{"entity": "researcher", "timestamp": "2026-08-20T21:13:08.756Z", "family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "affiliations": ["Department of Medicine Solna, Science for Life Laboratory, Karolinska Institute Solna, Solna, Sweden.", "Division of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9"}}, "publications": [{"entity": "publication", "iuid": "ecf043c12388471b9ad9ffce190a577b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ecf043c12388471b9ad9ffce190a577b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ecf043c12388471b9ad9ffce190a577b"}}, "title": "Accurate Protein Dynamic Conformational Ensembles: Combining AlphaFold, MD, and Amide 15N(1H) NMR Relaxation.", "authors": [{"family": "Lesovoy", "given": "Dmitry", "initials": "D"}, {"family": "Roshchin", "given": "Konstantin", "initials": "K"}, {"family": "Sala", "given": "Benedetta Maria", "initials": "BM"}, {"family": "Sandalova", "given": "Tatyana", "initials": "T"}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}, {"family": "Agback", "given": "Tatiana", "initials": "T", "orcid": "0000-0003-1325-6024", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/45cf38c8b15946cda75b81cde94bbdfe.json"}}, {"family": "Agback", "given": "Peter", "initials": "P", "orcid": "0000-0003-2226-0746", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eae6fd83468f4ddfbbb7609d710dec6c.json"}}, {"family": "Orekhov", "given": "Vladislav", "initials": "V"}], "type": "journal article", "published": "2025-09-12", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "26", "issue": "18", "issn-l": null}, "abstract": "Conformational heterogeneity is essential for protein function, yet validating theoretical molecular dynamics (MD) ensembles remains a significant challenge. In this study, we present an approach that integrates free MD simulations, starting from an AlphaFold-generated structure, with refined experimental NMR-relaxation data to identify biologically relevant holistic time-resolved 4D conformational ensembles. Specifically, we select trajectory segments (RMSD plateaus) consistent with experimental observables. For the extracellular region of Streptococcus pneumoniae PsrSp, we found that only specific segments of the long MD trajectory aligned well with experimental data. The resulting ensembles revealed two regions with increased flexibility, both of which play important functional roles.", "doi": "10.3390/ijms26188917", "pmid": "41009484", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12469643"}, {"db": "pii", "key": "ijms26188917"}], "notes": [], "created": "2026-08-20T13:42:02.285Z", "modified": "2026-08-20T13:42:02.369Z"}, {"entity": "publication", "iuid": "2108b46955d444a39235fed52f4243dc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2108b46955d444a39235fed52f4243dc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2108b46955d444a39235fed52f4243dc"}}, "title": "Mutational insights into human kynurenine aminotransferase 1: modulation of transamination and \u03b2-elimination activities across diverse substrates.", "authors": [{"family": "Selvam", "given": "Arun Kumar", "initials": "AK", "orcid": "0000-0002-9854-2048", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e7a8d1d439a4ed0aebad8389a7253e2.json"}}, {"family": "Sun", "given": "Renhua", "initials": "R", "orcid": "0000-0002-8203-4946", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29b44e08db3a4482a6a40bbda52fe815.json"}}, {"family": "Razaghi", "given": "Ali", "initials": "A", "orcid": "0000-0001-8771-998X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b978f17f56764dfb8fbef3fd06d10214.json"}}, {"family": "Salter", "given": "Hugh", "initials": "H", "orcid": "0000-0001-5705-2950", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c405a1c865d34a769095ada5edc8d04b.json"}}, {"family": "Sandalova", "given": "Tatiana", "initials": "T", "orcid": "0000-0002-7694-6420", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ea3d2ec9e94fe3876f88bd0786c24b.json"}}, {"family": "Bj\u00f6rnstedt", "given": "Mikael", "initials": "M", "orcid": "0000-0003-2831-3837", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/08e79d991fab47c18b7390c7ddc12963.json"}}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}], "type": "journal article", "published": "2025-08-18", "journal": {"title": "Biochem. J.", "issn": "1470-8728", "volume": "482", "issue": "16", "pages": "1163-1180", "issn-l": "0264-6021"}, "abstract": "Human kynurenine aminotransferase 1 (hKYAT1) plays a crucial role in the transamination of aromatic amino acids and kynurenine. This promiscuous homodimeric enzyme transaminates various amino acids into their corresponding \u03b1-keto acids. Additionally, hKYAT1 is known to catalyze the \u03b2-elimination of cysteine-S conjugates and cysteine-Se conjugates. In this study, we performed mutational analyses of hKYAT1, targeting its catalytic, ligand-binding, and substrate-binding sites. The transamination activity of 13 mutant variants was systematically evaluated against sixteen different amino acid substrates, including kynurenine, selenomethionine (SeMet), and Se-methylselenocysteine (MSC), as well as for the \u03b2-elimination of SeMet and MSC. Our results demonstrate that mutations of residues E27 in the catalytic site and H279 in the substratestabilizing site significantly enhanced the transamination of several amino acids, including phenylalanine, tryptophan, histidine, and MSC. The H279F mutation increased transamination and \u03b2-elimination of MSC by 2- and 1.5-fold, respectively. Furthermore, mutation at the ligand-binding residues R398, F125, and N185 substantially reduced MSC transamination activity of hKYAT1. Interestingly, none of the tested mutations affected the transamination of l-kynurenine, a natural substrate of hKYAT1. Altogether, these findings support future investigation into hKYAT1 as a modifiable target in selenium-mediated anticancer approaches.", "doi": "10.1042/BCJ20253178", "pmid": "40785633", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12493182"}, {"db": "pii", "key": "236366"}], "notes": [], "created": "2026-08-20T09:28:22.125Z", "modified": "2026-08-20T09:28:22.422Z"}, {"entity": "publication", "iuid": "6827909de85a489e824ef89cfb1f3ad3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6827909de85a489e824ef89cfb1f3ad3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6827909de85a489e824ef89cfb1f3ad3"}}, "title": "Crystallographic and NMR Study of Streptococcus pneumonia LCP Protein PsrSp Indicate the