{"entity": "researcher", "timestamp": "2026-08-20T21:27:21.675Z", "family": "Buchmann", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-7442-3020", "affiliations": ["Division of Nanobiotechnology, SciLifeLab, Department of Protein Science, KTH Royal Institute of Technology, Tomtebodav\u00e4gen 23a, Solna, 171 65, Sweden.", "AIMES - Center for the Advancement of Integrated Medical and Engineering Sciences, Department of Neuroscience, Karolinska Institute, Stockholm, 17177, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d7fa19b55964898b15740e469f423a8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d7fa19b55964898b15740e469f423a8"}}, "publications": [{"entity": "publication", "iuid": "db35fa2c43da4f12accee901dc796a29", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/db35fa2c43da4f12accee901dc796a29.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/db35fa2c43da4f12accee901dc796a29"}}, "title": "In Situ Functionalization of Polar Polythiophene-Based Organic Electrochemical Transistor to Interface In Vitro Models.", "authors": [{"family": "Buchmann", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-7442-3020", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d7fa19b55964898b15740e469f423a8.json"}}, {"family": "Stoop", "given": "Pepijn", "initials": "P"}, {"family": "Roekevisch", "given": "Kim", "initials": "K"}, {"family": "Jain", "given": "Saumey", "initials": "S", "orcid": "0000-0002-2810-2151", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/969496e3da804b54bea1cf345294433f.json"}}, {"family": "Kroon", "given": "Renee", "initials": "R", "orcid": "0000-0001-8053-4288", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8edb30ab10ad4bf3b9122d9ca6f6380d.json"}}, {"family": "M\u00fcller", "given": "Christian", "initials": "C", "orcid": "0000-0001-7859-7909", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c72e3ff85aa545c0a6ddec76712541db.json"}}, {"family": "Hamedi", "given": "Mahiar M", "initials": "MM", "orcid": "0000-0001-9088-1064", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ea65bd8c3fd642cbbd308e0641a0bc01.json"}}, {"family": "Zeglio", "given": "Erica", "initials": "E"}, {"family": "Herland", "given": "Anna", "initials": "A", "orcid": "0000-0002-5002-2537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/367ed0d139fe4136808b62ee61baa4f0.json"}}], "type": "journal article", "published": "2024-10-09", "journal": {"title": "ACS Appl Mater Interfaces", "issn": "1944-8252", "volume": "16", "issue": "40", "pages": "54292-54303", "issn-l": "1944-8244"}, "abstract": "Organic mixed ionic-electronic conductors are promising materials for interfacing and monitoring biological systems, with the aim of overcoming current challenges based on the mismatch between biological materials and convectional inorganic conductors. The conjugated polymer/polyelectrolyte complex poly(3,4-ethylenedioxythiophene):polystyrenesulfonate (PEDOT/PSS) is, up to date, the most widely used polymer for in vitro or in vivo measurements in the field of organic bioelectronics. However, PEDOT/PSS organic electrochemical transistors (OECTs) are limited by depletion mode operation and lack chemical groups that enable synthetic modifications for biointerfacing. Recently introduced thiophene-based polymers with oligoether side chains can operate in accumulation mode, and their chemical structure can be tuned during synthesis, for example, by the introduction of hydroxylated side chains. Here, we introduce a new thiophene-based conjugated polymer, p(g42T-T)-8% OH, where 8% of the glycol side chains are functionalized with a hydroxyl group. We report for the first time the compatibility of conjugated polymers containing ethylene glycol side chains in direct contact with cells. The additional hydroxyl group allows covalent modification of the surface of polymer films, enabling fine-tuning of the surface interaction properties of p(g42T-T)-8% OH with biological materials, either hindering or promoting cell adhesion. We further use p(g42T-T)-8% OH to fabricate the OECTs and demonstrate for the first time the monitoring of epithelial barrier formation of Caco-2 cells in vitro using accumulation mode OECTs. The conjugated polymer p(g42T-T)-8% OH allows organic-electronic-based materials to be easily modified and optimized to interface and monitor biological systems.", "doi": "10.1021/acsami.4c09197", "pmid": "39327895", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11472309"}], "notes": [], "created": "2026-08-20T08:08:22.084Z", "modified": "2026-08-20T08:08:22.221Z"}, {"entity": "publication", "iuid": "afae2549375b4f92939156b7e6029fe2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/afae2549375b4f92939156b7e6029fe2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/afae2549375b4f92939156b7e6029fe2"}}, "title": "Cleanroom-Free Direct Laser Micropatterning of Polymers for Organic Electrochemical Transistors in Logic Circuits and Glucose Biosensors.", "authors": [{"family": "Enrico", "given": "Alessandro", "initials": "A", "orcid": "0000-0002-8821-6759", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/637ef7e9c6a14e4597b4304013c988b7.json"}}, {"family": "Buchmann", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-7442-3020", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d7fa19b55964898b15740e469f423a8.json"}}, {"family": "De