{"entity": "researcher", "timestamp": "2026-08-22T07:47:50.567Z", "family": "R\u00f6nnblom", "given": "Lars", "initials": "L", "orcid": "0000-0001-9403-6503", "affiliations": ["Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala University, 751 85, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f7ec7a7befd44cc988091ba0858d3c0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f7ec7a7befd44cc988091ba0858d3c0"}}, "publications": [{"entity": "publication", "iuid": "bfd4734cef3f4020bb19944380df1494", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bfd4734cef3f4020bb19944380df1494.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bfd4734cef3f4020bb19944380df1494"}}, "title": "Author Correction: Genome-wide association study identifies Sj\u00f6gren's risk loci with functional implications in immune and glandular cells.", "authors": [{"family": "Khatri", "given": "Bhuwan", "initials": "B", "orcid": "0000-0001-5456-2963", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae3abd67955c451481d58522a1fe63dc.json"}}, {"family": "Tessneer", "given": "Kandice L", "initials": "KL"}, {"family": "Rasmussen", "given": "Astrid", "initials": "A"}, {"family": "Aghakhanian", "given": "Farhang", "initials": "F"}, {"family": "Reksten", "given": "Tove Ragna", "initials": "TR", "orcid": "0000-0001-8704-4943", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2364e0683f7c4794b3054d47c0da7f65.json"}}, {"family": "Adler", "given": "Adam", "initials": "A"}, {"family": "Alevizos", "given": "Ilias", "initials": "I"}, {"family": "Anaya", "given": "Juan-Manuel", "initials": "JM", "orcid": "0000-0002-6444-1249", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ac78b3cd9f44a52bf62f688d8c404b5.json"}}, {"family": "Aqrawi", "given": "Lara A", "initials": "LA"}, {"family": "Baecklund", "given": "Eva", "initials": "E"}, {"family": "Brun", "given": "Johan G", "initials": "JG"}, {"family": "Bucher", "given": "Sara Magnusson", "initials": "SM"}, {"family": "Eloranta", "given": "Maija-Leena", "initials": "ML"}, {"family": "Engelke", "given": "Fiona", "initials": "F", "orcid": "0000-0002-5673-1705", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d5ad69f0fa204d11b236a8fc94610d9e.json"}}, {"family": "Forsblad-d'Elia", "given": "Helena", "initials": "H"}, {"family": "Glenn", "given": "Stuart B", "initials": "SB"}, {"family": "Hammenfors", "given": "Daniel", "initials": "D"}, {"family": "Imgenberg-Kreuz", "given": "Juliana", "initials": "J"}, {"family": "Jensen", "given": "Janicke Liaaen", "initials": "JL", "orcid": "0000-0003-4276-9611", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/da5f017d5ba2439d892c8bede353a700.json"}}, {"family": "Johnsen", "given": "Svein Joar Augl\u00e6nd", "initials": "SJA", "orcid": "0000-0002-1591-9250", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c7aa8dc8c5624dc49c03ee71cb9f1960.json"}}, {"family": "Jonsson", "given": "Malin V", "initials": "MV", "orcid": "0000-0001-5655-5513", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9210dc3f3a7b4bf996bc5e0cb7abf357.json"}}, {"family": "Kvarnstr\u00f6m", "given": "Marika", "initials": "M", "orcid": "0000-0002-4948-8380", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aacc6c6071934db984c75b54814cc439.json"}}, {"family": "Kelly", "given": "Jennifer A", "initials": "JA"}, {"family": "Li", "given": "He", "initials": "H"}, {"family": "Mandl", "given": "Thomas", "initials": "T", "orcid": "0000-0002-7143-7088", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a3ae58ec5cc8471f91b1f5a23295df29.json"}}, {"family": "Mart\u00edn", "given": "Javier", "initials": "J"}, {"family": "Nocturne", "given": "Ga\u00e9tane", "initials": "G", "orcid": "0000-0001-6809-0733", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9dd6e01495e54106822650beb0beae0f.json"}}, {"family": "Norheim", "given": "Katrine Br\u00e6kke", "initials": "KB"}, {"family": "Palm", "given": "\u00d8yvind", "initials": "\u00d8"}, {"family": "Skarstein", "given": "Kathrine", "initials": "K"}, {"family": "Stolarczyk", "given": "Anna M", "initials": "AM"}, {"family": "Taylor", "given": "Kimberly E", "initials": "KE"}, {"family": "Teruel", "given": "Maria", "initials": "M", "orcid": "0000-0002-5315-2660", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04f62a08bce442bea19772c8765955a4.json"}}, {"family": "Theander", "given": "Elke", "initials": "E"}, {"family": "Venuturupalli", "given": "Swamy", "initials": "S"}, {"family": "Wallace", "given": "Daniel J", "initials": "DJ"}, {"family": "Grundahl", "given": "Kiely M", "initials": "KM"}, {"family": "Hefner", "given": "Kimberly