Importance of Dynamics in Four Long Loops for Ligand Specificity", "authors": [{"family": "Sandalova", "given": "Tatyana", "initials": "T"}, {"family": "Sala", "given": "Benedetta Maria", "initials": "BM"}, {"family": "Moche", "given": "Martin", "initials": "M", "orcid": "0000-0002-4834-7076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/34394d4441c548fba9faad777b1252be.json"}}, {"family": "Ljunggren", "given": "Hans Gustaf", "initials": "HG"}, {"family": "Alici", "given": "Evren", "initials": "E"}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B"}, {"family": "Agback", "given": "Tatiana", "initials": "T"}, {"family": "Lesovoy", "given": "Dmitry", "initials": "D"}, {"family": "Agback", "given": "Peter", "initials": "P", "orcid": "0000-0003-2226-0746", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eae6fd83468f4ddfbbb7609d710dec6c.json"}}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}], "type": "journal-article", "published": "2024-12-19", "journal": {"title": "Crystals", "issn": "2073-4352", "volume": "14", "issue": "12", "pages": "1094", "issn-l": null}, "abstract": null, "doi": "10.3390/cryst14121094", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:40:26.238Z", "modified": "2026-08-20T13:40:26.329Z"}, {"entity": "publication", "iuid": "f84542e7ea5746209e3f0e441627ad69", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f84542e7ea5746209e3f0e441627ad69.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f84542e7ea5746209e3f0e441627ad69"}}, "title": "SARS-CoV-2 N protein recruits G3BP to double membrane vesicles to promote translation of viral mRNAs.", "authors": [{"family": "Long", "given": "Siwen", "initials": "S"}, {"family": "Guzyk", "given": "Mykhailo", "initials": "M"}, {"family": "Perez Vidakovics", "given": "Laura", "initials": "L", "orcid": "0000-0003-4283-812X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/309ffd38d0f54f26bbe038eb242d7e2d.json"}}, {"family": "Han", "given": "Xiao", "initials": "X"}, {"family": "Sun", "given": "Renhua", "initials": "R", "orcid": "0000-0002-8203-4946", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29b44e08db3a4482a6a40bbda52fe815.json"}}, {"family": "Wang", "given": "Megan", "initials": "M", "orcid": "0000-0003-3000-3539", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c266ec5cfae49faa110c5b3f34b27ad.json"}}, {"family": "Panas", "given": "Marc D", "initials": "MD", "orcid": "0000-0002-7373-0341", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de0aacc7004d4b179d37401c8636ac8f.json"}}, {"family": "Urgard", "given": "Egon", "initials": "E"}, {"family": "Coquet", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-5967-4857", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d8f18ddaf044bdb80d800630d137993.json"}}, {"family": "Merits", "given": "Andres", "initials": "A"}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}, {"family": "McInerney", "given": "Gerald M", "initials": "GM", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/012d1aaf306b43dc89309b45ccc6b649.json"}}], "type": "journal article", "published": "2024-12-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "10607", "issn-l": "2041-1723"}, "abstract": "Ras-GTPase-activating protein SH3-domain-binding proteins (G3BP) are critical for the formation of stress granules (SGs) through their RNA- and ribosome-binding properties. SARS-CoV-2 nucleocapsid (N) protein exhibits strong binding affinity for G3BP and inhibits infection-induced SG formation soon after infection. To study the impact of the G3BP-N interaction on viral replication and pathogenesis in detail, we generated a mutant SARS-CoV-2 (RATA) that specifically lacks the G3BP-binding motif in the N protein. RATA triggers a stronger and more persistent SG response in infected cells, showing reduced replication across various cell lines, and greatly reduced pathogenesis in K18-hACE2 transgenic mice. At early times of infection, G3BP and WT N protein strongly colocalise with dsRNA and with non-structural protein 3 (nsp3), a component of the pore complex in double membrane vesicles (DMVs) from which nascent viral RNA emerges. Furthermore, G3BP-N complexes promote highly localized translation of viral mRNAs in the immediate vicinity of the DMVs and thus contribute to efficient viral gene expression and replication. In contrast, G3BP is absent from the DMVs in cells infected with RATA and translation of viral mRNAs is less efficient. This work provides a fuller understanding of the multifunctional roles of G3BP in SARS-CoV-2 infection.", "doi": "10.1038/s41467-024-54996-3", "pmid": "39638802", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11621422"}, {"db": "pii", "key": "10.1038/s41467-024-54996-3"}], "notes": [], "created": "2026-08-20T08:53:44.334Z", "modified": "2026-08-20T08:53:44.554Z"}, {"entity": "publication", "iuid": "0102d2378dc1467b93cf164440fd96fc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0102d2378dc1467b93cf164440fd96fc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0102d2378dc1467b93cf164440fd96fc"}}, "title": "Crystallographic and NMR studies of Streptococcus pneumonia LCP protein Psr Sp indicate the importance of dynamics in four long loops for ligand specificity", "authors": [{"family": "Sandalova", "given": "Tatyana", "initials": "T", "orcid": "0000-0002-7694-6420", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ea3d2ec9e94fe3876f88bd0786c24b.json"}}, {"family": "Sala", "given": "Benedetta Maria", "initials": "BM", "orcid": "0000-0002-1592-0817", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f03e2bb1aeba4436a2f1571f50335b87.json"}}, {"family": "Moche", "given": "Martin", "initials": "M", "orcid": "0000-0002-4834-7076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/34394d4441c548fba9faad777b1252be.json"}}, {"family": "Ljunggren", "given": "Hans