{"entity": "researcher", "timestamp": "2026-08-20T20:50:10.458Z", "family": "Nowak", "given": "Christoph", "initials": "C", "orcid": "0000-0001-8435-3978", "affiliations": ["Division of Family Medicine and Primary Care, Department of Neurobiology, Care Science and Society, Karolinska Institute, Huddinge, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/60b9c212e2234dae88d48ac2ce701915.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/60b9c212e2234dae88d48ac2ce701915"}}, "publications": [{"entity": "publication", "iuid": "d03b30b31a6340329b06b1fd7ac19066", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d03b30b31a6340329b06b1fd7ac19066.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d03b30b31a6340329b06b1fd7ac19066"}}, "title": "Author Correction: An online atlas of human plasma metabolite signatures of gut microbiome composition.", "authors": [{"family": "Dekkers", "given": "Koen F", "initials": "KF", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c290d03c7bbf457abdd06a151e3650fe.json"}}, {"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f55bfbbb6304ebc91c13c1ddefa0c42.json"}}, {"family": "Nowak", "given": "Christoph", "initials": "C", "orcid": "0000-0001-8435-3978", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60b9c212e2234dae88d48ac2ce701915.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a30a9d8a223487a955992023a18658e.json"}}, {"family": "Brunkwall", "given": "Louise", "initials": "L"}, {"family": "Nielsen", "given": "Nynne", "initials": "N"}, {"family": "Eklund", "given": "Aron C", "initials": "AC", "orcid": "0000-0003-0861-1001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee40b4fbb47f4d80ab454cdc064e1ea3.json"}}, {"family": "Bak Holm", "given": "Jacob", "initials": "J", "orcid": "0000-0003-1756-0875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27bea3fb86174b0da08cbaf68820ae98.json"}}, {"family": "Nielsen", "given": "H Bj\u00f8rn", "initials": "HB", "orcid": "0000-0003-2281-5713", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f42a7caf34014b1186783a3662375dd0.json"}}, {"family": "Ottosson", "given": "Filip", "initials": "F", "orcid": "0000-0002-8312-3545", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f18bcbc718e74439b675ea98e23a0e99.json"}}, {"family": "Lin", "given": "Yi-Ting", "initials": "YT"}, {"family": "Ahmad", "given": "Shafqat", "initials": "S"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J"}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "published erratum", "published": "2023-05-23", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "2971", "issn-l": "2041-1723"}, "abstract": null, "doi": "10.1038/s41467-023-38607-1", "pmid": "37221166", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10205746"}, {"db": "pii", "key": "10.1038/s41467-023-38607-1"}], "notes": [], "created": "2026-08-20T08:52:39.931Z", "modified": "2026-08-20T08:52:40.062Z"}, {"entity": "publication", "iuid": "e72b254291b34e53ae929198d59868ec", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e72b254291b34e53ae929198d59868ec.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e72b254291b34e53ae929198d59868ec"}}, "title": "An online atlas of human plasma metabolite signatures of gut microbiome composition.", "authors": [{"family": "Dekkers", "given": "Koen F", "initials": "KF", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c290d03c7bbf457abdd06a151e3650fe.json"}}, {"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f55bfbbb6304ebc91c13c1ddefa0c42.json"}}, {"family": "Nowak", "given": "Christoph", "initials": "C", "orcid": "0000-0001-8435-3978", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60b9c212e2234dae88d48ac2ce701915.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a30a9d8a223487a955992023a18658e.json"}}, {"family": "Brunkwall", "given": "Louise", "initials": "L"}, {"family": "Nielsen", "given": "Nynne", "initials": "N"}, {"family": "Eklund", "given": "Aron C", "initials": "AC", "orcid": "0000-0003-0861-1001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee40b4fbb47f4d80ab454cdc064e1ea3.json"}}, {"family": "Bak Holm", "given": "Jacob", "initials": "J", "orcid": "0000-0003-1756-0875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27bea3fb86174b0da08cbaf68820ae98.json"}}, {"family": "Nielsen", "given": "H Bj\u00f8rn", "initials": "HB", "orcid": "0000-0003-2281-5713", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f42a7caf34014b1186783a3662375dd0.json"}}, {"family": "Ottosson", "given": "Filip", "initials": "F", "orcid": "0000-0002-8312-3545", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f18bcbc718e74439b675ea98e23a0e99.json"}}, {"family": "Lin", "given": "Yi-Ting", "initials": "YT"}, {"family": "Ahmad", "given": "Shafqat", "initials": "S"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J"}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "journal article", "published": "2022-09-23", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "5370", "issn-l": "2041-1723"}, "abstract": "Human gut microbiota produce a variety of molecules, some of which enter the bloodstream and impact health. Conversely, dietary or pharmacological compounds may affect the microbiota before entering the circulation. Characterization of these interactions is an important step towards understanding the effects of the gut microbiota on health. In this cross-sectional study, we used deep metagenomic sequencing and ultra-high-performance liquid chromatography linked to mass spectrometry for a detailed characterization of the gut microbiota and plasma metabolome, respectively, of 8583 participants invited at age 50 to 64 from the population-based Swedish CArdioPulmonary bioImage Study. Here, we find that the gut microbiota explain up to 58% of the variance of individual plasma metabolites and we present 997 associations between alpha diversity and plasma metabolites and 546,819 associations between specific gut metagenomic species and plasma metabolites in an online atlas ( https://gutsyatlas.serve.scilifelab.se/ ). We exemplify the potential of this resource by presenting novel associations between dietary factors and oral medication with the gut microbiome, and