{"entity": "researcher", "timestamp": "2026-08-20T21:13:33.887Z", "family": "Papaleo", "given": "Elena", "initials": "E", "orcid": "0000-0002-7376-5894", "affiliations": ["Cancer Structural Biology, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark.", "Cancer Systems Biology, Section for Bioinformatics, Department of Health and Technology, Technical University of Denmark, 2800, Lyngby, Denmark."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e2492a361354d3284153234282250b4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e2492a361354d3284153234282250b4"}}, "publications": [{"entity": "publication", "iuid": "b25981287db84f73bd19eac26e4ec836", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b25981287db84f73bd19eac26e4ec836.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b25981287db84f73bd19eac26e4ec836"}}, "title": "Exploring the structural landscape of DNA maintenance proteins.", "authors": [{"family": "Schou", "given": "Kenneth B\u00f8dkter", "initials": "KB", "orcid": "0000-0002-7178-7133", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9e00137766a4cb6976c8f14edc7ca5b.json"}}, {"family": "Mandacaru", "given": "Samuel", "initials": "S"}, {"family": "Tahir", "given": "Muhammad", "initials": "M"}, {"family": "Tom", "given": "Nikola", "initials": "N"}, {"family": "Nilsson", "given": "Ann-Sofie", "initials": "AS"}, {"family": "Andersen", "given": "Jens S", "initials": "JS", "orcid": "0000-0002-6091-140X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee4837a015e14f4da5c1578fb1ebbf43.json"}}, {"family": "Tiberti", "given": "Matteo", "initials": "M", "orcid": "0000-0003-2529-3594", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fba03ff0228c4e77a8d7a34b7982d77c.json"}}, {"family": "Papaleo", "given": "Elena", "initials": "E", "orcid": "0000-0002-7376-5894", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e2492a361354d3284153234282250b4.json"}}, {"family": "Bartek", "given": "Jiri", "initials": "J", "orcid": "0000-0003-2013-7525", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/288939950c0c4c6393d35c84e5128b5f.json"}}], "type": "journal article", "published": "2024-09-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "7748", "issn-l": "2041-1723"}, "abstract": "Evolutionary annotation of genome maintenance (GM) proteins has conventionally been established by remote relationships within protein sequence databases. However, often no significant relationship can be established. Highly sensitive approaches to attain remote homologies based on iterative profile-to-profile methods have been developed. Still, these methods have not been systematically applied in the evolutionary annotation of GM proteins. Here, by applying profile-to-profile models, we systematically survey the repertoire of GM proteins from bacteria to man. We identify multiple GM protein candidates and annotate domains in numerous established GM proteins, among other PARP, OB-fold, Macro, TUDOR, SAP, BRCT, KU, MYB (SANT), and nuclease domains. We experimentally validate OB-fold and MIS18 (Yippee) domains in SPIDR and FAM72 protein families, respectively. Our results indicate that, surprisingly, despite the immense interest and long-term research efforts, the repertoire of genome stability caretakers is still not fully appreciated.", "doi": "10.1038/s41467-024-49983-7", "pmid": "39237506", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11377751"}, {"db": "pii", "key": "10.1038/s41467-024-49983-7"}, {"db": "PDB", "key": "6BZG"}, {"db": "PDB", "key": "1JEY"}, {"db": "PDB", "key": "3FA2"}, {"db": "PDB", "key": "7KK2"}, {"db": "PDB", "key": "6UEJ"}, {"db": "PDB", "key": "4B1G"}, {"db": "PDB", "key": "6I52"}, {"db": "PDB", "key": "7SFZ"}, {"db": "PDB", "key": "6G70"}, {"db": "PDB", "key": "2LLK"}, {"db": "PDB", "key": "1JJR"}, {"db": "figshare", "key": "10.6084/m9.figshare.26014669.v1"}, {"db": "figshare", "key": "10.6084/m9.figshare.26014621.v1"}, {"db": "figshare", "key": "10.6084/m9.figshare.26015185.v1"}, {"db": "figshare", "key": "10.6084/m9.figshare.26014609.v1"}, {"db": "figshare", "key": "10.6084/m9.figshare.26014858.v1"}, {"db": "figshare", "key": "10.6084/m9.figshare.26014900.v1"}, {"db": "figshare", "key": "10.6084/m9.figshare.26015095.v1"}, {"db": "figshare", "key": "10.6084/m9.figshare.26015680.v1"}, {"db": "figshare", "key": "10.6084/m9.figshare.26015332.v1"}], "notes": [], "created": "2026-08-20T08:53:30.804Z", "modified": "2026-08-20T08:53:31.017Z"}, {"entity": "publication", "iuid": "ecddf63436744689a1ed09649fa2610a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ecddf63436744689a1ed09649