Ferrari", "given": "Fabio", "initials": "F", "orcid": "0000-0003-0960-9931", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/21be7bf528794d57b0b1431da2a95247.json"}}, {"family": "Lin", "given": "Yunfan", "initials": "Y", "orcid": "0000-0002-6560-5209", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e0a9d5ca176d42eb958ae277ed28062f.json"}}, {"family": "Wang", "given": "Yazhou", "initials": "Y"}, {"family": "Yue", "given": "Wan", "initials": "W"}, {"family": "M\u00e5rtensson", "given": "Gustaf", "initials": "G", "orcid": "0000-0002-6041-4980", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/77d0e449fc994885908cf8c228ce2995.json"}}, {"family": "Stemme", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0001-9552-4234", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/122f084eea624e5a801c8fafa6d48f6a.json"}}, {"family": "Hamedi", "given": "Mahiar Max", "initials": "MM", "orcid": "0000-0001-9088-1064", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ea65bd8c3fd642cbbd308e0641a0bc01.json"}}, {"family": "Niklaus", "given": "Frank", "initials": "F", "orcid": "0000-0002-0525-8647", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cbba7fd047e8468288fc79b7b0275ff3.json"}}, {"family": "Herland", "given": "Anna", "initials": "A", "orcid": "0000-0002-5002-2537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/367ed0d139fe4136808b62ee61baa4f0.json"}}, {"family": "Zeglio", "given": "Erica", "initials": "E", "orcid": "0000-0002-6428-0633", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e9f9fe3dcb5e4c9891c6f463c32a1679.json"}}], "type": "journal article", "published": "2024-07-00", "journal": {"title": "Adv Sci (Weinh)", "issn": "2198-3844", "volume": "11", "issue": "27", "pages": "e2307042", "issn-l": null}, "abstract": "Organic electrochemical transistors (OECTs) are promising devices for bioelectronics, such as biosensors. However, current cleanroom-based microfabrication of OECTs hinders fast prototyping and widespread adoption of this technology for low-volume, low-cost applications. To address this limitation, a versatile and scalable approach for ultrafast laser microfabrication of OECTs is herein reported, where a femtosecond laser to pattern insulating polymers (such as parylene C or polyimide) is first used, exposing the underlying metal electrodes serving as transistor terminals (source, drain, or gate). After the first patterning step, conducting polymers, such as poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS), or semiconducting polymers, are spin-coated on the device surface. Another femtosecond laser patterning step subsequently defines the active polymer area contributing to the OECT performance by disconnecting the channel and gate from the surrounding spin-coated film. The effective OECT width can be defined with high resolution (down to 2 \u00b5m) in less than a second of exposure. Micropatterning the OECT channel area significantly improved the transistor switching performance in the case of PEDOT:PSS-based transistors, speeding up the devices by two orders of magnitude. The utility of this OECT manufacturing approach is demonstrated by fabricating complementary logic (inverters) and glucose biosensors, thereby showing its potential to accelerate OECT research.", "doi": "10.1002/advs.202307042", "pmid": "38225700", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11251563"}], "notes": [], "created": "2026-08-20T06:28:15.482Z", "modified": "2026-08-20T06:28:15.911Z"}, {"entity": "publication", "iuid": "754b9399b4a14490b9326e82661cbc9f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/754b9399b4a14490b9326e82661cbc9f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/754b9399b4a14490b9326e82661cbc9f"}}, "title": "Astrocyte 3D culture and bioprinting using peptide functionalized hyaluronan hydrogels.", "authors": [{"family": "Matthiesen", "given": "Isabelle", "initials": "I", "orcid": "0000-0003-4787-7785", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f57ebf85ca0d4d279b4852fd66f05251.json"}}, {"family": "Jury", "given": "Michael", "initials": "M", "orcid": "0000-0002-2803-2237", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/788e0c74b5874bf18585debca9bcae79.json"}}, {"family": "Rasti Boroojeni", "given": "Fatemeh", "initials": "F", "orcid": "0000-0002-3346-4755", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71244257d00b4117b1b7e67b4ebba989.json"}}, {"family": "Ludwig", "given": "Saskia L", "initials": "SL"}, {"family": "Holzreuter", "given": "Muriel", "initials": "M", "orcid": "0000-0002-7580-3049", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/07143f4b91674a28a565da46ed4441f4.json"}}, {"family": "Buchmann", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-7442-3020", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d7fa19b55964898b15740e469f423a8.json"}}, {"family": "\u00c5man