{"entity": "researcher", "timestamp": "2026-09-09T10:08:02.730Z", "family": "Collij", "given": "Lyduine E", "initials": "LE", "orcid": "0000-0001-6263-1762", "affiliations": ["Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, PO Box 7057, 1007MB, Amsterdam, The Netherlands.", "Amsterdam Neuroscience, Brain Imaging, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/6612222d48fd4bdcaa7c091d38efcc2b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/6612222d48fd4bdcaa7c091d38efcc2b"}}, "publications": [{"entity": "publication", "iuid": "41296afe1fb94394af66909057750160", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/41296afe1fb94394af66909057750160.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/41296afe1fb94394af66909057750160"}}, "title": "Hemispheric asymmetry of tau pathology is related to asymmetric amyloid deposition in Alzheimer's Disease.", "authors": [{"family": "Anij\u00e4rv", "given": "Toomas Erik", "initials": "TE", "orcid": "0000-0002-3650-4230", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/478837ec8fef4a8d9d4b39e088049614.json"}}, {"family": "Ossenkoppele", "given": "Rik", "initials": "R", "orcid": "0000-0003-1584-7477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9486d27ddd1b4b6485fa3ca10e0f3d82.json"}}, {"family": "Smith", "given": "Ruben", "initials": "R", "orcid": "0000-0001-7147-0112", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c69d9e76c884720afe20ce34b2c4d81.json"}}, {"family": "Pichet Binette", "given": "Alexa", "initials": "A", "orcid": "0000-0001-5218-3337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8f0967b7b694bcf96e30a051a5bbe9a.json"}}, {"family": "Collij", "given": "Lyduine E", "initials": "LE", "orcid": "0000-0001-6263-1762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6612222d48fd4bdcaa7c091d38efcc2b.json"}}, {"family": "Behjat", "given": "Harry H", "initials": "HH", "orcid": "0000-0001-6729-6801", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e5d1b40c4a8342eb841754961f1b3593.json"}}, {"family": "Rittmo", "given": "Jonathan", "initials": "J", "orcid": "0000-0001-5075-0166", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f46afd59d3a44a18a35c560c3d2e37f3.json"}}, {"family": "Karlsson", "given": "Linda", "initials": "L", "orcid": "0000-0002-0630-772X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ead4d76d56ff439ba30689e7dfe3aae2.json"}}, {"family": "Ahmadi", "given": "Khazar", "initials": "K", "orcid": "0000-0002-3371-6211", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5295cea5ead34b96a887d4055ccd659b.json"}}, {"family": "Strandberg", "given": "Olof", "initials": "O"}, {"family": "Alzheimer\u2019s Disease Neuroimaging Initiative", "given": "", "initials": ""}, {"family": "van Westen", "given": "Danielle", "initials": "D", "orcid": "0000-0001-8649-9874", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38afd81dca574f4a9884a1ce97b78e50.json"}}, {"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}, {"family": "Stomrud", "given": "Erik", "initials": "E"}, {"family": "Palmqvist", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-9267-1930", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fbd05e87cfb4057a1a7e41d9fb94aef.json"}}, {"family": "Mattsson-Carlgren", "given": "Niklas", "initials": "N", "orcid": "0000-0002-8885-7724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb26ae59b2a04f369c5ebc2f2375195a.json"}}, {"family": "Spotorno", "given": "Nicola", "initials": "N", "orcid": "0000-0001-5404-8788", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4851c8ec84264207bdf67c2fd04643da.json"}}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}], "type": "journal article", "published": "2025-09-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "8232", "issn-l": "2041-1723"}, "abstract": "The distribution of tau pathology in Alzheimer's disease (AD) shows remarkable inter-individual heterogeneity, including hemispheric asymmetry. However, the factors driving this asymmetry remain poorly understood. Here we explore whether tau asymmetry is linked to i) reduced inter-hemispheric brain connectivity (potentially restricting tau spread), or ii) asymmetry in amyloid-beta (A\u03b2) distribution (indicating greater hemisphere-specific vulnerability to AD pathology). We include 452 participants from the Swedish BioFINDER-2 cohort with evidence of both A\u03b2 pathology (CSF A\u03b242/40 or neocortical A\u03b2-PET) and tau pathology (temporal tau-PET), categorising them as left asymmetric (n = 102), symmetric (n = 306), or right