Gustaf", "initials": "HG", "orcid": "0000-0003-0908-7387", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a134515bf6242818aad27e86a8da06a.json"}}, {"family": "Alici", "given": "Evren", "initials": "E", "orcid": "0000-0001-5307-6648", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b15e3ead7914feb86af38946f373dfb.json"}}, {"family": "Henriques-Normark", "given": "Birgitta", "initials": "B", "orcid": "0000-0002-5429-4759", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40da20f498284552b13443f9109b7e32.json"}}, {"family": "Agback", "given": "Tatiana", "initials": "T", "orcid": "0000-0003-1325-6024", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/45cf38c8b15946cda75b81cde94bbdfe.json"}}, {"family": "Lesovoy", "given": "Dmitry", "initials": "D", "orcid": "0000-0002-9130-715X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/706f3a39328e4e17823901ccc52b27c1.json"}}, {"family": "Agback", "given": "Peter", "initials": "P", "orcid": "0000-0003-2226-0746", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eae6fd83468f4ddfbbb7609d710dec6c.json"}}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}], "type": "posted-content", "published": "2024-10-21", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.10.21.619401", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:58:53.965Z", "modified": "2026-08-20T10:58:54.223Z"}, {"entity": "publication", "iuid": "93555e317ef54e44bd5030caa6749aa4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/93555e317ef54e44bd5030caa6749aa4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/93555e317ef54e44bd5030caa6749aa4"}}, "title": "High Resolution Crystal Structure of the Pyruvate Kinase Tetramer in Complex with the Allosteric Activator Mitapivat/AG-348", "authors": [{"family": "Han", "given": "Xiao", "initials": "X", "orcid": "0000-0003-0879-4119", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/84f84bbd0b5a4d86b5512581773446ed.json"}}, {"family": "Sandalova", "given": "Tatyana", "initials": "T"}, {"family": "Zhang", "given": "Cheng", "initials": "C", "orcid": "0000-0002-3721-8586", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f46e4161be08458994efddb75ed75874.json"}}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}, {"family": "Sun", "given": "Renhua", "initials": "R", "orcid": "0000-0002-8203-4946", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29b44e08db3a4482a6a40bbda52fe815.json"}}], "type": "journal-article", "published": "2024-05-05", "journal": {"title": "Crystals", "issn": "2073-4352", "volume": "14", "issue": "5", "pages": "441", "issn-l": null}, "abstract": null, "doi": "10.3390/cryst14050441", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:40:24.382Z", "modified": "2026-08-20T13:40:24.520Z"}, {"entity": "publication", "iuid": "9a40e0f6d2394357b80dd513daada491", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9a40e0f6d2394357b80dd513daada491.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9a40e0f6d2394357b80dd513daada491"}}, "title": "Multiple pro-viral effects of the host protein G3BP in SARS-CoV-2 Infection", "authors": [{"family": "McInerney", "given": "Gerald", "initials": "G", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/012d1aaf306b43dc89309b45ccc6b649.json"}}, {"family": "Long", "given": "Siwen", "initials": "S"}, {"family": "Vidakovics", "given": "Laura Perez", "initials": "LP", "orcid": "0000-0003-4283-812X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/309ffd38d0f54f26bbe038eb242d7e2d.json"}}, {"family": "Han", "given": "Xiao", "initials": "X"}, {"family": "Sun", "given": "Renhua", "initials": "R"}, {"family": "Wang", "given": "Megan", "initials": "M"}, {"family": "Panas", "given": "Marc", "initials": "M", "orcid": "0000-0002-7373-0341", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de0aacc7004d4b179d37401c8636ac8f.json"}}, {"family": "Urgard", "given": "Egon", "initials": "E"}, {"family": "Merits", "given": "Andres", "initials": "A"}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}, {"family": "Guzyk", "given": "Mykhailo", "initials": "M"}, {"family": "Coquet", "given": "Jonathan", "initials": "J"}], "type": "posted-content", "published": "2024-04-08", "journal": {"issn-l": null}, "abstract": null, "doi": "10.21203/rs.3.rs-4145371/v1", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T12:59:23.028Z", "modified": "2026-08-20T12:59:23.107Z"}, {"entity": "publication", "iuid": "a71c46f25a9c401b977281217cb18601", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a71c46f25a9c401b977281217cb18601.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a71c46f25a9c401b977281217cb18601"}}, "title": "Long-Term Survival and Immune Response Dynamics in Melanoma Patients Undergoing TAPCells-Based Vaccination Therapy.", "authors": [{"family": "Tittarelli", "given": "Andr\u00e9s", "initials": "A", "orcid": "0000-0003-4129-9734", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4b33ae07f33248c2b87955e83d5fc6de.json"}}, {"family": "Pereda", "given": "Cristian", "initials": "C", "orcid": "0009-0000-1033-0247", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aab236d1354243cc942b474809e714ec.json"}}, {"family": "Gleisner", "given": "Mar\u00eda A", "initials": "MA", "orcid": "0000-0002-4172-9709", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa028fc3b7b54583805e12ba55ef11da.json"}}, {"family": "L\u00f3pez", "given": "Mercedes N", "initials": "MN"}, {"family": "Flores", "given": "Iv\u00e1n", "initials": "I"}, {"family": "Tempio", "given": "Fabi\u00e1n", "initials": "F"}, {"family": "Lladser", "given": "Alvaro", "initials": "A", "orcid": "0000-0002-5576-1478", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67fcde9ec88d497e91d5e64a2d785549.json"}}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}, {"family": "Gonz\u00e1lez", "given": "Ferm\u00edn E", "initials": "FE", "orcid": "0000-0002-4212-1009", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e9671a5793684845a35362cea70d03df.json"}}, {"family": "Dur\u00e1n-Aniotz", "given": "Claudia", "initials": "C", "orcid": "0000-0003-2503-8366", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f0c51284b534d0ab63339baa9f07682.json"}}, {"family": "Miranda", "given": "Juan P", "initials": "JP"}, {"family": "Larrondo", "given": "Milton", "initials": "M"}, {"family": "Salazar-Onfray", "given": "Flavio", "initials": "F", "orcid": "0000-0002-1848-5697", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9d4f0919a9b444a1a690c9fb6cb9c25f.json"}}], "type": "journal article", "published": "2024-03-27", "journal": {"title": "Vaccines (Basel)", "issn": "2076-393X", "volume": "12", "issue": "4", "issn-l": null}, "abstract": "Cancer vaccines present a promising avenue for treating immune checkpoint blockers (ICBs)-refractory patients, fostering immune responses to modulate the tumor microenvironment. We revisit a phase I/II trial using Tumor Antigen-Presenting Cells (TAPCells) (NCT06152367), an autologous antigen-presenting cell vaccine loaded with heat-shocked allogeneic melanoma cell lysates. Initial findings showcased TAPCells inducing lysate-specific delayed-type hypersensitivity (DTH) reactions, correlating with prolonged survival. Here, we extend our analysis over 15 years, categorizing