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"https://publications-affiliated.scilifelab.se/researcher/02defb98c7c442b8aa54a0d19816d949.json"}}, {"family": "Gelernter", "given": "Joel", "initials": "J", "orcid": "0000-0002-4067-1859", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/867b957d5ca7406ab3bd969db1f7daa0.json"}}, {"family": "Mathews", "given": "Carol A", "initials": "CA"}, {"family": "Derks", "given": "Eske M", "initials": "EM", "orcid": "0000-0002-6292-6883", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ba4bce3f4c7d48b4990fdb6b34d64762.json"}}, {"family": "Mattheisen", "given": "Manuel", "initials": "M", "orcid": "0000-0002-8442-493X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc6a347bff244d59821f31a5aa0fd805.json"}}], "type": "journal article", "published": "2025-06-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "57", "issue": "6", "pages": "1389-1401", "issn-l": "1061-4036"}, "abstract": "Obsessive-compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including WDR6, DALRD3 and CTNND1 and multiple genes in the major histocompatibility complex (MHC) region. We estimated that ~11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and the cortex, along with D1 and D2 type dopamine receptor-containing medium spiny neurons. OCD genetic risk was shared with 65 of 112 additional phenotypes, including all the psychiatric disorders we examined. In particular, OCD shared genetic risk with anxiety, depression, anorexia nervosa and Tourette syndrome and was negatively associated with inflammatory bowel diseases, educational attainment and body mass index.", "doi": "10.1038/s41588-025-02189-z", "pmid": "40360802", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12165847"}, {"db": "pii", "key": "10.1038/s41588-025-02189-z"}], "notes": [], "created": "2026-08-20T09:00:15.281Z", "modified": "2026-08-20T09:00:18.805Z"}, {"entity": "publication", "iuid": "b3374ca6bf2a4921bba3c18225e4e1b6", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b3374ca6bf2a4921bba3c18225e4e1b6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b3374ca6bf2a4921bba3c18225e4e1b6"}}, "title": "Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.", "authors": [{"family": "Strom", "given": "Nora I", "initials": "NI", "orcid": "0000-0002-5261-8852", 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"https://publications-affiliated.scilifelab.se/researcher/f7e6f19a0a7b4d5ba54d250fdecaee46.json"}}, {"family": "Arnold", "given": "Paul D", "initials": "PD", "orcid": "0000-0003-2496-4624", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e7b167a809ea4cd8956ca066d58e4c29.json"}}, {"family": "Grice", "given": "Dorothy E", "initials": "DE", "orcid": "0000-0002-8833-2549", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/baf7b94523774b918bfd9bd7bacdb0b0.json"}}, {"family": "Knowles", "given": "James A", "initials": "JA", "orcid": "0000-0002-3307-5741", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/66d1c551ab074508ba442f0ce2168555.json"}}, {"family": "Ask", "given": "Helga", "initials": "H", "orcid": "0000-0003-0149-5319", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/69ada7e3440c4a399e67fb382ab13d28.json"}}, {"family": "Verweij", "given": "Karin J", "initials": "KJ", "orcid": "0000-0001-9868-7821", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/37c5146448f042dd84aca776c24de59e.json"}}, {"family": "Davis", "given": "Lea K", "initials": "LK", "orcid": "0000-0001-5143-2282", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7cd85392839d49e392ca9598f75f2e81.json"}}, {"family": "Smit", "given": "Dirk J", "initials": "DJ", "orcid": "0000-0001-8301-8860", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/72722d507e7447c5af1796829b4727e5.json"}}, {"family": "Crowley", "given": "James J", "initials": "JJ", "orcid": "0000-0001-9051-1557", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6a46d1ecc0e476bad9bbab566b4255a.json"}}, {"family": "Scharf", "given": "Jeremiah M", "initials": "JM", "orcid": "0000-0002-4742-5896", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9aa4f6673d74eeb90d62ec663421532.json"}}, {"family": "Stein", "given": "Murray B", "initials": "MB", "orcid": "0000-0001-9564-2871", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02defb98c7c442b8aa54a0d19816d949.json"}}, {"family": "Gelernter", "given": "Joel", "initials": "J", "orcid": "0000-0002-4067-1859", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/867b957d5ca7406ab3bd969db1f7daa0.json"}}, {"family": "Mathews", "given": "Carol A", "initials": "CA", "orcid": "0000-0003-2208-7058", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f3ca04cb775b44ec81c7d851f05d1e9c.json"}}, {"family": "Derks", "given": "Eske M", "initials": "EM", "orcid": "0000-0002-6292-6883", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ba4bce3f4c7d48b4990fdb6b34d64762.json"}}, {"family": "Mattheisen", "given": "Manuel", "initials": "M", "orcid": "0000-0002-8442-493X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc6a347bff244d59821f31a5aa0fd805.json"}}], "type": "journal article", "published": "2025-04-08", "journal": {"title": "medRxiv", "issn-l": null}, "abstract": "Obsessive-compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including WDR6, DALRD3, CTNND1 and multiple genes in the MHC region. We estimated that ~11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and cortex, along with D1- and D2-type dopamine receptor-containing medium spiny neurons. OCD genetic risk was shared with 65 of 112 additional phenotypes, including all of the psychiatric disorders we examined. In particular, OCD shared genetic risk with anxiety, depression, anorexia nervosa, and Tourette syndrome, and was negatively associated with inflammatory bowel diseases, educational attainment, and body mass index.", "doi": "10.1101/2024.03.13.24304161", "pmid": "38712091", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11071577"}, {"db": "pii", "key": "2024.03.13.24304161"}, {"db": "figshare", "key": "10.6084/m9.figshare.28451894"}], "notes": [], "created": "2026-08-20T10:52:45.924Z", "modified": "2026-08-20T10:52:50.588Z"}, {"entity": "publication", "iuid": "00e346ce54bf4f329ebeaf39f9b52aa7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/00e346ce54bf4f329ebeaf39f9b52aa7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/00e346ce54bf4f329ebeaf39f9b52aa7"}}, "title": "A burden of rare copy number variants in obsessive-compulsive disorder.", "authors": [{"family": "Halvorsen", "given": "Matthew W", "initials": "MW", "orcid": "0000-0002-6707-2418", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b3d072e2d5314d5abb6e07121e26e906.json"}}, {"family": "de Schipper", "given": "Elles", "initials": "E"}, {"family": "B\u00e4ckman", "given": "Julia", "initials": "J"}, {"family": "Strom", "given": "Nora I", "initials": "NI", "orcid": "0000-0002-5261-8852", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d805c34a1b224409bdaaba1ed7ae3137.json"}}, {"family": "Hagen", "given": "Kristen", "initials": "K", "orcid": "0000-0002-4286-1277", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e702371110c2474c849cd2c62fa35e83.json"}}, {"family": "Nordic OCD and Related Disorders Consortium (NORDiC)", "given": "", "initials": ""}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/612a779b69494f1ca9b6c5f1d84fd711.json"}}, {"family": "Karlsson", "given": "Elinor K", "initials": "EK", "orcid": "0000-0002-4343-3776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81b5c82fcb904394b6a6b1d811863fa0.json"}}, {"family": "Pedersen", "given": "Nancy