{"entity": "researcher", "timestamp": "2026-09-26T11:33:21.492Z", "family": "Taebnia", "given": "Nayere", "initials": "N", "orcid": "0000-0003-0707-278X", "affiliations": ["Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 17165, Sweden.", "Center for Molecular Medicine, Karolinska Institutet and University Hospital, Stockholm, 17176, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/600585cfcb3d415f812b84f968f44a1a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/600585cfcb3d415f812b84f968f44a1a"}}, "publications": [{"entity": "publication", "iuid": "c9ef8fab86524738a07c4e7828f611dd", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c9ef8fab86524738a07c4e7828f611dd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c9ef8fab86524738a07c4e7828f611dd"}}, "title": "Engineering biomimetic tissue barrier models on chips: From design and fabrication to applications in disease modeling and drug screening.", "authors": [{"family": "Nasiri", "given": "Rohollah", "initials": "R", "orcid": "0000-0002-8245-692X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aaecdaea25fc438e937adfea37188ae1.json"}}, {"family": "Madadelahi", "given": "Masoud", "initials": "M"}, {"family": "Nikmaneshi", "given": "Mohammad Reza", "initials": "MR"}, {"family": "Gokce", "given": "Begum", "initials": "B"}, {"family": "Bijarchi", "given": "Mohamad Ali", "initials": "MA"}, {"family": "Shah", "given": "Shilp", "initials": "S"}, {"family": "Tirp\u00e1kov\u00e1", "given": "Zuzana", "initials": "Z"}, {"family": "Van Gastel", "given": "Dirkje", "initials": "D"}, {"family": "Taebnia", "given": "Nayere", "initials": "N", "orcid": "0000-0003-0707-278X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/600585cfcb3d415f812b84f968f44a1a.json"}}, {"family": "de Barros", "given": "Natan Roberto", "initials": "NR"}, {"family": "Zhu", "given": "Yangzhi", "initials": "Y"}, {"family": "Morcimen", "given": "Zehra Gul", "initials": "ZG"}, {"family": "Gulicli", "given": "Baris", "initials": "B"}, {"family": "Habibey", "given": "Rouhollah", "initials": "R"}, {"family": "Sendemir", "given": "Aylin", "initials": "A"}, {"family": "Jain", "given": "Saumey", "initials": "S", "orcid": "0000-0002-2810-2151", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/969496e3da804b54bea1cf345294433f.json"}}, {"family": "Enrico", "given": "Alessandro", "initials": "A"}, {"family": "Lauschke", "given": "Volker M", "initials": "VM", "orcid": "0000-0002-1140-6204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/82048d4da61547d08aa9d2bb3bae12dd.json"}}, {"family": "Dokmeci", "given": "Mehmet Remzi", "initials": "MR"}, {"family": "Pratx", "given": "Guillem", "initials": "G"}, {"family": "Khademhosseini", "given": "Ali", "initials": "A", "orcid": "0000-0002-2692-1524", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c666c085d1334bd3a6c776a992c204bd.json"}}, {"family": "Herland", "given": "Anna", "initials": "A", "orcid": "0000-0002-5002-2537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/367ed0d139fe4136808b62ee61baa4f0.json"}}], "type": "journal article", "published": "2026-04-00", "journal": {"title": "Biomaterials", "issn": "1878-5905", "volume": "327", "pages": "123739", "issn-l": "0142-9612"}, "abstract": "Replicating the in vitro properties of tissue barriers-such as the blood-brain barrier, gut, skin, lung, kidney, retina, nasal epithelium, and placenta-is crucial for many applications, including drug screening, studying molecular transport, drug delivery, and disease modeling in preclinical studies. Organ-on-a-chip (OoC) platforms are advanced three-dimensional (3D) in vitro models that aim to replicate various aspects of organ functionality within microfluidic systems by providing microenvironments akin to native tissue. When used to model the interface between two different tissue compartments, OoC technology offers a promising platform for more accurately replicating the physiology and pathophysiology of various tissue barriers in the body. This review focuses on the state-of-the-art biomimetic tissue barrier models, ranging