asymmetric (n = 44) based on temporal lobe tau-PET uptake distribution. We assess edge-wise inter-hemispheric functional (RSfMRI; n = 318) and structural connectivity (dMRI; n = 352) but find no association between tau asymmetry and connectivity. In contrast, we observe a strong association between tau and A\u03b2 laterality patterns based on PET uptake (n = 233; \u03b2 = 0.632, p < 0.001), which we replicate in three independent cohorts (n = 234; \u03b2 = 0.535, p < 0.001). In a longitudinal A\u03b2-positive sample, we show that baseline A\u03b2 asymmetry predicts progression of tau laterality over time (n = 289; \u03b2 = 0.025, p = 0.028). These findings suggest that tau asymmetry is not associated with a weaker inter-hemispheric connectivity but might reflect hemispheric differences in vulnerability to A\u03b2 pathology, underscoring the role of regional vulnerability in determining the distribution of AD pathology.", "doi": "10.1038/s41467-025-63564-2", "pmid": "40913038", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12413461"}, {"db": "pii", "key": "10.1038/s41467-025-63564-2"}], "notes": [], "created": "2026-08-21T11:50:12.353Z", "modified": "2026-08-21T11:50:12.696Z"}, {"entity": "publication", "iuid": "d5e68a98d6c94abb9646df1e1a48dec1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d5e68a98d6c94abb9646df1e1a48dec1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d5e68a98d6c94abb9646df1e1a48dec1"}}, "title": "Two-step detection of Lewy body pathology via smell-function testing and CSF \u03b1-synuclein seed amplification.", "authors": [{"family": "Mastenbroek", "given": "Sophie E", "initials": "SE", "orcid": "0009-0006-2759-9588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9732ea66d3d9402f9cb1b1a3e9b34fc8.json"}}, {"family": "Collij", "given": "Lyduine E", "initials": "LE", "orcid": "0000-0001-6263-1762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6612222d48fd4bdcaa7c091d38efcc2b.json"}}, {"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}, {"family": "Caldera", "given": "Serena", "initials": "S"}, {"family": "Serrano", "given": "Geidy E", "initials": "GE"}, {"family": "Adler", "given": "Charles H", "initials": "CH"}, {"family": "Vargiu", "given": "Claudia Marina", "initials": "CM", "orcid": "0009-0009-2921-6829", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c57306acd0a4f36a786bd7452ce821a.json"}}, {"family": "Palmqvist", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-9267-1930", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fbd05e87cfb4057a1a7e41d9fb94aef.json"}}, {"family": "Barkhof", "given": "Frederik", "initials": "F", "orcid": "0000-0003-3543-3706", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/adc9cefa2eb14e599fa41988ea003192.json"}}, {"family": "Parchi", "given": "Piero", "initials": "P", "orcid": "0000-0002-9444-9524", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a3f20dbf9b984aec85c74d9aea2eac69.json"}}, {"family": "Beach", "given": "Thomas G", "initials": "TG"}, {"family": "Ossenkoppele", "given": "Rik", "initials": "R", "orcid": "0000-0003-1584-7477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9486d27ddd1b4b6485fa3ca10e0f3d82.json"}}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}], "type": "journal article", "published": "2025-08-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "7182", "issn-l": "2041-1723"}, "abstract": "Cerebrospinal fluid (CSF) \u03b1-synuclein (\u03b1-syn) seed amplification assays (SAAs) can detect Lewy body pathology (LBP) with high accuracy but are invasive and costly. To address these challenges, this study evaluated a two-step workflow combining prescreening via smell-function testing with confirmatory CSF \u03b1-syn SAA testing only in individuals with reduced smell, for predicting postmortem LBP status. Among 358 autopsied participants, the two-step workflow predicted brain LBP with high accuracy overall (94%), and within clinical subgroups (clinical parkinsonism=95%; clinical Alzheimer's disease [AD]=94%; clinically unimpaired [CU]=93%). It reduced the need for confirmatory CSF testing by 43% overall (23% clinical parkinsonism; 35% clinical AD; 80% CU). In an independent in vivo cohort (N=1209), the workflow predicted CSF \u03b1-syn SAA status with 79% accuracy and reduced CSF testing by 26%. This approach may reduce invasive CSF testing, alleviating patient burden and lowering healthcare