L", "initials": "NL"}, {"family": "Wallert", "given": "John", "initials": "J"}, {"family": "Bulik", "given": "Cynthia M", "initials": "CM", "orcid": "0000-0001-7772-3264", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a787d2c77134fc4a20aa46b738881d0.json"}}, {"family": "Fund\u00edn", "given": "Bengt", "initials": "B"}, {"family": "Land\u00e9n", "given": "Mikael", "initials": "M", "orcid": "0000-0002-4496-6451", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e788f5999d644719a8c4816c88d7de3.json"}}, {"family": "Kvale", "given": "Gerd", "initials": "G"}, {"family": "Hansen", "given": "Bjarne", "initials": "B"}, {"family": "Haavik", "given": "Jan", "initials": "J", "orcid": "0000-0001-7865-2808", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/19a75dabdfdb48338e8e6ceb8800347a.json"}}, {"family": "Mattheisen", "given": "Manuel", "initials": "M", "orcid": "0000-0002-8442-493X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc6a347bff244d59821f31a5aa0fd805.json"}}, {"family": "R\u00fcck", "given": "Christian", "initials": "C", "orcid": "0000-0002-8742-0168", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9565fd9a92884bcd921f490c7a6c821b.json"}}, {"family": "Mataix-Cols", "given": "David", "initials": "D", "orcid": "0000-0002-4545-0924", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4e4cd9916d7420cb7ca20a9a107ff94.json"}}, {"family": "Crowley", "given": "James J", "initials": "JJ", "orcid": "0000-0001-9051-1557", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6a46d1ecc0e476bad9bbab566b4255a.json"}}], "type": "journal article", "published": "2025-04-00", "journal": {"title": "Mol. Psychiatry", "issn": "1476-5578", "volume": "30", "issue": "4", "pages": "1510-1517", "issn-l": "1359-4184"}, "abstract": "Current genetic research on obsessive-compulsive disorder (OCD) supports contributions to risk specifically from common single nucleotide variants (SNVs), along with rare coding SNVs and small insertion-deletions (indels). The contribution to OCD risk from rare copy number variants (CNVs), however, has not been formally assessed at a similar scale. Here we describe an analysis of rare CNVs called from genotype array data in 2248 deeply phenotyped OCD cases and 3608 unaffected controls from Sweden and Norway. Cases carry an elevated burden of CNVs \u226530 kb in size (OR = 1.12, P = 1.77 \u00d7 10-3). The excess rate of these CNVs in cases versus controls was around 0.07 (95% CI 0.02-0.11, P = 2.58 \u00d7 10-3). This signal was largely driven by CNVs overlapping protein-coding regions (OR = 1.19, P = 3.08 \u00d7 10-4), particularly deletions impacting loss-of-function intolerant genes (pLI >0.995, OR = 4.12, P = 2.54 \u00d7 10-5). We did not identify any specific locus where CNV burden was associated with OCD case status at genome-wide significance, but we noted non-random recurrence of CNV deletions in cases (permutation P = 2.60 \u00d7 10-3). In cases where sufficient clinical data were available (n = 1612) we found that carriers of neurodevelopmental duplications were more likely to have comorbid autism (P < 0.001), and that carriers of deletions overlapping neurodevelopmental genes had lower treatment response (P = 0.02). The results demonstrate a contribution of rare CNVs to OCD risk, and suggest that studies of rare coding variation in OCD would have increased power to identify risk genes if this class of variation were incorporated into formal tests.", "doi": "10.1038/s41380-024-02763-7", "pmid": "39463448", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11919692"}, {"db": "pii", "key": "10.1038/s41380-024-02763-7"}], "notes": [], "created": "2026-08-20T08:48:07.296Z", "modified": "2026-08-20T08:48:07.839Z"}, {"entity": "publication", "iuid": "6fbcd70f6fdd47ca8a9de8bc69c85c7d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6fbcd70f6fdd47ca8a9de8bc69c85c7d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6fbcd70f6fdd47ca8a9de8bc69c85c7d"}}, "title": "Hemangiosarcoma Cells Promote Conserved Host-derived Hematopoietic Expansion.", "authors": [{"family": "Kim", "given": "Jong Hyuk", "initials": "JH", "orcid": "0000-0002-1645-0036", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3553b69d2420463ca6a24d52696a7da7.json"}}, {"family": "Schulte", "given": "Ashley J", "initials": "AJ", "orcid": "0009-0001-3114-7844", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dff7cb5e2ffe42a6a726370fba006723.json"}}, {"family": "Sarver", "given": "Aaron L", "initials": "AL", "orcid": "0000-0002-7098-301X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/beadd13747cb47319ec33a0189e53d54.json"}}, {"family": "Lee", "given": "Donghee", "initials": "D", "orcid": "0009-0005-4763-1437", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8ab7e28c5c44eb59c6e5fcdfd854aba.json"}}, {"family": "Angelos", "given": "Mathew G", "initials": "MG", "orcid": "0000-0002-9903-5021", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/606375e1eb2245e4a4d82b4fbd59668b.json"}}, {"family": "Frantz", "given": "Aric M", "initials": "AM", "orcid": "0009-0002-0451-0393", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/83b88d1f9f564e45bdd85ea79834b3a3.json"}}, {"family": "Forster", "given": "Colleen L", "initials": "CL", "orcid": "0000-0001-5593-882X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7a2713a420d44e4c8afddc5c34e33e2f.json"}}, {"family": "O'Brien", "given": "Timothy D", "initials": "TD", "orcid": "0000-0001-9742-0930", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7c093e1b3a44ec39a321a8428865c89.json"}}, {"family": "Cornax", "given": "Ingrid", "initials": "I", "orcid": "0009-0004-3688-9056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/392165707de44a3b81aaa32d9df9e1aa.json"}}, {"family": "O'Sullivan", "given": "M Gerard", "initials": "MG", "orcid": "0000-0002-5463-1153", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bef38481c6f246368c5ef5f2742898aa.json"}}, {"family": "Cheng", "given": "Nuojin", "initials": "N", "orcid": "0000-0001-6926-8994", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d3abf87dbd0448ecb3631056062a2eb3.json"}}, {"family": "Lewellen", "given": "Mitzi", "initials": "M", "orcid": "0009-0005-9026-9883", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d639a59fa1ef4cb8bd36cb765023c63d.json"}}, {"family": "Oseth", "given": "LeAnn", "initials": "L", "orcid": "0009-0001-9259-3776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c57f2daa06444a17bf617f0eae15d37e.json"}}, {"family": "Kumar", "given": "Sunil", "initials": "S", "orcid": "0000-0002-1112-088X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76c174002a114229b186481106d696e4.json"}}, {"family": "Bullman", "given": "Susan", "initials": "S", "orcid": "0000-0002-7713-0810", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67edad9be25e4ff8b31ae0a0495b34a2.json"}}, {"family": "Pedamallu", "given": "Chandra Sekhar", "initials": "CS", "orcid": "0000-0002-7899-0206", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bfeb738cca3c443388e13f2f0c7a1af2.json"}}, {"family": "Goyal", "given": "Sagar M", "initials": "SM", "orcid": "0000-0002-7781-3080", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2bfd8c2b945942a2a92b6a26ffdc07a6.json"}}, {"family": "Meyerson", "given": "Matthew", "initials": "M", "orcid": "0000-0002-9133-8108", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f6cb18decbaf4406bee815ef4eb83408.json"}}, {"family": "Lund", "given": "Troy