patients into short-term (<36 months) and long-term (\u226536 months) survivors, exploring novel associations between clinical outcomes and demographic, genetic, and immunologic parameters. Notably, DTHpos patients exhibit a 53.1% three-year survival compared to 16.1% in DTHneg patients. Extended remissions are observed in long-term survivors, particularly DTHpos/M1cneg patients. Younger age, stage III disease, and moderate immune events also benefit short-term survivors. Immunomarkers like increased C-type lectin domain family 2 member D on CD4+ T cells and elevated interleukin-17A were detected in long-term survivors. In contrast, toll-like receptor-4 D229G polymorphism and reduced CD32 on B cells are associated with reduced survival. TAPCells achieved stable long remissions in 35.2% of patients, especially M1cneg/DTHpos cases. Conclusions: Our study underscores the potential of vaccine-induced immune responses in melanoma, emphasizing the identification of emerging biological markers and clinical parameters for predicting long-term remission.", "doi": "10.3390/vaccines12040357", "pmid": "38675738", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11053591"}, {"db": "pii", "key": "vaccines12040357"}], "notes": [], "created": "2026-08-20T13:43:21.587Z", "modified": "2026-08-20T13:43:21.931Z"}, {"entity": "publication", "iuid": "8979c7df59254dd9822b926c7a0cb26a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8979c7df59254dd9822b926c7a0cb26a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8979c7df59254dd9822b926c7a0cb26a"}}, "title": "Towards understanding of allostery in MALT1: a possible role of interdomain motions as revealed by NMR and AlphaFold", "authors": [{"family": "Wallerstein", "given": "Johan", "initials": "J", "orcid": "0009-0005-9832-5210", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d318a6953cbe4263a46c9712c43bc477.json"}}, {"family": "Han", "given": "Xiao", "initials": "X"}, {"family": "Levkovets", "given": "Maria", "initials": "M", "orcid": "0000-0002-1805-9057", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5db1b8e1e0f94daba38a0b5836322f49.json"}}, {"family": "Lesovoy", "given": "Dmitry", "initials": "D", "orcid": "0000-0002-9130-715X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/706f3a39328e4e17823901ccc52b27c1.json"}}, {"family": "Malmodin", "given": "Daniel", "initials": "D", "orcid": "0000-0001-8528-0141", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/679de38a489d47c9a9225481c83624ef.json"}}, {"family": "Mirabello", "given": "Claudio", "initials": "C", "orcid": "0000-0001-7868-034X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4ca88bb3cf24e2591c447ec929502e6.json"}}, {"family": "Wallner", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0002-3772-8279", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/330342e0d01d4a0683bd6bda49064c21.json"}}, {"family": "Sun", "given": "Renhua", "initials": "R", "orcid": "0000-0002-8203-4946", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29b44e08db3a4482a6a40bbda52fe815.json"}}, {"family": "Sandalova", "given": "Tatyana", "initials": "T", "orcid": "0000-0002-7694-6420", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ea3d2ec9e94fe3876f88bd0786c24b.json"}}, {"family": "Agback", "given": "Peter", "initials": "P"}, {"family": "Karlsson", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0002-1821-4715", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c237ffc07068465286d7b903683ed3ab.json"}}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}, {"family": "Agback", "given": "Tatiana", "initials": "T", "orcid": "0000-0003-1325-6024", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/45cf38c8b15946cda75b81cde94bbdfe.json"}}, {"family": "Orekhov", "given": "Vladislav", "initials": "V", "orcid": "0000-0002-7892-6896", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2bf27272cbc40e7b01f24b4324f0fb2.json"}}], "type": "posted-content", "published": "2024-02-01", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.02.01.578365", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:51:57.455Z", "modified": "2026-08-20T10:51:57.825Z"}, {"entity": "publication", "iuid": "c2f76c44eb7f4e60b25591e87657cc4d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c2f76c44eb7f4e60b25591e87657cc4d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c2f76c44eb7f4e60b25591e87657cc4d"}}, "title": "Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH.", "authors": [{"family": "Schulte", "given": "Tim", "initials": "T"}, {"family": "Panas", "given": "Marc D", "initials": "MD"}, {"family": "Han", "given": "Xiao", "initials": "X", "orcid": "0000-0003-0879-4119", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/84f84bbd0b5a4d86b5512581773446ed.json"}}, {"family": "Williams", "given": "Lucy", "initials": "L"}, {"family": "Kedersha", "given": "Nancy", "initials": "N"}, {"family": "Fleck", "given": "Jonas Simon", "initials": "JS"}, {"family": "Tan", "given": "Timothy J C", "initials": "TJC"}, {"family": "Dopico", "given": "Xaquin Castro", "initials": "XC", "orcid": "0000-0002-9005-6774", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/473ffce480ca4f2e8f75ad7bb4097e17.json"}}, {"family": "Olsson", "given": "Anders", "initials": "A"}, {"family": "Morro", "given": "Ainhoa Moliner", "initials": "AM"}, {"family": "Hanke", "given": "Leo", "initials": "L", "orcid": "0000-0001-5514-2418", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1c38fa28e3d4733978f027a582c2230.json"}}, {"family": "Nilvebrant", "given": "Johan", "initials": "J"}, {"family": "Giang", "given": "Kim Anh", "initials": "KA"}, {"family": "Nygren", "given": "Per-\u00c5ke", "initials": "P\u00c5"}, {"family": "Anderson", "given": "Paul", "initials": "P"}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}, {"family": "McInerney", "given": "Gerald M", "initials": "GM", "orcid": "0000-0003-2257-7241", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/012d1aaf306b43dc89309b45ccc6b649.json"}}], "type": "journal article", "published": "2023-05-00", "journal": {"title": "Open Biol", "issn": "2046-2441", "volume": "13", "issue": "5", "pages": "220369", "issn-l": "2046-2441"}, "abstract": "G3BP is the central node within stress-induced protein-RNA interaction networks known as stress granules (SGs). The SG-associated proteins Caprin-1 and USP10 bind mutually exclusively to the NTF2 domain of G3BP1, promoting and inhibiting SG formation, respectively. Herein, we present the crystal structure of G3BP1-NTF2 in complex with a Caprin-1-derived