S", "initials": "KS"}, {"family": "Radfar", "given": "Lida", "initials": "L"}, {"family": "Lewis", "given": "David M", "initials": "DM"}, {"family": "Stone", "given": "Donald U", "initials": "DU"}, {"family": "Kaufman", "given": "C Erick", "initials": "CE"}, {"family": "Brennan", "given": "Michael T", "initials": "MT"}, {"family": "Guthridge", "given": "Joel M", "initials": "JM"}, {"family": "James", "given": "Judith A", "initials": "JA", "orcid": "0000-0002-9574-7355", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/01fa31a7bc6f482ea22ae6969f99bf58.json"}}, {"family": "Scofield", "given": "R Hal", "initials": "RH"}, {"family": "Gaffney", "given": "Patrick M", "initials": "PM"}, {"family": "Criswell", "given": "Lindsey A", "initials": "LA", "orcid": "0000-0002-0761-7543", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e359060b05f6496bb7b54ddf452edd5b.json"}}, {"family": "Jonsson", "given": "Roland", "initials": "R"}, {"family": "Eriksson", "given": "Per", "initials": "P"}, {"family": "Bowman", "given": "Simon J", "initials": "SJ"}, {"family": "Omdal", "given": "Roald", "initials": "R"}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L", "orcid": "0000-0001-9403-6503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f7ec7a7befd44cc988091ba0858d3c0.json"}}, {"family": "Warner", "given": "Blake", "initials": "B", "orcid": "0000-0002-4961-018X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d4e750520d3446988133b6100b9e415e.json"}}, {"family": "Rischmueller", "given": "Maureen", "initials": "M"}, {"family": "Witte", "given": "Torsten", "initials": "T"}, {"family": "Farris", "given": "A Darise", "initials": "AD"}, {"family": "Mariette", "given": "Xavier", "initials": "X", "orcid": "0000-0002-4244-5417", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/52d0be208fab43c3a9df9f8bc31d85f4.json"}}, {"family": "Alarcon-Riquelme", "given": "Marta E", "initials": "ME", "orcid": "0000-0002-7632-4154", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c48331ec5e40452d881c55b371b294a5.json"}}, {"family": "PRECISESADS Clinical Consortium", "given": "", "initials": ""}, {"family": "Shiboski", "given": "Caroline H", "initials": "CH"}, {"family": "Sj\u00f6gren\u2019s International Collaborative Clinical Alliance (SICCA)", "given": "", "initials": ""}, {"family": "Wahren-Herlenius", "given": "Marie", "initials": "M", "orcid": "0000-0002-0915-7245", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0db5190dbe894a5e9cd961e66ba5c75d.json"}}, {"family": "Ng", "given": "Wan-Fai", "initials": "WF"}, {"family": "UK Primary Sj\u00f6gren\u2019s Syndrome Registry", "given": "", "initials": ""}, {"family": "Sivils", "given": "Kathy L", "initials": "KL"}, {"family": "Adrianto", "given": "Indra", "initials": "I", "orcid": "0000-0002-9973-3057", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7144fdb14294feb80652b30a378f2d4.json"}}, {"family": "Nordmark", "given": "Gunnel", "initials": "G", "orcid": "0000-0002-3829-7431", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f618934952594d76a747bcbe2c27bbf2.json"}}, {"family": "Lessard", "given": "Christopher J", "initials": "CJ", "orcid": "0000-0003-2440-3843", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98c4cca86c5248dea32dcda1d15f3d90.json"}}], "type": "published erratum", "published": "2022-10-31", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "13", "issue": "1", "pages": "6519", "issn-l": "2041-1723"}, "abstract": null, "doi": "10.1038/s41467-022-34311-8", "pmid": "36316359", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9622850"}, {"db": "pii", "key": "10.1038/s41467-022-34311-8"}], "notes": [], "created": "2026-08-21T11:49:13.082Z", "modified": "2026-08-21T11:49:14.125Z"}, {"entity": "publication", "iuid": "ea84f97c334944af84873e7fb4677f24", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ea84f97c334944af84873e7fb4677f24.