C", "initials": "TC", "orcid": "0000-0001-9174-8919", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5a03b56b36ae42739bb6631f8977033c.json"}}, {"family": "Breen", "given": "Matthew", "initials": "M", "orcid": "0000-0002-8901-4155", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/095f4b50bfba438abcff667f8ca7a542.json"}}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/612a779b69494f1ca9b6c5f1d84fd711.json"}}, {"family": "Dickerson", "given": "Erin B", "initials": "EB", "orcid": "0000-0002-9757-4961", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7bc292f101d6424da83e53676c97f341.json"}}, {"family": "Kaufman", "given": "Dan S", "initials": "DS", "orcid": "0000-0002-2003-2494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/19dd6d7d4300442ca82b24096dadeb04.json"}}, {"family": "Modiano", "given": "Jaime F", "initials": "JF", "orcid": "0000-0001-6398-7648", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ba4bb579a21472dab716ebf61874801.json"}}], "type": "journal article", "published": "2024-06-11", "journal": {"title": "Cancer Res Commun", "issn": "2767-9764", "volume": "4", "issue": "6", "pages": "1467-1480", "issn-l": null}, "abstract": "Hemangiosarcoma and angiosarcoma are soft-tissue sarcomas of blood vessel-forming cells in dogs and humans, respectively. These vasoformative sarcomas are aggressive and highly metastatic, with disorganized, irregular blood-filled vascular spaces. Our objective was to define molecular programs which support the niche that enables progression of canine hemangiosarcoma and human angiosarcoma. Dog-in-mouse hemangiosarcoma xenografts recapitulated the vasoformative and highly angiogenic morphology and molecular characteristics of primary tumors. Blood vessels in the tumors were complex and disorganized, and they were lined by both donor and host cells. In a series of xenografts, we observed that the transplanted hemangiosarcoma cells created exuberant myeloid hyperplasia and gave rise to lymphoproliferative tumors of mouse origin. Our functional analyses indicate that hemangiosarcoma cells generate a microenvironment that supports expansion and differentiation of hematopoietic progenitor populations. Furthermore, gene expression profiling data revealed hemangiosarcoma cells expressed a repertoire of hematopoietic cytokines capable of regulating the surrounding stromal cells. We conclude that canine hemangiosarcomas, and possibly human angiosarcomas, maintain molecular properties that provide hematopoietic support and facilitate stromal reactions, suggesting their potential involvement in promoting the growth of hematopoietic tumors.\n\nWe demonstrate that hemangiosarcomas regulate molecular programs supporting hematopoietic expansion and differentiation, providing insights into their potential roles in creating a permissive stromal-immune environment for tumor progression.", "doi": "10.1158/2767-9764.CRC-23-0441", "pmid": "38757809", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11166094"}, {"db": "pii", "key": "745407"}], "notes": [], "created": "2026-08-20T12:14:53.714Z", "modified": "2026-08-20T12:14:54.666Z"}, {"entity": "publication", "iuid": "423e19a9f50f4ce787723017cade475a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/423e19a9f50f4ce787723017cade475a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/423e19a9f50f4ce787723017cade475a"}}, "title": "Using evolutionary constraint to define novel candidate driver genes in medulloblastoma.", "authors": [{"family": "Roy", "given": "Ananya", "initials": "A"}, {"family": "Sakthikumar", "given": "Sharadha", "initials": "S"}, {"family": "Kozyrev", "given": "Sergey V", "initials": "SV"}, {"family": "Nordin", "given": "Jessika", "initials": "J", "orcid": "0000-0002-8414-2190", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a285875862f24b6fa0b378550da371fa.json"}}, {"family": "Pensch", "given": "Raphaela", "initials": "R", "orcid": "0000-0002-0313-8369", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca3190f9abf5474fae557aa4c8bbea3d.json"}}, {"family": "M\u00e4kel\u00e4inen", "given": "Suvi", "initials": "S"}, {"family": "Pettersson", "given": "Mats", "initials": "M", "orcid": "0000-0002-7372-9076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2310759fe6e4fd0b4a48ba9c35d3f84.json"}}, {"family": "Zoonomia Consortium", "given": "", "initials": ""}, {"family": "Karlsson", "given": "Elinor K", "initials": "EK", "orcid": "0000-0002-4343-3776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81b5c82fcb904394b6a6b1d811863fa0.json"}}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/612a779b69494f1ca9b6c5f1d84fd711.json"}}, {"family": "Forsberg-Nilsson", "given": "Karin", "initials": "K"}], "type": "journal article", "published": "2023-08-15", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "120", "issue": "33", "pages": "e2300984120", "issn-l": "0027-8424"}, "abstract": "Current knowledge of cancer genomics remains biased against noncoding mutations. To systematically search for regulatory noncoding mutations, we assessed mutations in conserved positions in the genome under the assumption that these are more likely to be functional than mutations in positions with low conservation. To this end, we use whole-genome sequencing data from the International Cancer Genome Consortium and combined it with evolutionary constraint inferred from 240 mammals, to identify genes enriched in noncoding constraint mutations (NCCMs), mutations likely to be regulatory in nature. We compare medulloblastoma (MB), which is malignant, to pilocytic astrocytoma (PA), a primarily benign tumor, and find highly different NCCM frequencies between the two, in agreement with the fact that malignant cancers tend to have more mutations. In PA, a high NCCM frequency only affects the BRAF locus, which is the most commonly mutated gene in PA. In contrast, in MB, >500 genes have high levels of NCCMs. Intriguingly, several loci with NCCMs in MB are associated with different ages of onset, such as the HOXB cluster in young MB patients. In adult patients, NCCMs occurred in, e.g., the WASF-2/AHDC1/FGR locus. One of these NCCMs led to increased expression of the SRC kinase FGR and augmented responsiveness of MB cells to dasatinib, a SRC kinase inhibitor. Our analysis thus points to different molecular pathways in different patient groups. These newly identified putative candidate driver mutations may aid in patient stratification in MB and could be valuable for future selection of personalized treatment options.", "doi": "10.1073/pnas.2300984120", "pmid": "37549291", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10438395"}], "notes": [], "created": "2026-08-20T09:31:26.073Z", "modified": "2026-08-20T09:31:26.234Z"}, {"entity": "publication", "iuid": "c7590809e3954fe399b662f54d35606c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c7590809e3954fe399b662f54d35606c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c7590809e3954fe399b662f54d35606c"}}, "title": "Multiple Genetic Loci Associated with Pug Dog Thoracolumbar Myelopathy.", "authors": [{"family": "Brander", "given": "Gustaf", "initials": "G", "orcid": "0000-0002-9549-4909", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e1bb9b8988545c5afa1a0499af45004.json"}}, {"family": "Rohdin", "given": "Cecilia", "initials": "C"}, {"family": "Bianchi", "given": "Matteo", "initials": "M"}, {"family": "Bergvall", "given": "Kerstin", "initials": "K"}, {"family": "Andersson", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0001-5131-3144", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/52a4de0ac8e245919d68e7d96dd49914.json"}}, {"family": "Ljungvall", "given": "Ingrid", "initials": "I"}, {"family": "Hultin