Tr\u00e4ger", "given": "Andrea", "initials": "A", "orcid": "0000-0001-6180-8917", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5de952fb4f584849a7567537d861de0a.json"}}, {"family": "Seleg\u00e5rd", "given": "Robert", "initials": "R", "orcid": "0000-0002-1781-1489", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cb5b515710f4a77ab1fa32005577093.json"}}, {"family": "Winkler", "given": "Thomas E", "initials": "TE", "orcid": "0000-0002-2331-4833", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/851879d753574f5a80716e94dcc24590.json"}}, {"family": "Aili", "given": "Daniel", "initials": "D", "orcid": "0000-0002-7001-9415", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3624d34bc7734e329c0d4b465b5ac567.json"}}, {"family": "Herland", "given": "Anna", "initials": "A", "orcid": "0000-0002-5002-2537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/367ed0d139fe4136808b62ee61baa4f0.json"}}], "type": "journal article", "published": "2023-01-30", "journal": {"title": "Sci Technol Adv Mater", "issn": "1468-6996", "volume": "24", "issue": "1", "pages": "2165871", "issn-l": null}, "abstract": "Astrocytes play an important role in the central nervous system, contributing to the development of and maintenance of synapses, recycling of neurotransmitters, and the integrity and function of the blood-brain barrier. Astrocytes are also linked to the pathophysiology of various neurodegenerative diseases. Astrocyte function and organization are tightly regulated by interactions mediated by the extracellular matrix (ECM). Engineered hydrogels can mimic key aspects of the ECM and can allow for systematic studies of ECM-related factors that govern astrocyte behaviour. In this study, we explore the interactions between neuroblastoma (SH-SY5Y) and glioblastoma (U87) cell lines and human fetal primary astrocytes (FPA) with a modular hyaluronan-based hydrogel system. Morphological analysis reveals that FPA have a higher degree of interactions with the hyaluronan-based gels compared to the cell lines. This interaction is enhanced by conjugation of cell-adhesion peptides (cRGD and IKVAV) to the hyaluronan backbone. These effects are retained and pronounced in 3D bioprinted structures. Bioprinted FPA using cRGD functionalized hyaluronan show extensive and defined protrusions and multiple connections between neighboring cells. Possibilities to tailor and optimize astrocyte-compatible ECM-mimicking hydrogels that can be processed by means of additive biofabrication can facilitate the development of advanced tissue and disease models of the central nervous system.", "doi": "10.1080/14686996.2023.2165871", "pmid": "36733710", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9888471"}, {"db": "pii", "key": "2165871"}], "notes": [], "created": "2026-08-20T09:35:23.675Z", "modified": "2026-08-20T09:35:23.876Z"}, {"entity": "publication", "iuid": "849a8ded05594d20977cfe01243da26a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/849a8ded05594d20977cfe01243da26a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/849a8ded05594d20977cfe01243da26a"}}, "title": "Astrocyte 3D Culture and Bioprinting using Peptide Functionalized Hyaluronan Hydrogels", "authors": [{"family": "Matthiesen", "given": "Isabelle", "initials": "I", "orcid": "0000-0003-4787-7785", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f57ebf85ca0d4d279b4852fd66f05251.json"}}, {"family": "Jury", "given": "Michael", "initials": "M", "orcid": "0000-0003-4079-4282", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4527b2ae00a94fcb80c1abb0abac64bb.json"}}, {"family": "Boroojeni", "given": "Fatemeh Rasti", "initials": "FR", "orcid": "0000-0002-3346-4755", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71244257d00b4117b1b7e67b4ebba989.json"}}, {"family": "Ludwig", "given": "Saskia L", "initials": "SL"}, {"family": "Holzreuter", "given": "Muriel", "initials": "M", "orcid": "0000-0002-7580-3049", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/07143f4b91674a28a565da46ed4441f4.json"}}, {"family": "Buchmann", "given": "Sebastian", "initials": "S", "orcid": "0000-0001-7442-3020", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d7fa19b55964898b15740e469f423a8.json"}}, {"family": "Tr\u00e4ger", "given": "Andrea", "initials": "A", "orcid": "0000-0001-6180-8917", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5de952fb4f584849a7567537d861de0a.json"}}, {"family": "Seleg\u00e5rd", "given": "Robert", "initials": "R", "orcid": "0000-0002-1781-1489", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cb5b515710f4a77ab1fa32005577093.json"}}, {"family": "Winkler", "given": "Thomas E", "initials": "TE", "orcid": "0000-0002-2331-4833", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/851879d753574f5a80716e94dcc24590.json"}}, {"family": "Aili", "given": "Daniel", "initials": "D", "orcid": "0000-0002-7001-9415", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3624d34bc7734e329c0d4b465b5ac567.json"}}, {"family": "Herland", "given": "Anna", "initials": "A", "orcid": "0000-0002-5002-2537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/367ed0d139fe4136808b62ee61baa4f0.json"}}], "type": "posted-content", "published": "2022-10-15", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.10.13.510969", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:41:37.557Z", "modified": "2026-08-20T10:41:37.823Z"}]}