costs.", "doi": "10.1038/s41467-025-62458-7", "pmid": "40764485", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12325632"}, {"db": "pii", "key": "10.1038/s41467-025-62458-7"}], "notes": [], "created": "2026-08-20T08:54:03.905Z", "modified": "2026-08-20T08:54:04.105Z"}, {"entity": "publication", "iuid": "07ddd2fbfa834fd29a1a0a9a83c4fcf2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/07ddd2fbfa834fd29a1a0a9a83c4fcf2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/07ddd2fbfa834fd29a1a0a9a83c4fcf2"}}, "title": "Disease progression modelling reveals heterogeneity in trajectories of Lewy-type \u03b1-synuclein pathology.", "authors": [{"family": "Mastenbroek", "given": "Sophie E", "initials": "SE", "orcid": "0009-0006-2759-9588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9732ea66d3d9402f9cb1b1a3e9b34fc8.json"}}, {"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}, {"family": "Collij", "given": "Lyduine E", "initials": "LE", "orcid": "0000-0001-6263-1762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6612222d48fd4bdcaa7c091d38efcc2b.json"}}, {"family": "Serrano", "given": "Geidy E", "initials": "GE"}, {"family": "Tremblay", "given": "C\u00e9cilia", "initials": "C"}, {"family": "Young", "given": "Alexandra L", "initials": "AL", "orcid": "0000-0002-7772-781X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8a71365a32a4f4da1a29a925e5334c3.json"}}, {"family": "Arce", "given": "Richard A", "initials": "RA"}, {"family": "Shill", "given": "Holly A", "initials": "HA"}, {"family": "Driver-Dunckley", "given": "Erika D", "initials": "ED"}, {"family": "Mehta", "given": "Shyamal H", "initials": "SH"}, {"family": "Belden", "given": "Christine M", "initials": "CM"}, {"family": "Atri", "given": "Alireza", "initials": "A"}, {"family": "Choudhury", "given": "Parichita", "initials": "P"}, {"family": "Barkhof", "given": "Frederik", "initials": "F", "orcid": "0000-0003-3543-3706", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/adc9cefa2eb14e599fa41988ea003192.json"}}, {"family": "Adler", "given": "Charles H", "initials": "CH"}, {"family": "Ossenkoppele", "given": "Rik", "initials": "R", "orcid": "0000-0003-1584-7477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9486d27ddd1b4b6485fa3ca10e0f3d82.json"}}, {"family": "Beach", "given": "Thomas G", "initials": "TG"}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}], "type": "journal article", "published": "2024-06-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "5133", "issn-l": "2041-1723"}, "abstract": "Lewy body (LB) diseases, characterized by the aggregation of misfolded \u03b1-synuclein proteins, exhibit notable clinical heterogeneity. This may be due to variations in accumulation patterns of LB neuropathology. Here we apply a data-driven disease progression model to regional neuropathological LB density scores from 814 brain donors with Lewy pathology. We describe three inferred trajectories of LB pathology that are characterized by differing clinicopathological presentation and longitudinal antemortem clinical progression. Most donors (81.9%) show earliest pathology in the olfactory bulb, followed by accumulation in either limbic (60.8%) or brainstem (21.1%) regions. The remaining donors (18.1%) initially exhibit abnormalities in brainstem regions. Early limbic pathology is associated with Alzheimer's disease-associated characteristics while early brainstem pathology is associated with progressive motor impairment and substantial LB pathology outside of the brain. Our data provides evidence for heterogeneity in the temporal spread of LB pathology, possibly explaining some of the clinical disparities observed in Lewy body disease.", "doi": "10.1038/s41467-024-49402-x", "pmid": "38879548", "labels": {"Jacob W Vogel": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC11180185"}, {"db": "pii", "key": "10.1038/s41467-024-49402-x"}], "notes": [], "created": "2025-03-19T11:17:02.737Z", "modified": "2025-03-19T11:19:08.814Z"}, {"entity": "publication", "iuid": "0740518bfbe543128aa1cd363b3509f8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0740518bfbe543128aa1cd363b3509f8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0740518bfbe543128aa1cd363b3509f8"}}, "title": "A data-driven study of Alzheimer's disease related amyloid and tau pathology progression.", "authors": [{"family": "Aksman", "given": "Leon M", "initials": "LM", "orcid": "0000-0003-2342-0780", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/215408c0a9f9472ca3ff3ec8e53cf4d6.json"}}, {"family": "Oxtoby", "given": "Neil