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"0028-0836"}, "abstract": null, "doi": "10.1038/s41586-021-03287-8", "pmid": "33731935", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8009763"}, {"db": "pii", "key": "10.1038/s41586-021-03287-8"}], "notes": [], "created": "2026-08-20T08:56:24.854Z", "modified": "2026-08-20T08:57:10.035Z"}, {"entity": "publication", "iuid": "bf2cb9d3c9e34c97be339d2b8fbb480d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bf2cb9d3c9e34c97be339d2b8fbb480d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bf2cb9d3c9e34c97be339d2b8fbb480d"}}, "title": "LifeTime and improving European healthcare through cell-based interceptive medicine.", "authors": [{"family": "Rajewsky", "given": "Nikolaus", "initials": "N", "orcid": "0000-0002-4785-4332", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0cf747828b154767998f0cae7fbb34d5.json"}}, {"family": "Almouzni", "given": "Genevi\u00e8ve", "initials": "G", 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"Vallot", "given": "C\u00e9line", "initials": "C", "orcid": "0000-0003-1601-2359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3094c4eff5fd46349912630f1770636a.json"}}, {"family": "van Oudenaarden", "given": "Alexander", "initials": "A", "orcid": "0000-0002-9442-3551", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/33649d3f227046eea9f3b3ce835d9057.json"}}, {"family": "Vidal", "given": "Marie", "initials": "M", "orcid": "0000-0003-1186-9994", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/077f341fdc4441d681ee1ecbd8edd039.json"}}, {"family": "Voet", "given": "Thierry", "initials": "T"}, {"family": "LifeTime Community Working Groups", "given": "", "initials": ""}], "type": "journal article", "published": "2020-11-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "587", "issue": "7834", "pages": "377-386", "issn-l": "0028-0836"}, "abstract": "Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during the progression from health to disease. The analysis of large molecular and clinical datasets will identify molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. The timely detection and interception of disease embedded in an ethical and patient-centred vision will be achieved through interactions across academia, hospitals, patient associations, health data management systems and industry. The application of this strategy to key medical challenges in cancer, neurological and neuropsychiatric disorders, and infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.", "doi": "10.1038/s41586-020-2715-9", "pmid": "32894860", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7656507"}, {"db": "pii", "key": "10.1038/s41586-020-2715-9"}], "notes": [], "created": "2026-08-20T08:56:17.301Z", "modified": "2026-08-20T08:56:55.192Z"}, {"entity": "publication", "iuid": "850dfd898fe04091b094d635a7e78f01", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/850dfd898fe04091b094d635a7e78f01.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/850dfd898fe04091b094d635a7e78f01"}}, "title": "Human Developmental Cell Atlas: milestones achieved and the roadmap ahead", "authors": [{"family": "Haniffa", "given": "Muzlifah", 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"https://publications-affiliated.scilifelab.se/researcher/f7e2fc512ac4498e9d12a76beb28051a.json"}}, {"family": "Treutlein", "given": "Barbara", "initials": "B", "orcid": "0000-0002-3299-5597", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/827307c0e5a34cba9b30eaf6c1a86cd6.json"}}, {"family": "Vento-Tormo", "given": "Roser", "initials": "R", "orcid": "0000-0002-9870-8474", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0cc6169d1b9944a1b1d2e99a1959e443.json"}}, {"family": "Webb", "given": "Simone", "initials": "S"}], "type": "posted-content", "published": "2020-10-12", "journal": {"issn-l": null}, "abstract": null, "doi": "10.21203/rs.3.rs-73986/v1", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:00:02.580Z", "modified": "2026-08-20T13:00:03.225Z"}, {"entity": "publication", "iuid": "7c811c1015bb487e9329ae1df36f749f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7c811c1015bb487e9329ae1df36f749f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7c811c1015bb487e9329ae1df36f749f"}}, "title": "Molecular architecture of the developing mouse brain", "authors": [{"family": "La Manno", "given": "Gioele", "initials": "G", "orcid": "0000-0003-1428-8757", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c431f72915cf4181872876d2720a74fa.json"}}, {"family": "Siletti", "given": "Kimberly", "initials": "K", "orcid": "0000-0001-7620-8973", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/be5a15f0812348eebff9201d865e591e.json"}}, {"family": "Furlan", "given": "Alessandro", "initials": "A", "orcid": "0000-0001-5149-6331", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4cdd5c0aadde4db8bcfac5416cec3513.json"}}, {"family": "Gyllborg", "given": "Daniel", "initials": "D", "orcid": "0000-0002-1429-6426", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a6778b611eb4a62a76b763daa8955f5.json"}}, {"family": "Vinsland", "given": "Elin", "initials": "E", "orcid": "0000-0001-9695-9192", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/70392d97034c4e66aa1cf5b5c2ee9e76.json"}}, {"family": "Langseth", "given": "Christoffer Mattsson", "initials": "CM", "orcid": "0000-0003-2230-8594", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4d73b090432c4a5397dfe4d8433c72cf.json"}}, {"family": "Khven", "given": "Irina", "initials": "I"}, {"family": "Johnsson", "given": "Anna", "initials": "A"}, {"family": "Nilsson", "given": "Mats", "initials": "M", "orcid": "0000-0001-9985-0387", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3311155f09a64b4f88d673da2a40627b.json"}}, {"family": "L\u00f6nnerberg", "given": "Peter", "initials": "P"}, {"family": "Linnarsson", "given": "Sten", "initials": "S", "orcid": "0000-0002-3491-3444", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/638b2874e1144bf497bc96f9bce5ccb9.json"}}], "type": "posted-content", "published": "2020-07-03", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.07.02.184051", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T09:57:45.464Z", "modified": "2026-08-20T09:57:45.719Z"}, {"entity": "publication", "iuid": "1257393c779c439ea064f759b3fef725", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1257393c779c439ea064f759b3fef725.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1257393c779c439ea064f759b3fef725"}}, "title": "Alternative TSSs are co-regulated in single cells in the mouse brain.", "authors": [{"family": "Karlsson", "given": "Kasper", "initials": "K", "orcid": "0000-0003-0162-1354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9b820b640d69404d9034db5089a4fddd.json"}}, {"family": "L\u00f6nnerberg", "given": "Peter", "initials": "P"}, {"family": "Linnarsson", "given": "Sten", "initials": "S", "orcid": "0000-0002-3491-3444", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/638b2874e1144bf497bc96f9bce5ccb9.json"}}], "type": "journal article", "published": "2017-05-11", "journal": {"title": "Mol Syst Biol", "issn": "1744-4292", "volume": "13", "issue": "5", "pages": "930", "issn-l": "1744-4292"}, "abstract": "Alternative transcription start sites (TSSs) have been extensively studied genome-wide for many cell types and have been shown to be important during development and to regulate transcript abundance between cell types. Likewise, single-cell gene expression has been extensively studied for many cell types. However, how single cells use TSSs has not yet been examined. In particular, it is unknown whether alternative TSSs are independently expressed, or whether they are co-activated or even mutually exclusive in single cells. Here, we use a previously published single-cell RNA-seq dataset, comprising thousands of cells, to study alternative TSS usage. We find that alternative TSS usage is a regulated process, and the correlation between two TSSs expressed in single cells of the same cell type is surprisingly high. Our findings indicate that TSSs generally are regulated by common factors rather than being independently regulated or stochastically expressed.", "doi": "10.15252/msb.20167374", "pmid": "28495919", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5448164"}], "notes": [], "created": "2026-08-20T12:51:49.270Z", "modified": "2026-08-20T12:51:49.367Z"}]}