short linear motif (SLiM). Caprin-1 interacts with His-31 and His-62 within a third NTF2-binding site outside those covered by USP10, as confirmed using biochemical and biophysical-binding assays. Nano-differential scanning fluorimetry revealed reduced thermal stability of G3BP1-NTF2 at acidic pH. This destabilization was counterbalanced significantly better by bound USP10 than Caprin-1. The G3BP1/USP10 complex immunoprecipated from human U2OS cells was more resistant to acidic buffer washes than G3BP1/Caprin-1. Acidification of cellular condensates by approximately 0.5 units relative to the cytosol was detected by ratiometric fluorescence analysis of pHluorin2 fused to G3BP1. Cells expressing a Caprin-1/FGDF chimera with higher G3BP1-binding affinity had reduced Caprin-1 levels and slightly reduced condensate sizes. This unexpected finding may suggest that binding of the USP10-derived SLiM to NTF2 reduces the propensity of G3BP1 to enter condensates.", "doi": "10.1098/rsob.220369", "pmid": "37161291", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10170197"}, {"db": "figshare", "key": "10.6084/m9.figshare.c.6626084"}], "notes": [], "created": "2026-08-20T09:52:56.809Z", "modified": "2026-08-20T09:52:56.938Z"}, {"entity": "publication", "iuid": "650246f643f34db2a3ca461cb6740c53", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/650246f643f34db2a3ca461cb6740c53.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/650246f643f34db2a3ca461cb6740c53"}}, "title": "A gene-centric approach to biomarker discovery identifies transglutaminase 1 as an epidermal autoantigen.", "authors": [{"family": "Landegren", "given": "Nils", "initials": "N", "orcid": "0000-0002-6163-9540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6765f1617f51434baf93e4683965f03a.json"}}, {"family": "Ishii", "given": "Norito", "initials": "N", "orcid": "0000-0002-1199-6611", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/510d3f97277d4d9dae7b5645a3eae5df.json"}}, {"family": "Aranda-Guill\u00e9n", "given": "Maribel", "initials": "M", "orcid": "0000-0003-0050-704X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c0c18f520e34593865f7ed850f34a17.json"}}, {"family": "Gunnarsson", "given": "H\u00f6r\u00f0ur Ingi", "initials": "HI"}, {"family": "Sardh", "given": "Fabian", "initials": "F"}, {"family": "Hallgren", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "St\u00e5hle", "given": "Mona", "initials": "M", "orcid": "0000-0002-3916-9343", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51d5039a78a4471d879d9159ae862a12.json"}}, {"family": "Hagforsen", "given": "Eva", "initials": "E"}, {"family": "Bradley", "given": "Maria", "initials": "M", "orcid": "0000-0001-7192-5041", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/469e5ac8c9a34e538e477b772bd83ead.json"}}, {"family": "Edqvist", "given": "Per-Henrik D", "initials": "PD", "orcid": "0000-0002-8330-0134", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5219527c2dc6480da474f3c47dff9318.json"}}, {"family": "Pont\u00e9n", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0703-3940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f5294424542413c9ba4432c839c2b63.json"}}, {"family": "M\u00e4kitie", "given": "Outi", "initials": "O", "orcid": "0000-0002-4547-001X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/79b7b7154e694a85b1498dd78fe370c0.json"}}, {"family": "Eidsmo", "given": "Liv", "initials": "L"}, {"family": "Norl\u00e9n", "given": "Lars", "initials": "L"}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}, {"family": "Dahlbom", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-0560-9275", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aec88dbb6f8946d3b841a64083918ec9.json"}}, {"family": "Korponay-Szab\u00f3", "given": "Ilma", "initials": "I", "orcid": "0000-0003-0554-2629", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a26fdc4f1ee450b9369daee14accef7.json"}}, {"family": "Agardh", "given": "Daniel", "initials": "D", "orcid": "0000-0003-1435-1234", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/233900b2f8ed45828493bd305291abf0.json"}}, {"family": "Alimohammadi", "given": "Mohammad", "initials": "M", "orcid": "0000-0001-5937-1963", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fcc0aab3164a451ca01cb9b2b7493148.json"}}, {"family": "Eriksson", "given": "Daniel", "initials": "D", "orcid": "0000-0001-5473-3312", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b8847907a59147cf95d312afa115a3d3.json"}}, {"family": "Hashimoto", "given": "Takashi", "initials": "T", "orcid": "0000-0002-0144-3255", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8edf83e7ea8f40bc80434031352b3c4c.json"}}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O", "orcid": "0000-0001-6091-9914", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48f52710708f4b3291e5b5a4eefca8f5.json"}}], "type": "journal article", "published": "2021-12-21", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "118", "issue": "51", "issn-l": "0027-8424"}, "abstract": "Autoantigen discovery is a critical challenge for the understanding and diagnosis of autoimmune diseases. While autoantibody markers in current clinical use have been identified through studies focused on individual disorders, we postulated that a reverse approach starting with a putative autoantigen to explore multiple disorders might hold promise. We here targeted the epidermal protein transglutaminase 1 (TGM1) as a member of a protein family prone to autoimmune attack. By screening sera from patients with various acquired skin disorders, we identified seropositive subjects with the blistering mucocutaneous disease paraneoplastic pemphigus. Validation in further subjects confirmed TGM1 autoantibodies as a 55% sensitive and 100% specific marker for paraneoplastic pemphigus. This gene-centric approach leverages the wealth of data available for human genes and may prove generally applicable for biomarker discovery in autoimmune diseases.", "doi": "10.1073/pnas.2100687118", "pmid": "34911754", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8713791"}, {"db": "pii", "key": "2100687118"}], "notes": [], "created": "2026-08-20T09:30:57.213Z", "modified": "2026-08-20T09:30:57.722Z"}, {"entity": "publication", "iuid": "e09b19d3e5094597b9ab77bfc8a50ea0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e09b19d3e5094597b9ab77bfc8a50ea0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e09b19d3e5094597b9ab77bfc8a50ea0"}}, "title": "A Novel mRNA-Mediated and MicroRNA-Guided Approach to