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ea84f97c334944af84873e7fb4677f24"}}, "title": "Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma.", "authors": [{"family": "Nilsson", "given": "Magnus", "initials": "M", "orcid": "0000-0002-8412-5796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bcdafceeb31345f4a014eb0f724df9b0.json"}}, {"family": "Rhedin", "given": "Magdalena", "initials": "M", "orcid": "0000-0002-8380-9723", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/084b938f6f4848e49b40fc584c282687.json"}}, {"family": "Hendrickx", "given": "Ramon", "initials": "R"}, {"family": "Berglund", "given": "Susanne", "initials": "S", "orcid": "0000-0002-8706-7982", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7baed3f2125c4e5d93f2c9f9658b318a.json"}}, {"family": "Piras", "given": "Antonio", "initials": "A", "orcid": "0000-0003-3052-1715", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/edf45455e77c4a8cb36a0a579120e357.json"}}, {"family": "Blomgran", "given": "Parmis", "initials": "P", "orcid": "0000-0002-2654-1361", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/628416808cce4fffb4d42fa7cec89de6.json"}}, {"family": "Cavallin", "given": "Anders", "initials": "A", "orcid": "0000-0001-9986-317X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/602c69edb67146bfa0400d4319bde226.json"}}, {"family": "Collins", "given": "Mia", "initials": "M", "orcid": "0000-0001-6792-2059", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8ecfa54490a4e10b075e6da86beb1ee.json"}}, {"family": "Dahl", "given": "G\u00f6ran", "initials": "G"}, {"family": "Dekkak", "given": "Bilel", "initials": "B", "orcid": "0000-0002-8430-7098", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9086b0ca850c46aab64bb19f55a6a917.json"}}, {"family": "Ericsson", "given": "Therese", "initials": "T"}, {"family": "Hagberg", "given": "Niklas", "initials": "N", "orcid": "0000-0003-2064-2716", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/be3f2835d0c04a85af2d67c158b17b06.json"}}, {"family": "Holmberg", "given": "Ann Aurell", "initials": "AA"}, {"family": "Leffler", "given": "Agnes", "initials": "A", "orcid": "0000-0003-0737-5115", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9d37a0671d98418590e6282ee6bc28e1.json"}}, {"family": "Lundqvist", "given": "Anders J", "initials": "AJ"}, {"family": "Markou", "given": "Thomais", "initials": "T", "orcid": "0000-0001-8720-9429", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3206efbcacd444e4a3b9f94f36891af1.json"}}, {"family": "Pinkerton", "given": "James", "initials": "J", "orcid": "0000-0002-5273-1150", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a44ca292da384f67b3632c64f68456a5.json"}}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L", "orcid": "0000-0001-9403-6503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f7ec7a7befd44cc988091ba0858d3c0.json"}}, {"family": "Siu", "given": "Stacey", "initials": "S"}, {"family": "Taylor", "given": "Vanessa", "initials": "V"}, {"family": "Wennberg", "given": "Tiiu", "initials": "T", "orcid": "0000-0002-2572-3657", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8d60b2de8c9a4b1db77fdbe4324d4044.json"}}, {"family": "Zervas", "given": "Dimitrios", "initials": "D", "orcid": "0000-0001-8401-3818", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1d8681b31fa4357b21c5f791aea8ee0.json"}}, {"family": "Laurence", "given": "Arian D J", "initials": "ADJ", "orcid": "0000-0003-0942-8292", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1afd125c90524a85a9967f3a895928b4.json"}}, {"family": "Mitra", "given": "Suman", "initials": "S", "orcid": "0000-0002-3426-371X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cdedb7aa4704437792ac5c016696d32c.json"}}, {"family": "Belvisi", "given": "Maria G", "initials": "MG", "orcid": "0000-0003-1652-4370", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4ac679c2a89482cb9d177926de712ec.json"}}, {"family": "Birrell", "given": "Mark", "initials": "M", "orcid": "0000-0001-6392-2086", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b093a61c6516476c83e9f368ad5782bd.json"}}, {"family": "Borde", "given": "Annika", "initials": "A", "orcid": "0000-0001-8992-0599", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a9c1dc6de694642a48f91810239fd62.json"}}], "type": "journal article", "published": "2022-08-31", "journal": {"title": "Drug Des Devel Ther", "issn": "1177-8881", "volume": "16", "pages": "2901-2917", "issn-l": null}, "abstract": "Janus kinase 1 (JAK1) is implicated in multiple inflammatory pathways that are critical for the pathogenesis of asthma, including the interleukin (IL)-4, IL-5, IL-13, and thymic stromal lymphopoietin cytokine signaling pathways, which have previously been targeted to treat allergic asthma. Here, we describe the development of AZD0449 and AZD4604, two novel and highly selective JAK1 inhibitors with promising properties for inhalation.\n\nThe effects of AZD0449 and AZD4604 in JAK1 signaling pathways were assessed by measuring phosphorylation of signal transducer and activator of transcription (STAT) proteins and chemokine release using immunoassays of whole blood from healthy human volunteers and rats. Pharmacokinetic studies performed on rats evaluated AZD0449 at a lung deposited dose of 52 \u03bcg/kg and AZD4604 at 30 \u00b5g/kg. The efficacy of AZD0449 and AZD4604 was assessed by evaluating lung inflammation (cell count and cytokine levels) and the late asthmatic response (average enhanced pause [Penh]).