from two-channel tissue barrier-on-a-chip systems with a thin porous membrane to hydrogel-based membrane models. Specifically, it explores the engineering of tissue barrier-on-a-chip platforms, highlighting various fabrication techniques for microfluidic chips and membranes, as well as methods for functional characterization of the engineered tissue barriers. Additionally, we discuss the development of organ-specific barrier models and multi-organ-on-a-chip systems for studying inter-organ communication. Finally, we highlight the current challenges in the field and future directions in advancing tissue barrier modeling using OoC technology.", "doi": "10.1016/j.biomaterials.2025.123739", "pmid": "41072391", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS2120593"}, {"db": "pmc", "key": "PMC12646612"}, {"db": "pii", "key": "S0142-9612(25)00658-1"}], "notes": [], "created": "2026-08-20T06:43:33.679Z", "modified": "2026-09-25T19:40:09.117Z"}, {"entity": "publication", "iuid": "f76642cc9a9c4fc89e012227444987a1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f76642cc9a9c4fc89e012227444987a1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f76642cc9a9c4fc89e012227444987a1"}}, "title": "Primary Human Tissue Models for Metabolic Dysfunction-Associated Liver Disease - toward Streamlining Drug Discovery with Patient-Derived Assays.", "authors": [{"family": "Youhanna", "given": "Sonia", "initials": "S"}, {"family": "Taebnia", "given": "Nayere", "initials": "N", "orcid": "0000-0003-0707-278X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/600585cfcb3d415f812b84f968f44a1a.json"}}, {"family": "Liang", "given": "Yingxin", "initials": "Y"}, {"family": "Cheng", "given": "Ningtao", "initials": "N"}, {"family": "Wang", "given": "Yi", "initials": "Y"}, {"family": "Michel", "given": "Maurice", "initials": "M", "orcid": "0000-0003-3261-2493", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f4696e361fe4aa3823d263674d1a498.json"}}, {"family": "Lauschke", "given": "Volker M", "initials": "VM", "orcid": "0000-0002-1140-6204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/82048d4da61547d08aa9d2bb3bae12dd.json"}}], "type": "journal article", "published": "2025-12-00", "journal": {"title": "Adv Biol (Weinh)", "issn": "2701-0198", "volume": "9", "issue": "12", "pages": "e00337", "issn-l": null}, "abstract": "Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form metabolic dysfunction-associated steatohepatitis (MASH) are prevalent chronic liver diseases that are closely linked to metabolic syndrome, type 2 diabetes, and cardiovascular complications. Despite their rising incidence and growing socioeconomic burden, effective therapies remain limited. Traditional preclinical models often fail to replicate the complexity of human MASLD, particularly in capturing the interplay between patient-specific predisposition, metabolic dysfunction, immune activation and progressive fibrosis. In this review, a comprehensive overview of emerging human-based in vitro and ex vivo platforms is provided for use in MASLD research, including conventional 2D cultures, organoids, 3D spheroids, precision-cut liver slices, microphysiological systems, and bioprinted constructs. Their utility is evaluated for modeling different stages of MASLD and MASH and their alignment with key disease hallmarks is discussed. Furthermore, the different models are assessed for their capability to model pathophysiologically relevant nutritional exposure, to emulate genetic risk factors, to reflect the complex hepatic cell repertoire and to conduct high-throughput drug screenings. Recent successful applications of MASLD and MASH models are highlighted in drug discovery and development. Together, these insights aim to guide the refinement of human MASLD models to narrow the translational gap in MASH drug development.", "doi": "10.1002/adbi.202500337", "pmid": "41200938", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12712776"}], "notes": [], "created": "2026-09-23T11:32:48.287Z", "modified": "2026-09-23T11:32:48.422Z"}]}