Specifically Eradicate Drug-Resistant Hepatocellular Carcinoma Cell Lines by Se-Methylselenocysteine.", "authors": [{"family": "Selvam", "given": "Arun Kumar", "initials": "AK", "orcid": "0000-0002-9854-2048", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e7a8d1d439a4ed0aebad8389a7253e2.json"}}, {"family": "Jawad", "given": "Rim", "initials": "R"}, {"family": "Gramignoli", "given": "Roberto", "initials": "R", "orcid": "0000-0003-3362-4170", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a68ade86efde42e89d9e76ae394bac43.json"}}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}, {"family": "Salter", "given": "Hugh", "initials": "H"}, {"family": "Bj\u00f6rnstedt", "given": "Mikael", "initials": "M", "orcid": "0000-0003-2831-3837", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/08e79d991fab47c18b7390c7ddc12963.json"}}], "type": "journal article", "published": "2021-07-07", "journal": {"title": "Antioxidants (Basel)", "issn": "2076-3921", "volume": "10", "issue": "7", "issn-l": null}, "abstract": "Despite progress in the treatment of non-visceral malignancies, the prognosis remains poor for malignancies of visceral organs and novel therapeutic approaches are urgently required. We evaluated a novel therapeutic regimen based on treatment with Se-methylselenocysteine (MSC) and concomitant tumor-specific induction of Kynurenine aminotransferase 1 (KYAT1) in hepatocellular carcinoma (HCC) cell lines, using either vector-based and/or lipid nanoparticle-mediated delivery of mRNA. Supplementation of MSC in KYAT1 overexpressed cells resulted in significantly increased cytotoxicity, due to ROS formation, as compared to MSC alone. Furthermore, microRNA antisense-targeted sites for miR122, known to be widely expressed in normal hepatocytes while downregulated in hepatocellular carcinoma, were added to specifically limit cytotoxicity in HCC cells, thereby limiting the off-target effects. KYAT1 expression was significantly reduced in cells with high levels of miR122 supporting the concept of miR-guided induction of tumor-specific cytotoxicity. The addition of alpha-ketoacid favored the production of methylselenol, enhancing the cytotoxic efficacy of MSC in HCC cells, with no effects on primary human hepatocytes. Altogether, the proposed regimen offers great potential to safely and specifically target hepatic tumors that are currently untreatable.", "doi": "10.3390/antiox10071094", "pmid": "34356326", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8301172"}, {"db": "pii", "key": "antiox10071094"}], "notes": [], "created": "2026-08-20T13:38:24.049Z", "modified": "2026-08-20T13:38:24.268Z"}, {"entity": "publication", "iuid": "a4a5c1bd18fa4fde8ae8b3be118e6710", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a4a5c1bd18fa4fde8ae8b3be118e6710.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a4a5c1bd18fa4fde8ae8b3be118e6710"}}, "title": "PD-1 expression on NK cells can be related to cytokine stimulation and tissue residency", "authors": [{"family": "Wagner", "given": "Arnika K", "initials": "AK", "orcid": "0000-0002-0339-8259", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c11bf281adcd401c8a11244b59f34506.json"}}, {"family": "Kadri", "given": "Nadir", "initials": "N"}, {"family": "Tibbitt", "given": "Chris", "initials": "C"}, {"family": "van de Ven", "given": "Koen", "initials": "K"}, {"family": "Bagawath-Singh", "given": "Sunitha", "initials": "S", "orcid": "0000-0002-2812-545X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2dbc874ed9724712afd3abc601bb2b71.json"}}, {"family": "Oliinyk", "given": "Denys", "initials": "D", "orcid": "0000-0002-2814-460X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/07bb166278c74fa18cf730623daa1885.json"}}, {"family": "LeGresly", "given": "Eric", "initials": "E"}, {"family": "Campbell", "given": "Nicole", "initials": "N", "orcid": "0000-0002-9402-274X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/44be047769b94f0db594ce5176a66ec1.json"}}, {"family": "Trittel", "given": "Stephanie", "initials": "S", "orcid": "0000-0002-9719-9161", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b1cde35a1dc04260a06207bf6fc58084.json"}}, {"family": "Riese", "given": "Peggy", "initials": "P"}, {"family": "Sandalova", "given": "Tatyana", "initials": "T", "orcid": "0000-0002-7694-6420", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ea3d2ec9e94fe3876f88bd0786c24b.json"}}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}, {"family": "K\u00e4rre", "given": "Klas", "initials": "K", "orcid": "0000-0001-8869-3195", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/54bd101849144707881fc6ec4aa58629.json"}}, {"family": "Chambers", "given": "Benedict J", "initials": "BJ", "orcid": "0000-0003-0437-8441", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/164ec85f86504556beafe8fe34405592.json"}}], "type": "posted-content", "published": "2021-03-30", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.03.29.437486", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:03:40.354Z", "modified": "2026-08-20T10:03:40.634Z"}, {"entity": "publication", "iuid": "48085d36a8e64ee3885505ea6ba80e8b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/48085d36a8e64ee3885505ea6ba80e8b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/48085d36a8e64ee3885505ea6ba80e8b"}}, "title": "SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity.", "authors": [{"family": "De Meo", "given": "Simone", "initials": "S", "orcid": "0000-0001-7542-8077", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/45816f4396764f2fbf97673e37834fcd.json"}}, {"family": "Dell'Oste", "given": "Valentina", "initials": "V"}, {"family": "Molfetta", "given": "Rosa", "initials": "R", "orcid": "0000-0003-2904-6371", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6203296a7de648838c9ccec8b91be518.json"}}, {"family": "Tassinari", "given": "Valentina", "initials": "V"}, {"family": "Lotti", "given": "Lavinia Vittoria", "initials": "LV", "orcid": "0000-0002-5114-6953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6cca542320a24996ad80047cd28a689c.json"}}, {"family": "Vespa", "given": "Simone", "initials": "S", "orcid": "0000-0001-6146-9302", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76b512d912dd4e268df765161735daa4.json"}}, {"family": "Pignoloni", "given": "Benedetta", "initials": "B"}, {"family": "Covino", "given": "Daniela