\n\nBoth compounds inhibited JAK1-dependent cytokine signaling pathways in a dose-dependent manner in human and rat leukocytes. After intratracheal administration in rats, both compounds exhibited low systemic exposures and medium-to-long terminal lung half-lives (AZD0449, 34 hours; AZD4604, 5 hours). Both compounds inhibited STAT3 and STAT5 phosphorylation in lung tissue from ovalbumin (OVA)-challenged rats. AZD0449 and AZD4604 also inhibited eosinophilia in the lung and reduced the late asthmatic response, measured as Penh in the OVA rat model.\n\nAZD0449 and AZD4604 show potential as inhibitors of signaling pathways involved in asthmatic immune responses, with target engagement demonstrated locally in the lung. These findings support the clinical development of AZD0449 and AZD4604 for the treatment of patients with asthma.", "doi": "10.2147/DDDT.S354291", "pmid": "36068788", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9441147"}, {"db": "pii", "key": "354291"}], "notes": [], "created": "2026-08-21T12:55:21.199Z", "modified": "2026-08-21T12:55:21.937Z"}, {"entity": "publication", "iuid": "6a9f77fa28684d3abf0118aa1d269abc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6a9f77fa28684d3abf0118aa1d269abc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6a9f77fa28684d3abf0118aa1d269abc"}}, "title": "Contributions of de novo variants to systemic lupus erythematosus.", "authors": [{"family": "Alml\u00f6f", "given": "Jonas Carlsson", "initials": "JC"}, {"family": "Nystedt", "given": "Sara", "initials": "S"}, {"family": "Mechtidou", "given": "Aikaterini", "initials": "A"}, {"family": "Leonard", "given": "Dag", "initials": "D"}, {"family": "Eloranta", "given": "Maija-Leena", "initials": "ML"}, {"family": "Grosso", "given": "Giorgia", "initials": "G"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C", "orcid": "0000-0003-0900-2048", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9fcc24622ec440bac6996072cceea0e.json"}}, {"family": "Bengtsson", "given": "Anders A", "initials": "AA"}, {"family": "J\u00f6nsen", "given": "Andreas", "initials": "A"}, {"family": "Gunnarsson", "given": "Iva", "initials": "I"}, {"family": "Svenungsson", "given": "Elisabet", "initials": "E"}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L", "orcid": "0000-0001-9403-6503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5f7ec7a7befd44cc988091ba0858d3c0.json"}}, {"family": "Sandling", "given": "Johanna K", "initials": "JK", "orcid": "0000-0003-1382-2321", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c5bbdb0cf40c48198ea04ede2fb33377.json"}}, {"family": "Syv\u00e4nen", "given": "Ann-Christine", "initials": "AC"}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Eur. J. Hum. Genet.", "issn": "1476-5438", "volume": "29", "issue": "1", "pages": "184-193", "issn-l": "1018-4813"}, "abstract": "By performing whole-genome sequencing in a Swedish cohort of 71 parent-offspring trios, in which the child in each family is affected by systemic lupus erythematosus (SLE, OMIM 152700), we investigated the contribution of de novo variants to risk of SLE. We found de novo single nucleotide variants (SNVs) to be significantly enriched in gene promoters in SLE patients compared with healthy controls at a level corresponding to 26 de novo promoter SNVs more in each patient than expected. We identified 12 de novo SNVs in promoter regions of genes that have been previously implicated in SLE, or that have functions that could be of relevance to SLE. Furthermore, we detected three missense de novo SNVs, five de novo insertion-deletions, and three de novo structural variants with potential to affect the expression of genes that are relevant for SLE. Based on enrichment analysis, disease-affecting de novo SNVs are expected to occur in one-third of SLE patients. This study shows that de novo variants in promoters commonly contribute to the genetic risk of SLE. The fact that de novo SNVs in SLE were enriched to promoter regions highlights the importance of using whole-genome sequencing for identification of de novo variants.", "doi": "10.1038/s41431-020-0698-5", "pmid": "32724065", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7852530"}, {"db": "pii", "key": "10.1038/s41431-020-0698-5"}], "notes": [], "created": "2026-08-21T11:47:58.766Z", "modified": "2026-08-21T11:47:58.955Z"}]}