J\u00e4derlund", "given": "Karin", "initials": "K"}, {"family": "H\u00e4ggstr\u00f6m", "given": "Jens", "initials": "J", "orcid": "0000-0003-3402-023X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/72f5852ea390478a8f8dcaa0a4d8390c.json"}}, {"family": "Hedhammar", "given": "\u00c5ke", "initials": "\u00c5"}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/612a779b69494f1ca9b6c5f1d84fd711.json"}}, {"family": "Tengvall", "given": "Katarina", "initials": "K"}], "type": "journal article", "published": "2023-02-01", "journal": {"title": "Genes (Basel)", "issn": "2073-4425", "volume": "14", "issue": "2", "issn-l": "2073-4425"}, "abstract": "Pug dogs with thoracolumbar myelopathy (PDM) present with a specific clinical phenotype that includes progressive pelvic limb ataxia and paresis, commonly accompanied by incontinence. Vertebral column malformations and lesions, excessive scar tissue of the meninges, and central nervous system inflammation have been described. PDM has a late onset and affects more male than female dogs. The breed-specific presentation of the disorder suggests that genetic risk factors are involved in the disease development. To perform a genome-wide search for PDM-associated loci, we applied a Bayesian model adapted for mapping complex traits (BayesR) and a cross-population extended haplotype homozygosity test (XP-EHH) in 51 affected and 38 control pugs. Nineteen associated loci (harboring 67 genes in total, including 34 potential candidate genes) and three candidate regions under selection (with four genes within or next to the signal) were identified. The multiple candidate genes identified have implicated functions in bone homeostasis, fibrotic scar tissue, inflammatory responses, or the formation, regulation, and differentiation of cartilage, suggesting the potential relevance of these processes to the pathogenesis of PDM.", "doi": "10.3390/genes14020385", "pmid": "36833311", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9957375"}, {"db": "pii", "key": "genes14020385"}], "notes": [], "created": "2026-08-20T13:40:54.626Z", "modified": "2026-08-20T13:40:54.785Z"}, {"entity": "publication", "iuid": "8b9b4c80163b4b61b0bff465ae4bb6ae", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8b9b4c80163b4b61b0bff465ae4bb6ae.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8b9b4c80163b4b61b0bff465ae4bb6ae"}}, "title": "Insights into mammalian TE diversity via the curation of 248 mammalian genome assemblies", "authors": [{"family": "Osmanski", "given": "Austin B", "initials": "AB", "orcid": "0000-0002-1485-6446", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9dda01496474b11a018f3c629f18d1b.json"}}, {"family": "Paulat", "given": "Nicole S", "initials": "NS", "orcid": "0000-0002-6881-2588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ca5ca8c8acd4c65b5836fecb4b443a0.json"}}, {"family": "Korstian", "given": "Jenny", "initials": "J", "orcid": "0000-0003-3872-8948", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8f961ea9153345278a8acd0586608b41.json"}}, {"family": "Grimshaw", "given": "Jenna R", "initials": "JR", "orcid": "0000-0001-7673-5167", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/47c81a9b846f488d9b140dcfcb28edaf.json"}}, {"family": "Halsey", "given": "Michaela", "initials": "M"}, {"family": "Sullivan", "given": "Kevin A M", "initials": "KAM"}, {"family": "Moreno-Santill\u00e1n", "given": "Diana D", "initials": "DD", "orcid": "0000-0003-2153-0732", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80c929d82dfe4c969e2b68bd20b99263.json"}}, {"family": "Crookshanks", "given": "Claudia", "initials": "C"}, {"family": "Roberts", "given": "Jacquelyn", "initials": "J"}, {"family": "Garcia", "given": "Carlos", "initials": "C"}, {"family": "Johnson", "given": "Matthew G", "initials": "MG", "orcid": "0000-0002-1958-6334", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6507717463ae46e3ad96fb00d4544a11.json"}}, {"family": "Densmore", "given": "Llewellyn D", "initials": "LD"}, {"family": "Stevens", "given": "Richard D", "initials": "RD"}, {"family": "Rosen", "given": "Jeb", "initials": "J", "orcid": "0000-0002-8832-1276", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7405a278ed5f428c9ba38968182d409f.json"}}, {"family": "Storer", "given": "Jessica M", "initials": "JM"}, {"family": "Hubley", "given": "Robert", "initials": "R", "orcid": "0000-0001-9261-3821", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/86b6fe3c9be54bc58dd8c750dda51aa3.json"}}, {"family": "Smit", "given": "Arian F A", "initials": "AFA", "orcid": "0000-0003-2088-3165", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ddf0080c6ee44cbe830114f0ab126884.json"}}, {"family": "D\u00e1valos", "given": "Liliana M", "initials": "LM", "orcid": "0000-0002-4327-7697", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7d8a875eb2704b75ac10564ffb83c3b0.json"}}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/612a779b69494f1ca9b6c5f1d84fd711.json"}}, {"family": "Karlsson", "given": "Elinor K", "initials": "EK", "orcid": "0000-0002-4343-3776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81b5c82fcb904394b6a6b1d811863fa0.json"}}, {"family": "Ray", "given": "David A", "initials": "DA", "orcid": "0000-0002-3340-3987", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6392a5497414b98999823cbafd67d4b.json"}}], "type": "posted-content", "published": "2022-12-30", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.12.28.522108", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:43:12.222Z", "modified": "2026-08-20T10:43:12.564Z"}, {"entity": "publication", "iuid": "aad4619ecdcc4770ae68236724ac91a1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/aad4619ecdcc4770ae68236724ac91a1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/aad4619ecdcc4770ae68236724ac91a1"}}, "title": "Three-dimensional genome re-wiring in loci with Human Accelerated Regions", "authors": [{"family": "Keough", "given": "Kathleen C", "initials": "KC", "orcid": "0000-0002-7481-0511", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27ba6707b77e4d0eb914e71063dab333.json"}}, {"family": "Whalen", "given": "Sean", "initials": "S", "orcid": "0000-0002-6648-3610", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d06b9f8ca8ea41c4acba0e438ea0d373.json"}}, {"family": "Inoue", "given": "Fumitaka", "initials": "F", "orcid": "0000-0003-0657-434X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/edd281f2f6b44ff1b562e0d25ccc9847.json"}}, {"family": "Przytycki", "given": "Pawel F", "initials": "PF", "orcid": "0000-0002-3360-6936", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3670767ba35043cea5f52291ebdd1c95.json"}}, {"family": "Fair", "given": "Tyler", "initials": "T"}, {"family": "Deng", "given": "Chengyu", "initials": "C", "orcid": "0000-0003-3595-9935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f8a8d461a553410f8ad4f788c852d811.json"}}, {"family": "Steyert", "given": "Marilyn", "initials": "M", "orcid": "0000-0003-4095-4776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6a58ddff29044f1da8d5e8b3043ff770.json"}}, {"family": "Ryu", "given": "Hane", "initials": "H"}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/612a779b69494f1ca9b6c5f1d84fd711.json"}}, {"family": "Karlsson", "given": "Elinor", "initials": "E", "orcid": "0000-0002-4343-3776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81b5c82fcb904394b6a6b1d811863fa0.json"}}, {"family": "Nowakowski", "given": "Tomasz", "initials": "T"}, {"family": "Ahituv", "given": "Nadav", "initials": "N", "orcid": "0000-0002-7434-8144", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/86098b2cd2ed490c8366e5ccc292e915.json"}}, {"family": "Pollen", "given": "Alex", "initials": "A", "orcid": "0000-0003-3263-8634", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1e4e6cdef8fb466d8f1c600aeefd2c44.json"}}, {"family": "Pollard", "given": "Katherine