{"entity": "researcher", "timestamp": "2026-08-20T21:34:58.080Z", "family": "Singh", "given": "Kailash", "initials": "K", "orcid": "0000-0002-6771-7757", "affiliations": ["Department of Medical Cell Biology, Uppsala University, 75123 Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/64dc76ffd32c4c2f824837132dcab1c7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/64dc76ffd32c4c2f824837132dcab1c7"}}, "publications": [{"entity": "publication", "iuid": "a7740def41024df6b9b34524bf1d45ad", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a7740def41024df6b9b34524bf1d45ad.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a7740def41024df6b9b34524bf1d45ad"}}, "title": "Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells.", "authors": [{"family": "Luo", "given": "Zhengkang", "initials": "Z"}, {"family": "Lundin", "given": "Sara", "initials": "S"}, {"family": "Mejia-Cordova", "given": "Mariela", "initials": "M"}, {"family": "Hassani", "given": "Imane", "initials": "I"}, {"family": "Blixt", "given": "Martin", "initials": "M"}, {"family": "Hjelmqvist", "given": "Daisy", "initials": "D"}, {"family": "Lau", "given": "Joey", "initials": "J", "orcid": "0000-0002-8302-3253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f5eb1f51bb1455998df895c889f7309.json"}}, {"family": "Espes", "given": "Daniel", "initials": "D"}, {"family": "Carlsson", "given": "Per-Ola", "initials": "PO"}, {"family": "Sandler", "given": "Stellan", "initials": "S"}, {"family": "Singh", "given": "Kailash", "initials": "K", "orcid": "0000-0002-6771-7757", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/64dc76ffd32c4c2f824837132dcab1c7.json"}}], "type": "journal article", "published": "2021-11-30", "journal": {"title": "Int J Mol Sci", "issn": "1422-0067", "volume": "22", "issue": "23", "issn-l": null}, "abstract": "The anti-inflammatory role of regulatory B cells (Breg cells) has been associated with IL-35 based on studies of experimental autoimmune uveitis and encephalitis. The role of Breg cells and IL-35+ Breg cells for type 1 diabetes (T1D) remains to be investigated. We studied PBMCs from T1D subjects and healthy controls (HC) and found lowered proportions of Breg cells and IL-35+ Breg cells in T1D. To elucidate the role of Breg cells, the lymphoid organs of two mouse models of T1D were examined. Lower proportions of Breg cells and IL-35+ Breg cells were found in the animal models of T1D compared with control mice. In addition, the systemic administration of recombinant mouse IL-35 prevented hyperglycemia after multiple low dose streptozotocin (MLDSTZ) injections and increased the proportions of Breg cells and IL-35+ Breg cells. A higher proportion of IFN-\u03b3+ cells among Breg cells were found in the PBMCs of the T1D subjects. In the MLDSTZ mice, IL-35 administration decreased the proportions of IFN-\u03b3+ cells among the Breg cells. Our data illustrate that Breg cells may play an important role in the development of T1D and that IL-35 treatment prevents the development of hyperglycemia by maintaining the phenotype of the Breg cells under an experimental T1D condition.", "doi": "10.3390/ijms222312988", "pmid": "34884797", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8657454"}, {"db": "pii", "key": "ijms222312988"}], "notes": [], "created": "2026-08-20T13:41:32.520Z", "modified": "2026-08-20T13:41:32.616Z"}]}