{"entity": "researcher", "timestamp": "2026-09-23T15:22:29.542Z", "family": "Yao", "given": "Chen", "initials": "C", "orcid": "0000-0002-3944-7788", "affiliations": ["Framingham Heart Study, Framingham, Massachusetts, United States of America.", "Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/6447432a72274279b3dc705f28caf4dc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/6447432a72274279b3dc705f28caf4dc"}}, "publications": [{"entity": "publication", "iuid": "1106727cdef949768289eae1dff6d75b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1106727cdef949768289eae1dff6d75b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1106727cdef949768289eae1dff6d75b"}}, "title": "Publisher Correction: 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{"family": "Shen", "given": "Jincheng", "initials": "J"}, {"family": "Bartz", "given": "Traci M", "initials": "TM"}, {"family": "Brody", "given": "Jennifer A", "initials": "JA", "orcid": "0000-0001-8509-148X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f5e5e63068a4762ba2c4ca10f30aa78.json"}}, {"family": "Montasser", "given": "May E", "initials": "ME"}, {"family": "O'Connell", "given": "Jeff R", "initials": "JR"}, {"family": "Yao", "given": "Chen", "initials": "C", "orcid": "0000-0002-3944-7788", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6447432a72274279b3dc705f28caf4dc.json"}}, {"family": "Xia", "given": "Rui", "initials": "R"}, {"family": "Boerwinkle", "given": "Eric", "initials": "E"}, {"family": "Grove", "given": "Megan", "initials": "M"}, {"family": "Guan", "given": "Weihua", "initials": "W"}, {"family": "Liliane", "given": "Pfeiffer", "initials": "P"}, {"family": "Singmann", "given": "Paula", "initials": 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"given": "Andrea", "initials": "A"}, {"family": "Levy", "given": "Daniel", "initials": "D"}, {"family": "Fornage", "given": "Myriam", "initials": "M", "orcid": "0000-0003-0677-8158", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f637ca1a5edd4ece9dd2f88f3620f0b2.json"}}, {"family": "Irvin", "given": "Marguerite R", "initials": "MR"}, {"family": "Assimes", "given": "Themistocles L", "initials": "TL", "orcid": "0000-0003-2349-0009", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/610f47c94b0c4fe2bb2da6921aa8a1ef.json"}}], "type": "published erratum", "published": "2021-07-06", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "4256", "issn-l": "2041-1723"}, "abstract": null, "doi": "10.1038/s41467-021-24600-z", "pmid": "34230475", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8260765"}, {"db": "pii", "key": "10.1038/s41467-021-24600-z"}], "notes": [], "created": "2026-09-23T14:32:19.774Z", "modified": "2026-09-23T14:32:20.368Z"}, {"entity": "publication", "iuid": "0c374c8dd6264e7b9c429188d0bd9910", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0c374c8dd6264e7b9c429188d0bd9910.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0c374c8dd6264e7b9c429188d0bd9910"}}, "title": "A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.", "authors": [{"family": "Jhun", "given": "Min-A", "initials": "MA", "orcid": "0000-0002-2445-7553", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7e02ae9a17d24397bcca6faf84e6f4b9.json"}}, {"family": "Mendelson", "given": "Michael", "initials": "M", "orcid": "0000-0001-7590-3958", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2da1f411dca24980956dc45ab71e0ad7.json"}}, {"family": "Wilson", "given": "Rory", "initials": "R", "orcid": 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"initials": "D"}, {"family": "Spector", "given": "Tim D", "initials": "TD", "orcid": "0000-0002-9795-0365", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d79b7af2d7a4f1da46ac2ee2bb1eb0b.json"}}, {"family": "Chen", "given": "Yii-der Ida", "initials": "YI"}, {"family": "Damcott", "given": "Coleen", "initials": "C", "orcid": "0000-0001-6233-7395", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2488d95e3b8d4950998fdc3ab3c67bbc.json"}}, {"family": "Shuldiner", "given": "Alan R", "initials": "AR"}, {"family": "Absher", "given": "Devin M", "initials": "DM"}, {"family": "Horvath", "given": "Steve", "initials": "S", "orcid": "0000-0002-4110-3589", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/64ebb5c28f4e420c8836e7d67353b24d.json"}}, {"family": "Tsao", "given": "Philip S", "initials": "PS", "orcid": "0000-0001-7274-9318", "researcher": {"href": 