fa2610a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ecddf63436744689a1ed09649fa2610a"}}, "title": "DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation.", "authors": [{"family": "Quaglia", "given": "Federica", "initials": "F", "orcid": "0000-0002-0341-4888", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6657e12ee16a450aaca2c23b04e5a283.json"}}, {"family": "M\u00e9sz\u00e1ros", "given": "B\u00e1lint", "initials": "B", "orcid": "0000-0003-0919-4449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f5847cba0f8f43e6b6827a40ddf47f2c.json"}}, {"family": "Salladini", "given": "Edoardo", "initials": "E", "orcid": "0000-0002-5152-5953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35587acab31f476eafa5885746e56477.json"}}, {"family": "Hatos", "given": "Andr\u00e1s", "initials": "A", "orcid": "0000-0001-9224-9820", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c092bf996e3f4583835c054ab625bd82.json"}}, {"family": "Pancsa", "given": "Rita", "initials": "R", "orcid": "0000-0003-0849-9312", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/be46edae0a264d77be41af470f1d8329.json"}}, {"family": "Chemes", "given": "Luc\u00eda B", "initials": "LB", "orcid": "0000-0003-0192-9906", "researcher": {"href": 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"given": "Jordi", "initials": "J", "orcid": "0000-0001-9424-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2fbbb3361364312838215432c9afe16.json"}}, {"family": "Rocha", "given": "Alma Carolina Sanchez", "initials": "ACS", "orcid": "0000-0001-7395-9173", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5990e45196224751ac7443bf737a5c0b.json"}}, {"family": "Salas", "given": "Martin", "initials": "M", "orcid": "0000-0001-6352-1282", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09dfa3ad2fd74b0c9a96383cd03a6663.json"}}, {"family": "Sawicki", "given": "Luciana Rodriguez", "initials": "LR", "orcid": "0000-0001-5782-6573", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/403dbe24dc4e45aa987f0e62ce51d5b2.json"}}, {"family": "Schad", "given": "Eva", "initials": "E", "orcid": "0000-0002-3006-2910", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9351f3e947da424d8e20ad68127d8413.json"}}, {"family": "Shenoy", "given": "Aditi", "initials": "A", "orcid": "0000-0001-7748-2501", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35bef00b985a45d59602675316e3d706.json"}}, {"family": "Szaniszl\u00f3", "given": "Tam\u00e1s", "initials": "T", "orcid": "0000-0002-3130-9284", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2610135fd9b347229c2280fa5527d73c.json"}}, {"family": "Tsirigos", "given": "Konstantinos D", "initials": "KD", "orcid": "0000-0001-5280-1107", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/85e1896a52d04cb7b4475ebba4d17505.json"}}, {"family": "Veljkovic", "given": "Nevena", "initials": "N", "orcid": "0000-0001-6562-5800", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7a1d0994c8fb42c5abf35b0e82884c18.json"}}, {"family": "Parisi", "given": "Gustavo", "initials": "G", "orcid": "0000-0001-7444-1624", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/014eb4c06cbe4597ad14afc5f9146f6a.json"}}, {"family": "Ventura", "given": "Salvador", "initials": "S", "orcid": "0000-0002-9652-6351", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e0afcd4cf084de6be1e2e606f6e954c.json"}}, {"family": "Doszt\u00e1nyi", "given": "Zsuzsanna", "initials": "Z", "orcid": "0000-0002-3624-5937", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77615a3783aa490ebc0dc300958ea70f.json"}}, {"family": "Tompa", "given": "Peter", "initials": "P", "orcid": "0000-0001-8042-9939", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f930a048ce4e5b9d65c9d173bd9954.json"}}, {"family": "Tosatto", "given": "Silvio C E", "initials": "SCE", "orcid": "0000-0003-4525-7793", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/152b8eca864e44f1954ee4952c60aa0d.json"}}, {"family": "Piovesan", "given": "Damiano", "initials": "D", "orcid": "0000-0001-8210-2390", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/994db11834b0446895c5cd4b28be1d8b.json"}}], "type": "journal article", "published": "2022-01-07", "journal": {"title": "Nucleic Acids Res.", "issn": "1362-4962", "volume": "50", "issue": "D1", "pages": "D480-D487", "issn-l": "0305-1048"}, "abstract": "The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.", "doi": "10.1093/nar/gkab1082", "pmid": "34850135", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8728214"}, {"db": "pii", "key": "6439667"}], "notes": [], "created": "2026-08-20T09:49:35.446Z", "modified": "2026-08-20T09:49:37.565Z"}]}