microbial species strongly associated with the uremic toxin p-cresol sulfate. This resource can be used as the basis for targeted studies of perturbation of specific metabolites and for identification of candidate plasma biomarkers of gut microbiota composition.", "doi": "10.1038/s41467-022-33050-0", "pmid": "36151114", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9508139"}, {"db": "pii", "key": "10.1038/s41467-022-33050-0"}], "notes": [], "created": "2026-08-20T08:52:18.907Z", "modified": "2026-08-20T08:52:19.472Z"}, {"entity": "publication", "iuid": "1bdae64c008244cd8ad1d2488fa9e21d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1bdae64c008244cd8ad1d2488fa9e21d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1bdae64c008244cd8ad1d2488fa9e21d"}}, "title": "An online atlas of human plasma metabolite signatures of gut microbiome composition", "authors": [{"family": "Dekkers", "given": "Koen F", "initials": "KF", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c290d03c7bbf457abdd06a151e3650fe.json"}}, {"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f55bfbbb6304ebc91c13c1ddefa0c42.json"}}, {"family": "Nowak", "given": "Christoph", "initials": "C", "orcid": "0000-0001-8435-3978", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60b9c212e2234dae88d48ac2ce701915.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U", "orcid": "0000-0001-8367-5000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b833fa7c77f542aabd5b04f4d9c02afd.json"}}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a30a9d8a223487a955992023a18658e.json"}}, {"family": "Brunkwall", "given": "Louise", "initials": "L"}, {"family": "Nielsen", "given": "Nynne", "initials": "N", "orcid": "0000-0003-2281-5713", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f42a7caf34014b1186783a3662375dd0.json"}}, {"family": "Eklund", "given": "Aron C", "initials": "AC", "orcid": "0000-0003-0861-1001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee40b4fbb47f4d80ab454cdc064e1ea3.json"}}, {"family": "Holm", "given": "Jacob Bak", "initials": "JB", "orcid": "0000-0003-1756-0875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27bea3fb86174b0da08cbaf68820ae98.json"}}, {"family": "Nielsen", "given": "H Bj\u00f8rn", "initials": "HB"}, {"family": "Ottosson", "given": "Filip", "initials": "F", "orcid": "0000-0002-8312-3545", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f18bcbc718e74439b675ea98e23a0e99.json"}}, {"family": "Lin", "given": "Yi Ting", "initials": "YT", "orcid": "0000-0002-5833-0040", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36368cfa632140839b84bc166dd09b1a.json"}}, {"family": "Ahmad", "given": "Shafqat", "initials": "S", "orcid": "0000-0002-1914-5248", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/edbc11d091084a2392a8dfc062f070e8.json"}}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5faed1571d4742588095acc83e631dfc.json"}}, {"family": "Smith", "given": "J Gustav", "initials": "JG", "orcid": "0000-0001-6285-9935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98819c1b9e814b4388cfadc32b1f4e73.json"}}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J", "orcid": "0000-0002-6933-4637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/292b3ce479bf480487f49dc793084f22.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "posted-content", "published": "2021-12-30", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.12.23.21268179", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:07:54.099Z", "modified": "2026-08-20T10:07:54.434Z"}, {"entity": "publication", "iuid": "34511e43e9ea45bda7bbb6db940e2c8f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/34511e43e9ea45bda7bbb6db940e2c8f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/34511e43e9ea45bda7bbb6db940e2c8f"}}, "title": "Non-targeted urine metabolomics and associations with prevalent and incident type 2 diabetes.", "authors": [{"family": "Salihovic", "given": "Samira", "initials": "S"}, {"family": "Broeckling", "given": "Corey D", "initials": "CD"}, {"family": "Ganna", "given": "Andrea", "initials": "A"}, {"family": "Prenni", "given": "Jessica E", "initials": "JE"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "Berne", "given": "Christian", "initials": "C"}, {"family": "Lind", "given": "Lars", "initials": "L"}, {"family": "Ingelsson", "given": "Erik", "initials": "E"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J"}, {"family": "Nowak", "given": "Christoph", "initials": "C", "orcid": "0000-0001-8435-3978", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60b9c212e2234dae88d48ac2ce701915.json"}}], "type": "journal article", "published": "2020-10-05", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "10", "issue": "1", "pages": "16474", "issn-l": "2045-2322"}, "abstract": "Better risk prediction and new molecular targets are key priorities in type 2 diabetes (T2D) research. Little is known about the role of the urine metabolome in predicting the risk of T2D. We aimed to use non-targeted urine metabolomics to discover biomarkers and improve risk prediction for T2D. Urine samples from two community cohorts of 1,424 adults were analyzed by ultra-performance liquid chromatography/mass spectrometry (UPLC-MS). In a discovery/replication design, three out of 62 annotated metabolites were associated with prevalent T2D, notably lower urine levels of 3-hydroxyundecanoyl-carnitine. In participants without diabetes at baseline, LASSO regression in the training set selected six metabolites that improved prediction of T2D beyond established risk factors risk over up to 12 years' follow-up in the test sample, from C-statistic 0.866 to 0.892. Our results in one of the largest non-targeted urinary metabolomics study to date demonstrate the role of the urine metabolome in identifying at-risk persons for T2D and suggest urine 3-hydroxyundecanoyl-carnitine as a biomarker candidate.", "doi": "10.1038/s41598-020-72456-y", "pmid": "33020500", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7536211"}, {"db": "pii", "key": "10.1038/s41598-020-72456-y"}], "notes": [], "created": "2026-08-20T09:05:03.459Z", "modified": "2026-08-20T09:05:03.537Z"}]}