S", "initials": "KS", "orcid": "0000-0002-9870-6196", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d080bc9bff548958f0c161612cdc4cf.json"}}], "type": "posted-content", "published": "2022-10-05", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.10.04.510859", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:41:21.778Z", "modified": "2026-08-20T10:41:22.106Z"}, {"entity": "publication", "iuid": "b09c06812d9246c6941dc437ba05b1e1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b09c06812d9246c6941dc437ba05b1e1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b09c06812d9246c6941dc437ba05b1e1"}}, "title": "Evolution of the ancestral mammalian karyotype and syntenic regions.", "authors": [{"family": "Damas", "given": "Joana", "initials": "J", "orcid": "0000-0003-4857-2510", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f60eb6afeabc435ea1e6378786162fa8.json"}}, {"family": "Corbo", "given": "Marco", "initials": "M"}, {"family": "Kim", "given": "Jaebum", "initials": "J"}, {"family": "Turner-Maier", "given": "Jason", "initials": "J"}, {"family": "Farr\u00e9", "given": "Marta", "initials": "M"}, {"family": "Larkin", "given": "Denis M", "initials": "DM"}, {"family": "Ryder", "given": "Oliver A", "initials": "OA", "orcid": "0000-0003-2427-763X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d18635ed6fa42d4bbcfddadae70e308.json"}}, {"family": "Steiner", "given": "Cynthia", "initials": "C"}, {"family": "Houck", "given": "Marlys L", "initials": "ML"}, {"family": "Hall", "given": "Shaune", "initials": "S"}, {"family": "Shiue", "given": "Lily", "initials": "L"}, {"family": "Thomas", "given": "Stephen", "initials": "S"}, {"family": "Swale", "given": "Thomas", "initials": "T"}, {"family": "Daly", "given": "Mark", "initials": "M"}, {"family": "Korlach", "given": "Jonas", "initials": "J"}, {"family": "Uliano-Silva", "given": "Marcela", "initials": "M"}, {"family": "Mazzoni", "given": "Camila J", "initials": "CJ"}, {"family": "Birren", "given": "Bruce W", "initials": "BW"}, {"family": "Genereux", "given": "Diane P", "initials": "DP", "orcid": "0000-0001-5770-0989", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/352ee25047c544aaa486a69e7e3333fc.json"}}, {"family": "Johnson", "given": "Jeremy", "initials": "J"}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/612a779b69494f1ca9b6c5f1d84fd711.json"}}, {"family": "Karlsson", "given": "Elinor K", "initials": "EK", "orcid": "0000-0002-4343-3776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81b5c82fcb904394b6a6b1d811863fa0.json"}}, {"family": "Nweeia", "given": "Martin T", "initials": "MT", "orcid": "0000-0001-7079-4123", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4846b6d146a4a7288db1543583a0158.json"}}, {"family": "Johnson", "given": "Rebecca N", "initials": "RN", "orcid": "0000-0003-3035-2827", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5486418f837c4e9199e31f61b20887cd.json"}}, {"family": "Zoonomia Consortium", "given": "", "initials": ""}, {"family": "Lewin", "given": "Harris A", "initials": "HA", "orcid": "0000-0002-1043-7287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5059da24204049c696aec45b62526759.json"}}], "type": "journal article", "published": "2022-10-04", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "119", "issue": "40", "pages": "e2209139119", "issn-l": "0027-8424"}, "abstract": "Decrypting the rearrangements that drive mammalian chromosome evolution is critical to understanding the molecular bases of speciation, adaptation, and disease susceptibility. Using 8 scaffolded and 26 chromosome-scale genome assemblies representing 23/26 mammal orders, we computationally reconstructed ancestral karyotypes and syntenic relationships at 16 nodes along the mammalian phylogeny. Three different reference genomes (human, sloth, and cattle) representing phylogenetically distinct mammalian superorders were used to assess reference bias in the reconstructed ancestral karyotypes and to expand the number of clades with reconstructed genomes. The mammalian ancestor likely had 19 pairs of autosomes, with nine of the smallest chromosomes shared with the common ancestor of all amniotes (three still conserved in extant mammals), demonstrating a striking conservation of synteny for \u223c320 My of vertebrate evolution. The numbers and types of chromosome rearrangements were classified for transitions between the ancestral mammalian karyotype, descendent ancestors, and extant species. For example, 94 inversions, 16 fissions, and 14 fusions that occurred over 53 My differentiated the therian from the descendent eutherian ancestor. The highest breakpoint rate was observed between the mammalian and therian ancestors (3.9 breakpoints/My). Reconstructed mammalian ancestor chromosomes were found to have distinct evolutionary histories reflected in their rates and types of rearrangements. The distributions of genes, repetitive elements, topologically associating domains, and actively transcribed regions in multispecies homologous synteny blocks and evolutionary breakpoint regions indicate that purifying selection acted over millions of years of vertebrate evolution to maintain syntenic relationships of developmentally important genes and regulatory landscapes of gene-dense chromosomes.", "doi": "10.1073/pnas.2209139119", "pmid": "36161960", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9550189"}], "notes": [], "created": "2026-08-20T09:31:15.877Z", "modified": "2026-08-20T09:31:15.982Z"}, {"entity": "publication", "iuid": "3841603fbf9e43e6a1460db8f686ef9e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3841603fbf9e43e6a1460db8f686ef9e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3841603fbf9e43e6a1460db8f686ef9e"}}, "title": "Why sequence all eukaryotes?", "authors": [{"family": "Blaxter", "given": "Mark", "initials": "M", "orcid": "0000-0003-2861-949X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9b785bc131a241c4815ab5ef1576709b.json"}}, {"family": "Archibald", "given": "John M", "initials": "JM", "orcid": "0000-0001-7255-780X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9381e61c33164dca82411b18b9fcc0d3.json"}}, {"family": "Childers", "given": "Anna K", "initials": "AK", "orcid": "0000-0002-0747-8539", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b04257eed5dd48a7b631d8c8e78c2df1.json"}}, {"family": "Coddington", "given": "Jonathan A", "initials": "JA", "orcid": "0000-0001-6004-7730", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/efae0bfdf0c64e86a175c8921b1af0b4.json"}}, {"family": "Crandall", "given": "Keith A", "initials": "KA", "orcid": "0000-0002-0836-3389", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/853c5da68a5a4c96bd2248b21bd15ba7.json"}}, {"family": "Di Palma", "given": "Federica", "initials": "F", "orcid": "0000-0002-4394-0102", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3cf0785a103c45368f4e1cca6e5cb5f7.json"}}, {"family": "Durbin", "given": "Richard", "initials": "R", "orcid": "0000-0002-9130-1006", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a8972546b724b0d9c6ed69a766cc41b.json"}}, {"family": "Edwards", "given": "Scott V", "initials": "SV", "orcid": "0000-0003-2535-6217", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/249a83cc8fb240609cd7bd76c6c79e2c.json"}}, {"family": "Graves", "given": "Jennifer