6360-3894", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/01086c5b29ea46f4a7a648fc3aebf4ad.json"}}], "type": "journal article", "published": "2025-01-18", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "812", "issn-l": "2041-1723"}, "abstract": "Perception, a cognitive construct, emerges through sensorimotor integration (SMI). The genetic mechanisms that shape SMI required for perception are unknown. Here, we demonstrate in mice that expression of the autism/intellectual disability gene, Syngap1, in cortical excitatory neurons is required for the formation of somatomotor networks that promote SMI-mediated perception. Cortical Syngap1 expression was necessary and sufficient for setting tactile sensitivity, sustaining tactile object exploration, and promoting tactile learning. Mice with deficient Syngap1 expression exhibited impaired neural dynamics induced by exploratory touches within a cortical-thalamic network that promotes attention and perception. Disrupted neuronal dynamics were associated with circuit-specific long-range synaptic connectivity abnormalities. Our data support a model where autonomous Syngap1 expression in cortical excitatory neurons promotes cognitive abilities through the assembly of long-range circuits that integrate temporally-overlapping sensory and motor signals, a process that promotes perception and attention. These data provide systems-level insights into the robust association between Syngap1 expression and cognitive ability.", "doi": "10.1038/s41467-025-56125-0", "pmid": "39827187", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11743135"}, {"db": "pii", "key": "10.1038/s41467-025-56125-0"}], "notes": [], "created": "2026-08-20T08:53:51.706Z", "modified": "2026-08-20T08:53:51.905Z"}, {"entity": "publication", "iuid": "339affbf320f4f53b5e2f7032318337a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/339affbf320f4f53b5e2f7032318337a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/339affbf320f4f53b5e2f7032318337a"}}, "title": "Syngap1 Promotes Cognitive Function through Regulation of Cortical Sensorimotor Dynamics.", "authors": [{"family": "Vaissiere", "given": "Thomas", "initials": "T", "orcid": "0000-0001-9510-7510", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4135290c6693466da098d5ded94694af.json"}}, {"family": "Michaelson", "given": "Sheldon D", "initials": "SD"}, {"family": "Creson", "given": "Thomas", "initials": "T"}, {"family": "Goins", "given": "Jessie", "initials": "J"}, {"family": "F\u00fcrth", "given": "Daniel", "initials": "D", "orcid": "0000-0002-6017-3419", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6709d239a58943ee88187f2b8e6139f6.json"}}, {"family": "Balazsfi", "given": "Diana", "initials": "D"}, {"family": "Rojas", "given": "Camilo", "initials": "C"}, {"family": "Golovin", "given": "Randall", "initials": "R", "orcid": "0000-0003-1510-6126", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0517212f049b49d280864cbdb7c442f5.json"}}, {"family": "Meletis", "given": "Konstantinos", "initials": "K", "orcid": "0000-0001-5665-4781", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/314d93feac4048799b81ca9cb04fc078.json"}}, {"family": "Miller", "given": "Courtney A", "initials": "CA"}, {"family": "O'Connor", "given": "Daniel", "initials": "D", "orcid": "0000-0002-9193-6714", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/46ba3b8146db4197b839b1ddba28993c.json"}}, {"family": "Fontolan", "given": "Lorenzo", "initials": "L", "orcid": "0000-0002-1566-6636", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/01b2eb79cb874bdeaf1e158716b94686.json"}}, {"family": "Rumbaugh", "given": "Gavin", "initials": "G", "orcid": "0000-0001-6360-3894", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/01086c5b29ea46f4a7a648fc3aebf4ad.json"}}], "type": "journal article", "published": "2024-09-27", "journal": {"title": "bioRxiv", "issn": "2692-8205", "issn-l": null}, "abstract": "Perception, a cognitive construct, emerges through sensorimotor integration (SMI). The genetic mechanisms that shape SMI required for perception are unknown. Here, we demonstrate in mice that expression of the autism/intellectual disability gene, Syngap1, in cortical excitatory neurons is required for formation of somatomotor networks that promote SMI-mediated perception. Cortical Syngap1 expression was necessary and sufficient for setting tactile sensitivity, sustaining tactile object exploration, and promoting tactile learning. Mice with deficient Syngap1 expression exhibited impaired neural dynamics induced by exploratory touches within a cortical-thalamic network known to promote attention and perception. Disrupted neuronal dynamics were associated with circuit-specific long-range synaptic connectivity abnormalities. Our data support a model where autonomous Syngap1 expression in cortical excitatory neurons promotes cognitive abilities through assembly of circuits that integrate temporally-overlapping sensory and motor signals, a process that promotes perception and attention. These data provide systems-level insights into the robust association between Syngap1 expression and cognitive ability.", "doi": "10.1101/2023.09.27.559787", "pmid": "37808765", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10557642"}, {"db": "pii", "key": "2023.09.27.559787"}], "notes": [], "created": "2026-08-20T10:48:06.721Z", "modified": "2026-08-20T10:48:06.924Z"}, {"entity": "publication", "iuid": "03f0627505c042dabb3e4cb4c05d2c38", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/03f0627505c042dabb3e4cb4c05d2c38.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/03f0627505c042dabb3e4cb4c05d2c38"}}, "title": "Detection of protein-protein interactions by bio-orthogonal fluorogenic proximity probes", "authors": [{"family": "Torell", "given": "Andreas", "initials": "A"}, {"family": "Larsson", "given": "N Alfred", "initials": "NA"}, {"family": "Phillipson", "given": "Storm", "initials": "S"}, {"family": "Odell", "given": "Luke R", "initials": "LR", "orcid": "0000-0001-7658-5103", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49395660c6af4fce9ad0f7f8fc793744.json"}}, {"family": "F\u00fcrth", "given": "Daniel", "initials": "D", "orcid": "0000-0002-6017-3419", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6709d239a58943ee88187f2b8e6139f6.json"}}], "type": "posted-content", "published": "2024-08-20", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.08.20.608485", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:56:09.959Z", "modified": "2026-08-20T10:56:10.003Z"}]}