P", "initials": "NP", "orcid": "0000-0003-0203-3909", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2408e58de5794533979e1f8f15ba217d.json"}}, {"family": "Scelsi", "given": "Marzia A", "initials": "MA"}, {"family": "Wijeratne", "given": "Peter A", "initials": "PA", "orcid": "0000-0002-4885-6241", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6567732a74d64c9d93d0e691ab3e0a8e.json"}}, {"family": "Young", "given": "Alexandra L", "initials": "AL", "orcid": "0000-0002-7772-781X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8a71365a32a4f4da1a29a925e5334c3.json"}}, {"family": "Lopes Alves", "given": "Isadora", "initials": "I"}, {"family": "Collij", "given": "Lyduine E", "initials": "LE", "orcid": "0000-0001-6263-1762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6612222d48fd4bdcaa7c091d38efcc2b.json"}}, {"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}, {"family": "Barkhof", "given": "Frederik", "initials": "F"}, {"family": "Alexander", "given": "Daniel C", "initials": "DC"}, {"family": "Altmann", "given": "Andre", "initials": "A", "orcid": "0000-0002-9265-2393", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c629171e9c0749e39088eeee9272eea4.json"}}, {"family": "ADNI", "given": "", "initials": ""}], "type": "journal article", "published": "2023-07-11", "journal": {"title": "Brain", "issn": "1460-2156", "issn-l": "0006-8950", "volume": null, "issue": null, "pages": null}, "abstract": "Amyloid-beta is thought to facilitate the spread of tau throughout the neocortex in Alzheimer's disease, though how this occurs is not well understood. This is because of the spatial discordance between amyloid-beta, which accumulates in the neocortex, and tau, which accumulates in the medial temporal lobe during aging. There is evidence that in some cases amyloid-beta-independent tau spreads beyond the medial temporal lobe where it may interact with neocortical amyloid-beta. This suggests that there may be multiple distinct spatiotemporal subtypes of Alzheimer's-related protein aggregation, with potentially different demographic and genetic risk profiles. We investigated this hypothesis, applying data-driven disease progression subtyping models to post-mortem neuropathology and in vivo PET based measures from two large observational studies: the Alzheimer's Disease Neuroimaging Initiative and the Religious Orders Study and Rush Memory and Aging Project. We consistently identified 'amyloid-first' and 'tau-first' subtypes using cross-sectional information from both studies. In the amyloid-first subtype, extensive neocortical amyloid-beta precedes the spread of tau beyond the medial temporal lobe, while in the tau-first subtype mild tau accumulates in medial temporal and neocortical areas prior to interacting with amyloid-beta. As expected, we found a higher prevalence of the amyloid-first subtype among apolipoprotein E (APOE) \u03b54 allele carriers while the tau-first subtype was more common among APOE \u03b54 non-carriers. Within tau-first APOE \u03b54 carriers, we found an increased rate of amyloid-beta accumulation (via longitudinal amyloid PET), suggesting that this rare group may belong within the Alzheimer's disease continuum. We also found that tau-first APOE \u03b54 carriers had several fewer years of education than other groups, suggesting a role for modifiable risk factors in facilitating amyloid-beta-independent tau. Tau-first APOE \u03b54 non-carriers, in contrast, recapitulated many of the features of Primary Age-related Tauopathy. The rate of longitudinal amyloid-beta and tau accumulation (both measured via PET) within this group did not differ from normal aging, supporting the distinction of Primary Age-related Tauopathy from Alzheimer's disease. We also found reduced longitudinal subtype consistency within tau-first APOE \u03b54 non-carriers, suggesting additional heterogeneity within this group. Our findings support the idea that amyloid-beta and tau may begin as independent processes in spatially disconnected regions, with widespread neocortical tau resulting from the local interaction of amyloid-beta and tau. The site of this interaction may be subtype-dependent: medial temporal lobe in amyloid-first, neocortex in tau-first. These insights into the dynamics of amyloid-beta and tau may inform research and clinical trials that target these pathologies.", "doi": "10.1093/brain/awad232", "pmid": "37433038", "labels": {"Jacob W Vogel": null, "DDLS Fellow": null}, "xrefs": [{"db": "pii", "key": "7222857"}], "notes": [], "created": "2023-10-25T16:52:13.310Z", "modified": "2023-11-29T06:41:22.561Z"}]}