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"https://publications-affiliated.scilifelab.se/researcher/0c5fb80d13ae47648fa86a2a9806bf7b.json"}}, {"family": "Waldenberger", "given": "Melanie", "initials": "M", "orcid": "0000-0003-0583-5093", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f9bd14a640340a780af3ac53f2a41d1.json"}}, {"family": "Hou", "given": "Lifang", "initials": "L"}, {"family": "Whitsel", "given": "Eric A", "initials": "EA"}, {"family": "Baccarelli", "given": "Andrea", "initials": "A"}, {"family": "Levy", "given": "Daniel", "initials": "D"}, {"family": "Fornage", "given": "Myriam", "initials": "M", "orcid": "0000-0003-0677-8158", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f637ca1a5edd4ece9dd2f88f3620f0b2.json"}}, {"family": "Irvin", "given": "Marguerite R", "initials": "MR"}, {"family": "Assimes", "given": "Themistocles L", "initials": "TL", "orcid": "0000-0003-2349-0009", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/610f47c94b0c4fe2bb2da6921aa8a1ef.json"}}], "type": "journal article", "published": "2021-06-28", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "3987", "issn-l": "2041-1723"}, "abstract": "Here we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. We observe a high concordance in the direction of effects across racial/ethnic groups, a high correlation of effect sizes between high-density lipoprotein and triglycerides, a modest overlap of associations with epigenome-wide association studies of other cardio-metabolic traits, and a largely non-overlap with lipid loci identified to date through genome-wide association studies. Thirty CpGs reached significance in at least 2 racial/ethnic groups including 7 that showed association with the expression of an annotated gene. CpGs annotated to CPT1A showed evidence of being influenced by triglycerides levels. DNA methylation levels of circulating leukocytes show robust and consistent association with blood lipid levels across multiple racial/ethnic groups.", "doi": "10.1038/s41467-021-23899-y", "pmid": "34183656", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8238961"}, {"db": "pii", "key": "10.1038/s41467-021-23899-y"}, {"db": "Dryad", "key": "10.5061/dryad.qfttdz0d8"}], "notes": [], "created": "2026-09-23T09:29:50.456Z", "modified": "2026-09-23T09:29:51.545Z"}, {"entity": "publication", "iuid": "64f79b28d01346c98f84686af46ee1a8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/64f79b28d01346c98f84686af46ee1a8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/64f79b28d01346c98f84686af46ee1a8"}}, "title": "Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach.", "authors": [{"family": "Mendelson", "given": "Michael M", "initials": "MM"}, {"family": "Marioni", "given": "Riccardo E", "initials": "RE"}, {"family": "Joehanes", "given": "Roby", "initials": "R"}, {"family": "Liu", "given": "Chunyu", "initials": "C"}, {"family": "Hedman", "given": "\u00c5sa K", "initials": "\u00c5K", "orcid": "0000-0001-5413-204X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb844167d63c4be6916c84634f383f33.json"}}, {"family": "Aslibekyan", "given": "Stella", "initials": "S"}, {"family": "Demerath", "given": "Ellen W", "initials": "EW"}, {"family": "Guan", "given": "Weihua", "initials": "W"}, {"family": "Zhi", "given": "Degui", "initials": "D"}, {"family": "Yao", "given": "Chen", "initials": "C", "orcid": "0000-0002-3944-7788", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6447432a72274279b3dc705f28caf4dc.json"}}, {"family": "Huan", "given": "Tianxiao", "initials": "T", "orcid": "0000-0001-5840-9413", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d0c9c629fba41d5ab309567c5bdae11.json"}}, {"family": "Willinger", "given": "Christine", "initials": "C"}, {"family": "Chen", "given": "Brian", "initials": "B", "orcid": "0000-0001-9065-3301", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6047a4d8551411aab5bd6260cc0f13d.json"}}, {"family": "Courchesne", "given": "Paul", "initials": "P"}, {"family": "Multhaup", "given": "Michael", "initials": "M"}, {"family": "Irvin", "given": "Marguerite R", "initials": "MR"}, {"family": "Cohain", "given": "Ariella", "initials": "A", "orcid": "0000-0003-2375-0683", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/af5d07c68c354e1ea8385953f41780da.json"}}, {"family": "Schadt", "given": "Eric E", "initials": "EE"}, {"family": "Grove", "given": "Megan