Angela", "initials": "DA"}, {"family": "Fantuzzi", "given": "Laura", "initials": "L", "orcid": "0000-0002-0869-2596", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04696ef921a34f8486dd738dbe6c1c5e.json"}}, {"family": "Bona", "given": "Roberta", "initials": "R", "orcid": "0000-0002-9226-3734", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/61fb350bc6ee4dc4bdbb8c9b4e6f2fe7.json"}}, {"family": "Zingoni", "given": "Alessandra", "initials": "A", "orcid": "0000-0003-0906-1566", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76c0f8c614e74dbdb41bce0e656fd6f3.json"}}, {"family": "Nardone", "given": "Ilaria", "initials": "I", "orcid": "0000-0002-3868-3666", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8416dfb4905b4e98a654f2f5542a3e80.json"}}, {"family": "Biolatti", "given": "Matteo", "initials": "M", "orcid": "0000-0001-7675-0762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0094a40b253241209e6f0790165d37f2.json"}}, {"family": "Coscia", "given": "Alessandra", "initials": "A"}, {"family": "Paolini", "given": "Rossella", "initials": "R", "orcid": "0000-0001-7605-1531", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ffbaf0e5ed14356b1cb42470824be69.json"}}, {"family": "Benkirane", "given": "Monsef", "initials": "M"}, {"family": "Edfors", "given": "Fredrik", "initials": "F"}, {"family": "Sandalova", "given": "Tatyana", "initials": "T"}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}, {"family": "Hiscott", "given": "John", "initials": "J"}, {"family": "Landolfo", "given": "Santo", "initials": "S"}, {"family": "Santoni", "given": "Angela", "initials": "A"}, {"family": "Cerboni", "given": "Cristina", "initials": "C", "orcid": "0000-0002-0371-9534", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/539ba8ca7737405db5e61f3e608a235a.json"}}], "type": "journal article", "published": "2020-09-00", "journal": {"title": "PLoS Pathog", "issn": "1553-7374", "volume": "16", "issue": "9", "pages": "e1008855", "issn-l": "1553-7366"}, "abstract": "SAMHD1 is a host restriction factor that functions to restrict both retroviruses and DNA viruses, based on its nuclear deoxynucleotide triphosphate (dNTP) hydrolase activity that limits availability of intracellular dNTP pools. In the present study, we demonstrate that SAMHD1 expression was increased following human cytomegalovirus (HCMV) infection, with only a modest effect on infectious virus production. SAMHD1 was rapidly phosphorylated at residue T592 after infection by cellular cyclin-dependent kinases, especially Cdk2, and by the viral kinase pUL97, resulting in a significant fraction of phosho-SAMHD1 being relocalized to the cytoplasm of infected fibroblasts, in association with viral particles and dense bodies. Thus, our findings indicate that HCMV-dependent SAMHD1 cytoplasmic delocalization and inactivation may represent a potential novel mechanism of HCMV evasion from host antiviral restriction activities.", "doi": "10.1371/journal.ppat.1008855", "pmid": "32986788", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7544099"}, {"db": "pii", "key": "PPATHOGENS-D-19-02166"}], "notes": [], "created": "2026-08-20T12:44:51.406Z", "modified": "2026-08-20T12:44:51.847Z"}, {"entity": "publication", "iuid": "b9199c74ab13436cb33b162ed38990cb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b9199c74ab13436cb33b162ed38990cb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b9199c74ab13436cb33b162ed38990cb"}}, "title": "Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination.", "authors": [{"family": "Duru", "given": "Adil Doganay", "initials": "AD"}, {"family": "Sun", "given": "Renhua", "initials": "R", "orcid": "0000-0002-8203-4946", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29b44e08db3a4482a6a40bbda52fe815.json"}}, {"family": "Allerbring", "given": "Eva B", "initials": "EB", "orcid": "0000-0002-9575-0466", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4e1d21522744419bb23561be759c76b5.json"}}, {"family": "Chadderton", "given": "Jesseka", "initials": "J", "orcid": "0000-0002-2784-3556", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0eb3a07ef04c4ef0b79629452bbd0bd9.json"}}, {"family": "Kadri", "given": "Nadir", "initials": "N"}, {"family": "Han", "given": "Xiao", "initials": "X"}, {"family": "Peqini", "given": "Kaliroi", "initials": "K"}, {"family": "Uchtenhagen", "given": "Hannes", "initials": "H", "orcid": "0000-0002-4342-1919", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/86b1228a42d4486c983058d76828cfd1.json"}}, {"family": "Madhurantakam", "given": "Chaithanya", "initials": "C"}, {"family": "Pellegrino", "given": "Sara", "initials": "S", "orcid": "0000-0002-2325-3583", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0d6ed24c4914ce4b6cd0f699f121b52.json"}}, {"family": "Sandalova", "given": "Tatyana", "initials": "T"}, {"family": "Nygren", "given": "Per-\u00c5ke", "initials": "P\u00c5", "orcid": "0000-0003-4214-6991", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/db3f3b9b876c486e9c8acaa5efcfff18.json"}}, {"family": "Turner", "given": "Stephen J", "initials": "SJ", "orcid": "0000-0002-1002-0000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6098f38a6784bf1ace7e09d718a70ec.json"}}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}], "type": "journal article", "published": "2020-05-00", "journal": {"title": "PLoS Pathog", "issn": "1553-7374", "volume": "16", "issue": "5", "pages": "e1008244", "issn-l": "1553-7366"}, "abstract": "Viral escape from CD8+ cytotoxic T lymphocyte responses correlates with disease progression and represents a significant challenge for vaccination. Here, we demonstrate that CD8+ T cell recognition of the naturally occurring MHC-I-restricted LCMV-associated immune escape variant Y4F is restored following vaccination with a proline-altered peptide ligand (APL). The APL increases MHC/peptide (pMHC) complex stability, rigidifies the peptide and facilitates T cell receptor (TCR) recognition through reduced entropy costs. Structural analyses of pMHC complexes before and after TCR binding, combined with biophysical analyses, revealed that although the TCR binds similarly to all complexes, the p3P modification alters the conformations of a very limited amount of specific MHC and peptide residues, facilitating efficient TCR recognition. This approach can be easily introduced in peptides restricted to other MHC alleles, and can be combined with currently available and future vaccination protocols in order to prevent viral immune