{"entity": "researcher", "timestamp": "2026-09-28T12:22:42.010Z", "family": "Yazdi", "given": "Samira", "initials": "S", "orcid": "0000-0003-2198-4590", "affiliations": ["Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c6d3b64800c44fdbb2211cc5230a42d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c6d3b64800c44fdbb2211cc5230a42d"}}, "publications": [{"entity": "publication", "iuid": "b0dd278be5de46709e098456c7e0855e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b0dd278be5de46709e098456c7e0855e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b0dd278be5de46709e098456c7e0855e"}}, "title": "A drug pocket at the lipid bilayer-potassium channel interface.", "authors": [{"family": "Ottosson", "given": "Nina E", "initials": "NE", "orcid": "0000-0003-2159-6731", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/435eb22b7d194cb5969454cc3e180e9a.json"}}, {"family": "Silver\u00e5 Ejneby", "given": "Malin", "initials": "M", "orcid": "0000-0002-8151-5430", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ad77e0bdda864923a0a4c5d108a4ddd7.json"}}, {"family": "Wu", "given": "Xiongyu", "initials": "X"}, {"family": "Yazdi", "given": "Samira", "initials": "S", "orcid": "0000-0003-2198-4590", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c6d3b64800c44fdbb2211cc5230a42d.json"}}, {"family": "Konradsson", "given": "Peter", "initials": "P"}, {"family": "Lindahl", "given": "Erik", "initials": "E", "orcid": "0000-0002-2734-2794", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9eb30fa60f9b4b95842ac9d9f3a0eaa9.json"}}, {"family": "Elinder", "given": "Fredrik", "initials": "F", "orcid": "0000-0001-9125-5583", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6af26d4c0637492696fb91a3417fe902.json"}}], "type": "journal article", "published": "2017-10-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "3", "issue": "10", "pages": "e1701099", "issn-l": "2375-2548"}, "abstract": "Many pharmaceutical drugs against neurological and cardiovascular disorders exert their therapeutic effects by binding to specific sites on voltage-gated ion channels of neurons or cardiomyocytes. To date, all molecules targeting known ion channel sites bind to protein pockets that are mainly surrounded by water. We describe a lipid-protein drug-binding pocket of a potassium channel. We synthesized and electrophysiologically tested 125 derivatives, analogs, and related compounds to dehydroabietic acid. Functional data in combination with docking and molecular dynamics simulations mapped a binding site for small-molecule compounds at the interface between the lipid bilayer and the transmembrane segments S3 and S4 of the voltage-sensor domain. This fundamentally new binding site for small-molecule compounds paves the way for the design of new types of drugs against diseases caused by altered excitability.", "doi": "10.1126/sciadv.1701099", "pmid": "29075666", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5656419"}, {"db": "pii", "key": "1701099"}], "notes": [], "created": "2018-12-05T12:07:48.359Z", "modified": "2026-09-23T11:46:19.431Z"}]}