{"entity": "researcher", "timestamp": "2026-08-22T06:56:29.080Z", "family": "Olsson", "given": "Anna-Karin", "initials": "AK", "orcid": "0000-0002-5438-7293", "affiliations": ["Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Biomedical Center, Box 582, 75123, Uppsala, Sweden. anna-karin.olsson@imbim.uu.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/65e94cd4e81f4728a66393ee6f067482.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/65e94cd4e81f4728a66393ee6f067482"}}, "publications": [{"entity": "publication", "iuid": "ab76d85118ec4afd902d21865ee33c79", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ab76d85118ec4afd902d21865ee33c79.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ab76d85118ec4afd902d21865ee33c79"}}, "title": "Neutrophil extracellular traps in the pathology of cancer and other inflammatory diseases.", "authors": [{"family": "Herre", "given": "Melanie", "initials": "M", "orcid": "0000-0002-9925-4531", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f3eaab4be595445ea39148a5bc2ea228.json"}}, {"family": "Cedervall", "given": "Jessica", "initials": "J", "orcid": "0000-0002-9251-3318", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d0c756e54d634faea619cee35ea70500.json"}}, {"family": "Mackman", "given": "Nigel", "initials": "N", "orcid": "0000-0002-9170-7700", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3417c0b6ae604ca296899b2a0a5df0a6.json"}}, {"family": "Olsson", "given": "Anna-Karin", "initials": "AK", "orcid": "0000-0002-5438-7293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65e94cd4e81f4728a66393ee6f067482.json"}}], "type": "journal article", "published": "2023-01-01", "journal": {"title": "Physiol Rev", "issn": "1522-1210", "volume": "103", "issue": "1", "pages": "277-312", "issn-l": null}, "abstract": "Neutrophil extracellular trap (NET) formation, first described in 2004 as a previously unknown strategy of neutrophils to fight microbes, has attracted an increasing interest in the research community. NETs are formed when neutrophils externalize their decondensed chromatin together with content from their azurophilic granules. In addition to their role in defense against microbes, NETs have been implicated as mediators of pathology in sterile inflammation, such as cancer and autoimmunity, and their potential as therapeutic targets is actively explored. However, targeting of NETs is challenging since the beneficial effects of their removal need to be balanced against the potential harmful loss of their function in microbial defense. Moreover, depending on the stimuli or species, NETs can be formed via distinct mechanisms and are not always made up of the same components, making direct comparisons between various studies challenging. This review focuses on the role of NETs in cancer-associated pathology, such as thrombosis, organ dysfunction, and metastasis. Different strategies to target NETs, by either preventing their formation or degrading existing ones, are also discussed.", "doi": "10.1152/physrev.00062.2021", "pmid": "35951483", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9576172"}], "notes": [], "created": "2026-08-21T12:28:08.476Z", "modified": "2026-08-21T12:28:08.665Z"}, {"entity": "publication", "iuid": "0eba6956785849dc9804fbd235fdf2c7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0eba6956785849dc9804fbd235fdf2c7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0eba6956785849dc9804fbd235fdf2c7"}}, "title": "Correction to: Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden.", "authors": [{"family": "Femel", "given": "Julia", "initials": "J"}, {"family": "van Hooren", "given": "Luuk", "initials": "L"}, {"family": "Herre", "given": "Melanie", "initials": "M"}, {"family": "Cedervall", "given": "Jessica", "initials": "J"}, {"family": "Saupe", "given": "Falk", "initials": "F"}, {"family": "Huijbers", "given": "Elisabeth J M", "initials": "EJM"}, {"family": "Verboogen", "given": "Danielle R J", "initials": "DRJ"}, {"family": "Reichel", "given": "Matthias", "initials": "M"}, {"family": "Thijssen", "given": "Victor L", "initials": "VL"}, {"family": "Griffioen", "given": "Arjan