A M", "initials": "JAM", "orcid": "0000-0001-6480-7856", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48044e7f378c41e28b58ae92e1102efb.json"}}, {"family": "Hackett", "given": "Kevin J", "initials": "KJ", "orcid": "0000-0002-7459-7175", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc72dad2a31b443db715bf82966f44f4.json"}}, {"family": "Hall", "given": "Neil", "initials": "N", "orcid": "0000-0003-2808-0009", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bc8087425525426994b690f1ae2637e0.json"}}, {"family": "Jarvis", "given": "Erich D", "initials": "ED"}, {"family": "Johnson", "given": "Rebecca N", "initials": "RN", "orcid": "0000-0003-3035-2827", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5486418f837c4e9199e31f61b20887cd.json"}}, {"family": "Karlsson", "given": "Elinor K", "initials": "EK", "orcid": "0000-0002-4343-3776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81b5c82fcb904394b6a6b1d811863fa0.json"}}, {"family": "Kress", "given": "W John", "initials": "WJ", "orcid": "0000-0002-0140-5267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/25477498e7dd41e7891088988a40713e.json"}}, {"family": "Kuraku", "given": "Shigehiro", "initials": "S", "orcid": "0000-0003-1464-8388", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/be2fb1e4a3e548498f5590365dedc81e.json"}}, {"family": "Lawniczak", "given": "Mara K N", "initials": "MKN"}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/612a779b69494f1ca9b6c5f1d84fd711.json"}}, {"family": "Lopez", "given": "Jose V", "initials": "JV", "orcid": "0000-0002-1637-4125", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d60d31a72bb64d6894367a3ffc1785e7.json"}}, {"family": "Moran", "given": "Nancy A", "initials": "NA", "orcid": "0000-0003-2983-9769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/74c685964435471096e5dbc580505cb8.json"}}, {"family": "Robinson", "given": "Gene E", "initials": "GE", "orcid": "0000-0003-4828-4068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/86d1dc6e76694345ba735e5612bff820.json"}}, {"family": "Ryder", "given": "Oliver A", "initials": "OA", "orcid": "0000-0003-2427-763X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d18635ed6fa42d4bbcfddadae70e308.json"}}, {"family": "Shapiro", "given": "Beth", "initials": "B"}, {"family": "Soltis", "given": "Pamela S", "initials": "PS", "orcid": "0000-0001-9310-8659", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7c4308f7e0e84bbfaad58eac840db765.json"}}, {"family": "Warnow", "given": "Tandy", "initials": "T", "orcid": "0000-0001-7717-3514", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/072c8f6823984406aedb974d6a97f7dc.json"}}, {"family": "Zhang", "given": "Guojie", "initials": "G", "orcid": "0000-0001-6860-1521", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ec2e418a32c4161abc876171467f5ea.json"}}, {"family": "Lewin", "given": "Harris A", "initials": "HA", "orcid": "0000-0002-1043-7287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5059da24204049c696aec45b62526759.json"}}], "type": "journal article", "published": "2022-01-25", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "119", "issue": "4", "issn-l": "0027-8424"}, "abstract": "Life on Earth has evolved from initial simplicity to the astounding complexity we experience today. Bacteria and archaea have largely excelled in metabolic diversification, but eukaryotes additionally display abundant morphological innovation. How have these innovations come about and what constraints are there on the origins of novelty and the continuing maintenance of biodiversity on Earth? The history of life and the code for the working parts of cells and systems are written in the genome. The Earth BioGenome Project has proposed that the genomes of all extant, named eukaryotes-about 2 million species-should be sequenced to high quality to produce a digital library of life on Earth, beginning with strategic phylogenetic, ecological, and high-impact priorities. Here we discuss why we should sequence all eukaryotic species, not just a representative few scattered across the many branches of the tree of life. We suggest that many questions of evolutionary and ecological significance will only be addressable when whole-genome data representing divergences at all of the branchings in the tree of life or all species in natural ecosystems are available. We envisage that a genomic tree of life will foster understanding of the ongoing processes of speciation, adaptation, and organismal dependencies within entire ecosystems. These explorations will resolve long-standing problems in phylogenetics, evolution, ecology, conservation, agriculture, bioindustry, and medicine.", "doi": "10.1073/pnas.2115636118", "pmid": "35042801", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8795522"}, {"db": "pii", "key": "2115636118"}], "notes": [], "created": "2026-08-20T09:31:06.931Z", "modified": "2026-08-20T09:31:07.517Z"}, {"entity": "publication", "iuid": "626310cbddb14ff48c80c0f9372c585b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/626310cbddb14ff48c80c0f9372c585b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/626310cbddb14ff48c80c0f9372c585b"}}, "title": "The Earth BioGenome Project 2020: Starting the clock.", "authors": [{"family": "Lewin", "given": "Harris A", "initials": "HA", "orcid": "0000-0002-1043-7287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5059da24204049c696aec45b62526759.json"}}, {"family": "Richards", "given": "Stephen", "initials": "S", "orcid": "0000-0001-8959-5466", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8005cf3b343461388e2b82a2c61c293.json"}}, {"family": "Lieberman Aiden", "given": "Erez", "initials": "E"}, {"family": "Allende", "given": "Miguel L", "initials": "ML", "orcid": "0000-0002-2783-2152", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27d6fdda2e7b4487b651c852c3f3cd11.json"}}, {"family": "Archibald", "given": "John M", "initials": "JM"}, {"family": "B\u00e1lint", "given": "Mikl\u00f3s", "initials": "M"}, {"family": "Barker", "given": "Katharine B", "initials": "KB"}, {"family": "Baumgartner", "given": "Bridget", "initials": "B"}, {"family": "Belov", "given": "Katherine", "initials": "K"}, {"family": "Bertorelle", "given": "Giorgio", "initials": "G"}, {"family": "Blaxter", "given": "Mark L", "initials": "ML", "orcid": "0000-0003-2861-949X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9b785bc131a241c4815ab5ef1576709b.json"}}, {"family": "Cai", "given": "Jing", "initials": "J"}, {"family": "Caperello", "given": "Nicolette D", "initials": "ND"}, {"family": "Carlson", "given": "Keith", "initials": "K"}, {"family": "Castilla-Rubio", "given": "Juan Carlos", "initials": "JC"}, {"family": "Chaw", "given": "Shu-Miaw", "initials": "SM"}, {"family": "Chen", "given": "Lei", "initials": "L"}, {"family": "Childers", "given": "Anna K", "initials": "AK"}, {"family": "Coddington", "given": "Jonathan A", "initials": "JA", "orcid": "0000-0001-6004-7730", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/efae0bfdf0c64e86a175c8921b1af0b4.json"}}, {"family": "Conde", "given": "Dalia A", "initials": "DA", "orcid": "0000-0002-7923-8163", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b73243e2df04c5a8d771456b262a4bf.json"}}, {"family": "Corominas", "given": "Montserrat", "initials": "M", "orcid": "0000-0002-0724-8346", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0805b84e0e824c93a51262f4fdc8f8e2.json"}}, {"family": "Crandall", "given": "Keith A", "initials": "KA", "orcid": "0000-0002-0836-3389", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/853c5da68a5a4c96bd2248b21bd15ba7.json"}}, {"family": "Crawford", "given": "Andrew