{"entity": "researcher", "timestamp": "2026-08-21T19:59:28.154Z", "family": "Brazier", "given": "Thomas", "initials": "T", "orcid": "0000-0001-5990-7545", "affiliations": ["Unit\u00e9 Mixte de Recherche (UMR) 6553 - ECOBIO (Ecosystems, Biodiversity, Evolution), University of Rennes, CNRS, Rennes, France."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c955dd4d8414331bbe62b381d6d80cd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c955dd4d8414331bbe62b381d6d80cd"}}, "publications": [{"entity": "publication", "iuid": "abef138033ac44268dfc781c96902b40", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/abef138033ac44268dfc781c96902b40.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/abef138033ac44268dfc781c96902b40"}}, "title": "Diversity in Recombination Hotspot Characteristics and Gene Structure Shape Fine-Scale Recombination Patterns in Plant Genomes.", "authors": [{"family": "Brazier", "given": "Thomas", "initials": "T", "orcid": "0000-0001-5990-7545", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c955dd4d8414331bbe62b381d6d80cd.json"}}, {"family": "Gl\u00e9min", "given": "Sylvain", "initials": "S", "orcid": "0000-0001-7260-4573", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29fc40d151df40ada3c5caf7ddc6049f.json"}}], "type": "journal article", "published": "2024-09-04", "journal": {"title": "Mol. Biol. Evol.", "issn": "1537-1719", "volume": "41", "issue": "9", "issn-l": "0737-4038"}, "abstract": "During the meiosis of many eukaryote species, crossovers tend to occur within narrow regions called recombination hotspots. In plants, it is generally thought that gene regulatory sequences, especially promoters and 5' to 3' untranslated regions, are enriched in hotspots, but this has been characterized in a handful of species only. We also lack a clear description of fine-scale variation in recombination rates within genic regions and little is known about hotspot position and intensity in plants. To address this question, we constructed fine-scale recombination maps from genetic polymorphism data and inferred recombination hotspots in 11 plant species. We detected gradients of recombination in genic regions in most species, yet gradients varied in intensity and shape depending on specific hotspot locations and gene structure. To further characterize recombination gradients, we decomposed them according to gene structure by rank and number of exons. We generalized the previously observed pattern that recombination hotspots are organized around the boundaries of coding sequences, especially 5' promoters. However, our results also provided new insight into the relative importance of the 3' end of genes in some species and the possible location of hotspots away from genic regions in some species. Variation among species seemed driven more by hotspot location among and within genes than by differences in size or intensity among species. Our results shed light on the variation in recombination rates at a very fine scale, revealing the diversity and complexity of genic recombination gradients emerging from the interaction between hotspot location and gene structure.", "doi": "10.1093/molbev/msae183", "pmid": "39302634", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11414407"}, {"db": "pii", "key": "7762553"}], "notes": [], "created": "2026-08-21T12:10:32.815Z", "modified": "2026-08-21T12:10:32.897Z"}, {"entity": "publication", "iuid": "ca5fefb489654cceabed8e7725a6ed80", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ca5fefb489654cceabed8e7725a6ed80.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ca5fefb489654cceabed8e7725a6ed80"}}, "title": "Diversity and determinants of recombination landscapes in flowering plants.", "authors": [{"family": "Brazier", "given": "Thomas", "initials": "T", "orcid": "0000-0001-5990-7545", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c955dd4d8414331bbe62b381d6d80cd.json"}}, {"family": "Gl\u00e9min", "given": "Sylvain", "initials": "S", "orcid": "0000-0001-7260-4573", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/29fc40d151df40ada3c5caf7ddc6049f.json"}}], "type": "journal article", "published": "2022-08-00", "journal": {"title": "PLoS Genet", "issn": "1553-7404", "volume": "18", "issue": "8", "pages": "e1010141", "issn-l": "1553-7390"}, "abstract": "During meiosis, crossover rates are not randomly distributed along the chromosome and their location may have a strong impact on the functioning and evolution of the genome. To date, the broad diversity of recombination landscapes among plants has rarely been investigated and a formal comparative genomic approach is still needed to characterize and assess the determinants of recombination landscapes among species and chromosomes. We gathered genetic maps and genomes for 57 flowering plant species, corresponding to 665 chromosomes, for which we estimated large-scale recombination landscapes. We found that the number of crossover per chromosome spans a limited range (between one to five/six) whatever the genome size, and that there is no single relationship across species between genetic map length and chromosome size. Instead, we found a general relationship between the relative size of chromosomes and recombination rate, while the absolute length constrains the basal recombination rate for each species. At the chromosome level, we identified two main patterns (with a few exceptions) and we proposed a conceptual model explaining the broad-scale distribution of crossovers where both telomeres and centromeres play a role. These patterns correspond globally to the underlying gene distribution, which affects how efficiently genes are shuffled at meiosis. These results raised new questions not only on the evolution of recombination rates but also on their distribution along chromosomes.", "doi": "10.1371/journal.pgen.1010141", "pmid": "36040927", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9467342"}, {"db": "pii", "key": "PGENETICS-D-22-00286"}], "notes": [], "created": "2026-08-21T12:45:11.443Z", "modified": "2026-08-21T12:45:11.501Z"}]}