L", "initials": "ML", "orcid": "0000-0001-6764-2508", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b0774d7faa054abf9b2082690c4c4768.json"}}, {"family": "Bressler", "given": "Jan", "initials": "J"}, {"family": "North", "given": "Kari", "initials": "K"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Gustafsson", "given": "Stefan", "initials": "S"}, {"family": "Shah", "given": "Sonia", "initials": "S"}, {"family": "McRae", "given": "Allan F", "initials": "AF"}, {"family": "Harris", "given": "Sarah E", "initials": "SE"}, {"family": "Gibson", "given": "Jude", "initials": "J"}, {"family": "Redmond", "given": "Paul", "initials": "P"}, {"family": "Corley", "given": "Janie", "initials": "J"}, {"family": "Murphy", "given": "Lee", "initials": "L", "orcid": "0000-0001-6467-7449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2cee3ce58a3644b089afa48fcc223c2d.json"}}, {"family": "Starr", "given": "John M", "initials": "JM"}, {"family": "Kleinbrink", "given": "Erica", "initials": "E", "orcid": "0000-0002-8565-207X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0de0f74ab4e04960a4f368eaa75a4fff.json"}}, {"family": "Lipovich", "given": "Leonard", "initials": "L", "orcid": "0000-0002-0531-3570", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f03b5b84f0b482d909e1f9d88bd7afa.json"}}, {"family": "Visscher", "given": "Peter M", "initials": "PM"}, {"family": "Wray", "given": "Naomi R", "initials": "NR"}, {"family": "Krauss", "given": "Ronald M", "initials": "RM"}, {"family": "Fallin", "given": "Daniele", "initials": "D", "orcid": "0000-0002-9948-3908", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/74c4d0e5bc03413d8122cef45df67581.json"}}, {"family": "Feinberg", "given": "Andrew", "initials": "A"}, {"family": "Absher", "given": "Devin M", "initials": "DM", "orcid": "0000-0003-4405-1646", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f4029877b6546d7879277ada01f94c3.json"}}, {"family": "Fornage", "given": "Myriam", "initials": "M"}, {"family": "Pankow", "given": "James S", "initials": "JS"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Fox", "given": "Caroline", "initials": "C"}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "Arnett", "given": "Donna K", "initials": "DK"}, {"family": "Boerwinkle", "given": "Eric", "initials": "E"}, {"family": "Liang", "given": "Liming", "initials": "L"}, {"family": "Levy", "given": "Daniel", "initials": "D"}, {"family": "Deary", "given": "Ian J", "initials": "IJ"}], "type": "journal article", "published": "2017-01-00", "journal": {"title": "PLoS Med.", "issn": "1549-1676", "volume": "14", "issue": "1", "pages": "e1002215", "issn-l": "1549-1277"}, "abstract": "The link between DNA methylation, obesity, and adiposity-related diseases in the general population remains uncertain.\n\nWe conducted an association study of body mass index (BMI) and differential methylation for over 400,000 CpGs assayed by microarray in whole-blood-derived DNA from 3,743 participants in the Framingham Heart Study and the Lothian Birth Cohorts, with independent replication in three external cohorts of 4,055 participants. We examined variations in whole blood gene expression and conducted Mendelian randomization analyses to investigate the functional and clinical relevance of the findings. We identified novel and previously reported BMI-related differential methylation at 83 CpGs that replicated across cohorts; BMI-related differential methylation was associated with concurrent changes in the expression of genes in lipid metabolism pathways. Genetic instrumental variable analysis of alterations in methylation at one of the 83 replicated CpGs, cg11024682 (intronic to sterol regulatory element binding transcription factor 1 [SREBF1]), demonstrated links to BMI, adiposity-related traits, and coronary artery disease. Independent genetic instruments for expression of SREBF1 supported the findings linking methylation to adiposity and cardiometabolic disease. Methylation at a substantial proportion (16 of 83) of the identified loci was found to be secondary to differences in BMI. However, the cross-sectional nature of the data limits definitive causal determination.\n\nWe present robust associations of BMI with differential DNA methylation at numerous loci in blood cells. BMI-related DNA methylation and gene expression provide mechanistic insights into the relationship between DNA methylation, obesity, and adiposity-related diseases.", "doi": "10.1371/journal.pmed.1002215", "pmid": "28095459", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5240936"}, {"db": "pii", "key": "PMEDICINE-D-16-00194"}], "notes": [], "created": "2026-09-23T06:34:49.078Z", "modified": "2026-09-23T06:34:49.493Z"}]}