W", "initials": "AW"}, {"family": "Hellman", "given": "Lars", "initials": "L"}, {"family": "Dimberg", "given": "Anna", "initials": "A"}, {"family": "Olsson", "given": "Anna-Karin", "initials": "AK", "orcid": "0000-0002-5438-7293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65e94cd4e81f4728a66393ee6f067482.json"}}], "type": "published erratum", "published": "2022-10-00", "journal": {"title": "Cancer Immunol. Immunother.", "issn": "1432-0851", "volume": "71", "issue": "10", "pages": "2581", "issn-l": "0340-7004"}, "abstract": null, "doi": "10.1007/s00262-022-03175-8", "pmid": "35226107", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9463351"}, {"db": "pii", "key": "10.1007/s00262-022-03175-8"}], "notes": [], "created": "2026-08-20T06:39:33.923Z", "modified": "2026-08-20T06:39:33.994Z"}, {"entity": "publication", "iuid": "da7193f42b1c472d90e42c46890a14de", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/da7193f42b1c472d90e42c46890a14de.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/da7193f42b1c472d90e42c46890a14de"}}, "title": "Vaccination against galectin-1 promotes cytotoxic T-cell infiltration in melanoma and reduces tumor burden.", "authors": [{"family": "Femel", "given": "Julia", "initials": "J"}, {"family": "van Hooren", "given": "Luuk", "initials": "L"}, {"family": "Herre", "given": "Melanie", "initials": "M"}, {"family": "Cedervall", "given": "Jessica", "initials": "J"}, {"family": "Saupe", "given": "Falk", "initials": "F"}, {"family": "Huijbers", "given": "Elisabeth J M", "initials": "EJM"}, {"family": "Verboogen", "given": "Danielle R J", "initials": "DRJ"}, {"family": "Reichel", "given": "Matthias", "initials": "M"}, {"family": "Thijssen", "given": "Victor L", "initials": "VL"}, {"family": "Griffioen", "given": "Arjan W", "initials": "AW"}, {"family": "Hellman", "given": "Lars", "initials": "L"}, {"family": "Dimberg", "given": "Anna", "initials": "A"}, {"family": "Olsson", "given": "Anna-Karin", "initials": "AK", "orcid": "0000-0002-5438-7293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65e94cd4e81f4728a66393ee6f067482.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "Cancer Immunol. Immunother.", "issn": "1432-0851", "volume": "71", "issue": "8", "pages": "2029-2040", "issn-l": "0340-7004"}, "abstract": "Galectin-1 (Gal1) is a glycan-binding protein that promotes tumor progression by several distinct mechanisms. Through direct binding to vascular endothelial growth factor (VEGF)-receptor 2, Gal1 is able to induce VEGF-like signaling, which contributes to tumor angiogenesis. Furthermore, several studies have demonstrated an immunosuppressive function of Gal1 through effects on both effector and regulatory T cells. Elevated Gal1 expression and secretion have been shown in many tumor types, and high Gal1 serum levels have been connected to poor prognosis in cancer patients. These findings suggest that therapeutic strategies directed against Gal1 would enable simultaneous targeting of angiogenesis, immune evasion and metastasis. In the current study, we have analyzed the potential of Gal1 as a cancer vaccine target. We show that it is possible to generate high anti-Gal1 antibody levels in mice immunized with a recombinant vaccine protein consisting of bacterial sequences fused to Gal1. Growth of Gal1 expressing melanomas was significantly impaired in the immunized mice compared to the control group. This was associated with improved perfusion of the tumor vasculature, as well as increased infiltration of macrophages and cytotoxic T cells (CTLs). The level of granzyme B, mainly originating from CTLs in our model, was significantly elevated in Gal1 vaccinated mice and correlated with a decrease in tumor burden. We conclude that vaccination against Gal1 is a promising pro-immunogenic approach for cancer therapy that could potentially enhance the effect of other immunotherapeutic strategies due to its ability to promote CTL influx in tumors.", "doi": "10.1007/s00262-021-03139-4", "pmid": "35018481", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9293851"}, {"db": "pii", "key": "10.1007/s00262-021-03139-4"}], "notes": [], "created": "2026-08-20T06:39:32.076Z", "modified": "2026-08-20T06:39:32.157Z"}]}