J", "initials": "AJ"}, {"family": "DiPalma", "given": "Federica", "initials": "F"}, {"family": "Durbin", "given": "Richard", "initials": "R", "orcid": "0000-0002-9130-1006", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a8972546b724b0d9c6ed69a766cc41b.json"}}, {"family": "Ebenezer", "given": "ThankGod E", "initials": "TE"}, {"family": "Edwards", "given": "Scott V", "initials": "SV", "orcid": "0000-0003-2535-6217", "researcher": {"href": 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"https://publications-affiliated.scilifelab.se/researcher/f2fe02e097b342508301397260ef7cc3.json"}}, {"family": "Janke", "given": "Axel", "initials": "A", "orcid": "0000-0002-9394-1904", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ef0f0bab20e45cca4e726c84b8645f2.json"}}, {"family": "Jarvis", "given": "Erich D", "initials": "ED"}, {"family": "Johnson", "given": "Warren E", "initials": "WE", "orcid": "0000-0002-5954-186X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aa69a0b1643541b0b490e0c1186c8307.json"}}, {"family": "Jones", "given": "Steven J M", "initials": "SJM"}, {"family": "Karlsson", "given": "Elinor K", "initials": "EK", "orcid": "0000-0002-4343-3776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81b5c82fcb904394b6a6b1d811863fa0.json"}}, {"family": "Kersey", "given": "Paul J", "initials": "PJ"}, {"family": "Kim", "given": "Jin-Hyoung", "initials": "JH"}, {"family": "Kress", "given": "W John", "initials": "WJ", "orcid": "0000-0002-0140-5267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/25477498e7dd41e7891088988a40713e.json"}}, {"family": "Kuraku", "given": "Shigehiro", "initials": "S"}, {"family": "Lawniczak", "given": "Mara K N", "initials": "MKN"}, {"family": "Leebens-Mack", "given": "James H", "initials": "JH", "orcid": "0000-0003-4811-2231", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b52ac9ce6dba4bee8dae7b594242c49b.json"}}, {"family": "Li", "given": "Xueyan", "initials": "X"}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/612a779b69494f1ca9b6c5f1d84fd711.json"}}, {"family": "Liu", "given": "Xin", "initials": "X"}, {"family": "Lopez", "given": "Jose V", "initials": "JV"}, {"family": "Marques-Bonet", "given": "Tomas", "initials": "T", "orcid": "0000-0002-5597-3075", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1091cb5bfe394d459969d24bb1c22c66.json"}}, {"family": "Mazard", "given": "Sophie", "initials": "S"}, {"family": "Mazet", "given": "Jonna A K", "initials": "JAK", "orcid": "0000-0002-8712-5951", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9daa6d747c704145a06420aa76ce3426.json"}}, {"family": "Mazzoni", "given": "Camila J", "initials": "CJ"}, {"family": "Myers", "given": "Eugene W", "initials": "EW", "orcid": "0000-0002-6580-7839", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bf74ba4bae3546eca812b29793341604.json"}}, {"family": "O'Neill", "given": "Rachel J", "initials": "RJ"}, {"family": "Paez", "given": "Sadye", "initials": "S"}, {"family": "Park", "given": "Hyun", "initials": "H"}, {"family": "Robinson", "given": "Gene E", "initials": "GE", "orcid": "0000-0003-4828-4068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/86d1dc6e76694345ba735e5612bff820.json"}}, {"family": "Roquet", "given": "Cristina", "initials": "C", "orcid": "0000-0001-8748-3743", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/82e0bb00dab543318861f81cb3569541.json"}}, {"family": "Ryder", "given": "Oliver A", "initials": "OA", "orcid": "0000-0003-2427-763X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d18635ed6fa42d4bbcfddadae70e308.json"}}, {"family": "Sabir", "given": "Jamal S M", "initials": "JSM", "orcid": "0000-0003-4785-9894", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b644127a1d8740bba24dc2fef3c23c81.json"}}, {"family": "Shaffer", "given": "H Bradley", "initials": "HB", "orcid": "0000-0002-5795-9242", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/910008f9a77840e5ada4302460516dec.json"}}, {"family": "Shank", "given": "Timothy M", "initials": "TM"}, {"family": "Sherkow", "given": "Jacob S", "initials": "JS", "orcid": "0000-0002-9724-9261", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ac5a78ced4f490499d8ea3358a73741.json"}}, {"family": "Soltis", "given": "Pamela S", "initials": "PS", "orcid": "0000-0001-9310-8659", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7c4308f7e0e84bbfaad58eac840db765.json"}}, {"family": "Tang", "given": "Boping", "initials": "B", "orcid": "0000-0002-3241-7914", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ab99aedf62e948c5839d1912180fc2b9.json"}}, {"family": "Tedersoo", "given": "Leho", "initials": "L"}, {"family": "Uliano-Silva", "given": "Marcela", "initials": "M"}, {"family": "Wang", "given": "Kun", "initials": "K"}, {"family": "Wei", "given": "Xiaofeng", "initials": "X"}, {"family": "Wetzer", "given": "Regina", "initials": "R"}, {"family": "Wilson", "given": "Julia L", "initials": "JL"}, {"family": "Xu", "given": "Xun", "initials": "X"}, {"family": "Yang", "given": "Huanming", "initials": "H"}, {"family": "Yoder", "given": "Anne D", "initials": "AD", "orcid": "0000-0002-1781-9552", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2f4e827f5db545de84e8ae91e7603fc1.json"}}, {"family": "Zhang", "given": "Guojie", "initials": "G", "orcid": "0000-0001-6860-1521", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ec2e418a32c4161abc876171467f5ea.json"}}], "type": "introductory journal article", "published": "2022-01-25", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "119", "issue": "4", "issn-l": "0027-8424"}, "abstract": null, "doi": "10.1073/pnas.2115635118", "pmid": "35042800", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8795548"}, {"db": "pii", "key": "2115635118"}], "notes": [], "created": "2026-08-20T09:31:03.855Z", "modified": "2026-08-20T09:31:05.035Z"}, {"entity": "publication", "iuid": "b6189b5801bb417783640d54af89c9ae", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b6189b5801bb417783640d54af89c9ae.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b6189b5801bb417783640d54af89c9ae"}}, "title": "3D genomics across the tree of life reveals condensin II as a determinant of architecture type.", "authors": [{"family": "Hoencamp", "given": "Claire", "initials": "C", "orcid": "0000-0003-2047-4724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ff4cc8a913fd439cbcfea504ae71e822.json"}}, 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"issn-l": "0036-8075"}, "abstract": "We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional (3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedly during eukaryotic evolution. The type of genome architecture that an organism exhibits correlates with the absence of condensin II subunits. Moreover, condensin II depletion converts the architecture of the human genome to a state resembling that seen in organisms such as fungi or mosquitoes. In this state, centromeres cluster together at nucleoli, and heterochromatin domains merge. We propose a physical model in which lengthwise compaction of chromosomes by condensin II during mitosis determines chromosome-scale genome architecture, with effects that are retained during the subsequent interphase. This mechanism likely has been conserved since the last common ancestor of all eukaryotes.", "doi": "10.1126/science.abe2218", "pmid": "34045355", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1704706"}, {"db": "pmc", "key": "PMC8172041"}, {"db": "pii", "key": "372/6545/984"}], "notes": [], "created": "2026-08-20T11:59:25.344Z", "modified": "2026-08-20T11:59:27.055Z"}, {"entity": "publication", "iuid": "ed19a0d3a6a54e6286ae3864d7b22467", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ed19a0d3a6a54e6286ae3864d7b22467.