escape.", "doi": "10.1371/journal.ppat.1008244", "pmid": "32365082", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7224568"}, {"db": "pii", "key": "PPATHOGENS-D-19-02081"}], "notes": [], "created": "2026-08-20T12:44:43.219Z", "modified": "2026-08-20T12:44:43.362Z"}, {"entity": "publication", "iuid": "1055a6a0b35b492e97418386361864f9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1055a6a0b35b492e97418386361864f9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1055a6a0b35b492e97418386361864f9"}}, "title": "Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination", "authors": [{"family": "Duru", "given": "Adil Doganay", "initials": "AD"}, {"family": "Sun", "given": "Renhua", "initials": "R", "orcid": "0000-0002-8203-4946", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29b44e08db3a4482a6a40bbda52fe815.json"}}, {"family": "Allerbring", "given": "Eva B", "initials": "EB", "orcid": "0000-0002-9575-0466", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4e1d21522744419bb23561be759c76b5.json"}}, {"family": "Chadderton", "given": "Jesseka", "initials": "J"}, {"family": "Kadri", "given": "Nadir", "initials": "N"}, {"family": "Han", "given": "Xiao", "initials": "X"}, {"family": "Uchtenhagen", "given": "Hannes", "initials": "H", "orcid": "0000-0002-4342-1919", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/86b1228a42d4486c983058d76828cfd1.json"}}, {"family": "Madhurantakam", "given": "Chaithanya", "initials": "C"}, {"family": "Pellegrino", "given": "Sara", "initials": "S", "orcid": "0000-0002-2325-3583", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0d6ed24c4914ce4b6cd0f699f121b52.json"}}, {"family": "Sandalova", "given": "Tatyana", "initials": "T"}, {"family": "Nygren", "given": "Per \u00c5ke", "initials": "P\u00c5", "orcid": "0000-0003-4214-6991", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/db3f3b9b876c486e9c8acaa5efcfff18.json"}}, {"family": "Turner", "given": "Stephen J", "initials": "SJ", "orcid": "0000-0002-1002-0000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6098f38a6784bf1ace7e09d718a70ec.json"}}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}], "type": "posted-content", "published": "2019-12-02", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/862144", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:15:31.089Z", "modified": "2026-08-20T11:15:31.236Z"}, {"entity": "publication", "iuid": "6f1e68a887874972a845352f114505f8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6f1e68a887874972a845352f114505f8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6f1e68a887874972a845352f114505f8"}}, "title": "Breadth and Dynamics of HLA-A2- and HLA-B7-Restricted CD8+ T Cell Responses against Nonstructural Viral Proteins in Acute Human Tick-Borne Encephalitis Virus Infection.", "authors": [{"family": "Lampen", "given": "Margit H", "initials": "MH"}, {"family": "Uchtenhagen", "given": "Hannes", "initials": "H"}, {"family": "Blom", "given": "Kim", "initials": "K"}, {"family": "Varnait\u0117", "given": "Renata", "initials": "R"}, {"family": "Pakalniene", "given": "Jolita", "initials": "J", "orcid": "0000-0002-3252-3901", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aca673b9b6c2464c881c4527fc25c386.json"}}, {"family": "Dailidyte", "given": "Laura", "initials": "L"}, {"family": "W\u00e4lchli", "given": "S\u00e9bastien", "initials": "S", "orcid": "0000-0001-5869-1746", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ecde283fb32d48b891e43a954721dd1a.json"}}, {"family": "Lindquist", "given": "Lars", "initials": "L", "orcid": "0000-0002-3530-7382", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4773e96b8754118b236ae01c8757b52.json"}}, {"family": "Mickiene", "given": "Aukse", "initials": "A"}, {"family": "Micha\u00eblsson", "given": "Jakob", "initials": "J", "orcid": "0000-0001-6948-7281", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b1d4eb97634409a99a53c55e2bdcf86.json"}}, {"family": "Schumacher", "given": "Ton N", "initials": "TN"}, {"family": "Ljunggren", "given": "Hans-Gustaf", "initials": "HG"}, {"family": "Sandberg", "given": "Johan K", "initials": "JK", "orcid": "0000-0002-6275-0750", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d33bfbd945e647ac82e2d2699df02cb9.json"}}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}, {"family": "Gredmark-Russ", "given": "Sara", "initials": "S", "orcid": "0000-0002-2446-4323", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/901576abf4ff4aa6963c9e8d0610f08d.json"}}], "type": "journal article", "published": "2018-07-02", "journal": {"title": "Immunohorizons", "issn": "2573-7732", "volume": "2", "issue": "6", "pages": "172-184", "issn-l": null}, "abstract": "Tick-borne encephalitis virus (TBEV) is a leading cause of viral meningoencephalitis in many parts of Europe and eastwards in Asia, with high morbidity and often long-term neurologic sequelae. With no treatment available, studies of the immune response to TBEV are essential for the understanding of the immunopathogenesis of tick-borne encephalitis and for the development of therapeutics. We have previously demonstrated that CD8+ T cell responses in peripheral blood in patients with acute TBEV peak at around 7 d after hospitalization in the neuroinvasive phase of the disease. In this study, we identified six novel TBEV HLA-A2- and HLA-B7-restricted epitopes, all derived from the nonstructural proteins of TBEV. This identification allowed for a comprehensive phenotypic and temporal analysis of the HLA-A2- and HLA-B7-restricted Ag-specific CD8+ T cell response during the acute stages of human TBEV infection. HLA-A2- and HLA-B7-restricted TBEV epitope-specific effector cells predominantly displayed a CD45RA-CCR7-CD27+CD57- phenotype at day 7, which transitioned into separate distinct phenotypes for HLA-A2- and HLA-B7-restricted TBEV-specific CD8+ T cells, respectively. At day 21, the most prevalent phenotype in the HLA-A2-restricted CD8+ T cell populations was CD45RA-CCR7-CD27+CD57+, whereas the HLA-B7-restricted CD8+ T cell population was predominantly CD45RA+CCR7-CD27+CD57+ Almost all TBEV epitope-specific CD8+ T cells expressed \u03b14 and \u03b21 integrins at days 7 and 21, whereas the bulk CD8+ T cells expressed lower integrin levels. Taken together, human TBEV infection elicits broad responses to multiple epitopes, predominantly derived from the nonstructural part of the virus, establishing distinct maturation patterns for HLA-A2- and HLA-B7-restricted TBEV epitope-specific CD8+ T cells.", "doi": "10.4049/immunohorizons.1800029", "pmid": "31022685", "labels": [], "xrefs": [{"db": "pii", "key": "2/6/172"}], "notes": [], "created": "2026-08-20T13:44:37.482Z", "modified": "2026-08-20T13:44:37.736Z"}]}