{"entity": "researcher", "timestamp": "2026-07-22T16:10:22.437Z", "family": "Larsen", "given": "Filip J", "initials": "FJ", "orcid": "0000-0002-1343-8656", "affiliations": ["\u00c5strand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/63564df3b52d4e4ebc7ec2d9dd2e49ac.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/63564df3b52d4e4ebc7ec2d9dd2e49ac"}}, "publications": [{"entity": "publication", "iuid": "8d71bb0c8d5a4afea0ba7cdff99bb345", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8d71bb0c8d5a4afea0ba7cdff99bb345.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8d71bb0c8d5a4afea0ba7cdff99bb345"}}, "title": "Complex I is bypassed during high intensity exercise.", "authors": [{"family": "Nilsson", "given": "Avlant", "initials": "A", "orcid": "0000-0002-9476-4516", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f2e21dbc1c624f6a841c59e959e948e4.json"}}, {"family": "Bj\u00f6rnson", "given": "Elias", "initials": "E", "orcid": "0000-0002-0003-6463", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c5435f61cd24205af6a5d770a9a0451.json"}}, {"family": "Flockhart", "given": "Mikael", "initials": "M", "orcid": "0000-0002-7743-9295", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1490d76702754143a3963b24055f10dd.json"}}, {"family": "Larsen", "given": "Filip J", "initials": "FJ", "orcid": "0000-0002-1343-8656", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/63564df3b52d4e4ebc7ec2d9dd2e49ac.json"}}, {"family": "Nielsen", "given": "Jens", "initials": "J", "orcid": "0000-0002-9955-6003", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/33f2b49a39ed4e54ba77dfe397ed3087.json"}}], "type": "journal article", "published": "2019-11-07", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "10", "issue": "1", "pages": "5072"}, "abstract": "Human muscles are tailored towards ATP synthesis. When exercising at high work rates muscles convert glucose to lactate, which is less nutrient efficient than respiration. There is hence a trade-off between endurance and power. Metabolic models have been developed to study how limited catalytic capacity of enzymes affects ATP synthesis. Here we integrate an enzyme-constrained metabolic model with proteomics data from muscle fibers. We find that ATP synthesis is constrained by several enzymes. A metabolic bypass of mitochondrial complex I is found to increase the ATP synthesis rate per gram of protein compared to full respiration. To test if this metabolic mode occurs in vivo, we conduct a high resolved incremental exercise tests for five subjects. Their gas exchange at different work rates is accurately reproduced by a whole-body metabolic model incorporating complex I bypass. The study therefore shows how proteome allocation influences metabolism during high intensity exercise.", "doi": "10.1038/s41467-019-12934-8", "pmid": "31699973", "labels": {"Avlant Nilsson": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC6838197"}, {"db": "pii", "key": "10.1038/s41467-019-12934-8"}], "notes": [], "created": "2025-03-20T11:09:42.939Z", "modified": "2025-03-21T13:17:16.987Z"}]}