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ed19a0d3a6a54e6286ae3864d7b22467"}}, "title": "The meadow jumping mouse genome and transcriptome suggest mechanisms of hibernation", "authors": [{"family": "Cong", "given": "Qian", "initials": "Q", "orcid": "0000-0002-8909-0414", "researcher": {"href": 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"initials": "OA", "orcid": "0000-0003-2427-763X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d18635ed6fa42d4bbcfddadae70e308.json"}}, {"family": "Nweeia", "given": "Martin T", "initials": "MT", "orcid": "0000-0001-7079-4123", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4846b6d146a4a7288db1543583a0158.json"}}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/612a779b69494f1ca9b6c5f1d84fd711.json"}}, {"family": "Teeling", "given": "Emma C", "initials": "EC", "orcid": "0000-0002-3309-1346", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/28069443db794cb596e58aea060d9dea.json"}}, {"family": "Karlsson", "given": "Elinor K", "initials": "EK", "orcid": "0000-0002-4343-3776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81b5c82fcb904394b6a6b1d811863fa0.json"}}, {"family": "Lewin", "given": "Harris A", "initials": "HA", "orcid": "0000-0002-1043-7287", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5059da24204049c696aec45b62526759.json"}}], "type": "comparative study", "published": "2020-09-08", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "117", "issue": "36", "pages": "22311-22322", "issn-l": "0027-8424"}, "abstract": "The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 (ACE2), is now undergoing extensive scrutiny to understand the routes of transmission and sensitivity in different species. Here, we utilized a unique dataset of ACE2 sequences from 410 vertebrate species, including 252 mammals, to study the conservation of ACE2 and its potential to be used as a receptor by SARS-CoV-2. We designed a five-category binding score based on the conservation properties of 25 amino acids important for the binding between ACE2 and the SARS-CoV-2 spike protein. Only mammals fell into the medium to very high categories and only catarrhine primates into the very high category, suggesting that they are at high risk for SARS-CoV-2 infection. We employed a protein structural analysis to qualitatively assess whether amino acid changes at variable residues would be likely to disrupt ACE2/SARS-CoV-2 spike protein binding and found the number of predicted unfavorable changes significantly correlated with the binding score. Extending this analysis to human population data, we found only rare (frequency <0.001) variants in 10/25 binding sites. In addition, we found significant signals of selection and accelerated evolution in the ACE2 coding sequence across all mammals, and specific to the bat lineage. Our results, if confirmed by additional experimental data, may lead to the identification of intermediate host species for SARS-CoV-2, guide the selection of animal models of COVID-19, and assist the conservation of animals both in native habitats and in human care.", "doi": "10.1073/pnas.2010146117", "pmid": "32826334", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7486773"}, {"db": "pii", "key": "2010146117"}], "notes": [], "created": "2026-08-20T09:30:48.684Z", "modified": "2026-08-20T09:30:49.333Z"}, {"entity": "publication", "iuid": "96454a1397bc498088524ab353dfaadb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/96454a1397bc498088524ab353dfaadb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/96454a1397bc498088524ab353dfaadb"}}, "title": "A new long-read dog assembly uncovers thousands of exons and functional elements missing in the previous reference", "authors": [{"family": "Wang", "given": "Chao", "initials": "C", "orcid": "0000-0003-3936-4023", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cfac9dfcdfc04a88b002ffe4ee8a5bb4.json"}}, {"family": "Wallerman", "given": "Ola", "initials": "O", "orcid": "0000-0003-1037-7904", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/567836f4582a4f79b9fbb362c656b8c9.json"}}, {"family": "Arendt", "given": "Maja Louise", "initials": "ML", "orcid": "0000-0003-1404-172X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f488b6df9c149a3bf6a26be886073cc.json"}}, {"family": "Sundstr\u00f6m", "given": "Elisabeth", "initials": "E", "orcid": "0000-0001-9526-8541", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7ba04d84aa2401da56c1b438d7ee741.json"}}, {"family": "Karlsson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0003-0198-4796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a000fad9c474ed09fdc5c136d3f0493.json"}}, {"family": "Nordin", "given": "Jessika", "initials": "J", "orcid": "0000-0002-8414-2190", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a285875862f24b6fa0b378550da371fa.json"}}, {"family": "M\u00e4kel\u00e4inen", "given": "Suvi", "initials": "S", "orcid": "0000-0001-7378-4991", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f7781ef7a4f4e9daa8621c0f9910180.json"}}, {"family": "Pielberg", "given": "Gerli Rosengren", "initials": "GR", "orcid": "0000-0001-5582-7054", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e85a82d4887740cca6450039a1025043.json"}}, {"family": "Hanson", "given": "Jeanette", "initials": "J", "orcid": "0000-0001-5596-9538", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d5cbb6bf2a24ba7a809f822d450acb3.json"}}, {"family": "Ohlsson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0002-7735-7919", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f98b0d8854e0431881c5ce2179d4383b.json"}}, {"family": "Saellstr\u00f6m", "given": "Sara", "initials": "S", "orcid": "0000-0001-5253-5830", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/85a961c79c6541a99bd227f3846fc56b.json"}}, {"family": "R\u00f6nnberg", "given": "Henrik", "initials": "H", "orcid": "0000-0001-6098-5364", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/46c497dfc2b3477b95906859a654cf41.json"}}, {"family": "Ljungvall", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-6617-0454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf94e422f2bf4db3a4c873b9882ca4c6.json"}}, {"family": "H\u00e4ggstr\u00f6m", "given": "Jens", "initials": "J", "orcid": "0000-0003-3402-023X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/72f5852ea390478a8f8dcaa0a4d8390c.json"}}, {"family": "Bergstr\u00f6m", "given": "Tomas F", "initials": "TF", "orcid": "0000-0002-7480-2669", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f503392d65ac4ab1a4b1d459ea0f37bb.json"}}, {"family": "Hedhammar", "given": "\u00c5ke", "initials": "\u00c5", "orcid": "0000-0001-7048-3851", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04f22152817b4e3e8fb7890e1566791a.json"}}, {"family": "Meadows", "given": "Jennifer R S", "initials": "JRS", "orcid": "0000-0002-0850-230X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f363e8d74594ffeb0d68aa6d774b242.json"}}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K", "orcid": "0000-0001-8338-0253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/612a779b69494f1ca9b6c5f1d84fd711.json"}}], "type": "posted-content", "published": "2020-07-02", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2020.07.02.185108", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T09:57:48.394Z", "modified": "2026-08-20T09:57:48.992Z"}]}